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The map label for this gene is trxA [H]

Identifier: 50841970

GI number: 50841970

Start: 537474

End: 537839

Strand: Direct

Name: trxA [H]

Synonym: PPA0487

Alternate gene names: 50841970

Gene position: 537474-537839 (Clockwise)

Preceding gene: 50841969

Following gene: 50841971

Centisome position: 20.99

GC content: 56.28

Gene sequence:

>366_bases
GTGGCTACCGTCGCATTGACTAAAGACAACTTCTCCTCGACCATCGATTCCAATGATGTCGTTCTCATTGACTTCTGGGC
CTCCTGGTGTGGACCATGCCAGCGGTTTTCACCAATCTATGAGGACGCCAGTGGACGTCACTCTGACGTGACCTTCGCCA
AGGTCGACACCGAGGACCAGCAGGAACTGTCTGCCGGTCTGGAGATCACCTCCATCCCGACGATCATGGCCTTCCGTGCC
GGATACCTTGTTTTCCGCCAGTCAGGCCTGCTGCAAGGTCGCCAGCTTGATGAGCTTATTGAGAAGGTCAAGGAGATCGA
CGTCGAGGATCTCAAGAAGCAGGCCGCGGCCCAAAACCAGGGCTGA

Upstream 100 bases:

>100_bases
TCGGGAATAGCCTGGCGCCTGATGCTGTTTGACGACATACGGGCCGAGGCGCCACGGCGTTGCGGTCGACCGAACCCAAG
CAATTACCGGGAGGTACAAC

Downstream 100 bases:

>100_bases
CACCGGGCTTTCCATACCCAGCTGAAACGCGGAGCTCAGGGCCGGCGGCAGGTGGTAGCGTCCTGCTGTCGGCCTGTGCT
TCGTCATATCTCATGAGACG

Product: thiol-disulfide isomerase

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 121; Mature: 120

Protein sequence:

>121_residues
MATVALTKDNFSSTIDSNDVVLIDFWASWCGPCQRFSPIYEDASGRHSDVTFAKVDTEDQQELSAGLEITSIPTIMAFRA
GYLVFRQSGLLQGRQLDELIEKVKEIDVEDLKKQAAAQNQG

Sequences:

>Translated_121_residues
MATVALTKDNFSSTIDSNDVVLIDFWASWCGPCQRFSPIYEDASGRHSDVTFAKVDTEDQQELSAGLEITSIPTIMAFRA
GYLVFRQSGLLQGRQLDELIEKVKEIDVEDLKKQAAAQNQG
>Mature_120_residues
ATVALTKDNFSSTIDSNDVVLIDFWASWCGPCQRFSPIYEDASGRHSDVTFAKVDTEDQQELSAGLEITSIPTIMAFRAG
YLVFRQSGLLQGRQLDELIEKVKEIDVEDLKKQAAAQNQG

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4758304, Length=83, Percent_Identity=36.144578313253, Blast_Score=73, Evalue=4e-14,
Organism=Homo sapiens, GI50592994, Length=85, Percent_Identity=34.1176470588235, Blast_Score=67, Evalue=4e-12,
Organism=Homo sapiens, GI21361403, Length=90, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1788936, Length=83, Percent_Identity=46.9879518072289, Blast_Score=82, Evalue=1e-17,
Organism=Escherichia coli, GI87082331, Length=100, Percent_Identity=30, Blast_Score=66, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=91, Percent_Identity=39.5604395604396, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17554386, Length=106, Percent_Identity=33.0188679245283, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17569137, Length=82, Percent_Identity=36.5853658536585, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32566189, Length=82, Percent_Identity=36.5853658536585, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193209454, Length=82, Percent_Identity=36.5853658536585, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71980565, Length=86, Percent_Identity=30.2325581395349, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=86, Percent_Identity=31.3953488372093, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI115532254, Length=124, Percent_Identity=29.8387096774194, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115532252, Length=124, Percent_Identity=29.8387096774194, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17507705, Length=98, Percent_Identity=30.6122448979592, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=82, Percent_Identity=34.1463414634146, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=90, Percent_Identity=32.2222222222222, Blast_Score=67, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6323072, Length=89, Percent_Identity=31.4606741573034, Blast_Score=66, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319925, Length=79, Percent_Identity=32.9113924050633, Blast_Score=63, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24658597, Length=86, Percent_Identity=34.8837209302326, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639068, Length=99, Percent_Identity=27.2727272727273, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 13431; Mature: 13300

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVALTKDNFSSTIDSNDVVLIDFWASWCGPCQRFSPIYEDASGRHSDVTFAKVDTEDQ
CCEEEEECCCCCCCCCCCCEEEEEEHHHHCCHHHHCCHHHHCCCCCCCCEEEEEECCCHH
QELSAGLEITSIPTIMAFRAGYLVFRQSGLLQGRQLDELIEKVKEIDVEDLKKQAAAQNQ
HHHHCCCCHHCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCC
G
C
>Mature Secondary Structure 
ATVALTKDNFSSTIDSNDVVLIDFWASWCGPCQRFSPIYEDASGRHSDVTFAKVDTEDQ
CEEEEECCCCCCCCCCCCEEEEEEHHHHCCHHHHCCHHHHCCCCCCCCEEEEEECCCHH
QELSAGLEITSIPTIMAFRAGYLVFRQSGLLQGRQLDELIEKVKEIDVEDLKKQAAAQNQ
HHHHCCCCHHCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9359865; 10632710 [H]