Click here to switch to the map view.

The map label for this gene is fhuB [H]

Identifier: 49188217

GI number: 49188217

Start: 5119282

End: 5119932

Strand: Reverse

Name: fhuB [H]

Synonym: BAS5232

Alternate gene names: 49188217

Gene position: 5119932-5119282 (Counterclockwise)

Preceding gene: 49188218

Following gene: 49188216

Centisome position: 97.92

GC content: 42.86

Gene sequence:

>651_bases
ATGTTCGTTATCGCATCTTTTATTGGTGCAGCGTTTGGAGCGAGCATTGTATATGGAATTGGGTCTTCTTCACCAGGTGG
ATTAACGCCTGTGAAATTAGCTTTAGCAGGAGCAGCAATTAGTGCTTTATTAGGGGCCATTTCATCTGGCATTGCACTGT
ACTTCAATCTTGCCCAAGAGGTGAGTATGTGGAATGCGGGCGGAGTTGCTGGAGTGAAATGGGAAAGCATCAATATGCTA
GTGCCAATCGGTCTAGTTTGTCTCTTTATCGCGATTATGATGTCGAGGTATATTACGATTTTGAGCTTCGGTGAAGAAAT
TGCGATTGGACTTGGTCAAAATACGACATTAATTAAATTTATCGGAACAGTACTTGTTCTTGTGTTAACTGGTTCTGCAG
TTTCTATGGCAGGGTCGGTTGGATTTGTTGGTCTTGTAATCCCGCATATGACTCGTTTCCTTGTAGGCTCAGACTATAGA
TGGGTTATCCCATGTTCTGCAGTTTTAGGTGGGCTGTTAATTGAATGTGCAGATATGTTATCTCGCGTTATTAATCCGCC
GTTTGAAACGCCAATTGGAGCAATTACAGCGCTAATTGGAGTTCCATTCTTCCTCTACTTAGCACGTAACGAAGGGAGAG
GGAAAATGTGA

Upstream 100 bases:

>100_bases
TGACGCGAAATCCACTTGCTTCTCCATCATTAATGGGTATTACAGATGGGGCTGTATTTGGAATTGCAATTATGCATTCT
TCCCTAATTCACCTTATTTA

Downstream 100 bases:

>100_bases
GGACAAGTGTCTTAACAAAAAAGAACGTTTCTGTTTTAACAATTTTAGTAGGATTAATCGTTACTGTATTTTTAGTGAGT
TTAAATACAGGGACATTTAA

Product: ABC transporter permease, C-terminal

Products: ADP; phosphate; ferric enterobactin [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MFVIASFIGAAFGASIVYGIGSSSPGGLTPVKLALAGAAISALLGAISSGIALYFNLAQEVSMWNAGGVAGVKWESINML
VPIGLVCLFIAIMMSRYITILSFGEEIAIGLGQNTTLIKFIGTVLVLVLTGSAVSMAGSVGFVGLVIPHMTRFLVGSDYR
WVIPCSAVLGGLLIECADMLSRVINPPFETPIGAITALIGVPFFLYLARNEGRGKM

Sequences:

>Translated_216_residues
MFVIASFIGAAFGASIVYGIGSSSPGGLTPVKLALAGAAISALLGAISSGIALYFNLAQEVSMWNAGGVAGVKWESINML
VPIGLVCLFIAIMMSRYITILSFGEEIAIGLGQNTTLIKFIGTVLVLVLTGSAVSMAGSVGFVGLVIPHMTRFLVGSDYR
WVIPCSAVLGGLLIECADMLSRVINPPFETPIGAITALIGVPFFLYLARNEGRGKM
>Mature_216_residues
MFVIASFIGAAFGASIVYGIGSSSPGGLTPVKLALAGAAISALLGAISSGIALYFNLAQEVSMWNAGGVAGVKWESINML
VPIGLVCLFIAIMMSRYITILSFGEEIAIGLGQNTTLIKFIGTVLVLVLTGSAVSMAGSVGFVGLVIPHMTRFLVGSDYR
WVIPCSAVLGGLLIECADMLSRVINPPFETPIGAITALIGVPFFLYLARNEGRGKM

Specific function: Part of the ABC transporter complex fhuBGCD involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786805, Length=211, Percent_Identity=36.0189573459716, Blast_Score=125, Evalue=1e-30,
Organism=Escherichia coli, GI1790740, Length=182, Percent_Identity=34.0659340659341, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1790741, Length=182, Percent_Identity=37.3626373626374, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1788004, Length=189, Percent_Identity=31.7460317460317, Blast_Score=74, Evalue=5e-15,
Organism=Escherichia coli, GI1786347, Length=196, Percent_Identity=30.6122448979592, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1786804, Length=192, Percent_Identity=28.125, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 22422; Mature: 22422

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVIASFIGAAFGASIVYGIGSSSPGGLTPVKLALAGAAISALLGAISSGIALYFNLAQE
CEEHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VSMWNAGGVAGVKWESINMLVPIGLVCLFIAIMMSRYITILSFGEEIAIGLGQNTTLIKF
HHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCHHHHH
IGTVLVLVLTGSAVSMAGSVGFVGLVIPHMTRFLVGSDYRWVIPCSAVLGGLLIECADML
HHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHH
SRVINPPFETPIGAITALIGVPFFLYLARNEGRGKM
HHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MFVIASFIGAAFGASIVYGIGSSSPGGLTPVKLALAGAAISALLGAISSGIALYFNLAQE
CEEHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VSMWNAGGVAGVKWESINMLVPIGLVCLFIAIMMSRYITILSFGEEIAIGLGQNTTLIKF
HHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCHHHHH
IGTVLVLVLTGSAVSMAGSVGFVGLVIPHMTRFLVGSDYRWVIPCSAVLGGLLIECADML
HHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHH
SRVINPPFETPIGAITALIGVPFFLYLARNEGRGKM
HHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; ferric enterobactin [Periplasm]; H2O [C]

Specific reaction: ATP + ferric enterobactin [Periplasm] + H2O = ADP + phosphate + ferric enterobactin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377; 8388528 [H]