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The map label for this gene is ykcC [H]

Identifier: 49188272

GI number: 49188272

Start: 5170994

End: 5171965

Strand: Direct

Name: ykcC [H]

Synonym: BAS5287

Alternate gene names: 49188272

Gene position: 5170994-5171965 (Clockwise)

Preceding gene: 49188271

Following gene: 49188274

Centisome position: 98.9

GC content: 36.11

Gene sequence:

>972_bases
ATGCAAAAATTAATCTCGGTTGTAGTTCCTATGTACTTCGAGGAAGAAGTAGCACAGGAATGTTATAACCGTTTAAAGTC
CGTTATGCTTCAAAATGATATTAATTACGAGTTTGTCTTTGTAAACGACGGTAGTACAGATCGTACAATGGAAATCTTAT
CTGAGATTGCAGCAAATGATTACCGTACAAAAATCGTTAACTTCGCTCGTAACTTTGGTCACCAAGTAGCTGTTACAGCT
GGTATCGCTGCTGCAAAAGGTGACGCTATTGTAATTATAGATGCAGACTTACAAGATCCGCCTGAAGTTATTCCTGAACT
TATTGCAAAATGGGAAGAAGGATATGAAGTTGTTTATGCAAAACGTAAGCAACGTAAAGGTGAAACTTGGTTTAAACTTT
TAACAGCTAAATATTTCTATAAGTTCTTAAACTACATGTCTGATATCGATATCCCAAAAGATACTGGTGATTTCCGAATC
ATCGATCGCAAAGTAGCTGATGTTTTCAATCAAATGACTGAGCGAAATCGCTTCATCCGCGGTATGATGTCTTGGGTTGG
CTTCCGCCAAACGTATGTTGAATATGAACGCGATGAGCGCTTTGCTGGTGAAACAAAATATCCATTAAAGAAAATGATTA
AATTTGCATCTGACGGCATTATTGCATTTTCGACAAAGCCATTACGCATCGTTATGTCTTTAGGTTTATTATCAGTTCTA
ATTTCTATAATTGTCTTACTATATACAATTACTGTGAAAATTATCGGCAATGGTACACAAACAGGTTGGGCATCTATTAT
GGTTGCTATTACATTCTTTAGCGGTATTCAATTACTTGGTCTTGGAATCGTTGGTCAGTATATCGCTCGTATTTATGACG
AAAGTAAAAACCGTCCGATTTATATCGTAAAAGAAACAATCAACATTGACCAAGAAGAGACTGCACTGAAAAAAGAAAAA
GTGAATGCATAA

Upstream 100 bases:

>100_bases
GGTTATAAATTTTGTCCTTAATAAAATTTGGACATTCAACCAAACGGAAAAGGCTACTAATTAAACTGAAACAATTTATT
AAAAATACGGAGGATACAAC

Downstream 100 bases:

>100_bases
TAAAAAAGGTAACAATGAAAACTATCATTGTTACCTTTTTATATTGTAATAGCCCATAAGTCTCAAACGAAATTCTTTTA
AATTTGGATATACTTCTAAA

Product: glycosyl transferase, group 2 family protein

Products: GDP; dolichyl D-mannosyl phosphate

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MQKLISVVVPMYFEEEVAQECYNRLKSVMLQNDINYEFVFVNDGSTDRTMEILSEIAANDYRTKIVNFARNFGHQVAVTA
GIAAAKGDAIVIIDADLQDPPEVIPELIAKWEEGYEVVYAKRKQRKGETWFKLLTAKYFYKFLNYMSDIDIPKDTGDFRI
IDRKVADVFNQMTERNRFIRGMMSWVGFRQTYVEYERDERFAGETKYPLKKMIKFASDGIIAFSTKPLRIVMSLGLLSVL
ISIIVLLYTITVKIIGNGTQTGWASIMVAITFFSGIQLLGLGIVGQYIARIYDESKNRPIYIVKETINIDQEETALKKEK
VNA

Sequences:

>Translated_323_residues
MQKLISVVVPMYFEEEVAQECYNRLKSVMLQNDINYEFVFVNDGSTDRTMEILSEIAANDYRTKIVNFARNFGHQVAVTA
GIAAAKGDAIVIIDADLQDPPEVIPELIAKWEEGYEVVYAKRKQRKGETWFKLLTAKYFYKFLNYMSDIDIPKDTGDFRI
IDRKVADVFNQMTERNRFIRGMMSWVGFRQTYVEYERDERFAGETKYPLKKMIKFASDGIIAFSTKPLRIVMSLGLLSVL
ISIIVLLYTITVKIIGNGTQTGWASIMVAITFFSGIQLLGLGIVGQYIARIYDESKNRPIYIVKETINIDQEETALKKEK
VNA
>Mature_323_residues
MQKLISVVVPMYFEEEVAQECYNRLKSVMLQNDINYEFVFVNDGSTDRTMEILSEIAANDYRTKIVNFARNFGHQVAVTA
GIAAAKGDAIVIIDADLQDPPEVIPELIAKWEEGYEVVYAKRKQRKGETWFKLLTAKYFYKFLNYMSDIDIPKDTGDFRI
IDRKVADVFNQMTERNRFIRGMMSWVGFRQTYVEYERDERFAGETKYPLKKMIKFASDGIIAFSTKPLRIVMSLGLLSVL
ISIIVLLYTITVKIIGNGTQTGWASIMVAITFFSGIQLLGLGIVGQYIARIYDESKNRPIYIVKETINIDQEETALKKEK
VNA

Specific function: Involved In O Antigen Modification. Catalyzes The Transfer Of The Glucose Residue From Udp-Glucose To A Lipid Carrier (By Similarity). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 2 family. GtrB subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503363, Length=237, Percent_Identity=27.0042194092827, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1788692, Length=300, Percent_Identity=43, Blast_Score=243, Evalue=9e-66,
Organism=Escherichia coli, GI1788588, Length=324, Percent_Identity=33.3333333333333, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1787259, Length=92, Percent_Identity=36.9565217391304, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24585265, Length=232, Percent_Identity=27.1551724137931, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001173 [H]

Pfam domain/function: PF00535 Glycos_transf_2 [H]

EC number: 2.4.1.83

Molecular weight: Translated: 37029; Mature: 37029

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLISVVVPMYFEEEVAQECYNRLKSVMLQNDINYEFVFVNDGSTDRTMEILSEIAAND
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCH
YRTKIVNFARNFGHQVAVTAGIAAAKGDAIVIIDADLQDPPEVIPELIAKWEEGYEVVYA
HHHHHHHHHHHCCCEEEEECCHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHH
KRKQRKGETWFKLLTAKYFYKFLNYMSDIDIPKDTGDFRIIDRKVADVFNQMTERNRFIR
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
GMMSWVGFRQTYVEYERDERFAGETKYPLKKMIKFASDGIIAFSTKPLRIVMSLGLLSVL
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHH
ISIIVLLYTITVKIIGNGTQTGWASIMVAITFFSGIQLLGLGIVGQYIARIYDESKNRPI
HHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
YIVKETINIDQEETALKKEKVNA
EEEEECCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MQKLISVVVPMYFEEEVAQECYNRLKSVMLQNDINYEFVFVNDGSTDRTMEILSEIAAND
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCH
YRTKIVNFARNFGHQVAVTAGIAAAKGDAIVIIDADLQDPPEVIPELIAKWEEGYEVVYA
HHHHHHHHHHHCCCEEEEECCHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHH
KRKQRKGETWFKLLTAKYFYKFLNYMSDIDIPKDTGDFRIIDRKVADVFNQMTERNRFIR
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
GMMSWVGFRQTYVEYERDERFAGETKYPLKKMIKFASDGIIAFSTKPLRIVMSLGLLSVL
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHH
ISIIVLLYTITVKIIGNGTQTGWASIMVAITFFSGIQLLGLGIVGQYIARIYDESKNRPI
HHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
YIVKETINIDQEETALKKEKVNA
EEEEECCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GDPmannose; dolichyl phosphate

Specific reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]