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The map label for this gene is comFA [H]

Identifier: 49188028

GI number: 49188028

Start: 4914369

End: 4915724

Strand: Reverse

Name: comFA [H]

Synonym: BAS5042

Alternate gene names: 49188028

Gene position: 4915724-4914369 (Counterclockwise)

Preceding gene: 49188029

Following gene: 49188027

Centisome position: 94.01

GC content: 40.04

Gene sequence:

>1356_bases
TTGCTGATGCTCGCTGGAAAGCAGTTACTATTAGAAGAACTCCCTTCAGATTTACGGAGAGAATTAAGTGATTTGAAAAA
GGAGGGAGAGGTCATATGTGTACAAGGCGTAATAAAGAAGGCTTCTAAATATATATGTCAGCGCTGCGGGAATATAGAGC
AGCGGCTATTTGCATCATTTTTATGTAAAAGGTGCAGTAAAGTATGTACGTATTGCCGGAAGTGTATAACGATGGGGAGA
GTTAGTGAATGTGCTGTACTTGTTCGCGGGATTCATGAAAGAAAAGGAGAAAGGGAATTACATTCGTTACAGTGGAAAGG
GAGTTTGTCTCTTGGTCAGGAGCTGGCGGCGCAAGGTGTTATAGAAGCTATTAAGCAAAAAGAATCTTTTTTTATTTGGG
CTGTGTGCGGGGCTGGAAAAACAGAAATGTTATTTTACGGTATAGAAGAGGCACTTCAAAAAGGAGAAAGAGTGTGTATC
GCAACGCCAAGGACGGACGTTGTACTGGAATTAGTACCGAGATTACAAGAAGTGTTTCCAAGTATAAATGTAGCTGCTTT
ATACGGAGGGAGTGTAGATCGTGAAAAAGATGCAGCGTTAGTCGTTGCAACGACGCATCAATTGTTACGTTATTATAGAG
CGTTTCATGTAATGATTGTAGATGAGATTGATGCCTTCCCGTATCATGTGGATCAAATGTTACAGTATGCAGTGCAGCAA
GCGATGAAAGAGAAAGCAGCGCGTATTTATTTAACGGCAACCCCTGATGAAAAGTGGAAGCGCAATTTCAGAACGGGGAA
ACAAAAAGGTATCATTGTCTCTGGACGATACCATCGTCATCCGTTACCAGTTCCTCTATTTAGTTGGTGCGGAAATTGGA
AGAAAAGCCTCCATCATAAAAAAATTCCTCGTGTGTTACTACAATGGTTAAAAATGTACGTAAACAAAAAATACCCTATT
TTTTTATTTGTTCCTCATGTGCGATATATAGAAGAAATAGGCCTGTTATTGAAAGGGTTGGATCATAGAATCGATGGCGT
ACATGCAGAAGATCCGATGAGAAAAGAAAAAGTGGAAGCGTTTAGAAAGGGAGACATTCCGTTATTAGTTACAACGACAA
TTTTAGAAAGAGGGGTAATTGTGAAGAACTTACAAGTGGCTGTGTTAGGGGCTGAAGAAGAAATATTTTCAGAAAGTGCG
CTCGTACAAATTGCAGGCCGAGCAGGTCGTAGTTTTGAAGAACCGTATGGTGAGGTTGTTTATTTTCATTACGGTAAGAC
AGAGTCGATGGTACGTGCGAAAAGACATATTCAAAGTATGAACAAAAGTGCGAAAGAACAAGGATTAATTGATTAA

Upstream 100 bases:

>100_bases
TGTGTATAAAGTCGATAGCTTACTATTTTATAAGTAGGTTATCGGCTTTTTTGAGTTTTTACGAGATTATAAGAAAGGTT
TATAGTAATGCTGGGGGTGG

Downstream 100 bases:

>100_bases
TGCATTGTTTACTTTGTGATGAATATATGTTGGAAACAGTTAGTTGGTACACTTTCTTTGTAAAGTCTCATAAAAAATAT
GTATGTGATAGATGTGAGCG

Product: comF operon protein 1

Products: NA

Alternate protein names: ATP-dependent helicase ComFA [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MLMLAGKQLLLEELPSDLRRELSDLKKEGEVICVQGVIKKASKYICQRCGNIEQRLFASFLCKRCSKVCTYCRKCITMGR
VSECAVLVRGIHERKGERELHSLQWKGSLSLGQELAAQGVIEAIKQKESFFIWAVCGAGKTEMLFYGIEEALQKGERVCI
ATPRTDVVLELVPRLQEVFPSINVAALYGGSVDREKDAALVVATTHQLLRYYRAFHVMIVDEIDAFPYHVDQMLQYAVQQ
AMKEKAARIYLTATPDEKWKRNFRTGKQKGIIVSGRYHRHPLPVPLFSWCGNWKKSLHHKKIPRVLLQWLKMYVNKKYPI
FLFVPHVRYIEEIGLLLKGLDHRIDGVHAEDPMRKEKVEAFRKGDIPLLVTTTILERGVIVKNLQVAVLGAEEEIFSESA
LVQIAGRAGRSFEEPYGEVVYFHYGKTESMVRAKRHIQSMNKSAKEQGLID

Sequences:

>Translated_451_residues
MLMLAGKQLLLEELPSDLRRELSDLKKEGEVICVQGVIKKASKYICQRCGNIEQRLFASFLCKRCSKVCTYCRKCITMGR
VSECAVLVRGIHERKGERELHSLQWKGSLSLGQELAAQGVIEAIKQKESFFIWAVCGAGKTEMLFYGIEEALQKGERVCI
ATPRTDVVLELVPRLQEVFPSINVAALYGGSVDREKDAALVVATTHQLLRYYRAFHVMIVDEIDAFPYHVDQMLQYAVQQ
AMKEKAARIYLTATPDEKWKRNFRTGKQKGIIVSGRYHRHPLPVPLFSWCGNWKKSLHHKKIPRVLLQWLKMYVNKKYPI
FLFVPHVRYIEEIGLLLKGLDHRIDGVHAEDPMRKEKVEAFRKGDIPLLVTTTILERGVIVKNLQVAVLGAEEEIFSESA
LVQIAGRAGRSFEEPYGEVVYFHYGKTESMVRAKRHIQSMNKSAKEQGLID
>Mature_451_residues
MLMLAGKQLLLEELPSDLRRELSDLKKEGEVICVQGVIKKASKYICQRCGNIEQRLFASFLCKRCSKVCTYCRKCITMGR
VSECAVLVRGIHERKGERELHSLQWKGSLSLGQELAAQGVIEAIKQKESFFIWAVCGAGKTEMLFYGIEEALQKGERVCI
ATPRTDVVLELVPRLQEVFPSINVAALYGGSVDREKDAALVVATTHQLLRYYRAFHVMIVDEIDAFPYHVDQMLQYAVQQ
AMKEKAARIYLTATPDEKWKRNFRTGKQKGIIVSGRYHRHPLPVPLFSWCGNWKKSLHHKKIPRVLLQWLKMYVNKKYPI
FLFVPHVRYIEEIGLLLKGLDHRIDGVHAEDPMRKEKVEAFRKGDIPLLVTTTILERGVIVKNLQVAVLGAEEEIFSESA
LVQIAGRAGRSFEEPYGEVVYFHYGKTESMVRAKRHIQSMNKSAKEQGLID

Specific function: Involved in transformation (competence for DNA uptake). Required for DNA uptake but not for binding. May provide the driving force for transport of DNA through an aqueous channel [H]

COG id: COG4098

COG function: function code L; Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 51519; Mature: 51519

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMLAGKQLLLEELPSDLRRELSDLKKEGEVICVQGVIKKASKYICQRCGNIEQRLFASF
CEEECCHHHHHHHCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHH
LCKRCSKVCTYCRKCITMGRVSECAVLVRGIHERKGERELHSLQWKGSLSLGQELAAQGV
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHH
IEAIKQKESFFIWAVCGAGKTEMLFYGIEEALQKGERVCIATPRTDVVLELVPRLQEVFP
HHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCC
SINVAALYGGSVDREKDAALVVATTHQLLRYYRAFHVMIVDEIDAFPYHVDQMLQYAVQQ
CCCEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHH
AMKEKAARIYLTATPDEKWKRNFRTGKQKGIIVSGRYHRHPLPVPLFSWCGNWKKSLHHK
HHHHHHCEEEEEECCCHHHHHHHCCCCCCCEEEECCCCCCCCCCHHHHHCCCHHHHHHHH
KIPRVLLQWLKMYVNKKYPIFLFVPHVRYIEEIGLLLKGLDHRIDGVHAEDPMRKEKVEA
HHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
FRKGDIPLLVTTTILERGVIVKNLQVAVLGAEEEIFSESALVQIAGRAGRSFEEPYGEVV
HHCCCCCEEEHHHHHHCCCEEECEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
YFHYGKTESMVRAKRHIQSMNKSAKEQGLID
EEEECCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLMLAGKQLLLEELPSDLRRELSDLKKEGEVICVQGVIKKASKYICQRCGNIEQRLFASF
CEEECCHHHHHHHCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHH
LCKRCSKVCTYCRKCITMGRVSECAVLVRGIHERKGERELHSLQWKGSLSLGQELAAQGV
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHH
IEAIKQKESFFIWAVCGAGKTEMLFYGIEEALQKGERVCIATPRTDVVLELVPRLQEVFP
HHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCC
SINVAALYGGSVDREKDAALVVATTHQLLRYYRAFHVMIVDEIDAFPYHVDQMLQYAVQQ
CCCEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHH
AMKEKAARIYLTATPDEKWKRNFRTGKQKGIIVSGRYHRHPLPVPLFSWCGNWKKSLHHK
HHHHHHCEEEEEECCCHHHHHHHCCCCCCCEEEECCCCCCCCCCHHHHHCCCHHHHHHHH
KIPRVLLQWLKMYVNKKYPIFLFVPHVRYIEEIGLLLKGLDHRIDGVHAEDPMRKEKVEA
HHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
FRKGDIPLLVTTTILERGVIVKNLQVAVLGAEEEIFSESALVQIAGRAGRSFEEPYGEVV
HHCCCCCEEEHHHHHHCCCEEECEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
YFHYGKTESMVRAKRHIQSMNKSAKEQGLID
EEEECCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8412657; 9384377 [H]