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The map label for this gene is wecC [H]

Identifier: 49188106

GI number: 49188106

Start: 5001135

End: 5002418

Strand: Reverse

Name: wecC [H]

Synonym: BAS5120

Alternate gene names: 49188106

Gene position: 5002418-5001135 (Counterclockwise)

Preceding gene: 49188107

Following gene: 49188105

Centisome position: 95.67

GC content: 36.14

Gene sequence:

>1284_bases
ATGAAAATTTGTACAATGGGACTAGGTTATATCGGATTACCGACATCAGCAATGTTTGCAAAATATGGAACAGAGGTAGT
GGGTGTAGACATCCATCAGAAAGTAGTAGATAAGCTAAATAATGGTGAAATTCATATTGAAGAACCAGGTCTTGGAGAAG
TTGTAAAGGAAGTAGTTGCAAATGGAAAATTCCGTGCATCTTTAACACCAGAAGAAGCAGATGCATTTATTATTTCTGTT
CCAACACCAAATCATGATGATGAACATAAGTCTTGTGATTTATCATATGTTTTAACAGCTACAGAAAAAGTATTACCATT
TGTAAAAAAAGGAAATGTAATCATTGTTGAGTCTACAATTGCACCGCGTAGCATGGATGATTATGTAAAACCCTTAGTAG
AAGAAGCTGGATTTACGGTGGGAGAGGATATTTACCTTGTTCATTGCCCAGAGCGAGTTCTTCCAGGACAAATTTTACAT
GAGTTAGTACACAATAATCGTATTGTGGGAGGCGTAACTCCTGCTTGTGCAGAAGCTGGTGCTCGTGTTTATGGTGTGTT
TGTAGAAGGCGAAATTATTAAAACAAATGCAAAAACAGCAGAAATGTCGAAGCTTATGGAAAATACATTCCGTGATGTAA
ATATCGCGCTTGCAAATGAGTTAACAAAAGTGTGTAACTCACTAGATATCAATGTATTAGATGTAATTGAAATGGCTAAT
AAACATCCACGTGTAAACTTACACTATCCAGGCCCTGGGGTAGGTGGGCACTGTTTAGCAGTTGATCCATATTTTATTGT
TGCAAAAGCACCTGAGTTAGCAAACATTATAAAATTGTCTCGTGAAACAAATGTTTCTATGCCACATTATGTGACTGAAA
AAGTAAAAGAATTGCTTGCAGGTGTTGAAAATCCAAAGGTAGCAGCATTTGGTGTGACATATAAAGGGAATGTAGATGAT
ATGCGTGAAAGTCCAGCAATGGATGTAATTGATTTAATCCGAAATGAAGGAATCACAGTTTCAGCACATGATCCGCATGT
AGAATCTGATTTCTTTGAATTACATTCTGCAGAAGAAGCTGTTAAGGACGCCCATTTGATTCTTGTATTAACAGATCATG
ATGAATTTAAAACAATGAATTATGATTCATTGGCACCGTACATGGCGAAAACTGTTGTTTTTGATACACGTAATTGTGTA
CAAGCAGTATCAACGGGTGAAATGAAAATCATCAATTTCGGTACTTTATATGAGGCATTGAATAAAAATGTGATGATGGT
ATGA

Upstream 100 bases:

>100_bases
AAACTTTCAAGTTTGGTAAAGTATAATTAAAGATGTTATTACTGGTTGTTTAATAATCTATTAATAAAATAATATATTTA
TAAGATTGGGGAAATTAATT

Downstream 100 bases:

>100_bases
AATCGTTAAAAACTATTATTAAAGAACAATATGAAAATCTATATTTAATCCGAAGATTATCATTATATGAATTAAAACAG
GCTTATGCAGGTAATTTATT

Product: UDP-N-acetyl-D-mannosamine dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MKICTMGLGYIGLPTSAMFAKYGTEVVGVDIHQKVVDKLNNGEIHIEEPGLGEVVKEVVANGKFRASLTPEEADAFIISV
PTPNHDDEHKSCDLSYVLTATEKVLPFVKKGNVIIVESTIAPRSMDDYVKPLVEEAGFTVGEDIYLVHCPERVLPGQILH
ELVHNNRIVGGVTPACAEAGARVYGVFVEGEIIKTNAKTAEMSKLMENTFRDVNIALANELTKVCNSLDINVLDVIEMAN
KHPRVNLHYPGPGVGGHCLAVDPYFIVAKAPELANIIKLSRETNVSMPHYVTEKVKELLAGVENPKVAAFGVTYKGNVDD
MRESPAMDVIDLIRNEGITVSAHDPHVESDFFELHSAEEAVKDAHLILVLTDHDEFKTMNYDSLAPYMAKTVVFDTRNCV
QAVSTGEMKIINFGTLYEALNKNVMMV

Sequences:

>Translated_427_residues
MKICTMGLGYIGLPTSAMFAKYGTEVVGVDIHQKVVDKLNNGEIHIEEPGLGEVVKEVVANGKFRASLTPEEADAFIISV
PTPNHDDEHKSCDLSYVLTATEKVLPFVKKGNVIIVESTIAPRSMDDYVKPLVEEAGFTVGEDIYLVHCPERVLPGQILH
ELVHNNRIVGGVTPACAEAGARVYGVFVEGEIIKTNAKTAEMSKLMENTFRDVNIALANELTKVCNSLDINVLDVIEMAN
KHPRVNLHYPGPGVGGHCLAVDPYFIVAKAPELANIIKLSRETNVSMPHYVTEKVKELLAGVENPKVAAFGVTYKGNVDD
MRESPAMDVIDLIRNEGITVSAHDPHVESDFFELHSAEEAVKDAHLILVLTDHDEFKTMNYDSLAPYMAKTVVFDTRNCV
QAVSTGEMKIINFGTLYEALNKNVMMV
>Mature_427_residues
MKICTMGLGYIGLPTSAMFAKYGTEVVGVDIHQKVVDKLNNGEIHIEEPGLGEVVKEVVANGKFRASLTPEEADAFIISV
PTPNHDDEHKSCDLSYVLTATEKVLPFVKKGNVIIVESTIAPRSMDDYVKPLVEEAGFTVGEDIYLVHCPERVLPGQILH
ELVHNNRIVGGVTPACAEAGARVYGVFVEGEIIKTNAKTAEMSKLMENTFRDVNIALANELTKVCNSLDINVLDVIEMAN
KHPRVNLHYPGPGVGGHCLAVDPYFIVAKAPELANIIKLSRETNVSMPHYVTEKVKELLAGVENPKVAAFGVTYKGNVDD
MRESPAMDVIDLIRNEGITVSAHDPHVESDFFELHSAEEAVKDAHLILVLTDHDEFKTMNYDSLAPYMAKTVVFDTRNCV
QAVSTGEMKIINFGTLYEALNKNVMMV

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=455, Percent_Identity=23.956043956044, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI296040443, Length=446, Percent_Identity=24.2152466367713, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI296040438, Length=359, Percent_Identity=21.4484679665738, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI48994968, Length=404, Percent_Identity=45.2970297029703, Blast_Score=357, Evalue=1e-100,
Organism=Escherichia coli, GI1788340, Length=375, Percent_Identity=26.4, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17560350, Length=437, Percent_Identity=26.7734553775744, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17136908, Length=441, Percent_Identity=25.3968253968254, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46831; Mature: 46831

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKICTMGLGYIGLPTSAMFAKYGTEVVGVDIHQKVVDKLNNGEIHIEEPGLGEVVKEVVA
CEEEEECCCCCCCCHHHHHHHHCCEEEEECHHHHHHHCCCCCEEEEECCCHHHHHHHHHH
NGKFRASLTPEEADAFIISVPTPNHDDEHKSCDLSYVLTATEKVLPFVKKGNVIIVESTI
CCCEEEECCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCEEEEECCC
APRSMDDYVKPLVEEAGFTVGEDIYLVHCPERVLPGQILHELVHNNRIVGGVTPACAEAG
CCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCEEEECCCHHHHHCC
ARVYGVFVEGEIIKTNAKTAEMSKLMENTFRDVNIALANELTKVCNSLDINVLDVIEMAN
CEEEEEEEECEEEECCCCHHHHHHHHHHHHHHEEHHHHHHHHHHHCCCCCHHHHHHHHHC
KHPRVNLHYPGPGVGGHCLAVDPYFIVAKAPELANIIKLSRETNVSMPHYVTEKVKELLA
CCCEEEEECCCCCCCCEEEEECCEEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHC
GVENPKVAAFGVTYKGNVDDMRESPAMDVIDLIRNEGITVSAHDPHVESDFFELHSAEEA
CCCCCCEEEEEEEEECCHHHHHCCCCHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHH
VKDAHLILVLTDHDEFKTMNYDSLAPYMAKTVVFDTRNCVQAVSTGEMKIINFGTLYEAL
HCCCEEEEEEECCCHHEECCCHHHHHHHHHHEEECCHHHHHHHCCCCEEEEEHHHHHHHH
NKNVMMV
CCCEECC
>Mature Secondary Structure
MKICTMGLGYIGLPTSAMFAKYGTEVVGVDIHQKVVDKLNNGEIHIEEPGLGEVVKEVVA
CEEEEECCCCCCCCHHHHHHHHCCEEEEECHHHHHHHCCCCCEEEEECCCHHHHHHHHHH
NGKFRASLTPEEADAFIISVPTPNHDDEHKSCDLSYVLTATEKVLPFVKKGNVIIVESTI
CCCEEEECCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCEEEEECCC
APRSMDDYVKPLVEEAGFTVGEDIYLVHCPERVLPGQILHELVHNNRIVGGVTPACAEAG
CCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCEEEECCCHHHHHCC
ARVYGVFVEGEIIKTNAKTAEMSKLMENTFRDVNIALANELTKVCNSLDINVLDVIEMAN
CEEEEEEEECEEEECCCCHHHHHHHHHHHHHHEEHHHHHHHHHHHCCCCCHHHHHHHHHC
KHPRVNLHYPGPGVGGHCLAVDPYFIVAKAPELANIIKLSRETNVSMPHYVTEKVKELLA
CCCEEEEECCCCCCCCEEEEECCEEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHC
GVENPKVAAFGVTYKGNVDDMRESPAMDVIDLIRNEGITVSAHDPHVESDFFELHSAEEA
CCCCCCEEEEEEEEECCHHHHHCCCCHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHH
VKDAHLILVLTDHDEFKTMNYDSLAPYMAKTVVFDTRNCVQAVSTGEMKIINFGTLYEAL
HCCCEEEEEEECCCHHEECCCHHHHHHHHHHEEECCHHHHHHHCCCCEEEEEHHHHHHHH
NKNVMMV
CCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA