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The map label for this gene is gpmA

Identifier: 50841849

GI number: 50841849

Start: 411768

End: 412517

Strand: Reverse

Name: gpmA

Synonym: PPA0364

Alternate gene names: 50841849

Gene position: 412517-411768 (Counterclockwise)

Preceding gene: 50841850

Following gene: 50841846

Centisome position: 16.11

GC content: 62.13

Gene sequence:

>750_bases
ATGACTGCAAAGCTCATCCTGCTCCGCCATGGCGAGAGCGAATGGAACTCCAAGAACCTCTTCACCGGCTGGGTGGACGT
CGATCTCAACGAGAAGGGCGAGGGCGAGGCTCGTCACGCCGCCGACCTGCTCAAGCAGGAAAACCTCCTGCCCGATATCG
TCCACACCTCGCTGCTACGTCGTGCTATCCATACCGCCTACCTAGCCCTTGACGGCTGCGACCGCCATTGGATCCCGGTG
CATCGCTCCTGGCGCCTCAACGAGCGTCACTACGGTGCGCTGCAGGGTCTCAACAAGGCTGAGACCAAGGAGAAGTACGG
CAACGACCAGTTCATGGCTTGGCGTCGCTCCTACGATGTTCGTCCACCGGACCTTGACCGCGACAGCGAATTCAGCCAGT
TCCATGACCCGCGGTACGCCGACATCCCGGCGTCCGAGCGTCCGGTCGCCGAGTGTCTCAAAGACGTCGTGGCCCGCATG
GTGCCGTACTTCACCTCTGATATTGCTGCCGACCTTAAGGACGGCAAGACGGTGCTCGTGGCTGCTCACGGTAACTCCCT
GCGCGCCCTCGTCAAGCACCTCGACGAGATCAGTGACGAGGACATCGCCGGCCTCAACATCCCGACCGGTATCCCGCTGT
TCTACGAGCTTGACGACAACCTCAAGCCCGTGACTAGGGGGGGCCGCTACCTCGACCCTGAGGCCGCTGCCGCCGGCGCC
AAGGCAGTCGCTAACCAGGGAAACAAGTAA

Upstream 100 bases:

>100_bases
GAGATCACCGGATCTAACTACCGAGGGACATAACGACTGCAATCCCGCAGATGGGGTAGGGGACGCGAATGCTATTCCCC
AGACACACTATGGTGGAACC

Downstream 100 bases:

>100_bases
GCCTGCCCGCAGGCTGCTGAAGCTGCTTGATGCAACTCGACGGTGCCGCCAGAAATATCGGGGCACCGTCGAGTTGCATG
AAGCTAGAGCTTTAGGCAAT

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MTAKLILLRHGESEWNSKNLFTGWVDVDLNEKGEGEARHAADLLKQENLLPDIVHTSLLRRAIHTAYLALDGCDRHWIPV
HRSWRLNERHYGALQGLNKAETKEKYGNDQFMAWRRSYDVRPPDLDRDSEFSQFHDPRYADIPASERPVAECLKDVVARM
VPYFTSDIAADLKDGKTVLVAAHGNSLRALVKHLDEISDEDIAGLNIPTGIPLFYELDDNLKPVTRGGRYLDPEAAAAGA
KAVANQGNK

Sequences:

>Translated_249_residues
MTAKLILLRHGESEWNSKNLFTGWVDVDLNEKGEGEARHAADLLKQENLLPDIVHTSLLRRAIHTAYLALDGCDRHWIPV
HRSWRLNERHYGALQGLNKAETKEKYGNDQFMAWRRSYDVRPPDLDRDSEFSQFHDPRYADIPASERPVAECLKDVVARM
VPYFTSDIAADLKDGKTVLVAAHGNSLRALVKHLDEISDEDIAGLNIPTGIPLFYELDDNLKPVTRGGRYLDPEAAAAGA
KAVANQGNK
>Mature_248_residues
TAKLILLRHGESEWNSKNLFTGWVDVDLNEKGEGEARHAADLLKQENLLPDIVHTSLLRRAIHTAYLALDGCDRHWIPVH
RSWRLNERHYGALQGLNKAETKEKYGNDQFMAWRRSYDVRPPDLDRDSEFSQFHDPRYADIPASERPVAECLKDVVARMV
PYFTSDIAADLKDGKTVLVAAHGNSLRALVKHLDEISDEDIAGLNIPTGIPLFYELDDNLKPVTRGGRYLDPEAAAAGAK
AVANQGNK

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI50593010, Length=250, Percent_Identity=49.2, Blast_Score=250, Evalue=7e-67,
Organism=Homo sapiens, GI4502445, Length=248, Percent_Identity=48.3870967741936, Blast_Score=240, Evalue=8e-64,
Organism=Homo sapiens, GI40353764, Length=248, Percent_Identity=48.3870967741936, Blast_Score=240, Evalue=8e-64,
Organism=Homo sapiens, GI4505753, Length=247, Percent_Identity=49.7975708502024, Blast_Score=237, Evalue=6e-63,
Organism=Homo sapiens, GI71274132, Length=247, Percent_Identity=47.3684210526316, Blast_Score=224, Evalue=4e-59,
Organism=Homo sapiens, GI310129614, Length=161, Percent_Identity=49.6894409937888, Blast_Score=152, Evalue=2e-37,
Organism=Escherichia coli, GI1786970, Length=225, Percent_Identity=56, Blast_Score=273, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6322697, Length=246, Percent_Identity=61.3821138211382, Blast_Score=287, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6324516, Length=295, Percent_Identity=37.6271186440678, Blast_Score=173, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6320183, Length=297, Percent_Identity=37.3737373737374, Blast_Score=171, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24646216, Length=248, Percent_Identity=49.5967741935484, Blast_Score=249, Evalue=1e-66,
Organism=Drosophila melanogaster, GI85725270, Length=247, Percent_Identity=48.1781376518219, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI85725272, Length=247, Percent_Identity=48.1781376518219, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24650981, Length=247, Percent_Identity=48.1781376518219, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI28571817, Length=220, Percent_Identity=40, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24648979, Length=220, Percent_Identity=40, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI28571815, Length=220, Percent_Identity=40, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_PROAC (Q6AAU8)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055076.1
- ProteinModelPortal:   Q6AAU8
- GeneID:   2931500
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA0364
- NMPDR:   fig|267747.1.peg.353
- HOGENOM:   HBG658938
- OMA:   TGWKDPD
- ProtClustDB:   CLSK2763247
- BioCyc:   PACN267747:PPA0364-MONOMER
- BRENDA:   5.4.2.1
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 27991; Mature: 27860

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 10-10 ACT_SITE 183-183

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKLILLRHGESEWNSKNLFTGWVDVDLNEKGEGEARHAADLLKQENLLPDIVHTSLLR
CCEEEEEEECCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
RAIHTAYLALDGCDRHWIPVHRSWRLNERHYGALQGLNKAETKEKYGNDQFMAWRRSYDV
HHHHHHHHHCCCCCCCCCCCCCCEECCCHHHHHHHCCCHHHHHHHHCCCHHHHHHHCCCC
RPPDLDRDSEFSQFHDPRYADIPASERPVAECLKDVVARMVPYFTSDIAADLKDGKTVLV
CCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
AAHGNSLRALVKHLDEISDEDIAGLNIPTGIPLFYELDDNLKPVTRGGRYLDPEAAAAGA
EECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCHHHCCCCEECHHHHHHHH
KAVANQGNK
HHHHCCCCC
>Mature Secondary Structure 
TAKLILLRHGESEWNSKNLFTGWVDVDLNEKGEGEARHAADLLKQENLLPDIVHTSLLR
CEEEEEEECCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
RAIHTAYLALDGCDRHWIPVHRSWRLNERHYGALQGLNKAETKEKYGNDQFMAWRRSYDV
HHHHHHHHHCCCCCCCCCCCCCCEECCCHHHHHHHCCCHHHHHHHHCCCHHHHHHHCCCC
RPPDLDRDSEFSQFHDPRYADIPASERPVAECLKDVVARMVPYFTSDIAADLKDGKTVLV
CCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
AAHGNSLRALVKHLDEISDEDIAGLNIPTGIPLFYELDDNLKPVTRGGRYLDPEAAAAGA
EECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCHHHCCCCEECHHHHHHHH
KAVANQGNK
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA