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The map label for this gene is gpo [H]

Identifier: 50085206

GI number: 50085206

Start: 2068191

End: 2068673

Strand: Reverse

Name: gpo [H]

Synonym: ACIAD2085

Alternate gene names: 50085206

Gene position: 2068673-2068191 (Counterclockwise)

Preceding gene: 50085207

Following gene: 50085205

Centisome position: 57.49

GC content: 42.03

Gene sequence:

>483_bases
ATGACTAACCTTTACCAATTTGAAGCTGAGCTATTAGAAGGTGATACAAAATCACTAGCCGATTATCAGGGGAAAGTACT
TTTGATTGTCAATACAGCCAGCAAATGCGGGTTTACTCCCCAATTTGCGGGTCTGGAAAAAATATACGAAAAATATAAAG
ATCGTGGGTTTGAGGTTCTGGGCTTTCCGTGTAATCAATTTGGAGGACAAGACCCAGGAAGCAATAACGAAATCGGTGCT
TTTTGCCAGCGTAATTATGGTGTGAGCTTTCCTATGTTTGCCAAAGTGGACGTAAAAGGTCCTGAAGCGCATGCGATATT
TCGTTATTTGACTCGTGAAGCAAAGGGGATTTTGGGAAGTGAAAATATCAAATGGAATTTCACCAAGTTCTTGGTCGGAC
GCGACGGAAAAGTGTTGAATCGATATGCGCCAACCACCAAACCTGAGAGTCTGGAAGAAGATATCGAGAAAGCATTGGCA
TAA

Upstream 100 bases:

>100_bases
TTTTTGAAGATGGACCGCAGCCGACGGGATTACGCTATTGTGTCAATTCGGCATCATTACAACTAAAAACCGATGAAAAG
AATGATGAGGAAACTTATCC

Downstream 100 bases:

>100_bases
CTGAGTCGCTATTTATACATCTAATTCTATAAGTACAATGACTCATTTATCAAATCAGTTTTGGACCGATCCTCGTATGC
CTTATGTGGAAACACGTAGG

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 160; Mature: 159

Protein sequence:

>160_residues
MTNLYQFEAELLEGDTKSLADYQGKVLLIVNTASKCGFTPQFAGLEKIYEKYKDRGFEVLGFPCNQFGGQDPGSNNEIGA
FCQRNYGVSFPMFAKVDVKGPEAHAIFRYLTREAKGILGSENIKWNFTKFLVGRDGKVLNRYAPTTKPESLEEDIEKALA

Sequences:

>Translated_160_residues
MTNLYQFEAELLEGDTKSLADYQGKVLLIVNTASKCGFTPQFAGLEKIYEKYKDRGFEVLGFPCNQFGGQDPGSNNEIGA
FCQRNYGVSFPMFAKVDVKGPEAHAIFRYLTREAKGILGSENIKWNFTKFLVGRDGKVLNRYAPTTKPESLEEDIEKALA
>Mature_159_residues
TNLYQFEAELLEGDTKSLADYQGKVLLIVNTASKCGFTPQFAGLEKIYEKYKDRGFEVLGFPCNQFGGQDPGSNNEIGAF
CQRNYGVSFPMFAKVDVKGPEAHAIFRYLTREAKGILGSENIKWNFTKFLVGRDGKVLNRYAPTTKPESLEEDIEKALA

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI15618997, Length=154, Percent_Identity=44.8051948051948, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI75709200, Length=156, Percent_Identity=40.3846153846154, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI90903240, Length=156, Percent_Identity=40.3846153846154, Blast_Score=124, Evalue=4e-29,
Organism=Homo sapiens, GI192455698, Length=156, Percent_Identity=37.8205128205128, Blast_Score=120, Evalue=6e-28,
Organism=Homo sapiens, GI90903238, Length=131, Percent_Identity=41.2213740458015, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI4557629, Length=173, Percent_Identity=38.150289017341, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI41406084, Length=184, Percent_Identity=36.4130434782609, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI6006001, Length=178, Percent_Identity=33.1460674157303, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI33186887, Length=177, Percent_Identity=32.7683615819209, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI32967607, Length=181, Percent_Identity=30.939226519337, Blast_Score=78, Evalue=4e-15,
Organism=Escherichia coli, GI1788003, Length=170, Percent_Identity=44.7058823529412, Blast_Score=151, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17506887, Length=160, Percent_Identity=46.25, Blast_Score=154, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17535473, Length=160, Percent_Identity=43.75, Blast_Score=145, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI71993584, Length=157, Percent_Identity=36.9426751592357, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI193210707, Length=161, Percent_Identity=41.6149068322981, Blast_Score=119, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI193209493, Length=164, Percent_Identity=31.0975609756098, Blast_Score=99, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17550320, Length=164, Percent_Identity=29.2682926829268, Blast_Score=96, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71999642, Length=76, Percent_Identity=40.7894736842105, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71993573, Length=94, Percent_Identity=36.1702127659575, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319721, Length=159, Percent_Identity=50.9433962264151, Blast_Score=183, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6322228, Length=159, Percent_Identity=50.9433962264151, Blast_Score=175, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6322826, Length=159, Percent_Identity=41.5094339622642, Blast_Score=136, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24656772, Length=159, Percent_Identity=46.5408805031447, Blast_Score=139, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24656767, Length=159, Percent_Identity=46.5408805031447, Blast_Score=139, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24656777, Length=159, Percent_Identity=46.5408805031447, Blast_Score=139, Evalue=9e-34,
Organism=Drosophila melanogaster, GI85726443, Length=149, Percent_Identity=43.6241610738255, Blast_Score=122, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 17909; Mature: 17777

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1 ; PS00763 GLUTATHIONE_PEROXID_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNLYQFEAELLEGDTKSLADYQGKVLLIVNTASKCGFTPQFAGLEKIYEKYKDRGFEVL
CCCHHHHHHHHHCCCHHHHHHCCCCEEEEEECCHHCCCCCCHHHHHHHHHHHHHCCCEEE
GFPCNQFGGQDPGSNNEIGAFCQRNYGVSFPMFAKVDVKGPEAHAIFRYLTREAKGILGS
ECCHHHCCCCCCCCCCCHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCC
ENIKWNFTKFLVGRDGKVLNRYAPTTKPESLEEDIEKALA
CCCEEEEEEEEECCCCCEECCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TNLYQFEAELLEGDTKSLADYQGKVLLIVNTASKCGFTPQFAGLEKIYEKYKDRGFEVL
CCHHHHHHHHHCCCHHHHHHCCCCEEEEEECCHHCCCCCCHHHHHHHHHHHHHCCCEEE
GFPCNQFGGQDPGSNNEIGAFCQRNYGVSFPMFAKVDVKGPEAHAIFRYLTREAKGILGS
ECCHHHCCCCCCCCCCCHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCC
ENIKWNFTKFLVGRDGKVLNRYAPTTKPESLEEDIEKALA
CCCEEEEEEEEECCCCCEECCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]