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The map label for this gene is fabG [H]

Identifier: 50085113

GI number: 50085113

Start: 1964661

End: 1966061

Strand: Reverse

Name: fabG [H]

Synonym: ACIAD1976

Alternate gene names: 50085113

Gene position: 1966061-1964661 (Counterclockwise)

Preceding gene: 50085115

Following gene: 50085112

Centisome position: 54.63

GC content: 42.11

Gene sequence:

>1401_bases
ATGATTAAGATGATTGATCAATACCAAGCATTTACACAATCCCCAATCGGAAAGTTTGTTGTTAAAAATTTGGGCTTACC
ATCACCAGTGGTATTAGATCGTTTTGAAAGTGGTCAGCCAGTAATTAAAGGCGCTGTACTGATGGGTGCAGCACCATCAA
GTTCACTTACATCTGGGATTGCACAGGTGTTAAGTAATATTCATGCAGATAGCTATGCGGGTAATAATGCTGAGATTCAA
CAAGCGGCTGCTCAGGTGGGCTTGAATTTACGTGCATTTAACTCTGGCGATAAAGAATCCAAATTCAAGGCAGTTGTTTT
TGATGCTTCTGGTATTCAAAACTCAGAACAACTTGATGAGCTATATAAATTTTTTAATCCGATTGTTCGTCAGATTGAAA
GCTCTGGTCGTGTCATTGTTTTAGGAACCAGTCCTGAATCTGCTAAAACAGTCAAACAGGCAATTGCCCAGCGTGCGCTT
GAAGGTTTTATCAAGTCTGTAGGTAAAGAGTTTAAAAAAGGGATTACAGCGCAAGTCGTTTATGTTGATGAAGGGGCAGT
CAATAATATTGAGTCGACATTAAGATTTTTATTATCACCTCGTTCGGCTTATGTCTCTGGGCAGGTGATTCGTGTATCCA
AAGCAGAAGTCGTTCAAGTGGATTGGGATAAGCCTCTTGCGGGTAAAACGGCATTGGTCACTGGTGCAAGTCGTGGTATT
GGAGAAGCGATTGCACATGTTTTGGCACGTGATGGCGCGCATGTAATTTGTCTGGATGTACCTCAACAACAGGTAGATCT
TGACCGTGTTGCATCAGAGATTGGTGGTTCGGCTTTAGGTCTTGATATTACGGCTGCCGATGCAGGTGAGAAGATTAAAG
CTGCTGCAGCAAAACAAGGTGGTCTGGATATCATTGTGCATAATGCAGGTATTACCCGTGACAAAACTTTGGCAAATATG
AAGTCTGAGCTTTGGGATCTTGTCATCAATATTAACTTGAGCGCTGCTGAACGCATTAATGATTACTTGCTTGCCAATGA
TGGTTTAAATACCAATGGTCGAATTGTTTGTGTATCTTCAATTAGTGGTATTGCAGGCAATCTTGGTCAAACCAATTACG
CCGTGTCGAAAGCAGGTGTAATTGGTCTGGTTAAATTTACTGCGCCAATCCTTAAAAATGGTATTACGATTAATGCTGTT
GCGCCAGGTTTCATTGAAACGCAAATGACAGCCGCGATTCCTTTTGCAATTCGTGAAGCGGGGCGTCGTATGAATTCAAT
GAATCAGGGTGGCTTGCCTGTAGATGTTGCTGAAACGATTTCTTGGTTTGCTGCAACAGGATCTACGGGTATCAATGGAA
ATGTAGTGCGAGTTTGTGGACAAAGTCTACTTGGTGCATGA

Upstream 100 bases:

>100_bases
TTATTCAATCCACATGACTATCGAGCTAACACCTTTACAACATAAATCTGTTGAATGCGTGGCTTGACAACATGTTCAAA
ACATTAATTTGCATTAAGAG

Downstream 100 bases:

>100_bases
TACTGATCAACAAAGGGATGTGATAAGACATCCCTTTTGTTTTTAAATGAAACAACAATAGATTTTAATTAGAAGGTTCG
TTATGAATACTCGTCATTTT

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MIKMIDQYQAFTQSPIGKFVVKNLGLPSPVVLDRFESGQPVIKGAVLMGAAPSSSLTSGIAQVLSNIHADSYAGNNAEIQ
QAAAQVGLNLRAFNSGDKESKFKAVVFDASGIQNSEQLDELYKFFNPIVRQIESSGRVIVLGTSPESAKTVKQAIAQRAL
EGFIKSVGKEFKKGITAQVVYVDEGAVNNIESTLRFLLSPRSAYVSGQVIRVSKAEVVQVDWDKPLAGKTALVTGASRGI
GEAIAHVLARDGAHVICLDVPQQQVDLDRVASEIGGSALGLDITAADAGEKIKAAAAKQGGLDIIVHNAGITRDKTLANM
KSELWDLVININLSAAERINDYLLANDGLNTNGRIVCVSSISGIAGNLGQTNYAVSKAGVIGLVKFTAPILKNGITINAV
APGFIETQMTAAIPFAIREAGRRMNSMNQGGLPVDVAETISWFAATGSTGINGNVVRVCGQSLLGA

Sequences:

>Translated_466_residues
MIKMIDQYQAFTQSPIGKFVVKNLGLPSPVVLDRFESGQPVIKGAVLMGAAPSSSLTSGIAQVLSNIHADSYAGNNAEIQ
QAAAQVGLNLRAFNSGDKESKFKAVVFDASGIQNSEQLDELYKFFNPIVRQIESSGRVIVLGTSPESAKTVKQAIAQRAL
EGFIKSVGKEFKKGITAQVVYVDEGAVNNIESTLRFLLSPRSAYVSGQVIRVSKAEVVQVDWDKPLAGKTALVTGASRGI
GEAIAHVLARDGAHVICLDVPQQQVDLDRVASEIGGSALGLDITAADAGEKIKAAAAKQGGLDIIVHNAGITRDKTLANM
KSELWDLVININLSAAERINDYLLANDGLNTNGRIVCVSSISGIAGNLGQTNYAVSKAGVIGLVKFTAPILKNGITINAV
APGFIETQMTAAIPFAIREAGRRMNSMNQGGLPVDVAETISWFAATGSTGINGNVVRVCGQSLLGA
>Mature_466_residues
MIKMIDQYQAFTQSPIGKFVVKNLGLPSPVVLDRFESGQPVIKGAVLMGAAPSSSLTSGIAQVLSNIHADSYAGNNAEIQ
QAAAQVGLNLRAFNSGDKESKFKAVVFDASGIQNSEQLDELYKFFNPIVRQIESSGRVIVLGTSPESAKTVKQAIAQRAL
EGFIKSVGKEFKKGITAQVVYVDEGAVNNIESTLRFLLSPRSAYVSGQVIRVSKAEVVQVDWDKPLAGKTALVTGASRGI
GEAIAHVLARDGAHVICLDVPQQQVDLDRVASEIGGSALGLDITAADAGEKIKAAAAKQGGLDIIVHNAGITRDKTLANM
KSELWDLVININLSAAERINDYLLANDGLNTNGRIVCVSSISGIAGNLGQTNYAVSKAGVIGLVKFTAPILKNGITINAV
APGFIETQMTAAIPFAIREAGRRMNSMNQGGLPVDVAETISWFAATGSTGINGNVVRVCGQSLLGA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=256, Percent_Identity=36.71875, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI32483357, Length=247, Percent_Identity=32.3886639676113, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI4504505, Length=225, Percent_Identity=32.8888888888889, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI5031737, Length=254, Percent_Identity=29.1338582677165, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI33667109, Length=203, Percent_Identity=32.0197044334975, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI126723191, Length=181, Percent_Identity=33.1491712707182, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI40254992, Length=244, Percent_Identity=30.327868852459, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI126723750, Length=270, Percent_Identity=27.4074074074074, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI40807363, Length=195, Percent_Identity=27.6923076923077, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1787335, Length=193, Percent_Identity=44.0414507772021, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI87082100, Length=245, Percent_Identity=32.2448979591837, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI1789208, Length=248, Percent_Identity=27.4193548387097, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082160, Length=249, Percent_Identity=28.9156626506024, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790717, Length=196, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI2367175, Length=251, Percent_Identity=31.4741035856574, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI2367365, Length=237, Percent_Identity=29.957805907173, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789378, Length=261, Percent_Identity=29.5019157088123, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=240, Percent_Identity=36.25, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=34.6774193548387, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17568967, Length=167, Percent_Identity=35.3293413173653, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=27.1653543307087, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538182, Length=212, Percent_Identity=30.188679245283, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17559104, Length=266, Percent_Identity=30.8270676691729, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71994600, Length=248, Percent_Identity=30.241935483871, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=29.9595141700405, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=211, Percent_Identity=30.8056872037915, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=245, Percent_Identity=27.7551020408163, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=208, Percent_Identity=29.8076923076923, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=204, Percent_Identity=30.3921568627451, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=247, Percent_Identity=28.7449392712551, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=221, Percent_Identity=28.0542986425339, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=248, Percent_Identity=25.4032258064516, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193204405, Length=270, Percent_Identity=29.6296296296296, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=207, Percent_Identity=29.4685990338164, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24639444, Length=243, Percent_Identity=36.6255144032922, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI23397609, Length=245, Percent_Identity=32.6530612244898, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI18859837, Length=186, Percent_Identity=33.8709677419355, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17737361, Length=250, Percent_Identity=32.8, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355319, Length=202, Percent_Identity=33.6633663366337, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24644339, Length=246, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21357041, Length=244, Percent_Identity=31.1475409836066, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28571526, Length=190, Percent_Identity=32.6315789473684, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24643142, Length=187, Percent_Identity=32.620320855615, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 48915; Mature: 48915

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKMIDQYQAFTQSPIGKFVVKNLGLPSPVVLDRFESGQPVIKGAVLMGAAPSSSLTSGI
CCCHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHCCCCCCCCEEEEEEECCCCCHHHHHHH
AQVLSNIHADSYAGNNAEIQQAAAQVGLNLRAFNSGDKESKFKAVVFDASGIQNSEQLDE
HHHHHHCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCCEEEEEEECCCCCCHHHHHH
LYKFFNPIVRQIESSGRVIVLGTSPESAKTVKQAIAQRALEGFIKSVGKEFKKGITAQVV
HHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
YVDEGAVNNIESTLRFLLSPRSAYVSGQVIRVSKAEVVQVDWDKPLAGKTALVTGASRGI
EECCCCCCHHHHHHHHHHCCCHHHCCCEEEEEECCEEEEEECCCCCCCCEEEEECCCCCH
GEAIAHVLARDGAHVICLDVPQQQVDLDRVASEIGGSALGLDITAADAGEKIKAAAAKQG
HHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHCCC
GLDIIVHNAGITRDKTLANMKSELWDLVININLSAAERINDYLLANDGLNTNGRIVCVSS
CCEEEEECCCCCCHHHHHHHHHHHEEEEEEECCHHHHHCCCEEEECCCCCCCCEEEEEEC
ISGIAGNLGQTNYAVSKAGVIGLVKFTAPILKNGITINAVAPGFIETQMTAAIPFAIREA
CCCHHCCCCCCCCEEHHCCEEEHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHH
GRRMNSMNQGGLPVDVAETISWFAATGSTGINGNVVRVCGQSLLGA
HHHHHCCCCCCCCEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MIKMIDQYQAFTQSPIGKFVVKNLGLPSPVVLDRFESGQPVIKGAVLMGAAPSSSLTSGI
CCCHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHCCCCCCCCEEEEEEECCCCCHHHHHHH
AQVLSNIHADSYAGNNAEIQQAAAQVGLNLRAFNSGDKESKFKAVVFDASGIQNSEQLDE
HHHHHHCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCCEEEEEEECCCCCCHHHHHH
LYKFFNPIVRQIESSGRVIVLGTSPESAKTVKQAIAQRALEGFIKSVGKEFKKGITAQVV
HHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
YVDEGAVNNIESTLRFLLSPRSAYVSGQVIRVSKAEVVQVDWDKPLAGKTALVTGASRGI
EECCCCCCHHHHHHHHHHCCCHHHCCCEEEEEECCEEEEEECCCCCCCCEEEEECCCCCH
GEAIAHVLARDGAHVICLDVPQQQVDLDRVASEIGGSALGLDITAADAGEKIKAAAAKQG
HHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHCCC
GLDIIVHNAGITRDKTLANMKSELWDLVININLSAAERINDYLLANDGLNTNGRIVCVSS
CCEEEEECCCCCCHHHHHHHHHHHEEEEEEECCHHHHHCCCEEEECCCCCCCCEEEEEEC
ISGIAGNLGQTNYAVSKAGVIGLVKFTAPILKNGITINAVAPGFIETQMTAAIPFAIREA
CCCHHCCCCCCCCEEHHCCEEEHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHH
GRRMNSMNQGGLPVDVAETISWFAATGSTGINGNVVRVCGQSLLGA
HHHHHCCCCCCCCEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]