BacMap

Definition	Propionibacterium acnes KPA171202, complete genome.
Accession	NC_006085
Length	2,560,265

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The map label for this gene is adhP [C]

Identifier: 50842023

GI number: 50842023

Start: 590844

End: 591899

Strand: Reverse

Name: adhP [C]

Synonym: PPA0539

Alternate gene names: 50842023

Gene position: 591899-590844 (Counterclockwise)

Preceding gene: 50842024

Following gene: 50842022

Centisome position: 23.12

GC content: 60.04

Gene sequence:

>1056_bases
ATGAAGGCAGCACTAGTTGAGCAGTACCACGAACCATTAGCCATCAGGGATATTCCTGAGCCAGCTCATGATTCGGACGG
TGTGGTCGTCGAGGTGAAAGCCTGCGGCGTCTGTCGAAGCGACTGGCACGGCTGGCAGGGCGAGTGGCCAGGATTTACCG
GCGGCTCCTTGCCTCACATCTTCGGACACGAGTTCGTCGGGCTGGTCAGTGACATCGGCAACAACGTGAGCCGATACCGC
GTGGGAGACCGGGTGATTGTCCCCTTCACATTGGGTTGCGGTCACTGCGAGTACTGCCGGAGCGGTCATTCAAACGTCTG
CCCTACCGTGTCCATGCCCGGTTTCAGCTATGACGGCGGATTCGCGCAATATGTCACCGTCCCCGACGCAGATGCCAACC
TCGTGAAGCTCCCCGACGCCGTCGATTTCACCGATGCTGCGGGTATGGGCTGCCGCCTCATGACCGCCTACCACGGCATC
GTCGAGGTGGGACAGATCCACCCCGGTGACTGGCTTGTCGTCTATGGTGCAGGCGGCGTGGGTCTGTCGGCCACCCTCGT
CGCTACCAGCGCAGGGGCAAACGTCATTGCCGTCGACATCGCAGATGACAAACTTGCCTTGGCTCGCAAGGTCGGGGCTA
TCGCGACCATCAATTCGCGCGAAACCGACCCAGTGGAGGCAGTTCGTGAGCTGACCGACGGAGGCGCGGACAAGAGCGTC
GACGCCCTGGGCATTTCCGAAACTCTGCACAACGCGGTCAACTCATTGCGTTCCCGAGGAACCCATATTCAGATCGGCAT
GACTGCAGAGGGGCCAGTCGGCGACGTGGCGTTGACGATCAACGACCTCATTGCCAAGGAGATTGATTTCCGGGGGTCCT
TCGGAATGCCTGCCGTCGAGTTCCGTTACCTGCTCAATCAGGTTGCTGCGGGCAAGATGAAACCAGGCCAGCTCGTCACC
AAAACCATCGCACTGAGTGAGGTGAACGACGCTCTCACCGCCATGTCCACCTACAACACGGTGGGAACCACCGTCATTAC
CGACTTCACACGCTGA

Upstream 100 bases:

>100_bases
AGTGCCAGCAGGGCGTCGGACAGCCCGGGTGTATCGAATTTCTACGGCGCACCGGTTGTGACGTAGACCATAACGGGATC
AACAGAAAGCGGCACTAGCA

Downstream 100 bases:

>100_bases
GGCAGACCTTCGTGGTTGGGTGCAAACTGCGCGCCCAACCACGTTTGTGTCGCTACACAGCGTGGAATGGGACGGCGTAT
GACTGTTGCACGGCTAATGC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: ADH-HT [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MKAALVEQYHEPLAIRDIPEPAHDSDGVVVEVKACGVCRSDWHGWQGEWPGFTGGSLPHIFGHEFVGLVSDIGNNVSRYR
VGDRVIVPFTLGCGHCEYCRSGHSNVCPTVSMPGFSYDGGFAQYVTVPDADANLVKLPDAVDFTDAAGMGCRLMTAYHGI
VEVGQIHPGDWLVVYGAGGVGLSATLVATSAGANVIAVDIADDKLALARKVGAIATINSRETDPVEAVRELTDGGADKSV
DALGISETLHNAVNSLRSRGTHIQIGMTAEGPVGDVALTINDLIAKEIDFRGSFGMPAVEFRYLLNQVAAGKMKPGQLVT
KTIALSEVNDALTAMSTYNTVGTTVITDFTR

Sequences:

>Translated_351_residues
MKAALVEQYHEPLAIRDIPEPAHDSDGVVVEVKACGVCRSDWHGWQGEWPGFTGGSLPHIFGHEFVGLVSDIGNNVSRYR
VGDRVIVPFTLGCGHCEYCRSGHSNVCPTVSMPGFSYDGGFAQYVTVPDADANLVKLPDAVDFTDAAGMGCRLMTAYHGI
VEVGQIHPGDWLVVYGAGGVGLSATLVATSAGANVIAVDIADDKLALARKVGAIATINSRETDPVEAVRELTDGGADKSV
DALGISETLHNAVNSLRSRGTHIQIGMTAEGPVGDVALTINDLIAKEIDFRGSFGMPAVEFRYLLNQVAAGKMKPGQLVT
KTIALSEVNDALTAMSTYNTVGTTVITDFTR
>Mature_351_residues
MKAALVEQYHEPLAIRDIPEPAHDSDGVVVEVKACGVCRSDWHGWQGEWPGFTGGSLPHIFGHEFVGLVSDIGNNVSRYR
VGDRVIVPFTLGCGHCEYCRSGHSNVCPTVSMPGFSYDGGFAQYVTVPDADANLVKLPDAVDFTDAAGMGCRLMTAYHGI
VEVGQIHPGDWLVVYGAGGVGLSATLVATSAGANVIAVDIADDKLALARKVGAIATINSRETDPVEAVRELTDGGADKSV
DALGISETLHNAVNSLRSRGTHIQIGMTAEGPVGDVALTINDLIAKEIDFRGSFGMPAVEFRYLLNQVAAGKMKPGQLVT
KTIALSEVNDALTAMSTYNTVGTTVITDFTR

Specific function: Thermophilic NAD(+)-dependent alcohol dehydrogenase. Bears mainly an ethanol-dehydrogenase activity [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=376, Percent_Identity=30.0531914893617, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI34577061, Length=378, Percent_Identity=29.1005291005291, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI71565154, Length=373, Percent_Identity=28.1501340482574, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI71565152, Length=383, Percent_Identity=29.5039164490862, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI4501929, Length=377, Percent_Identity=29.1777188328912, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI262073058, Length=370, Percent_Identity=27.027027027027, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI71743840, Length=370, Percent_Identity=27.027027027027, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=25.4742547425474, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI4501939, Length=369, Percent_Identity=25.4742547425474, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI156627571, Length=340, Percent_Identity=25.2941176470588, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI194239674, Length=322, Percent_Identity=25.4658385093168, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI13236495, Length=322, Percent_Identity=25.4658385093168, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI22538446, Length=287, Percent_Identity=27.5261324041812, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI22538444, Length=287, Percent_Identity=27.5261324041812, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI194239676, Length=233, Percent_Identity=24.8927038626609, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI87081918, Length=352, Percent_Identity=33.2386363636364, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1787863, Length=359, Percent_Identity=31.1977715877437, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI1788075, Length=351, Percent_Identity=27.0655270655271, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI87082125, Length=348, Percent_Identity=29.0229885057471, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=26.099706744868, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI226510992, Length=307, Percent_Identity=28.9902280130293, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788073, Length=323, Percent_Identity=29.1021671826625, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1786825, Length=285, Percent_Identity=29.8245614035088, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1786552, Length=373, Percent_Identity=28.686327077748, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790718, Length=318, Percent_Identity=27.3584905660377, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788407, Length=283, Percent_Identity=29.3286219081272, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1786518, Length=227, Percent_Identity=32.15859030837, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1790485, Length=263, Percent_Identity=29.277566539924, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87082401, Length=309, Percent_Identity=28.1553398058252, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71988145, Length=352, Percent_Identity=29.2613636363636, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17562876, Length=331, Percent_Identity=31.1178247734139, Blast_Score=137, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17562584, Length=296, Percent_Identity=32.4324324324324, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17562878, Length=316, Percent_Identity=31.3291139240506, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17562582, Length=296, Percent_Identity=29.3918918918919, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI25146526, Length=302, Percent_Identity=27.1523178807947, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71997431, Length=302, Percent_Identity=26.8211920529801, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17565904, Length=247, Percent_Identity=26.7206477732794, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=351, Percent_Identity=29.9145299145299, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323729, Length=338, Percent_Identity=29.585798816568, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323961, Length=350, Percent_Identity=28.5714285714286, Blast_Score=135, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6319621, Length=351, Percent_Identity=30.1994301994302, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320033, Length=377, Percent_Identity=26.2599469496021, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6322619, Length=329, Percent_Identity=30.0911854103343, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319955, Length=329, Percent_Identity=30.0911854103343, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6319258, Length=324, Percent_Identity=28.3950617283951, Blast_Score=109, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6323099, Length=333, Percent_Identity=28.2282282282282, Blast_Score=106, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6319257, Length=323, Percent_Identity=26.625386996904, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319520, Length=344, Percent_Identity=24.4186046511628, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6323980, Length=225, Percent_Identity=31.5555555555556, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6319949, Length=219, Percent_Identity=31.5068493150685, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17737895, Length=371, Percent_Identity=27.2237196765499, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI17737897, Length=326, Percent_Identity=30.3680981595092, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17137530, Length=326, Percent_Identity=29.7546012269939, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI45550770, Length=356, Percent_Identity=24.438202247191, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45551930, Length=356, Percent_Identity=24.438202247191, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI221457811, Length=356, Percent_Identity=24.438202247191, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37075; Mature: 37075

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAALVEQYHEPLAIRDIPEPAHDSDGVVVEVKACGVCRSDWHGWQGEWPGFTGGSLPHI
CCCHHHHHHCCCEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHH
FGHEFVGLVSDIGNNVSRYRVGDRVIVPFTLGCGHCEYCRSGHSNVCPTVSMPGFSYDGG
HHHHHHHHHHHHCCCCEEEECCCEEEEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCCCC
FAQYVTVPDADANLVKLPDAVDFTDAAGMGCRLMTAYHGIVEVGQIHPGDWLVVYGAGGV
EEEEEECCCCCCCEEECCCCCCCCCCCCCCEEHHHHHHHHHEECEECCCCEEEEECCCCC
GLSATLVATSAGANVIAVDIADDKLALARKVGAIATINSRETDPVEAVRELTDGGADKSV
CCEEEEEEECCCCEEEEEEECCCHHHHHHHHCCEEEECCCCCCHHHHHHHHHCCCCCCCC
DALGISETLHNAVNSLRSRGTHIQIGMTAEGPVGDVALTINDLIAKEIDFRGSFGMPAVE
HHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEHHHHHHHHHCCCCCCCCCHHH
FRYLLNQVAAGKMKPGQLVTKTIALSEVNDALTAMSTYNTVGTTVITDFTR
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
>Mature Secondary Structure
MKAALVEQYHEPLAIRDIPEPAHDSDGVVVEVKACGVCRSDWHGWQGEWPGFTGGSLPHI
CCCHHHHHHCCCEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHH
FGHEFVGLVSDIGNNVSRYRVGDRVIVPFTLGCGHCEYCRSGHSNVCPTVSMPGFSYDGG
HHHHHHHHHHHHCCCCEEEECCCEEEEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCCCC
FAQYVTVPDADANLVKLPDAVDFTDAAGMGCRLMTAYHGIVEVGQIHPGDWLVVYGAGGV
EEEEEECCCCCCCEEECCCCCCCCCCCCCCEEHHHHHHHHHEECEECCCCEEEEECCCCC
GLSATLVATSAGANVIAVDIADDKLALARKVGAIATINSRETDPVEAVRELTDGGADKSV
CCEEEEEEECCCCEEEEEEECCCHHHHHHHHCCEEEECCCCCCHHHHHHHHHCCCCCCCC
DALGISETLHNAVNSLRSRGTHIQIGMTAEGPVGDVALTINDLIAKEIDFRGSFGMPAVE
HHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEHHHHHHHHHCCCCCCCCCHHH
FRYLLNQVAAGKMKPGQLVTKTIALSEVNDALTAMSTYNTVGTTVITDFTR
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8020473 [H]