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The map label for this gene is idhA [H]

Identifier: 50841952

GI number: 50841952

Start: 518116

End: 519183

Strand: Direct

Name: idhA [H]

Synonym: PPA0469

Alternate gene names: 50841952

Gene position: 518116-519183 (Clockwise)

Preceding gene: 50841950

Following gene: 50841953

Centisome position: 20.24

GC content: 58.24

Gene sequence:

>1068_bases
ATGACGGGCTTTGTGCTAACATTAGGGAGTCTTGCCGTTACTGGTGAGAATCCAGCTTTGTCGAACACAGGGGTTCACAG
CATGATCAGGATCGCCATCATTGGAGCCGGACGCATCGGTCACGTCCATGCCCGAGCCATTCAAGGACGCAACGATGTCA
CGTTGGCGCTCGTTTGTGACCCATTCGAGCAGAACGCGCGTGCTCTCGCTGGTGAGTATGACGTGCGCTATTGCTTGGAT
CCGGACGAGGTTTTCGACGACTCCACAATCGACGCTGTTGTCATTGGGTCTCCAACCCAGTTCCATGTCGACCATATCCT
CAAGGCCGTCAATGGTGGCAAACGAGTGATGTGTGAGAAGCCGATCGCACTGGACGTCGAGTCCGCCAAGAGGTGCATCA
ACGAACTGGGTGATCGCGCCGATCAGGTGATGATGGGGTTCAACCGCCGTTTCGACCCGACGTTCAGCGCGTTGAAGAGC
CGCCTCGACGATGGGGAGATCGGTAGCCTGCAGCAGCTCACCGTGATCTCCCGAGACCCGGCAGCCCCGTCGGCGTCCTA
CATCGCGGGGTCCGGGGGCATCTTCAAAGATATGACGATCCATGATTTCGACATGGTGCGGCATTTCCTTGGTGACATTG
CAGAGGTTAACGCCGTGGGCACCAATGTCTCCCCGGAGATCGCTGAGCAGGGCGACTTCGATCAAGTAATTGTCACCCTG
AAATCACGTGACGGCAAGCTCGCCACCATCATCAACTCGCGGACCTGCGCCTTCGGATACGATCAGCGTTTAGAGGCATT
TGGGGCCGACGGCATGCTTAGCGCCGACAACCTCACCGACGCCGCAGTGCGCATGGCCACTAGTACCCAAACCGACGCGA
AGACCGCAATCATGGACTTTTTCCTTGAGCGTTACGAAGACGCCTACCGCATCGAGTTGGAAACCTTCCTTGACTCGATC
GCCATCGGCGGTGCGGTTTCTCCGTCGGTGCGTGACGGCTATGAGGCCCTTGTCCTGGCCGATGCAGCTACGCGTAGCGC
CCAGGAGCATCGCGTCGTCGCCCTGTGA

Upstream 100 bases:

>100_bases
TCTTGGAGGCCTGAGCTCCTGTGCATCAGGCCGCTCTCGGTAGTATATGTCCTGTCAAATAGTGGGGCAATAGCTGTCGC
TGGCGTGGGAATCGGTATTG

Downstream 100 bases:

>100_bases
TGCCACTCGGTACGATCACGGGGTGAGCACCGATAACCAATGCTCGACGGGTTCGTTGTCCGGGGACGCTGAACCCGTCG
AAGTGCCGCCACAACACGGC

Product: putative myo-inositol 2-dehydrogenase

Products: NA

Alternate protein names: Myo-inositol 2-dehydrogenase; MI-dehydrogenase [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MTGFVLTLGSLAVTGENPALSNTGVHSMIRIAIIGAGRIGHVHARAIQGRNDVTLALVCDPFEQNARALAGEYDVRYCLD
PDEVFDDSTIDAVVIGSPTQFHVDHILKAVNGGKRVMCEKPIALDVESAKRCINELGDRADQVMMGFNRRFDPTFSALKS
RLDDGEIGSLQQLTVISRDPAAPSASYIAGSGGIFKDMTIHDFDMVRHFLGDIAEVNAVGTNVSPEIAEQGDFDQVIVTL
KSRDGKLATIINSRTCAFGYDQRLEAFGADGMLSADNLTDAAVRMATSTQTDAKTAIMDFFLERYEDAYRIELETFLDSI
AIGGAVSPSVRDGYEALVLADAATRSAQEHRVVAL

Sequences:

>Translated_355_residues
MTGFVLTLGSLAVTGENPALSNTGVHSMIRIAIIGAGRIGHVHARAIQGRNDVTLALVCDPFEQNARALAGEYDVRYCLD
PDEVFDDSTIDAVVIGSPTQFHVDHILKAVNGGKRVMCEKPIALDVESAKRCINELGDRADQVMMGFNRRFDPTFSALKS
RLDDGEIGSLQQLTVISRDPAAPSASYIAGSGGIFKDMTIHDFDMVRHFLGDIAEVNAVGTNVSPEIAEQGDFDQVIVTL
KSRDGKLATIINSRTCAFGYDQRLEAFGADGMLSADNLTDAAVRMATSTQTDAKTAIMDFFLERYEDAYRIELETFLDSI
AIGGAVSPSVRDGYEALVLADAATRSAQEHRVVAL
>Mature_354_residues
TGFVLTLGSLAVTGENPALSNTGVHSMIRIAIIGAGRIGHVHARAIQGRNDVTLALVCDPFEQNARALAGEYDVRYCLDP
DEVFDDSTIDAVVIGSPTQFHVDHILKAVNGGKRVMCEKPIALDVESAKRCINELGDRADQVMMGFNRRFDPTFSALKSR
LDDGEIGSLQQLTVISRDPAAPSASYIAGSGGIFKDMTIHDFDMVRHFLGDIAEVNAVGTNVSPEIAEQGDFDQVIVTLK
SRDGKLATIINSRTCAFGYDQRLEAFGADGMLSADNLTDAAVRMATSTQTDAKTAIMDFFLERYEDAYRIELETFLDSIA
IGGAVSPSVRDGYEALVLADAATRSAQEHRVVAL

Specific function: Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gfo/idh/mocA family [H]

Homologues:

Organism=Escherichia coli, GI1787574, Length=222, Percent_Identity=31.0810810810811, Blast_Score=88, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6323975, Length=211, Percent_Identity=26.0663507109005, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000683
- InterPro:   IPR004104 [H]

Pfam domain/function: PF01408 GFO_IDH_MocA; PF02894 GFO_IDH_MocA_C [H]

EC number: =1.1.1.18 [H]

Molecular weight: Translated: 38283; Mature: 38151

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGFVLTLGSLAVTGENPALSNTGVHSMIRIAIIGAGRIGHVHARAIQGRNDVTLALVCD
CCCEEEEECCEEEECCCCCCCCCCHHHEEEEEEEECCCCCCEEHHEECCCCCEEEEEEEC
PFEQNARALAGEYDVRYCLDPDEVFDDSTIDAVVIGSPTQFHVDHILKAVNGGKRVMCEK
CHHHCHHHHCCCCCEEEECCHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEECC
PIALDVESAKRCINELGDRADQVMMGFNRRFDPTFSALKSRLDDGEIGSLQQLTVISRDP
CCEECHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEEEEECCC
AAPSASYIAGSGGIFKDMTIHDFDMVRHFLGDIAEVNAVGTNVSPEIAEQGDFDQVIVTL
CCCCCCEEECCCCCEECCEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCEEEEEE
KSRDGKLATIINSRTCAFGYDQRLEAFGADGMLSADNLTDAAVRMATSTQTDAKTAIMDF
ECCCCEEEEEECCCEEECCCHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHH
FLERYEDAYRIELETFLDSIAIGGAVSPSVRDGYEALVLADAATRSAQEHRVVAL
HHHHCCCCEEEEHHHHHHHHHCCCCCCCCHHCCCEEEEEEHHHHCCHHCCEEEEC
>Mature Secondary Structure 
TGFVLTLGSLAVTGENPALSNTGVHSMIRIAIIGAGRIGHVHARAIQGRNDVTLALVCD
CCEEEEECCEEEECCCCCCCCCCHHHEEEEEEEECCCCCCEEHHEECCCCCEEEEEEEC
PFEQNARALAGEYDVRYCLDPDEVFDDSTIDAVVIGSPTQFHVDHILKAVNGGKRVMCEK
CHHHCHHHHCCCCCEEEECCHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEECC
PIALDVESAKRCINELGDRADQVMMGFNRRFDPTFSALKSRLDDGEIGSLQQLTVISRDP
CCEECHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEEEEECCC
AAPSASYIAGSGGIFKDMTIHDFDMVRHFLGDIAEVNAVGTNVSPEIAEQGDFDQVIVTL
CCCCCCEEECCCCCEECCEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCEEEEEE
KSRDGKLATIINSRTCAFGYDQRLEAFGADGMLSADNLTDAAVRMATSTQTDAKTAIMDF
ECCCCEEEEEECCCEEECCCHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHH
FLERYEDAYRIELETFLDSIAIGGAVSPSVRDGYEALVLADAATRSAQEHRVVAL
HHHHCCCCEEEEHHHHHHHHHCCCCCCCCHHCCCEEEEEEHHHHCCHHCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9802033; 11481431 [H]