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The map label for this gene is moaE2 [H]

Identifier: 50841984

GI number: 50841984

Start: 550267

End: 550689

Strand: Reverse

Name: moaE2 [H]

Synonym: PPA0500

Alternate gene names: 50841984

Gene position: 550689-550267 (Counterclockwise)

Preceding gene: 50841985

Following gene: 50841983

Centisome position: 21.51

GC content: 64.07

Gene sequence:

>423_bases
ATGCACGCCAAGATCAGTGACGAGCCGCTGAACGTCGCCAAGGTCGTCAGCTTGGTGAGTGACGACCGCAGTGGCGCTGT
CGTGACTTTCACCGGAGTGGTTCGCAACCACGATGGCGGCCAGTCCATTACAGCCATCGACTATAGTGCCCACCCCCATG
CCACGCAGATCTTGGCAGACCTAGTCGAACAGTGCGCCACGCGCGATGGCGTCCACGGCGTAGCTGCCGAGCACCGAATC
GGCCACGTGGAGGTCGGCGGGACAGCGATGGTCGTGGCCGTGTCGGCAGACCACCGCGGGCAAGCATTTGAGGCGGCCTG
TGAATTCGTCGACGCCGTTAAGGAAAGCCTGCCGGTGTGGAAGTGCCAATGGCTCACTGACGGCTCCCACGAATGGGCCG
GGCTGCCCGGGGAGGAGCCGTGA

Upstream 100 bases:

>100_bases
AGTGTGCACCCTGTTCGTCGACGGATCTGCTGTCCGCGGTGAACAGATCGTGCCCGCGAGAGCCCAGGTTGAGGTCCTTC
CACCATTTGCAGGAGGGTGA

Downstream 100 bases:

>100_bases
GCAGCTCTCGTTCCAGCGTGCCCGCCACGACGCCAAAGCCAGTGAGCATCGCACGGCACCTGCAACTGGTCTCCTCACTG
GCTACCGCACCCAAGACAGT

Product: molybdopterin synthase MoaE

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E 2; Molybdopterin-converting factor large subunit 2; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MHAKISDEPLNVAKVVSLVSDDRSGAVVTFTGVVRNHDGGQSITAIDYSAHPHATQILADLVEQCATRDGVHGVAAEHRI
GHVEVGGTAMVVAVSADHRGQAFEAACEFVDAVKESLPVWKCQWLTDGSHEWAGLPGEEP

Sequences:

>Translated_140_residues
MHAKISDEPLNVAKVVSLVSDDRSGAVVTFTGVVRNHDGGQSITAIDYSAHPHATQILADLVEQCATRDGVHGVAAEHRI
GHVEVGGTAMVVAVSADHRGQAFEAACEFVDAVKESLPVWKCQWLTDGSHEWAGLPGEEP
>Mature_140_residues
MHAKISDEPLNVAKVVSLVSDDRSGAVVTFTGVVRNHDGGQSITAIDYSAHPHATQILADLVEQCATRDGVHGVAAEHRI
GHVEVGGTAMVVAVSADHRGQAFEAACEFVDAVKESLPVWKCQWLTDGSHEWAGLPGEEP

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=128, Percent_Identity=30.46875, Blast_Score=71, Evalue=4e-13,
Organism=Escherichia coli, GI1787003, Length=121, Percent_Identity=35.5371900826446, Blast_Score=76, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17509279, Length=129, Percent_Identity=31.0077519379845, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356259, Length=137, Percent_Identity=27.007299270073, Blast_Score=66, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 14832; Mature: 14832

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAKISDEPLNVAKVVSLVSDDRSGAVVTFTGVVRNHDGGQSITAIDYSAHPHATQILAD
CCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEEEEEECCCCCEEEEEECCCCCCHHHHHHH
LVEQCATRDGVHGVAAEHRIGHVEVGGTAMVVAVSADHRGQAFEAACEFVDAVKESLPVW
HHHHHHCCCCCCCCCCCCCCCEEEECCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCE
KCQWLTDGSHEWAGLPGEEP
EEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MHAKISDEPLNVAKVVSLVSDDRSGAVVTFTGVVRNHDGGQSITAIDYSAHPHATQILAD
CCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEEEEEECCCCCEEEEEECCCCCCHHHHHHH
LVEQCATRDGVHGVAAEHRIGHVEVGGTAMVVAVSADHRGQAFEAACEFVDAVKESLPVW
HHHHHHCCCCCCCCCCCCCCCEEEECCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCE
KCQWLTDGSHEWAGLPGEEP
EEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]