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The map label for this gene is pdxA

Identifier: 50841785

GI number: 50841785

Start: 346613

End: 347653

Strand: Reverse

Name: pdxA

Synonym: PPA0296

Alternate gene names: 50841785

Gene position: 347653-346613 (Counterclockwise)

Preceding gene: 50841786

Following gene: 50841784

Centisome position: 13.58

GC content: 58.69

Gene sequence:

>1041_bases
ATGCCAAAGACACCACTTCTTGGAATCACAGAAGGTGACCCAGCCGGAATCGGACCGGAAATCACGGTCCAAGCCATCCA
CAACATGGCCGACGACCGATCCTTCATCCCCATCGTGTACGGCGATCCAGCCATCATCTCTCGGGCGTGCTCCGTCACCG
GATTGAGCGAGACCGTTCGTCGTGTCACCTCCGAGGAGCACATCGAGCCCGAATCGAATGTGATCAACGTCGTCGACACC
GGCACCGTTCCTCATGCCGATTCCATCGAGTGGGGAAGCGTCCAGGAACTCGCTGGGCGCGCGGCCATCGCTTCGATCGA
AGCAGCCACTGATGCGGCACTTTCGGGAAAGACCGACGGCGTTGTCACCTCCCCGATCAACAAGGAAGCTATATGGAAGA
CTGGCTCCGAGTTCCTAGGGCACACGGAGATGTTGGGGAGCCTATGCGGCACCCCGGACACCGACACGATGTTCGTCGTC
AGTGGGCTCAAGATCTTCTTTGCCACCAGGCATATGTCCTTGCGCGAGGCGGTTGATTCCATCAGACGCGATCTCATCGA
TCACGAGATTCACAAAGCGCTTCGAGCCCTCAAGGTGTTCGGCTGCAACTCACCGAAACTGGCGGTCGCCGCACTCAATC
CCCACGCTGGCGAGGGTGGACATTTTGGCACCGAGGAGATCGAGGTCCTTCGCCCTGCTGTCAAAAGCGCCTGCGCCGAG
GGTCACAACGTCGTCGGACCGGTTCCTGCAGATTCCGTCTTCCATAAGGGCGTCATCAGGGAGTACGACGGCGTCCTTTC
CCTATACCACGACCAGGGTCATATCGCCTCGAAGACCCTTGATTTTGACGGCACGGTCTCTGTCACAGCAGGACTCCCCA
TCCTCCGAACGTCGGTCGATCACGGCACGGCCTTCGACATCGCCGGTCAAGGTGCCGCCTCCCCCATGACCATGCAATCA
GCCCTGCACGTTGCCAGTGATTTTGCGAGATTTGTTCCGGTAATTCGAGAAGAGTATTTACCGAGCACAGGCCGCAACTG
A

Upstream 100 bases:

>100_bases
TCAATCCGAACCGCGGATCGTGTAGACGCGGGCCCATCACGATCGCATCATCAATCCCGCTCACCCCGAAAACCATCAAA
CGATAAAGGAGAGTAAGACC

Downstream 100 bases:

>100_bases
TGATTTCGAGGACGTCTATCTTCGATAATCTCAGGGGGTATTCCATGGCCATTAACTCAGTCAATAATTTAGAAACGACC
GACAAGGCCGACGCGAGCAA

Product: 4-hydroxythreonine-4-phosphate dehydrogenase 2

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MPKTPLLGITEGDPAGIGPEITVQAIHNMADDRSFIPIVYGDPAIISRACSVTGLSETVRRVTSEEHIEPESNVINVVDT
GTVPHADSIEWGSVQELAGRAAIASIEAATDAALSGKTDGVVTSPINKEAIWKTGSEFLGHTEMLGSLCGTPDTDTMFVV
SGLKIFFATRHMSLREAVDSIRRDLIDHEIHKALRALKVFGCNSPKLAVAALNPHAGEGGHFGTEEIEVLRPAVKSACAE
GHNVVGPVPADSVFHKGVIREYDGVLSLYHDQGHIASKTLDFDGTVSVTAGLPILRTSVDHGTAFDIAGQGAASPMTMQS
ALHVASDFARFVPVIREEYLPSTGRN

Sequences:

>Translated_346_residues
MPKTPLLGITEGDPAGIGPEITVQAIHNMADDRSFIPIVYGDPAIISRACSVTGLSETVRRVTSEEHIEPESNVINVVDT
GTVPHADSIEWGSVQELAGRAAIASIEAATDAALSGKTDGVVTSPINKEAIWKTGSEFLGHTEMLGSLCGTPDTDTMFVV
SGLKIFFATRHMSLREAVDSIRRDLIDHEIHKALRALKVFGCNSPKLAVAALNPHAGEGGHFGTEEIEVLRPAVKSACAE
GHNVVGPVPADSVFHKGVIREYDGVLSLYHDQGHIASKTLDFDGTVSVTAGLPILRTSVDHGTAFDIAGQGAASPMTMQS
ALHVASDFARFVPVIREEYLPSTGRN
>Mature_345_residues
PKTPLLGITEGDPAGIGPEITVQAIHNMADDRSFIPIVYGDPAIISRACSVTGLSETVRRVTSEEHIEPESNVINVVDTG
TVPHADSIEWGSVQELAGRAAIASIEAATDAALSGKTDGVVTSPINKEAIWKTGSEFLGHTEMLGSLCGTPDTDTMFVVS
GLKIFFATRHMSLREAVDSIRRDLIDHEIHKALRALKVFGCNSPKLAVAALNPHAGEGGHFGTEEIEVLRPAVKSACAEG
HNVVGPVPADSVFHKGVIREYDGVLSLYHDQGHIASKTLDFDGTVSVTAGLPILRTSVDHGTAFDIAGQGAASPMTMQSA
LHVASDFARFVPVIREEYLPSTGRN

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family

Homologues:

Organism=Escherichia coli, GI1786237, Length=329, Percent_Identity=34.0425531914894, Blast_Score=180, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXA_PROAC (Q6AB12)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055012.1
- HSSP:   P19624
- ProteinModelPortal:   Q6AB12
- SMR:   Q6AB12
- GeneID:   2932160
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA0296
- NMPDR:   fig|267747.1.peg.289
- HOGENOM:   HBG451136
- OMA:   PADSVFH
- ProtClustDB:   CLSK708077
- BioCyc:   PACN267747:PPA0296-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00536
- InterPro:   IPR005255
- TIGRFAMs:   TIGR00557

Pfam domain/function: PF04166 PdxA

EC number: =1.1.1.262

Molecular weight: Translated: 36660; Mature: 36529

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: BINDING 141-141 BINDING 142-142 BINDING 278-278 BINDING 296-296

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKTPLLGITEGDPAGIGPEITVQAIHNMADDRSFIPIVYGDPAIISRACSVTGLSETVR
CCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCHHHHHH
RVTSEEHIEPESNVINVVDTGTVPHADSIEWGSVQELAGRAAIASIEAATDAALSGKTDG
HHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
VVTSPINKEAIWKTGSEFLGHTEMLGSLCGTPDTDTMFVVSGLKIFFATRHMSLREAVDS
EEECCCCCHHHHHCHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
IRRDLIDHEIHKALRALKVFGCNSPKLAVAALNPHAGEGGHFGTEEIEVLRPAVKSACAE
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHC
GHNVVGPVPADSVFHKGVIREYDGVLSLYHDQGHIASKTLDFDGTVSVTAGLPILRTSVD
CCCCCCCCCCHHHHHHHHHHHHCCHHEEEECCCCEEEEEECCCCCEEEECCCCEEEECCC
HGTAFDIAGQGAASPMTMQSALHVASDFARFVPVIREEYLPSTGRN
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PKTPLLGITEGDPAGIGPEITVQAIHNMADDRSFIPIVYGDPAIISRACSVTGLSETVR
CCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCHHHHHH
RVTSEEHIEPESNVINVVDTGTVPHADSIEWGSVQELAGRAAIASIEAATDAALSGKTDG
HHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
VVTSPINKEAIWKTGSEFLGHTEMLGSLCGTPDTDTMFVVSGLKIFFATRHMSLREAVDS
EEECCCCCHHHHHCHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
IRRDLIDHEIHKALRALKVFGCNSPKLAVAALNPHAGEGGHFGTEEIEVLRPAVKSACAE
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHC
GHNVVGPVPADSVFHKGVIREYDGVLSLYHDQGHIASKTLDFDGTVSVTAGLPILRTSVD
CCCCCCCCCCHHHHHHHHHHHHCCHHEEEECCCCEEEEEECCCCCEEEECCCCEEEECCC
HGTAFDIAGQGAASPMTMQSALHVASDFARFVPVIREEYLPSTGRN
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA