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The map label for this gene is tkt [H]

Identifier: 50365165

GI number: 50365165

Start: 405124

End: 407091

Strand: Reverse

Name: tkt [H]

Synonym: Mfl349

Alternate gene names: 50365165

Gene position: 407091-405124 (Counterclockwise)

Preceding gene: 50365166

Following gene: 50365164

Centisome position: 51.32

GC content: 29.47

Gene sequence:

>1968_bases
ATGATAAACAAAAATAACAACAATTTAAATGCTTTAAGAATTTTAGGAGTTTCTGCAATTAATAAAGCAAATTCAGGTCA
CCCAGGTATTGTATTAGGCGCTGCACCAATCGTTTATACTTTATTTAACAAAATTATGAAACACAATCCTAAAAATCCTA
AGTGATTTGATAGAGATCGTTTTGTATTATCAGCAGGGCATGGAAGTGCTTTATTATATTCAGCATTACATTTAGCTGGT
TATAATTTATCAATGGATGAAATTAAAAACTTTAGACAATGAAATAGTAAAACACCAGGTCACCCTGAATCTCACTTAAC
TGAAGGGGTTGATGTAACAACTGGACCTTTAGGTCAAGGAATTGCTATGGCTGTTGGATTGGCAATTGCTGAATCTCATA
CAGCATCAGTATATAATCAATCAGATTTAAAATTAGTTGATCACCATACATTTGTTTTATGTGGTGATGGAGATTTACAA
GAAGGTGTAGCTCAAGAATCAATTAGTTTAGCTGGTAGATTAAAATTAAACAAATTAATTTTAATTCACGACTCAAATGA
TATTCAATTAGATGACAAAGTTGAAAAAGCTCAAAGTGAAAATATGCACGAAAGATTTAAAGCTGCTCAATGAAATACTT
TAAAAATTAATGATGGTGAAGATTTAGTAGCTATTGAAAAAGCTATTAATGATGCCAAAGTATCAGATAAACCTACATAT
ATTGAAGTTAAAACAATTATTGGTATAGGGGCCACAAAACAAGGGACTAGTGCAGTACACGGTGCCCCAATTGGTTCAGA
TATCGAAACAGTTAAAAACGTTTTTGATTGAAAATTTGATGATTTTGAAATACCAACTGATATTTATAAACATTGAAATG
AAAATATTTCAAAAAATTTAATAATTGAAAAAAAATGAAACGAAACATTAAATACTTTAAAAACTAAAAATCCAGAATTA
GCAAAACAATTTACAGATGCTATTAACAAAGAAATTAATTTTGATTTTGAAGCATTAAAAGGTAAAACTCCAGAAAAAGC
AGAAGCTACTAGAGTTAGTTCAGGAAACATTTGAGATAGCATAAATTCTCAAGTTAAATTTTTAATTGGTGGTTCAGCTG
ATTTAGTTTCATCAACAAGAATTAAAGGTGCTGATGGTCAATTTGATATTGATAACAGAAGTGGAAGAAATATTCTTTAT
GGTGTTAGAGAATTTGCTATGGGAGCTATAAATAATGGTATTCATCAACATGGTGGTTTAATTCCATTCTCAAGTGGATT
CTTTGTATTCTCAGATTACATGAAACCAGCAATGCGTTTATCATCAATTATGAATACACAACAATTGTTTATATTTACTC
ATGATTCAGTTGCTGTTGGAGAAGATGGACCAACTCATCAACCAATAGAGCAATTAGCAATGATTAGAAGTATTCCAAAT
CACATTACATTTAGACCAGCTGATTATGCTGAAACATTAGCATCTTATAAAATAGCTTTACAAGACTTAAAAAAATGTCC
TTCTACTTTAGTTTTAACTAGACAAGACTTAGTTCAATTACCACATAATGATGTTTATGAAGAAGTTAAAAAAGGAGCAT
ATATTATTTTTGATCAACCTAATGCTTCAGTAACTTTAATAGCAACAGGTAGTGAAGTTGGTTTAGCGATAGAAACAGCT
AAAAGACTAAAAGAAGATAACATCATTGCAAAAGTAGTTTCAATGCCTTCAACAAACTTATTTGATCAACAAGATCAATC
ATATAAAGATAAAATTATTGATAAATCAACTTTAAGAGTTTCAATTGAAATGGGAACAACTTATGGATGAAGCAAATATA
CAGGTGACAATGGATTAAACATTGGAATTGATGTTTTTGGAGCAAGTGCACCAGCTAATACAGTAATTAGTCAATATGGA
TTTACAAGTGAGCAAATTTTTAATAAAATTAAAAAGGTTATAAAATAA

Upstream 100 bases:

>100_bases
TTTAGAAATGGTTTTGAACAACAATTAAAAAGTACAAAAGTAATAGATGCACAAGGAAATGATGTAACACCAAGCAAACT
AAAGAATGAAGGAGATAAAT

Downstream 100 bases:

>100_bases
TTTAAAATTAAGAAAAAATAGAATAGAGTGAAATTATGGTATTATTAACAACAGAATTTTCAGCAGGAGGATTAGCAGGA
ATGCTAATCGGAGTTATCTT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 655; Mature: 655

Protein sequence:

>655_residues
MINKNNNNLNALRILGVSAINKANSGHPGIVLGAAPIVYTLFNKIMKHNPKNPKWFDRDRFVLSAGHGSALLYSALHLAG
YNLSMDEIKNFRQWNSKTPGHPESHLTEGVDVTTGPLGQGIAMAVGLAIAESHTASVYNQSDLKLVDHHTFVLCGDGDLQ
EGVAQESISLAGRLKLNKLILIHDSNDIQLDDKVEKAQSENMHERFKAAQWNTLKINDGEDLVAIEKAINDAKVSDKPTY
IEVKTIIGIGATKQGTSAVHGAPIGSDIETVKNVFDWKFDDFEIPTDIYKHWNENISKNLIIEKKWNETLNTLKTKNPEL
AKQFTDAINKEINFDFEALKGKTPEKAEATRVSSGNIWDSINSQVKFLIGGSADLVSSTRIKGADGQFDIDNRSGRNILY
GVREFAMGAINNGIHQHGGLIPFSSGFFVFSDYMKPAMRLSSIMNTQQLFIFTHDSVAVGEDGPTHQPIEQLAMIRSIPN
HITFRPADYAETLASYKIALQDLKKCPSTLVLTRQDLVQLPHNDVYEEVKKGAYIIFDQPNASVTLIATGSEVGLAIETA
KRLKEDNIIAKVVSMPSTNLFDQQDQSYKDKIIDKSTLRVSIEMGTTYGWSKYTGDNGLNIGIDVFGASAPANTVISQYG
FTSEQIFNKIKKVIK

Sequences:

>Translated_655_residues
MINKNNNNLNALRILGVSAINKANSGHPGIVLGAAPIVYTLFNKIMKHNPKNPK*FDRDRFVLSAGHGSALLYSALHLAG
YNLSMDEIKNFRQ*NSKTPGHPESHLTEGVDVTTGPLGQGIAMAVGLAIAESHTASVYNQSDLKLVDHHTFVLCGDGDLQ
EGVAQESISLAGRLKLNKLILIHDSNDIQLDDKVEKAQSENMHERFKAAQ*NTLKINDGEDLVAIEKAINDAKVSDKPTY
IEVKTIIGIGATKQGTSAVHGAPIGSDIETVKNVFD*KFDDFEIPTDIYKH*NENISKNLIIEKK*NETLNTLKTKNPEL
AKQFTDAINKEINFDFEALKGKTPEKAEATRVSSGNI*DSINSQVKFLIGGSADLVSSTRIKGADGQFDIDNRSGRNILY
GVREFAMGAINNGIHQHGGLIPFSSGFFVFSDYMKPAMRLSSIMNTQQLFIFTHDSVAVGEDGPTHQPIEQLAMIRSIPN
HITFRPADYAETLASYKIALQDLKKCPSTLVLTRQDLVQLPHNDVYEEVKKGAYIIFDQPNASVTLIATGSEVGLAIETA
KRLKEDNIIAKVVSMPSTNLFDQQDQSYKDKIIDKSTLRVSIEMGTTYG*SKYTGDNGLNIGIDVFGASAPANTVISQYG
FTSEQIFNKIKKVIK
>Mature_655_residues
MINKNNNNLNALRILGVSAINKANSGHPGIVLGAAPIVYTLFNKIMKHNPKNPK*FDRDRFVLSAGHGSALLYSALHLAG
YNLSMDEIKNFRQ*NSKTPGHPESHLTEGVDVTTGPLGQGIAMAVGLAIAESHTASVYNQSDLKLVDHHTFVLCGDGDLQ
EGVAQESISLAGRLKLNKLILIHDSNDIQLDDKVEKAQSENMHERFKAAQ*NTLKINDGEDLVAIEKAINDAKVSDKPTY
IEVKTIIGIGATKQGTSAVHGAPIGSDIETVKNVFD*KFDDFEIPTDIYKH*NENISKNLIIEKK*NETLNTLKTKNPEL
AKQFTDAINKEINFDFEALKGKTPEKAEATRVSSGNI*DSINSQVKFLIGGSADLVSSTRIKGADGQFDIDNRSGRNILY
GVREFAMGAINNGIHQHGGLIPFSSGFFVFSDYMKPAMRLSSIMNTQQLFIFTHDSVAVGEDGPTHQPIEQLAMIRSIPN
HITFRPADYAETLASYKIALQDLKKCPSTLVLTRQDLVQLPHNDVYEEVKKGAYIIFDQPNASVTLIATGSEVGLAIETA
KRLKEDNIIAKVVSMPSTNLFDQQDQSYKDKIIDKSTLRVSIEMGTTYG*SKYTGDNGLNIGIDVFGASAPANTVISQYG
FTSEQIFNKIKKVIK

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=578, Percent_Identity=28.5467128027682, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI4507521, Length=578, Percent_Identity=28.5467128027682, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI133778974, Length=572, Percent_Identity=27.4475524475524, Blast_Score=130, Evalue=3e-30,
Organism=Escherichia coli, GI48994911, Length=660, Percent_Identity=41.969696969697, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI1788808, Length=658, Percent_Identity=41.1854103343465, Blast_Score=489, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17539652, Length=669, Percent_Identity=25.1121076233184, Blast_Score=129, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6325331, Length=665, Percent_Identity=43.1578947368421, Blast_Score=468, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6319593, Length=665, Percent_Identity=41.0526315789474, Blast_Score=442, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24666278, Length=575, Percent_Identity=28.3478260869565, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI45551847, Length=658, Percent_Identity=24.6200607902736, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI45550715, Length=658, Percent_Identity=24.6200607902736, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24645119, Length=630, Percent_Identity=24.1269841269841, Blast_Score=141, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 70645; Mature: 70645

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINKNNNNLNALRILGVSAINKANSGHPGIVLGAAPIVYTLFNKIMKHNPKNPKFDRDRF
CCCCCCCCCEEEEEEEHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCEE
VLSAGHGSALLYSALHLAGYNLSMDEIKNFRQNSKTPGHPESHLTEGVDVTTGPLGQGIA
EEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCHHH
MAVGLAIAESHTASVYNQSDLKLVDHHTFVLCGDGDLQEGVAQESISLAGRLKLNKLILI
HHHHHHHHCCCHHHHCCCCCCEEEECEEEEEECCCCHHHHHHHHHHHHHCEEEEEEEEEE
HDSNDIQLDDKVEKAQSENMHERFKAAQNTLKINDGEDLVAIEKAINDAKVSDKPTYIEV
ECCCCCEECHHHHHHHHCCHHHHHHHHHCEEEECCCCCCHHHHHHHCCCCCCCCCCEEEE
KTIIGIGATKQGTSAVHGAPIGSDIETVKNVFDKFDDFEIPTDIYKHNENISKNLIIEKK
EEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCEEEEEC
NETLNTLKTKNPELAKQFTDAINKEINFDFEALKGKTPEKAEATRVSSGNIDSINSQVKF
CCHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHCCCCCCCCCCCCEEEE
LIGGSADLVSSTRIKGADGQFDIDNRSGRNILYGVREFAMGAINNGIHQHGGLIPFSSGF
EECCCHHHHHCCEECCCCCCEECCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCEECCCC
FVFSDYMKPAMRLSSIMNTQQLFIFTHDSVAVGEDGPTHQPIEQLAMIRSIPNHITFRPA
CHHHHHHHHHHHHHHHCCCEEEEEEEECCEEECCCCCCCCHHHHHHHHHHCCCCEEECCC
DYAETLASYKIALQDLKKCPSTLVLTRQDLVQLPHNDVYEEVKKGAYIIFDQPNASVTLI
HHHHHHHHHHHHHHHHHHCCHHEEEEHHHHHHCCCHHHHHHHHCCEEEEEECCCCCEEEE
ATGSEVGLAIETAKRLKEDNIIAKVVSMPSTNLFDQQDQSYKDKIIDKSTLRVSIEMGTT
EECCCCCEEHHHHHHHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHCCCCEEEEEEEECCC
YGSKYTGDNGLNIGIDVFGASAPANTVISQYGFTSEQIFNKIKKVIK
CCCCCCCCCCCEEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHC
>Mature Secondary Structure
MINKNNNNLNALRILGVSAINKANSGHPGIVLGAAPIVYTLFNKIMKHNPKNPKFDRDRF
CCCCCCCCCEEEEEEEHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCEE
VLSAGHGSALLYSALHLAGYNLSMDEIKNFRQNSKTPGHPESHLTEGVDVTTGPLGQGIA
EEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCHHH
MAVGLAIAESHTASVYNQSDLKLVDHHTFVLCGDGDLQEGVAQESISLAGRLKLNKLILI
HHHHHHHHCCCHHHHCCCCCCEEEECEEEEEECCCCHHHHHHHHHHHHHCEEEEEEEEEE
HDSNDIQLDDKVEKAQSENMHERFKAAQNTLKINDGEDLVAIEKAINDAKVSDKPTYIEV
ECCCCCEECHHHHHHHHCCHHHHHHHHHCEEEECCCCCCHHHHHHHCCCCCCCCCCEEEE
KTIIGIGATKQGTSAVHGAPIGSDIETVKNVFDKFDDFEIPTDIYKHNENISKNLIIEKK
EEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCEEEEEC
NETLNTLKTKNPELAKQFTDAINKEINFDFEALKGKTPEKAEATRVSSGNIDSINSQVKF
CCHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHCCCCCCCCCCCCEEEE
LIGGSADLVSSTRIKGADGQFDIDNRSGRNILYGVREFAMGAINNGIHQHGGLIPFSSGF
EECCCHHHHHCCEECCCCCCEECCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCEECCCC
FVFSDYMKPAMRLSSIMNTQQLFIFTHDSVAVGEDGPTHQPIEQLAMIRSIPNHITFRPA
CHHHHHHHHHHHHHHHCCCEEEEEEEECCEEECCCCCCCCHHHHHHHHHHCCCCEEECCC
DYAETLASYKIALQDLKKCPSTLVLTRQDLVQLPHNDVYEEVKKGAYIIFDQPNASVTLI
HHHHHHHHHHHHHHHHHHCCHHEEEEHHHHHHCCCHHHHHHHHCCEEEEEECCCCCEEEE
ATGSEVGLAIETAKRLKEDNIIAKVVSMPSTNLFDQQDQSYKDKIIDKSTLRVSIEMGTT
EECCCCCEEHHHHHHHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHCCCCEEEEEEEECCC
YGSKYTGDNGLNIGIDVFGASAPANTVISQYGFTSEQIFNKIKKVIK
CCCCCCCCCCCEEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]