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The map label for this gene is nuoD2 [H]

Identifier: 50841765

GI number: 50841765

Start: 324784

End: 325974

Strand: Reverse

Name: nuoD2 [H]

Synonym: PPA0276

Alternate gene names: 50841765

Gene position: 325974-324784 (Counterclockwise)

Preceding gene: 50841768

Following gene: 50841755

Centisome position: 12.73

GC content: 58.1

Gene sequence:

>1191_bases
ATGCGGCATCCTCAACGTGTGTTCAGTTCCATGCGAAAGATCATGTTCGTCATCGGATCGATGCCGTTAACGCATCCTAG
TCAATCCGCCGATGGTGACCCCGGCAAAAAATACGAGGTGACTCGGCTAGATCTCGGGCACCTTCACCCCACTCGGTCGG
GACTCGTCACTATCGCCACAACTGTCGATGACGACGTCATCATCTCTTCCCAGGTAAATGTCGGCACCCTTCACCGCGGT
GATGAAAAACTTTTCGAAGTTCGCGATTACCGCCAGATTCCGATGCTTGCATCACGTCATGACTGGACAGCTCCATTCAT
CGGTGAGACCGGCGCAGCCCATGCTATCGAGGACGCGATGGGCATTACCATCCCAACTCGCGTGGCATGGATACGAACCC
TGCTCGCTGAGTTCAGCAGAATCACCTCACACTTCACATTTTTGTCATGGGTAGGCCATCACTGTGATGATGCTGGCCTT
GAAAATGCGATCGCTACAGCAATTGAAAACGCCCGAAGGATCTGGCAGAGGTGCTCTGGAAATCGAATCCATCCTATGAT
CACCCGTATCGGGGGACTTCGGATCCATCCAGAGAGTGAATGGCAGCCCGCATTGGGTGAGTGGCTTGACGACGCTAATG
CGCTTGTGACGCGACTGCGTACCGCTCTCGACGCCACCGTCGGCGTGCGCGGCGTGGCCGTCATACCCACGAATATGATC
GATCGCTATGGTTTATCAGGGCCCGTCTCCCGGGCTAGCGGGGTCGACCTAGATACTCGACGGCGCACCGCGGTATACGA
CGAGCTGAAGTGGCCTGAGGTCGTCATAGAGCCCCGTGGTGACGCCTACTCACGACTGGCAACGTTATGTAACGATGCGG
CGGTGTCGTCGAGCCTATGCCGTCAGATCCTCGACCGGCTGCCGAGCTTGGACGGGCCTCTGGAGACTCGTCTACCAACC
GCCATCAAGGCCCCTCGGGGACGCACCTGGACGACTATAGAGGCCCTCTGGGGACGTGCCGGATACCTGCTAGAGTCCCG
CGGCAGCACGACACCGTGGCGGATGGCCTTGCGCACCCCGACCTTCGCCAACGTTCAAGTCTTGGAGGCGGTGCTTCCCG
GCACTCGAGTTGACGACGTTGAGGCCACCATTGCCTCCTTGGGATGGACGCTAGGAGACCTCGATAAGTGA

Upstream 100 bases:

>100_bases
GCCTTTACACTACAGCTTATATTCATGACCACGAAAATCACAAGGCGGATCCAGTTTTTTGTTGACGAATCGTTGTCGTG
AAGATGCATCTAGGCGTGCA

Downstream 100 bases:

>100_bases
GCTGGTATCGGGGTGACGCAACAACGCGGGGCCCAGCCGGAAGCTAGACCCCGCGTCACATTTGGCAAGCTAAGCGTCAG
GCCTGGCGACGAGTCTCGCG

Product: putative NADH dehydrogenase

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D 2; NDH-1 subunit D 2 [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MRHPQRVFSSMRKIMFVIGSMPLTHPSQSADGDPGKKYEVTRLDLGHLHPTRSGLVTIATTVDDDVIISSQVNVGTLHRG
DEKLFEVRDYRQIPMLASRHDWTAPFIGETGAAHAIEDAMGITIPTRVAWIRTLLAEFSRITSHFTFLSWVGHHCDDAGL
ENAIATAIENARRIWQRCSGNRIHPMITRIGGLRIHPESEWQPALGEWLDDANALVTRLRTALDATVGVRGVAVIPTNMI
DRYGLSGPVSRASGVDLDTRRRTAVYDELKWPEVVIEPRGDAYSRLATLCNDAAVSSSLCRQILDRLPSLDGPLETRLPT
AIKAPRGRTWTTIEALWGRAGYLLESRGSTTPWRMALRTPTFANVQVLEAVLPGTRVDDVEATIASLGWTLGDLDK

Sequences:

>Translated_396_residues
MRHPQRVFSSMRKIMFVIGSMPLTHPSQSADGDPGKKYEVTRLDLGHLHPTRSGLVTIATTVDDDVIISSQVNVGTLHRG
DEKLFEVRDYRQIPMLASRHDWTAPFIGETGAAHAIEDAMGITIPTRVAWIRTLLAEFSRITSHFTFLSWVGHHCDDAGL
ENAIATAIENARRIWQRCSGNRIHPMITRIGGLRIHPESEWQPALGEWLDDANALVTRLRTALDATVGVRGVAVIPTNMI
DRYGLSGPVSRASGVDLDTRRRTAVYDELKWPEVVIEPRGDAYSRLATLCNDAAVSSSLCRQILDRLPSLDGPLETRLPT
AIKAPRGRTWTTIEALWGRAGYLLESRGSTTPWRMALRTPTFANVQVLEAVLPGTRVDDVEATIASLGWTLGDLDK
>Mature_396_residues
MRHPQRVFSSMRKIMFVIGSMPLTHPSQSADGDPGKKYEVTRLDLGHLHPTRSGLVTIATTVDDDVIISSQVNVGTLHRG
DEKLFEVRDYRQIPMLASRHDWTAPFIGETGAAHAIEDAMGITIPTRVAWIRTLLAEFSRITSHFTFLSWVGHHCDDAGL
ENAIATAIENARRIWQRCSGNRIHPMITRIGGLRIHPESEWQPALGEWLDDANALVTRLRTALDATVGVRGVAVIPTNMI
DRYGLSGPVSRASGVDLDTRRRTAVYDELKWPEVVIEPRGDAYSRLATLCNDAAVSSSLCRQILDRLPSLDGPLETRLPT
AIKAPRGRTWTTIEALWGRAGYLLESRGSTTPWRMALRTPTFANVQVLEAVLPGTRVDDVEATIASLGWTLGDLDK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=405, Percent_Identity=26.4197530864197, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI260898743, Length=395, Percent_Identity=26.5822784810127, Blast_Score=122, Evalue=5e-28,
Organism=Escherichia coli, GI145693162, Length=388, Percent_Identity=27.8350515463918, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1789076, Length=368, Percent_Identity=26.6304347826087, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788832, Length=357, Percent_Identity=26.3305322128852, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17568379, Length=396, Percent_Identity=25.5050505050505, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17555284, Length=406, Percent_Identity=25.3694581280788, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI221459469, Length=389, Percent_Identity=25.706940874036, Blast_Score=147, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24638644, Length=389, Percent_Identity=26.9922879177378, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 43835; Mature: 43835

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHPQRVFSSMRKIMFVIGSMPLTHPSQSADGDPGKKYEVTRLDLGHLHPTRSGLVTIAT
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEE
TVDDDVIISSQVNVGTLHRGDEKLFEVRDYRQIPMLASRHDWTAPFIGETGAAHAIEDAM
ECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCHHHHHHHC
GITIPTRVAWIRTLLAEFSRITSHFTFLSWVGHHCDDAGLENAIATAIENARRIWQRCSG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
NRIHPMITRIGGLRIHPESEWQPALGEWLDDANALVTRLRTALDATVGVRGVAVIPTNMI
CCCCHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHH
DRYGLSGPVSRASGVDLDTRRRTAVYDELKWPEVVIEPRGDAYSRLATLCNDAAVSSSLC
HHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
RQILDRLPSLDGPLETRLPTAIKAPRGRTWTTIEALWGRAGYLLESRGSTTPWRMALRTP
HHHHHHCCCCCCCHHHCCCHHHCCCCCCCCHHHHHHHCCCCEEEECCCCCCCEEEEECCC
TFANVQVLEAVLPGTRVDDVEATIASLGWTLGDLDK
CCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRHPQRVFSSMRKIMFVIGSMPLTHPSQSADGDPGKKYEVTRLDLGHLHPTRSGLVTIAT
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEE
TVDDDVIISSQVNVGTLHRGDEKLFEVRDYRQIPMLASRHDWTAPFIGETGAAHAIEDAM
ECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCHHHHHHHC
GITIPTRVAWIRTLLAEFSRITSHFTFLSWVGHHCDDAGLENAIATAIENARRIWQRCSG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
NRIHPMITRIGGLRIHPESEWQPALGEWLDDANALVTRLRTALDATVGVRGVAVIPTNMI
CCCCHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHH
DRYGLSGPVSRASGVDLDTRRRTAVYDELKWPEVVIEPRGDAYSRLATLCNDAAVSSSLC
HHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
RQILDRLPSLDGPLETRLPTAIKAPRGRTWTTIEALWGRAGYLLESRGSTTPWRMALRTP
HHHHHHCCCCCCCHHHCCCHHHCCCCCCCCHHHHHHHCCCCEEEECCCCCCCEEEEECCC
TFANVQVLEAVLPGTRVDDVEATIASLGWTLGDLDK
CCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA