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The map label for this gene is mutT1 [H]

Identifier: 50841828

GI number: 50841828

Start: 393033

End: 393974

Strand: Reverse

Name: mutT1 [H]

Synonym: PPA0342

Alternate gene names: 50841828

Gene position: 393974-393033 (Counterclockwise)

Preceding gene: 50841829

Following gene: 50841827

Centisome position: 15.39

GC content: 58.81

Gene sequence:

>942_bases
ATGGGGGGACACAAGGGGCCTATCCAGGCAGCTGGCGCCGTCGTACTACGCGACATTGATGACGGGGCTCGTGAAGTACT
CGTCGTCCATCGTCCCAGTTACGACGACCTTTCCCTACCTAAGGGAAAACTCGAACCTGGCGAGGATCTTCCCACCACTG
CAGTGCGCGAAGTGGCCGAGGAAACCGGCATTAATATCCGGTTGACGATGCCTCTGCAACCCATCGAGTACACCGTCAAA
TACTCCACACGTGACGGCAAGCCAAAGTCGCGCGCCAAAGTCGTCTCCTGGTGGCTAGGGGTCGCCATCGGAGGGTCCAT
TGAGAATGCGACAGCCAGTCCTGAGGAGATCGATGGCGCCTTCTGGATGCCAACCGACCAGGCTCTTGAGCGCCTCACCT
ATCCCACCGACGTCCAGGTGCTCGAGGAGGCCCTCGACTTGCCGTCGACGTCAACAATCATCCTGGTACGACATGGCAAA
GCTGTCTCACGCAAAGAGTGGAACTCCCGTAAGAGACACGGTAAAGACGCCACACGCCCGTTGGAAAGGCGCGGTCGCCG
TCAGGCCAAGGCCTTGGCCGACTTGCTGAGCGCCTTTGGGGTGGCCCGCCTTGCAAGCTCATCATCGACGCGATGTATGC
AAACTCTTCAGCCATATGCCGACACCATTGGAGCGCAGATCACCGGGCTTGATGCTCTGAGCGAGGAGACACACGAAGCC
GACCCCCACAAGGCGACGTCAGCTATGAGAAAAATTATTGGCCGCGCGTTGGCAGACCCCAACCAACCAATTGCCATTTG
TGGCCATCGTCCGGTACTGCCGACGATGCGAGACGCCCTTGGCGGGGCGAATCGCCCTATGTCAACTGCGGAGTGCCTGA
TTGTTCACCTCGATGAAACGGGACGCACAATCCGCCAAGAGTGGCACTCATCACGGTACTAA

Upstream 100 bases:

>100_bases
ACTTGGACCGAGGTGTCACGCGGACCGGACGACATCCCCCTAACTGACTTACAAGAAGAACTCATCCGACGCACCCGCGA
CAGGAGGCGGTGAAACCGAG

Downstream 100 bases:

>100_bases
ACCAGCAGGTCACAAACTGCGTCTTAGGCGATTTCCTTCGGTCAAAGTGGCGACGGTGTTCACGTTGCGTTCACCTTGAC
GCGATCCCTGCGACATTTCC

Product: hypothetical protein

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MGGHKGPIQAAGAVVLRDIDDGAREVLVVHRPSYDDLSLPKGKLEPGEDLPTTAVREVAEETGINIRLTMPLQPIEYTVK
YSTRDGKPKSRAKVVSWWLGVAIGGSIENATASPEEIDGAFWMPTDQALERLTYPTDVQVLEEALDLPSTSTIILVRHGK
AVSRKEWNSRKRHGKDATRPLERRGRRQAKALADLLSAFGVARLASSSSTRCMQTLQPYADTIGAQITGLDALSEETHEA
DPHKATSAMRKIIGRALADPNQPIAICGHRPVLPTMRDALGGANRPMSTAECLIVHLDETGRTIRQEWHSSRY

Sequences:

>Translated_313_residues
MGGHKGPIQAAGAVVLRDIDDGAREVLVVHRPSYDDLSLPKGKLEPGEDLPTTAVREVAEETGINIRLTMPLQPIEYTVK
YSTRDGKPKSRAKVVSWWLGVAIGGSIENATASPEEIDGAFWMPTDQALERLTYPTDVQVLEEALDLPSTSTIILVRHGK
AVSRKEWNSRKRHGKDATRPLERRGRRQAKALADLLSAFGVARLASSSSTRCMQTLQPYADTIGAQITGLDALSEETHEA
DPHKATSAMRKIIGRALADPNQPIAICGHRPVLPTMRDALGGANRPMSTAECLIVHLDETGRTIRQEWHSSRY
>Mature_312_residues
GGHKGPIQAAGAVVLRDIDDGAREVLVVHRPSYDDLSLPKGKLEPGEDLPTTAVREVAEETGINIRLTMPLQPIEYTVKY
STRDGKPKSRAKVVSWWLGVAIGGSIENATASPEEIDGAFWMPTDQALERLTYPTDVQVLEEALDLPSTSTIILVRHGKA
VSRKEWNSRKRHGKDATRPLERRGRRQAKALADLLSAFGVARLASSSSTRCMQTLQPYADTIGAQITGLDALSEETHEAD
PHKATSAMRKIIGRALADPNQPIAICGHRPVLPTMRDALGGANRPMSTAECLIVHLDETGRTIRQEWHSSRY

Specific function: May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo- dGTP is inserted opposite dA and dC residues of template DNA with almost equa

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX; PF00300 PGAM [H]

EC number: NA

Molecular weight: Translated: 34247; Mature: 34116

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGHKGPIQAAGAVVLRDIDDGAREVLVVHRPSYDDLSLPKGKLEPGEDLPTTAVREVAE
CCCCCCCHHHCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
ETGINIRLTMPLQPIEYTVKYSTRDGKPKSRAKVVSWWLGVAIGGSIENATASPEEIDGA
HHCCEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCC
FWMPTDQALERLTYPTDVQVLEEALDLPSTSTIILVRHGKAVSRKEWNSRKRHGKDATRP
EECCHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCH
LERRGRRQAKALADLLSAFGVARLASSSSTRCMQTLQPYADTIGAQITGLDALSEETHEA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEECCHHHHHHHHCC
DPHKATSAMRKIIGRALADPNQPIAICGHRPVLPTMRDALGGANRPMSTAECLIVHLDET
CCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHCCCCCCCCCEEEEEEEECCC
GRTIRQEWHSSRY
CHHHHHHHHCCCC
>Mature Secondary Structure 
GGHKGPIQAAGAVVLRDIDDGAREVLVVHRPSYDDLSLPKGKLEPGEDLPTTAVREVAE
CCCCCCHHHCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
ETGINIRLTMPLQPIEYTVKYSTRDGKPKSRAKVVSWWLGVAIGGSIENATASPEEIDGA
HHCCEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCC
FWMPTDQALERLTYPTDVQVLEEALDLPSTSTIILVRHGKAVSRKEWNSRKRHGKDATRP
EECCHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCH
LERRGRRQAKALADLLSAFGVARLASSSSTRCMQTLQPYADTIGAQITGLDALSEETHEA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEECCHHHHHHHHCC
DPHKATSAMRKIIGRALADPNQPIAICGHRPVLPTMRDALGGANRPMSTAECLIVHLDET
CCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHCCCCCCCCCEEEEEEEECCC
GRTIRQEWHSSRY
CHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]