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The map label for this gene is ctpB [H]

Identifier: 49188018

GI number: 49188018

Start: 4904277

End: 4905713

Strand: Reverse

Name: ctpB [H]

Synonym: BAS5032

Alternate gene names: 49188018

Gene position: 4905713-4904277 (Counterclockwise)

Preceding gene: 49188019

Following gene: 49188017

Centisome position: 93.82

GC content: 37.79

Gene sequence:

>1437_bases
TTGAAACGTAGAGTTGCAATTATTGGAATGGTTGTTGCATTTTTAATTGGTGCTGGCGGAATGTTTGCAGGTATGTCTTT
ATTTGGGGTTAATCCAGCAGAAGTAACGCAAACAATTTCGAGTGGAAACGCTAGCACTGCGCAAGGGAATTTGGCAAAAA
TTAATGAGGCGTATGCACTAATTGATTCACGTTATGTGGAAGACGTGAAAGATGAAAAATTAGTCGAAGGTGCAATACAA
GGCATGTTGTCTACGCTGAAGGACCCTTATTCCACGTATATGGATAAAGAAACGGCTAAACAGTTTAGTGAATCGCTTGA
TCCTGAGTTAGAAGGGATCGGGGCTGAGGTGAACAAAACGGACGGTAAGCTTATTATCGTATCTCCAATTAAAGGCTCAC
CGGCAGAAAAGATTGGAATTAAACCGAATGACCAAATTTTATCTGTAGATGGAAATAGTGTGAAAGATTTATCACGTGAA
GAAGCAGTATTAAAGATTCGTGGTAAAAAAGGAACGACTGTTGCGATTGAAATTAAGCGTGCAGGAGTAGCTGATCCGAT
TGTATTTAAAATTAAGCGTGAAAAAATTCCAATCTTCACAGTGTTTAGCTCTGTGAAACAAGAGAGTGGAAAAGATATCG
GTTATATGCAAATCACTTCTTTTGCTGAAAATACAGCGAAAGAATTTAAGGATCAGTTAAAAGAGTTAGAGAAGAAAAAC
ATAAAAGGGCTAGTTATTGACGTGCGCGGTAATCCTGGTGGCTACTTAAATAGTGTAGAAGAGATACTAGGGGAAATTAT
GACGGATAAAAAGCCGATGCTACAAGTAGAGCAAAGAAATGGTGAGAAGAAGAAATTCTCTACGGAACTGAAAGAGAGAA
AGCCATATCCAATTTCAGTATTAATTGATAACGGAAGTGCTTCTGCTTCAGAGATTTTAGCGGGTGCGCTAAAAGAGGGA
GAAGGATACGATTTAATTGGTGAAAAAACGTTTGGTAAAGGTACTGTTCAGCAAGCTGTTCCATTTAAAGATGGCAGCAA
TATCAAATTAACGATGTTCAAATGGTTAACACCGGATGGAAACTGGATTCATAAAAAAGGAATCAAGCCAACTGTAGAAG
TGAAACAACCAGATTATTATCATGCGACACCAATTCAAATTGAAAAGACACTTTCATACAATGCAAATGATGTACAAGTA
AAACACGCACAAGAAATGCTTAAGAGTTTAGGATATGTACCAGGACGTGAAGATGGATACTTTAGTAAAGAGACAGAATC
AGCACTGAAAGCATTCCAAAATGCGAATAAGATGGAAGCGACAGGGCAGCTAGATAAAAAGACAGCTGAGGCGATTCAAA
CGAAAATTATTGAAAAAATCCGTTCTGGAGAAAATGATCTCCAATTACAGTCAGCATTAAAATTAATGGCGAAATAA

Upstream 100 bases:

>100_bases
CGTACAAGCTTATCATATAGTAGAAATAGGTAAAGGCATCACACGCTGTGTGATGCCTTTTGCTACACCACCTGTGTGTT
TTGGAAAGGGGAATTCCGCA

Downstream 100 bases:

>100_bases
AAAGAAATACAGGCAGTTTGCTGCCTGTATTTTTTTGTGTTAAACAAACGCTTGTCCAGTTATGATAATATAAAAAGAAA
GAATGATATAAATGGTGGTG

Product: carboxyl-terminal protease

Products: NA

Alternate protein names: C-terminal processing protease [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MKRRVAIIGMVVAFLIGAGGMFAGMSLFGVNPAEVTQTISSGNASTAQGNLAKINEAYALIDSRYVEDVKDEKLVEGAIQ
GMLSTLKDPYSTYMDKETAKQFSESLDPELEGIGAEVNKTDGKLIIVSPIKGSPAEKIGIKPNDQILSVDGNSVKDLSRE
EAVLKIRGKKGTTVAIEIKRAGVADPIVFKIKREKIPIFTVFSSVKQESGKDIGYMQITSFAENTAKEFKDQLKELEKKN
IKGLVIDVRGNPGGYLNSVEEILGEIMTDKKPMLQVEQRNGEKKKFSTELKERKPYPISVLIDNGSASASEILAGALKEG
EGYDLIGEKTFGKGTVQQAVPFKDGSNIKLTMFKWLTPDGNWIHKKGIKPTVEVKQPDYYHATPIQIEKTLSYNANDVQV
KHAQEMLKSLGYVPGREDGYFSKETESALKAFQNANKMEATGQLDKKTAEAIQTKIIEKIRSGENDLQLQSALKLMAK

Sequences:

>Translated_478_residues
MKRRVAIIGMVVAFLIGAGGMFAGMSLFGVNPAEVTQTISSGNASTAQGNLAKINEAYALIDSRYVEDVKDEKLVEGAIQ
GMLSTLKDPYSTYMDKETAKQFSESLDPELEGIGAEVNKTDGKLIIVSPIKGSPAEKIGIKPNDQILSVDGNSVKDLSRE
EAVLKIRGKKGTTVAIEIKRAGVADPIVFKIKREKIPIFTVFSSVKQESGKDIGYMQITSFAENTAKEFKDQLKELEKKN
IKGLVIDVRGNPGGYLNSVEEILGEIMTDKKPMLQVEQRNGEKKKFSTELKERKPYPISVLIDNGSASASEILAGALKEG
EGYDLIGEKTFGKGTVQQAVPFKDGSNIKLTMFKWLTPDGNWIHKKGIKPTVEVKQPDYYHATPIQIEKTLSYNANDVQV
KHAQEMLKSLGYVPGREDGYFSKETESALKAFQNANKMEATGQLDKKTAEAIQTKIIEKIRSGENDLQLQSALKLMAK
>Mature_478_residues
MKRRVAIIGMVVAFLIGAGGMFAGMSLFGVNPAEVTQTISSGNASTAQGNLAKINEAYALIDSRYVEDVKDEKLVEGAIQ
GMLSTLKDPYSTYMDKETAKQFSESLDPELEGIGAEVNKTDGKLIIVSPIKGSPAEKIGIKPNDQILSVDGNSVKDLSRE
EAVLKIRGKKGTTVAIEIKRAGVADPIVFKIKREKIPIFTVFSSVKQESGKDIGYMQITSFAENTAKEFKDQLKELEKKN
IKGLVIDVRGNPGGYLNSVEEILGEIMTDKKPMLQVEQRNGEKKKFSTELKERKPYPISVLIDNGSASASEILAGALKEG
EGYDLIGEKTFGKGTVQQAVPFKDGSNIKLTMFKWLTPDGNWIHKKGIKPTVEVKQPDYYHATPIQIEKTLSYNANDVQV
KHAQEMLKSLGYVPGREDGYFSKETESALKAFQNANKMEATGQLDKKTAEAIQTKIIEKIRSGENDLQLQSALKLMAK

Specific function: Involved in the signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro-sigma-K during sporulation. The signaling serine protease CtpB triggers pro-sigma-K processing by cleaving the regulatory protein

COG id: COG0793

COG function: function code M; Periplasmic protease

Gene ontology:

Cell location: Forespore intermembrane space. Note=Is expressed in both the mother cell and forespore compartments but that synthesis in the forespore is both necessary and sufficient for the proper timing of pro-sigma-K processing [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Escherichia coli, GI1788134, Length=308, Percent_Identity=31.8181818181818, Blast_Score=116, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR005151
- InterPro:   IPR004447
- InterPro:   IPR002477 [H]

Pfam domain/function: PF00595 PDZ; PF03572 Peptidase_S41; PF01471 PG_binding_1 [H]

EC number: =3.4.21.102 [H]

Molecular weight: Translated: 52437; Mature: 52437

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRRVAIIGMVVAFLIGAGGMFAGMSLFGVNPAEVTQTISSGNASTAQGNLAKINEAYAL
CCCHHHHHHHHHHHHHCCCCHHHCCHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
IDSRYVEDVKDEKLVEGAIQGMLSTLKDPYSTYMDKETAKQFSESLDPELEGIGAEVNKT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHCCCCHHCCCCCCCCC
DGKLIIVSPIKGSPAEKIGIKPNDQILSVDGNSVKDLSREEAVLKIRGKKGTTVAIEIKR
CCEEEEEECCCCCCHHCCCCCCCCCEEEECCCCHHHHCCCCEEEEEECCCCCEEEEEEEC
AGVADPIVFKIKREKIPIFTVFSSVKQESGKDIGYMQITSFAENTAKEFKDQLKELEKKN
CCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCC
IKGLVIDVRGNPGGYLNSVEEILGEIMTDKKPMLQVEQRNGEKKKFSTELKERKPYPISV
CCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCEEE
LIDNGSASASEILAGALKEGEGYDLIGEKTFGKGTVQQAVPFKDGSNIKLTMFKWLTPDG
EEECCCCCHHHHHHHHHCCCCCCEECCCCCCCCCCHHHCCCCCCCCCEEEEEEEEECCCC
NWIHKKGIKPTVEVKQPDYYHATPIQIEKTLSYNANDVQVKHAQEMLKSLGYVPGREDGY
CEEECCCCCCEEEECCCCCCCCCCEEEEEEECCCCCCEEHHHHHHHHHHCCCCCCCCCCC
FSKETESALKAFQNANKMEATGQLDKKTAEAIQTKIIEKIRSGENDLQLQSALKLMAK
CCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKRRVAIIGMVVAFLIGAGGMFAGMSLFGVNPAEVTQTISSGNASTAQGNLAKINEAYAL
CCCHHHHHHHHHHHHHCCCCHHHCCHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
IDSRYVEDVKDEKLVEGAIQGMLSTLKDPYSTYMDKETAKQFSESLDPELEGIGAEVNKT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHCCCCHHCCCCCCCCC
DGKLIIVSPIKGSPAEKIGIKPNDQILSVDGNSVKDLSREEAVLKIRGKKGTTVAIEIKR
CCEEEEEECCCCCCHHCCCCCCCCCEEEECCCCHHHHCCCCEEEEEECCCCCEEEEEEEC
AGVADPIVFKIKREKIPIFTVFSSVKQESGKDIGYMQITSFAENTAKEFKDQLKELEKKN
CCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCC
IKGLVIDVRGNPGGYLNSVEEILGEIMTDKKPMLQVEQRNGEKKKFSTELKERKPYPISV
CCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCEEE
LIDNGSASASEILAGALKEGEGYDLIGEKTFGKGTVQQAVPFKDGSNIKLTMFKWLTPDG
EEECCCCCHHHHHHHHHCCCCCCEECCCCCCCCCCHHHCCCCCCCCCEEEEEEEEECCCC
NWIHKKGIKPTVEVKQPDYYHATPIQIEKTLSYNANDVQVKHAQEMLKSLGYVPGREDGY
CEEECCCCCCEEEECCCCCCCCCCEEEEEEECCCCCCEEHHHHHHHHHHCCCCCCCCCCC
FSKETESALKAFQNANKMEATGQLDKKTAEAIQTKIIEKIRSGENDLQLQSALKLMAK
CCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9570401; 9384377 [H]