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The map label for this gene is menB [H]

Identifier: 49187739

GI number: 49187739

Start: 4631112

End: 4631930

Strand: Reverse

Name: menB [H]

Synonym: BAS4748

Alternate gene names: 49187739

Gene position: 4631930-4631112 (Counterclockwise)

Preceding gene: 49187740

Following gene: 49187738

Centisome position: 88.59

GC content: 44.81

Gene sequence:

>819_bases
ATGGCTATTGAATGGGTAAAAGAAGGCAATTACGAAGATATTATTTATTCAACATACAATGGTATCGCGAAGATTTCGAT
TAACCGCCCTGAAGTACATAACGCATTCCGTCCTAAAACGGTAATGGAGTTAATCGATGCTTTTGCACACGCTCGTGATG
ATGCAAATGTTGGCGTTATCATTTTAACAGGTGAAGGTGGACGTGCATTCTGTTCTGGCGGCGACCAAAAAGTTCGCGGT
CATGGTGGATATGTAGGTGACGACCAAATCCCACGTCTAAACGTATTAGACCTACAACGTCTAATTCGCGCAATTCCTAA
ACCAGTTATCGCAATGGTAGCAGGTTATGCAATTGGTGGAGGACACGTACTTCATATCGTATGTGACTTAACAATCGCTG
CAGACAACGCTGTATTCGGACAAACAGGTCCTAAAGTAGGAAGCTTTGACGGTGGATACGGAGCTGGTTACCTAGCTCGT
ATGGTAGGCCACAAGAAAGCTCGCGAAATTTGGTACCTATGCCGTCAATACAACGCTCAAGAAGCGCTTGATATGGGCTT
AGTAAACACAGTAGTACCATTAGAAGAACTTGAAGCAGAAACAGTACAATGGGCACAAGAAATCTTAGCAAACAGCCCAA
TGGCACTTCGCTTCCTAAAAGCTGCATTCAACGCAGACACAGACGGACTAGCTGGTATTCAACAACTAGCTGGAGATGCA
ACGTTATTGTACTACACAACTGACGAAGCAAAAGAAGGTCGCGACGCGTTCAAAGAAAAACGCAGTCCGGACTTCGGTCA
ATTCCCTCGTTTCCCGTGA

Upstream 100 bases:

>100_bases
AGTAAAGGGATTTCTAAAAACTATGCAGTGATGCTTTTTTCAGTTAAGAATGAAGTTACACTTATAGAGGAGATCAGAAA
TATACAAGGAGGTAGTTGTA

Downstream 100 bases:

>100_bases
TCAAACCAAAAGCGGAGCCGACTGTTTAGCCCCGTTGGCTAAGGTTCTTTCTTGTGCGGAAGGTTCTTAGACGGAAGGGG
CTAGGAGGCGCAGCTGGATG

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MAIEWVKEGNYEDIIYSTYNGIAKISINRPEVHNAFRPKTVMELIDAFAHARDDANVGVIILTGEGGRAFCSGGDQKVRG
HGGYVGDDQIPRLNVLDLQRLIRAIPKPVIAMVAGYAIGGGHVLHIVCDLTIAADNAVFGQTGPKVGSFDGGYGAGYLAR
MVGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEELEAETVQWAQEILANSPMALRFLKAAFNADTDGLAGIQQLAGDA
TLLYYTTDEAKEGRDAFKEKRSPDFGQFPRFP

Sequences:

>Translated_272_residues
MAIEWVKEGNYEDIIYSTYNGIAKISINRPEVHNAFRPKTVMELIDAFAHARDDANVGVIILTGEGGRAFCSGGDQKVRG
HGGYVGDDQIPRLNVLDLQRLIRAIPKPVIAMVAGYAIGGGHVLHIVCDLTIAADNAVFGQTGPKVGSFDGGYGAGYLAR
MVGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEELEAETVQWAQEILANSPMALRFLKAAFNADTDGLAGIQQLAGDA
TLLYYTTDEAKEGRDAFKEKRSPDFGQFPRFP
>Mature_271_residues
AIEWVKEGNYEDIIYSTYNGIAKISINRPEVHNAFRPKTVMELIDAFAHARDDANVGVIILTGEGGRAFCSGGDQKVRGH
GGYVGDDQIPRLNVLDLQRLIRAIPKPVIAMVAGYAIGGGHVLHIVCDLTIAADNAVFGQTGPKVGSFDGGYGAGYLARM
VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEELEAETVQWAQEILANSPMALRFLKAAFNADTDGLAGIQQLAGDAT
LLYYTTDEAKEGRDAFKEKRSPDFGQFPRFP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=262, Percent_Identity=33.969465648855, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI31542718, Length=262, Percent_Identity=32.0610687022901, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI4502327, Length=261, Percent_Identity=31.0344827586207, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI45643119, Length=217, Percent_Identity=27.1889400921659, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI260275230, Length=217, Percent_Identity=27.1889400921659, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI260274832, Length=217, Percent_Identity=27.1889400921659, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI70995211, Length=231, Percent_Identity=29.4372294372294, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI68989263, Length=227, Percent_Identity=27.7533039647577, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1788597, Length=274, Percent_Identity=69.3430656934307, Blast_Score=390, Evalue=1e-110,
Organism=Escherichia coli, GI1787659, Length=262, Percent_Identity=32.4427480916031, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI221142681, Length=265, Percent_Identity=31.6981132075472, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI87082183, Length=266, Percent_Identity=29.3233082706767, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1787660, Length=260, Percent_Identity=30.7692307692308, Blast_Score=85, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI25145438, Length=252, Percent_Identity=32.9365079365079, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17554946, Length=246, Percent_Identity=32.520325203252, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17540714, Length=207, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17549921, Length=216, Percent_Identity=25.9259259259259, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17534483, Length=280, Percent_Identity=27.5, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560910, Length=171, Percent_Identity=33.9181286549708, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17536985, Length=218, Percent_Identity=27.5229357798165, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17535521, Length=252, Percent_Identity=23.015873015873, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI20129971, Length=245, Percent_Identity=34.2857142857143, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24653477, Length=245, Percent_Identity=34.2857142857143, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24653139, Length=255, Percent_Identity=30.5882352941176, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21357171, Length=189, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI19922422, Length=274, Percent_Identity=24.0875912408759, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24650670, Length=207, Percent_Identity=30.4347826086957, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 29692; Mature: 29561

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIEWVKEGNYEDIIYSTYNGIAKISINRPEVHNAFRPKTVMELIDAFAHARDDANVGVI
CCEEEECCCCCCCEEEECCCCEEEEEECCCHHHCCCCHHHHHHHHHHHHHCCCCCCEEEE
ILTGEGGRAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIRAIPKPVIAMVAGYAIGG
EEECCCCEEEECCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCC
GHVLHIVCDLTIAADNAVFGQTGPKVGSFDGGYGAGYLARMVGHKKAREIWYLCRQYNAQ
CEEEEEEEEEEEECCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHH
EALDMGLVNTVVPLEELEAETVQWAQEILANSPMALRFLKAAFNADTDGLAGIQQLAGDA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCE
TLLYYTTDEAKEGRDAFKEKRSPDFGQFPRFP
EEEEEECCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AIEWVKEGNYEDIIYSTYNGIAKISINRPEVHNAFRPKTVMELIDAFAHARDDANVGVI
CEEEECCCCCCCEEEECCCCEEEEEECCCHHHCCCCHHHHHHHHHHHHHCCCCCCEEEE
ILTGEGGRAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIRAIPKPVIAMVAGYAIGG
EEECCCCEEEECCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCC
GHVLHIVCDLTIAADNAVFGQTGPKVGSFDGGYGAGYLARMVGHKKAREIWYLCRQYNAQ
CEEEEEEEEEEEECCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHH
EALDMGLVNTVVPLEELEAETVQWAQEILANSPMALRFLKAAFNADTDGLAGIQQLAGDA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCE
TLLYYTTDEAKEGRDAFKEKRSPDFGQFPRFP
EEEEEECCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]