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The map label for this gene is manA [H]

Identifier: 50841934

GI number: 50841934

Start: 496309

End: 497490

Strand: Reverse

Name: manA [H]

Synonym: PPA0451

Alternate gene names: 50841934

Gene position: 497490-496309 (Counterclockwise)

Preceding gene: 50841935

Following gene: 161621798

Centisome position: 19.43

GC content: 60.58

Gene sequence:

>1182_bases
ATGAAACGCCTGACCGGAACGGTTCGGACGTACTCCTGGGGCTCCTACGATGCGATCCCAGACATCCTCGGAAAAGAGGC
TGACGGAAAGCCGTGGGCCGAATACTGGCTCGGGGCCCATGAGACCTCGCCGTCGACCCTCGATGGCATACCGCTCACCG
ACTACATCCACGCTCACCCTGACGAACTCGGTGATCGCAGCCGAAAAGTCTTCGGTGCCCGCTTACCCTTTCTCCTCAAA
ATCCTCTCGGCCTACCACCCGTTAAGTCTGCAAGCTCATCCTGACGCCGCGATGGCACGGGCTGGATTCGCTCGAGAGAA
CCAGGACGGCATTGACGCTGACGACCCCCACCGCACCTTCGTCGACGATTGGCCCAAGCCCGAGATTCTCGTCGCCCTCA
GCGATTTTGAGGGGTTGTGCGGATTCCGCGATCCACACGAGACCCGTCAGCTGTTCGATGAGCTAGAGGTCCTCACCCCG
ACTGACCCGGTGTTGGGATCGCTGACCGAACGTTCCGGTTCGGCCGCCCTTGCCGAAACCTTCCTCAACTGCCTCGCGGG
GGACGACGTACGGCGTCAGATCGTCACCGAGGTGGTCTCAGGAGCCGTCAACCACGTAGGAGAGGACACACCCCTGGGAG
AGTTCGCTCGCACCGCCGTCGAGCTCGACGAGTACTTCCCCGGGGACCCCTCGATCCTGGCAGCGCTCATGCTCAATCGA
GTTCACCTGAAACCGGGCCAGGCGCTGTCTGTACCCCCGGGACTCATGCACTCATACCTATCGGGCACGGGCATTGAGAT
CATGGCCGATTCCAACAATGTCGTGCGTGGCGGACTCACCAACAAGCACATTGACATCGATTCCCTCATCCAAATCGTCT
CGTTCCAGACCCAGGAGCCACGGATCATTGCGGCGGAGGAGGTAGACCCGGGAATGCGCGTATTCCCGGGCATTGACGAC
CAGTTCCGACTCTGGCAGCTCGACCTCGACACCACCTGCCCCGCCATGATGCCGGCAAGCGAGCTAGCTCGAATACTCCT
CATTACGGATGGGTATGCGGTCTGTTCAGGCTCTCATGGAACTGACGAGATCGTACGCGGTCAGGCCGTCTGGATTCCGG
CTGGTGAACGGGTACAAATTGACGGAGACTGCGACGGATTTATTGCTGCCGCCGGGCTTTAA

Upstream 100 bases:

>100_bases
TTCAGCGGGTTCGCAGCCAGCAACGCCGCTCCCGTAGCGCACAACTGCTCAGATGACACCTACGACGTCGGCAACGATGC
GACATGACGAGAGGCACATT

Downstream 100 bases:

>100_bases
CCACAGCTGGCTGGTTGCCCGTGTGGGATTCGTGTCGATGCGAGAGGATGGGTTCATGGCACACAAAATGAACGTCGAGA
GTTTCAACCTGGACCACACC

Product: phosphomannose isomerase

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MKRLTGTVRTYSWGSYDAIPDILGKEADGKPWAEYWLGAHETSPSTLDGIPLTDYIHAHPDELGDRSRKVFGARLPFLLK
ILSAYHPLSLQAHPDAAMARAGFARENQDGIDADDPHRTFVDDWPKPEILVALSDFEGLCGFRDPHETRQLFDELEVLTP
TDPVLGSLTERSGSAALAETFLNCLAGDDVRRQIVTEVVSGAVNHVGEDTPLGEFARTAVELDEYFPGDPSILAALMLNR
VHLKPGQALSVPPGLMHSYLSGTGIEIMADSNNVVRGGLTNKHIDIDSLIQIVSFQTQEPRIIAAEEVDPGMRVFPGIDD
QFRLWQLDLDTTCPAMMPASELARILLITDGYAVCSGSHGTDEIVRGQAVWIPAGERVQIDGDCDGFIAAAGL

Sequences:

