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The map label for this gene is fda [H]

Identifier: 50085065

GI number: 50085065

Start: 1915285

End: 1916322

Strand: Reverse

Name: fda [H]

Synonym: ACIAD1925

Alternate gene names: 50085065

Gene position: 1916322-1915285 (Counterclockwise)

Preceding gene: 50085066

Following gene: 50085064

Centisome position: 53.25

GC content: 44.22

Gene sequence:

>1038_bases
ATGGCACTTATCTCATTGCGCCAGCTCTTGGATCACGCCGCAGAACATAACTACGGCGTACCAGCGTTTAATGTAAACAA
TCTTGAGCAAATGCGCGCGATCATGTTGGCAGCGGATGAAACCAACTCACCTGTTATTGTTCAAGCTTCGGCGGGTGCGC
GTAAATATGCAGGCGCTCCATTTTTACGTCACTTGATTTTGGCAGCAGTTGAAGAATGGCCACATATTCCTGTGGTAATG
CATCAAGACCATGGAACCAGCCCTGATGTATGTCAACGCTCTATCCAGTTAGGCTTTAGCTCGGTGATGATGGACGGATC
ACTTGGTTCTGATGGCAAAACACCAACTTCTTATGATTACAACGTTGATGTAACTCGTCGTGTAGTGGCTATGGCACATG
CATGTGGTGTATCCGTAGAAGGTGAAATTGGTTGTTTGGGCAGCCTTGAAACTGGTTTGGCGGGTGAAGAAGATGGCGTG
GGTGCAGAAGGTGTACTTGACCATTCACAACTTTTAACTTCTGTTGAAGAAGCGACTCAGTTTGTTGCAGATACCAATGT
CGATGCGCTTGCAATTGCAGTGGGTACCTCACACGGTGCTTATAAGTTTACTCGTCCACCTACAGGCGATATTCTAGCAA
TTGACCGCATTAAAGAAATTCACGCAGCTTTACCAAATACGCATCTTGTGATGCATGGTTCAAGCTCTGTACCTCAAGAC
TGGTTGAAAATTATCAATGAGCATGGTGGTCAAATTGGTGAAACTTACGGTGTGCCACTTGAGCAGCTTGTCGAAGCAAT
CAAGCATGGTGTTCGTAAAATCAATATTGATACCGATTTACGTTTGGCATCAACGGGTGCAATTCGTAGCTTTATGTCTG
AAAATCCAGCCGAATTTGATCCACGTAAATACTTGGCAAAAACTGTTGATGCAATGAAGCAGATTTGTATTGAACGTTAT
CAAGCGTTTGGTACAGCGGGCAATGCAGATAAAATTCGTCCTATTTCTTTAGAAGCGATGGTTGATCGTTATAAATAA

Upstream 100 bases:

>100_bases
GTCCCTGCAAATGCAGGGATTTTTTTGTGAAATTCTTTGATTTGTTGCTGAATTGAAATACATCACACTGTAGAATAGGC
GCACTACCTGGGAGGATATT

Downstream 100 bases:

>100_bases
TTAGTCCGAAATTCAGAAAAGCCCATTTGATGGGCTTTTCTTGTTTTTGATGAGGTAGAAATAGTGGAATTCATTGTTTT
AGCTGCACTATGTAGTGTGT

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MALISLRQLLDHAAEHNYGVPAFNVNNLEQMRAIMLAADETNSPVIVQASAGARKYAGAPFLRHLILAAVEEWPHIPVVM
HQDHGTSPDVCQRSIQLGFSSVMMDGSLGSDGKTPTSYDYNVDVTRRVVAMAHACGVSVEGEIGCLGSLETGLAGEEDGV
GAEGVLDHSQLLTSVEEATQFVADTNVDALAIAVGTSHGAYKFTRPPTGDILAIDRIKEIHAALPNTHLVMHGSSSVPQD
WLKIINEHGGQIGETYGVPLEQLVEAIKHGVRKINIDTDLRLASTGAIRSFMSENPAEFDPRKYLAKTVDAMKQICIERY
QAFGTAGNADKIRPISLEAMVDRYK

Sequences:

>Translated_345_residues
MALISLRQLLDHAAEHNYGVPAFNVNNLEQMRAIMLAADETNSPVIVQASAGARKYAGAPFLRHLILAAVEEWPHIPVVM
HQDHGTSPDVCQRSIQLGFSSVMMDGSLGSDGKTPTSYDYNVDVTRRVVAMAHACGVSVEGEIGCLGSLETGLAGEEDGV
GAEGVLDHSQLLTSVEEATQFVADTNVDALAIAVGTSHGAYKFTRPPTGDILAIDRIKEIHAALPNTHLVMHGSSSVPQD
WLKIINEHGGQIGETYGVPLEQLVEAIKHGVRKINIDTDLRLASTGAIRSFMSENPAEFDPRKYLAKTVDAMKQICIERY
QAFGTAGNADKIRPISLEAMVDRYK
>Mature_344_residues
ALISLRQLLDHAAEHNYGVPAFNVNNLEQMRAIMLAADETNSPVIVQASAGARKYAGAPFLRHLILAAVEEWPHIPVVMH
QDHGTSPDVCQRSIQLGFSSVMMDGSLGSDGKTPTSYDYNVDVTRRVVAMAHACGVSVEGEIGCLGSLETGLAGEEDGVG
AEGVLDHSQLLTSVEEATQFVADTNVDALAIAVGTSHGAYKFTRPPTGDILAIDRIKEIHAALPNTHLVMHGSSSVPQDW
LKIINEHGGQIGETYGVPLEQLVEAIKHGVRKINIDTDLRLASTGAIRSFMSENPAEFDPRKYLAKTVDAMKQICIERYQ
AFGTAGNADKIRPISLEAMVDRYK

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=327, Percent_Identity=32.1100917431193, Blast_Score=161, Evalue=6e-41,
Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=30.6990881458967, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1788072, Length=332, Percent_Identity=27.1084337349398, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1789293, Length=324, Percent_Identity=23.7654320987654, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 37237; Mature: 37105

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALISLRQLLDHAAEHNYGVPAFNVNNLEQMRAIMLAADETNSPVIVQASAGARKYAGAP
CHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHEECCCCCCEEEEECCCCCHHCCCH
FLRHLILAAVEEWPHIPVVMHQDHGTSPDVCQRSIQLGFSSVMMDGSLGSDGKTPTSYDY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCHHHHEECCCCCCCCCCCCCCCC
NVDVTRRVVAMAHACGVSVEGEIGCLGSLETGLAGEEDGVGAEGVLDHSQLLTSVEEATQ
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FVADTNVDALAIAVGTSHGAYKFTRPPTGDILAIDRIKEIHAALPNTHLVMHGSSSVPQD
HHHCCCCCEEEEEEECCCCCEEECCCCCCCEEHHHHHHHHHHHCCCCEEEEECCCCCCHH
WLKIINEHGGQIGETYGVPLEQLVEAIKHGVRKINIDTDLRLASTGAIRSFMSENPAEFD
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCCEEHHHHHHHHHHCCCCCCCC
PRKYLAKTVDAMKQICIERYQAFGTAGNADKIRPISLEAMVDRYK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHCC
>Mature Secondary Structure 
ALISLRQLLDHAAEHNYGVPAFNVNNLEQMRAIMLAADETNSPVIVQASAGARKYAGAP
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHEECCCCCCEEEEECCCCCHHCCCH
FLRHLILAAVEEWPHIPVVMHQDHGTSPDVCQRSIQLGFSSVMMDGSLGSDGKTPTSYDY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCHHHHEECCCCCCCCCCCCCCCC
NVDVTRRVVAMAHACGVSVEGEIGCLGSLETGLAGEEDGVGAEGVLDHSQLLTSVEEATQ
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FVADTNVDALAIAVGTSHGAYKFTRPPTGDILAIDRIKEIHAALPNTHLVMHGSSSVPQD
HHHCCCCCEEEEEEECCCCCEEECCCCCCCEEHHHHHHHHHHHCCCCEEEEECCCCCCHH
WLKIINEHGGQIGETYGVPLEQLVEAIKHGVRKINIDTDLRLASTGAIRSFMSENPAEFD
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCCEEHHHHHHHHHHCCCCCCCC
PRKYLAKTVDAMKQICIERYQAFGTAGNADKIRPISLEAMVDRYK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]