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The map label for this gene is lrgA [H]

Identifier: 49188278

GI number: 49188278

Start: 5179309

End: 5179740

Strand: Reverse

Name: lrgA [H]

Synonym: BAS5294

Alternate gene names: 49188278

Gene position: 5179740-5179309 (Counterclockwise)

Preceding gene: 49188279

Following gene: 49188277

Centisome position: 99.06

GC content: 31.02

Gene sequence:

>432_bases
ATGAGTACAAAAAAAGTATATAGTTTCTTATCACAAGCATTCATATTCTCAGCTATTATGTTAATTTCTAATATTATTGC
AACACATTTACCAATTCCAATGCCCTCATCGGTAATCGGGTTAGTCATTTTATTTAGTCTATTATGCTTAAAGGTTATTA
AATTGGAACAAGTTGAATCACTTGGAACAGCTTTAACAGGTATTATCGGATTCCTTTTCGTCCCATCAGGTATTTCAGTT
ATTAATTCCCTTGGTGTAATGGGACAATATTTTGTACAAATCTTAACTGTAATTGTTGTCGCAACAGTTATTTTACTTGC
TGTAACAGGATTATTTGCACAATTTATTTTAGGAAAAGATGAAAAAGAAACAGAAGATACAAAAGAATTGAAAGTAGTAA
ATAAAGGACGCAAGCACGGAAAAGTTGCGTAA

Upstream 100 bases:

>100_bases
TGTAACTGATTCTGTATATTTGACGTTCCGTTATGTAAACGCTTACTATAGCGGTTATATCCTATACAATAAAGGTACCA
AATCGAAAGAGGTGGCCAAA

Downstream 100 bases:

>100_bases
CCATTGTAGTATATATTGTTAGGAGGTAATGAACATGGCAAGCACAATGACTCCATATTTCGGAATCGTCGTTTCATTAA
TCGCATACGGAATCGGAACA

Product: murein hydrolase regulator LrgA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 143; Mature: 142

Protein sequence:

>143_residues
MSTKKVYSFLSQAFIFSAIMLISNIIATHLPIPMPSSVIGLVILFSLLCLKVIKLEQVESLGTALTGIIGFLFVPSGISV
INSLGVMGQYFVQILTVIVVATVILLAVTGLFAQFILGKDEKETEDTKELKVVNKGRKHGKVA

Sequences:

>Translated_143_residues
MSTKKVYSFLSQAFIFSAIMLISNIIATHLPIPMPSSVIGLVILFSLLCLKVIKLEQVESLGTALTGIIGFLFVPSGISV
INSLGVMGQYFVQILTVIVVATVILLAVTGLFAQFILGKDEKETEDTKELKVVNKGRKHGKVA
>Mature_142_residues
STKKVYSFLSQAFIFSAIMLISNIIATHLPIPMPSSVIGLVILFSLLCLKVIKLEQVESLGTALTGIIGFLFVPSGISVI
NSLGVMGQYFVQILTVIVVATVILLAVTGLFAQFILGKDEKETEDTKELKVVNKGRKHGKVA

Specific function: Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell

COG id: COG1380

COG function: function code R; Putative effector of murein hydrolase LrgA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CidA/LrgA family. LrgA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005538 [H]

Pfam domain/function: PF03788 LrgA [H]

EC number: NA

Molecular weight: Translated: 15424; Mature: 15293

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKKVYSFLSQAFIFSAIMLISNIIATHLPIPMPSSVIGLVILFSLLCLKVIKLEQVES
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LGTALTGIIGFLFVPSGISVINSLGVMGQYFVQILTVIVVATVILLAVTGLFAQFILGKD
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EKETEDTKELKVVNKGRKHGKVA
CCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
STKKVYSFLSQAFIFSAIMLISNIIATHLPIPMPSSVIGLVILFSLLCLKVIKLEQVES
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LGTALTGIIGFLFVPSGISVINSLGVMGQYFVQILTVIVVATVILLAVTGLFAQFILGKD
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EKETEDTKELKVVNKGRKHGKVA
CCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12721630 [H]