>Translated_393_residues
MKRLTGTVRTYSWGSYDAIPDILGKEADGKPWAEYWLGAHETSPSTLDGIPLTDYIHAHPDELGDRSRKVFGARLPFLLK
ILSAYHPLSLQAHPDAAMARAGFARENQDGIDADDPHRTFVDDWPKPEILVALSDFEGLCGFRDPHETRQLFDELEVLTP
TDPVLGSLTERSGSAALAETFLNCLAGDDVRRQIVTEVVSGAVNHVGEDTPLGEFARTAVELDEYFPGDPSILAALMLNR
VHLKPGQALSVPPGLMHSYLSGTGIEIMADSNNVVRGGLTNKHIDIDSLIQIVSFQTQEPRIIAAEEVDPGMRVFPGIDD
QFRLWQLDLDTTCPAMMPASELARILLITDGYAVCSGSHGTDEIVRGQAVWIPAGERVQIDGDCDGFIAAAGL
>Mature_393_residues
MKRLTGTVRTYSWGSYDAIPDILGKEADGKPWAEYWLGAHETSPSTLDGIPLTDYIHAHPDELGDRSRKVFGARLPFLLK
ILSAYHPLSLQAHPDAAMARAGFARENQDGIDADDPHRTFVDDWPKPEILVALSDFEGLCGFRDPHETRQLFDELEVLTP
TDPVLGSLTERSGSAALAETFLNCLAGDDVRRQIVTEVVSGAVNHVGEDTPLGEFARTAVELDEYFPGDPSILAALMLNR
VHLKPGQALSVPPGLMHSYLSGTGIEIMADSNNVVRGGLTNKHIDIDSLIQIVSFQTQEPRIIAAEEVDPGMRVFPGIDD
QFRLWQLDLDTTCPAMMPASELARILLITDGYAVCSGSHGTDEIVRGQAVWIPAGERVQIDGDCDGFIAAAGL

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=410, Percent_Identity=28.0487804878049, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1787899, Length=387, Percent_Identity=32.2997416020672, Blast_Score=179, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI71997620, Length=410, Percent_Identity=30.7317073170732, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17557650, Length=430, Percent_Identity=25.5813953488372, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320839, Length=328, Percent_Identity=29.5731707317073, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21356061, Length=420, Percent_Identity=26.4285714285714, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 42779; Mature: 42779

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLTGTVRTYSWGSYDAIPDILGKEADGKPWAEYWLGAHETSPSTLDGIPLTDYIHAHP
CCCCCCCEEEECCCCCCCCHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHCCC
DELGDRSRKVFGARLPFLLKILSAYHPLSLQAHPDAAMARAGFARENQDGIDADDPHRTF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCC
VDDWPKPEILVALSDFEGLCGFRDPHETRQLFDELEVLTPTDPVLGSLTERSGSAALAET
CCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHH
FLNCLAGDDVRRQIVTEVVSGAVNHVGEDTPLGEFARTAVELDEYFPGDPSILAALMLNR
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VHLKPGQALSVPPGLMHSYLSGTGIEIMADSNNVVRGGLTNKHIDIDSLIQIVSFQTQEP
HCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCCHHHHHHHHHCCCCCC
RIIAAEEVDPGMRVFPGIDDQFRLWQLDLDTTCPAMMPASELARILLITDGYAVCSGSHG
CEEEECCCCCCCEECCCCCCCEEEEEEECCCCCCCCCCHHHHCEEEEEECCCEEECCCCC
TDEIVRGQAVWIPAGERVQIDGDCDGFIAAAGL
CHHHHCCCEEEECCCCEEEECCCCCCEEEECCC
>Mature Secondary Structure
MKRLTGTVRTYSWGSYDAIPDILGKEADGKPWAEYWLGAHETSPSTLDGIPLTDYIHAHP
CCCCCCCEEEECCCCCCCCHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHCCC
DELGDRSRKVFGARLPFLLKILSAYHPLSLQAHPDAAMARAGFARENQDGIDADDPHRTF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCC
VDDWPKPEILVALSDFEGLCGFRDPHETRQLFDELEVLTPTDPVLGSLTERSGSAALAET
CCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHH
FLNCLAGDDVRRQIVTEVVSGAVNHVGEDTPLGEFARTAVELDEYFPGDPSILAALMLNR
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VHLKPGQALSVPPGLMHSYLSGTGIEIMADSNNVVRGGLTNKHIDIDSLIQIVSFQTQEP
HCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCCHHHHHHHHHCCCCCC
RIIAAEEVDPGMRVFPGIDDQFRLWQLDLDTTCPAMMPASELARILLITDGYAVCSGSHG
CEEEECCCCCCCEECCCCCCCEEEEEEECCCCCCCCCCHHHHCEEEEEECCCEEECCCCC
TDEIVRGQAVWIPAGERVQIDGDCDGFIAAAGL
CHHHHCCCEEEECCCCEEEECCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6397402; 9097039; 9278503 [H]