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The map label for this gene is dtxR [H]

Identifier: 50841968

GI number: 50841968

Start: 535554

End: 536252

Strand: Direct

Name: dtxR [H]

Synonym: PPA0485

Alternate gene names: 50841968

Gene position: 535554-536252 (Clockwise)

Preceding gene: 50841967

Following gene: 50841969

Centisome position: 20.92

GC content: 60.09

Gene sequence:

>699_bases
GTGAGTAGTGAACTCGTTGACACGACGGAGATGTATCTGCGGACTTTCTACGAGCTACTCGAGGAGGGTGTCGAACTGCG
TCGAGCCCGTATCGTTGAGCGGCTGCACCAGTCTGGCCCGACCGTCTCCCAGACCGTGGCTCGTATGGAGCGTGACGGCC
TTGTGGTCGTCGAGTCTGATCGCTCGATCTCGCTGACCCAGGAAGGCCACGACGTGGCTCAGACTGTTATGCGCAAGCAT
CGCCTGGCCGAGTGCCTGCTTACCCAAATCATTGGTCTTCGTCCCGACTTGGTGCACGATGAAGCCTGCCGCTGGGAGCA
CGTCATTTCCGGCGAAGTTGAGAAGCGCCTCACGGGGCTCCTCGAGAACCCTGATGTTTCTCCATACGGGTGCCCACTGC
CGCCTGAGCAGGCAGGGTGTCGTCCGGATGGTTCCGCCCGCTTTCGTGACGACTCCAAGCCCCTAGATGAGGTTATCGCC
GAGACTGGCTGCCCGGTCAGCGTGACCGTCACCCGGTTGTCGGAGTTCTTCCAAGCTACCGAGGGTAATCTCGCGGACGT
CTACGCTGCCGGCTTATTGCCGGGTAAGAGCGTCGAGGTCGATGATGACGCCGATGGTATTCGTTTGACGGGCCCCAGTG
GTTCTATCGTCGTCGATCCGGAGATTCTCTCGGGTCTGTTCGTCGCTCAGAATTCGTGA

Upstream 100 bases:

>100_bases
CGTAAGCAATGGCGCCCGAAAGATTGTTGACAGTTAGCTTGTCCAGTGGGCAAGCGGCTAGCGTCGTCCCTCGGCTGTGA
GGGCGGGGAAGAGGTGCACC

Downstream 100 bases:

>100_bases
GTTGCGCTGACTACGCCGTGATGGGTGTGCCTCAAGTCGTGTGTCCCAGCCAGTTGCCGGACCTGGACCAGATTGCCGCC
CTCTGCGAGTCAGGCTGGTA

Product: repressor

Products: NA

Alternate protein names: Iron-dependent diphtheria tox regulatory element; Tox regulatory factor [H]

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MSSELVDTTEMYLRTFYELLEEGVELRRARIVERLHQSGPTVSQTVARMERDGLVVVESDRSISLTQEGHDVAQTVMRKH
RLAECLLTQIIGLRPDLVHDEACRWEHVISGEVEKRLTGLLENPDVSPYGCPLPPEQAGCRPDGSARFRDDSKPLDEVIA
ETGCPVSVTVTRLSEFFQATEGNLADVYAAGLLPGKSVEVDDDADGIRLTGPSGSIVVDPEILSGLFVAQNS

Sequences:

>Translated_232_residues
MSSELVDTTEMYLRTFYELLEEGVELRRARIVERLHQSGPTVSQTVARMERDGLVVVESDRSISLTQEGHDVAQTVMRKH
RLAECLLTQIIGLRPDLVHDEACRWEHVISGEVEKRLTGLLENPDVSPYGCPLPPEQAGCRPDGSARFRDDSKPLDEVIA
ETGCPVSVTVTRLSEFFQATEGNLADVYAAGLLPGKSVEVDDDADGIRLTGPSGSIVVDPEILSGLFVAQNS
>Mature_231_residues
SSELVDTTEMYLRTFYELLEEGVELRRARIVERLHQSGPTVSQTVARMERDGLVVVESDRSISLTQEGHDVAQTVMRKHR
LAECLLTQIIGLRPDLVHDEACRWEHVISGEVEKRLTGLLENPDVSPYGCPLPPEQAGCRPDGSARFRDDSKPLDEVIAE
TGCPVSVTVTRLSEFFQATEGNLADVYAAGLLPGKSVEVDDDADGIRLTGPSGSIVVDPEILSGLFVAQNS

Specific function: Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression. Represses ripA under iron excess [H]

COG id: COG1321

COG function: function code K; Mn-dependent transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH dtxR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007167
- InterPro:   IPR001367
- InterPro:   IPR022689
- InterPro:   IPR022687
- InterPro:   IPR008988
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02742 Fe_dep_repr_C; PF01325 Fe_dep_repress [H]

EC number: NA

Molecular weight: Translated: 25431; Mature: 25300

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: PS50944 HTH_DTXR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSELVDTTEMYLRTFYELLEEGVELRRARIVERLHQSGPTVSQTVARMERDGLVVVESD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECC
RSISLTQEGHDVAQTVMRKHRLAECLLTQIIGLRPDLVHDEACRWEHVISGEVEKRLTGL
CCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LENPDVSPYGCPLPPEQAGCRPDGSARFRDDSKPLDEVIAETGCPVSVTVTRLSEFFQAT
HCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHC
EGNLADVYAAGLLPGKSVEVDDDADGIRLTGPSGSIVVDPEILSGLFVAQNS
CCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCEEECHHHHCCCHHCCCC
>Mature Secondary Structure 
SSELVDTTEMYLRTFYELLEEGVELRRARIVERLHQSGPTVSQTVARMERDGLVVVESD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECC
RSISLTQEGHDVAQTVMRKHRLAECLLTQIIGLRPDLVHDEACRWEHVISGEVEKRLTGL
CCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LENPDVSPYGCPLPPEQAGCRPDGSARFRDDSKPLDEVIAETGCPVSVTVTRLSEFFQAT
HCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHC
EGNLADVYAAGLLPGKSVEVDDDADGIRLTGPSGSIVVDPEILSGLFVAQNS
CCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCEEECHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2116013; 1735717; 14602910; 1502169; 1400485; 8823163; 7568230; 9697776; 10085021; 10339551 [H]