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The map label for this gene is pepA

Identifier: 49187782

GI number: 49187782

Start: 4681940

End: 4683424

Strand: Reverse

Name: pepA

Synonym: BAS4792

Alternate gene names: 49187782

Gene position: 4683424-4681940 (Counterclockwise)

Preceding gene: 49187783

Following gene: 49187780

Centisome position: 89.57

GC content: 39.93

Gene sequence:

>1485_bases
ATGTTCCAAGTACAAAAAGAATTAGCAAGCCATGAAGCGGTGGTTGTTGCCTTATTTGAGGAAGAGAAAACGAGTAGCTT
TGTACAAGAACTGGACAAAGCGTTTGAAGGACAATTACAAGTTTTATTAGAAGAGAAAGAACTTTCTACGAAGAAGAAAG
CTATTTCAAAAGTACATAGTTTAGGAAAAACAGATGTGAAACGTTATTATTTCGTTGGTTTAGGTAAGAAAGAATCTTAT
ACGACAGAAACATTACGTTCGGCTCTTGGTAAGACGTTTAAAACACTGCAAGCAGCAAAAGTACAAGATGCAGCAATCTT
ACTTGATTCTTTCGTAACAGAGAAATTAGACGCGATTGATGTCGCTCATATTGCGGCAGAAGTACAAGGCCTTGGTACAT
ATGAGTTACAAACGTATAAATCAGATAAAAAGGATCGTGTAGAGTTAGAGAAGTTTACGGCTATTACAGCGGAAGATGCA
CAGGAAATTGAAGCGGCATTAACAGTTGGCTACGTACATGGACGTGCAACAAATTCAGCTCGTACACTTGTAAATATGCC
GCCAAACGTATTAACAGCAACAAAGCTTGCTGAGTATGCTGTTGAGTTAGCGGAAAAGTATGATATGGATTATAAAGTTC
TTGAGAAAGAAGAGATGGAAGAGCTTGGTATGGGTGCATTACTTGCAGTAAACCAAGGTAGTGTAGAGCCACCAAAAATG
ATCGCTCTTATTTATAAAGGAAAAGAAGAGTGGACAGATGTTATTGGATTCGTTGGAAAAGGAATCACATATGATACAGG
TGGTTATTCTTTAAAACCACGTGAAGGTATGGTCGGTATGAAAGGTGATATGGGCGGTGCAGCTGCTGTATTAGGTGCGA
TGGAAATTATCGGTGAACTTCGCCCAGAGCAAAATGTGATCGCTGTTATTCCATCAACAGATAACGTTGTAAGTGGTACA
GCATTTAAGCCAGACGATGTAATCACATCTATGAGCGGAAAAACAATTGAAGTATTAAATACAGATGCAGAAGGTCGCTT
AGCATTAGCTGACGGTATTACGTATGCGAAAAAATTAGGTGCAAACTATTTGATTGATGTTGCGACATTAACAGGTGGTG
TAATTGTTGCACTTGGAAATCATACGACAGGTGCGATGACAAACAATGAAGAGTTGTTTGAGCAAGTACTAGAGGCATCT
ATGGAAACAGATGAATCTATTTGGCAATTACCGATTTTTGATCGTGATAAAGAGCGCGTGAGAAACAGTAAGTTTGCTGA
TTTAAATAACTCGCCAGGCCGCGAAGGACATGCGGTTATGGCAGGTACATTCATAGGTGAATTCGCTGAAGATACACCTT
GGGTACACTTAGACATCGCTGGAACATCTGAATCATCAGGAGCGCATGATTTAGGACCAGCTGGAGCAACAGGTGCAATG
GTACGTACACTTGCAACACTTGTTGAACGTTTCGGCGAAGAATAA

Upstream 100 bases:

>100_bases
ATAGGGACTAGATAGAATGTAACAGAAGTTAGAATTGTCGCATTTTATCGAAAATAAAGTTATAATAAAGGTAGAGTAGA
GAAATTTAGGGGGTCTGAAC

Downstream 100 bases:

>100_bases
GATTATAAGAGAAGGCTGTTCCTACATTTTGGAACAGCCTTTTTATTGATATATGTGGTGTTACGGCTGATGTAATTTCA
CTTTATAAAGAAATTGTATA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MFQVQKELASHEAVVVALFEEEKTSSFVQELDKAFEGQLQVLLEEKELSTKKKAISKVHSLGKTDVKRYYFVGLGKKESY
TTETLRSALGKTFKTLQAAKVQDAAILLDSFVTEKLDAIDVAHIAAEVQGLGTYELQTYKSDKKDRVELEKFTAITAEDA
QEIEAALTVGYVHGRATNSARTLVNMPPNVLTATKLAEYAVELAEKYDMDYKVLEKEEMEELGMGALLAVNQGSVEPPKM
IALIYKGKEEWTDVIGFVGKGITYDTGGYSLKPREGMVGMKGDMGGAAAVLGAMEIIGELRPEQNVIAVIPSTDNVVSGT
AFKPDDVITSMSGKTIEVLNTDAEGRLALADGITYAKKLGANYLIDVATLTGGVIVALGNHTTGAMTNNEELFEQVLEAS
METDESIWQLPIFDRDKERVRNSKFADLNNSPGREGHAVMAGTFIGEFAEDTPWVHLDIAGTSESSGAHDLGPAGATGAM
VRTLATLVERFGEE

Sequences:

>Translated_494_residues
MFQVQKELASHEAVVVALFEEEKTSSFVQELDKAFEGQLQVLLEEKELSTKKKAISKVHSLGKTDVKRYYFVGLGKKESY
TTETLRSALGKTFKTLQAAKVQDAAILLDSFVTEKLDAIDVAHIAAEVQGLGTYELQTYKSDKKDRVELEKFTAITAEDA
QEIEAALTVGYVHGRATNSARTLVNMPPNVLTATKLAEYAVELAEKYDMDYKVLEKEEMEELGMGALLAVNQGSVEPPKM
IALIYKGKEEWTDVIGFVGKGITYDTGGYSLKPREGMVGMKGDMGGAAAVLGAMEIIGELRPEQNVIAVIPSTDNVVSGT
AFKPDDVITSMSGKTIEVLNTDAEGRLALADGITYAKKLGANYLIDVATLTGGVIVALGNHTTGAMTNNEELFEQVLEAS
METDESIWQLPIFDRDKERVRNSKFADLNNSPGREGHAVMAGTFIGEFAEDTPWVHLDIAGTSESSGAHDLGPAGATGAM
VRTLATLVERFGEE
>Mature_494_residues
MFQVQKELASHEAVVVALFEEEKTSSFVQELDKAFEGQLQVLLEEKELSTKKKAISKVHSLGKTDVKRYYFVGLGKKESY
TTETLRSALGKTFKTLQAAKVQDAAILLDSFVTEKLDAIDVAHIAAEVQGLGTYELQTYKSDKKDRVELEKFTAITAEDA
QEIEAALTVGYVHGRATNSARTLVNMPPNVLTATKLAEYAVELAEKYDMDYKVLEKEEMEELGMGALLAVNQGSVEPPKM
IALIYKGKEEWTDVIGFVGKGITYDTGGYSLKPREGMVGMKGDMGGAAAVLGAMEIIGELRPEQNVIAVIPSTDNVVSGT
AFKPDDVITSMSGKTIEVLNTDAEGRLALADGITYAKKLGANYLIDVATLTGGVIVALGNHTTGAMTNNEELFEQVLEAS
METDESIWQLPIFDRDKERVRNSKFADLNNSPGREGHAVMAGTFIGEFAEDTPWVHLDIAGTSESSGAHDLGPAGATGAM
VRTLATLVERFGEE

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=494, Percent_Identity=33.1983805668016, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI47155554, Length=345, Percent_Identity=33.9130434782609, Blast_Score=160, Evalue=3e-39,
Organism=Escherichia coli, GI1790710, Length=487, Percent_Identity=37.782340862423, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI87082123, Length=390, Percent_Identity=34.3589743589744, Blast_Score=186, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=295, Percent_Identity=36.6101694915254, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17565172, Length=147, Percent_Identity=42.8571428571429, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24661038, Length=361, Percent_Identity=33.7950138504155, Blast_Score=205, Evalue=5e-53,
Organism=Drosophila melanogaster, GI21355725, Length=393, Percent_Identity=33.3333333333333, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI20129969, Length=469, Percent_Identity=27.5053304904051, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI21355645, Length=500, Percent_Identity=28.4, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24662223, Length=500, Percent_Identity=28.4, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI161077148, Length=472, Percent_Identity=26.9067796610169, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI20130057, Length=472, Percent_Identity=26.9067796610169, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI21357381, Length=294, Percent_Identity=36.3945578231293, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24662227, Length=381, Percent_Identity=28.0839895013123, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI221379063, Length=294, Percent_Identity=36.3945578231293, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI221379062, Length=294, Percent_Identity=36.3945578231293, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI19922386, Length=463, Percent_Identity=27.645788336933, Blast_Score=155, Evalue=8e-38,
Organism=Drosophila melanogaster, GI20129963, Length=363, Percent_Identity=28.6501377410468, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24646701, Length=324, Percent_Identity=30.2469135802469, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24646703, Length=324, Percent_Identity=30.2469135802469, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21358201, Length=324, Percent_Identity=30.2469135802469, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_BACAA (C3PDF7)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002869167.1
- ProteinModelPortal:   C3PDF7
- SMR:   C3PDF7
- EnsemblBacteria:   EBBACT00000128627
- GeneID:   7849302
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_5191
- GeneTree:   EBGT00050000002613
- ProtClustDB:   PRK00913
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 53514; Mature: 53514

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 272-272 ACT_SITE 346-346

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQVQKELASHEAVVVALFEEEKTSSFVQELDKAFEGQLQVLLEEKELSTKKKAISKVHS
CCCCHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHCCHHHHEEEHHHHHHHHHHHHHHHH
LGKTDVKRYYFVGLGKKESYTTETLRSALGKTFKTLQAAKVQDAAILLDSFVTEKLDAID
CCCHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAHIAAEVQGLGTYELQTYKSDKKDRVELEKFTAITAEDAQEIEAALTVGYVHGRATNSA
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHEECHHHHHHHHHHHHEEEEECCCCCCC
RTLVNMPPNVLTATKLAEYAVELAEKYDMDYKVLEKEEMEELGMGALLAVNQGSVEPPKM
CEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHCCCCEEEEECCCCCCCCCE
IALIYKGKEEWTDVIGFVGKGITYDTGGYSLKPREGMVGMKGDMGGAAAVLGAMEIIGEL
EEEEECCCHHHHHHHHHHCCCCEECCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHC
RPEQNVIAVIPSTDNVVSGTAFKPDDVITSMSGKTIEVLNTDAEGRLALADGITYAKKLG
CCCCCEEEEECCCCCEECCCCCCCHHHHHCCCCCEEEEEECCCCCCEEEHHCHHHHHHCC
ANYLIDVATLTGGVIVALGNHTTGAMTNNEELFEQVLEASMETDESIWQLPIFDRDKERV
CCCEEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCHHHH
RNSKFADLNNSPGREGHAVMAGTFIGEFAEDTPWVHLDIAGTSESSGAHDLGPAGATGAM
CCCCCCCCCCCCCCCCCEEEEEHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHH
VRTLATLVERFGEE
HHHHHHHHHHHCCC
>Mature Secondary Structure
MFQVQKELASHEAVVVALFEEEKTSSFVQELDKAFEGQLQVLLEEKELSTKKKAISKVHS
CCCCHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHCCHHHHEEEHHHHHHHHHHHHHHHH
LGKTDVKRYYFVGLGKKESYTTETLRSALGKTFKTLQAAKVQDAAILLDSFVTEKLDAID
CCCHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAHIAAEVQGLGTYELQTYKSDKKDRVELEKFTAITAEDAQEIEAALTVGYVHGRATNSA
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHEECHHHHHHHHHHHHEEEEECCCCCCC
RTLVNMPPNVLTATKLAEYAVELAEKYDMDYKVLEKEEMEELGMGALLAVNQGSVEPPKM
CEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHCCCCEEEEECCCCCCCCCE
IALIYKGKEEWTDVIGFVGKGITYDTGGYSLKPREGMVGMKGDMGGAAAVLGAMEIIGEL
EEEEECCCHHHHHHHHHHCCCCEECCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHC
RPEQNVIAVIPSTDNVVSGTAFKPDDVITSMSGKTIEVLNTDAEGRLALADGITYAKKLG
CCCCCEEEEECCCCCEECCCCCCCHHHHHCCCCCEEEEEECCCCCCEEEHHCHHHHHHCC
ANYLIDVATLTGGVIVALGNHTTGAMTNNEELFEQVLEASMETDESIWQLPIFDRDKERV
CCCEEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCHHHH
RNSKFADLNNSPGREGHAVMAGTFIGEFAEDTPWVHLDIAGTSESSGAHDLGPAGATGAM
CCCCCCCCCCCCCCCCCEEEEEHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHH
VRTLATLVERFGEE
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA