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The map label for this gene is vanSB [H]

Identifier: 49187697

GI number: 49187697

Start: 4591713

End: 4593566

Strand: Reverse

Name: vanSB [H]

Synonym: BAS4706

Alternate gene names: 49187697

Gene position: 4593566-4591713 (Counterclockwise)

Preceding gene: 49187698

Following gene: 49187695

Centisome position: 87.85

GC content: 32.31

Gene sequence:

>1854_bases
ATGAAAAAAGGGATTGTACTAAAGTTATTTACCCTCACAACAGCGCTATGTATGTTAATTTTAGCGACGATTTTTATTGG
ACAAACGATATTTTTTAAACAATATTATGCGAATCGAAAAGTAGAAGATATTAAAGTAAATTTAAATTCCTTTGAGAAGA
ATTATTTAAACTATGCAGGAAATACAGAAGAAATTAAGCGACTGGAGCAAGACTTTTTAAGAGAAAATAATACGTGGATT
ACGACATTAGATCAGAACGGGAATTTAAAGCATGCGGATGATTTTTATTTTGAGGTTACGATAGATCGCAAGCAACAGAA
GAGTTTTGGACAACAAATATTCAGAATTCCTTTATATAATCTCATCAATATAGAAGAGATTGATAATAAATCATCAAATC
CGTTTTTAGGCCAAGAAATTTATTTTTCTGGAGTGAAAAAAGAAGAAAGTTTTATTCCATTCTCTTTTTCGTTAGGTAAG
CAAAATTTGAATGGATCTAATAAACCGTTAGAAAAAGCATTTAATGAGAAAATGAGTAAATTAGATCAGGAGAAAAAGAA
AGCAGCTGAGGAACAATTCGGTAAGGAAAAGAAGCCGGTAGTTCAGGAGCAAGCTGCCCAAGAACCAGATGTTCACATAA
GAGGGCGTGTTACGAAAGTTCAGCTTCCGGATGTAACAGGTCCTATAAATCCAATTTATAAAAATAGCATCTTTTTAGAT
AACATAAAAGAATTTCAAACGGATTTATTATTGAAAGAGAGCAAGCACATACAATATGCAACACAAACAATGGACTATGA
AAAAAATGATATTAAATATAAATTATTAATCAAACCAATAAAAGAAAAAGACGAATCCGTCACATATATATATGCGATGG
CTTCTTTACAGCCTGTAGATGAAGCTGTACAAATGGTGCAAGATTACTACATTTACATCATTGCATTTGTAGTTGTTCTT
ATTTTTCTAGCTTCGTTCTATTACTCTAAGCAAATCGCAAAGCCGTTATTAAAAATAAATGATACAACGAAGAAAATAGC
GCATTTAGATTTCACAGAACAAATACCGATTACTTCAAAAGATGAAATTGGTGATTTATCGAAAAATATTAATACACTCT
CTAACAAATTAAATTCCCATATTGGACAGCTAGAACAAGATATTGAAAAGGAAAGAAAGTTAGAAAAGACGCGGAAAGAA
TTCATTTCTGGTGTTTCGCATGAACTAAAAACACCGCTGAGTATTATGAAAAGCTGTATTTCTATTTTAAAAGATGGAGT
AGCTGAGCATAAAAAAGAGTACTATTTTCAAGCGATGGAACGGGAAGTAGACAAAATGGATACTTTAATTTTGGATATGC
TGGAGTTAGCTAAATTTGAGTCAGGCACATATAAAATGAAAAAGGACCCATTTTATATCGATACAGTAATGGAAGCTATA
TGTGAACACCTTTCTGTAGAAATAGAGAAAAAAGAACTTCGTGTTCATAAACATATAGGTCCATTTGAAGTAGTCGCAAA
TCAAGGCCGGATTGAACAAGTCATCGTGAACTTCATTACGAATGCGATACGTTATACACCAAATAAAGAAGATATTATTA
TTTCTACAATAGATGAGAAGGATCATATAAAAGTATGTATTGAAAATAAAGGTACTCACATTGAAGAAGAGCAATTAGAT
AAAATTTGGGATCGTTTTTATCGCGTGGATGCAGCTCGCCAGCGTTCGCAAGGAGGAACAGGTCTTGGGCTTGCCATTTC
AAAGAATATTTTAGAACTACATGATGCTGAATATGGGGCAGAAAATACAGAAGATGGTGTGTTATTTTATTTCTATTTAC
CGAAAAAAGCGTAG

Upstream 100 bases:

>100_bases
CAGTTAATAGTCATATTCGTAATTTAAGAAATAAATTAGGAGAGAAAGCAAAGTACATTACAACTGTAGTACGAACGGGT
TATAAATTTGAGGGGAATGT

Downstream 100 bases:

>100_bases
ACAATATGATCTACGCTTTTTTTTTATTTTTTTCATATTATCTTTACCTAATCTTTATTTTTAATCAGTATAATTTGTTT
AGAAAATGAGGTTATGTAAG

Product: sensory box histidine kinase

Products: NA

Alternate protein names: Vancomycin B-type resistance protein vanSB; Vancomycin histidine protein kinase [H]

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MKKGIVLKLFTLTTALCMLILATIFIGQTIFFKQYYANRKVEDIKVNLNSFEKNYLNYAGNTEEIKRLEQDFLRENNTWI
TTLDQNGNLKHADDFYFEVTIDRKQQKSFGQQIFRIPLYNLINIEEIDNKSSNPFLGQEIYFSGVKKEESFIPFSFSLGK
QNLNGSNKPLEKAFNEKMSKLDQEKKKAAEEQFGKEKKPVVQEQAAQEPDVHIRGRVTKVQLPDVTGPINPIYKNSIFLD
NIKEFQTDLLLKESKHIQYATQTMDYEKNDIKYKLLIKPIKEKDESVTYIYAMASLQPVDEAVQMVQDYYIYIIAFVVVL
IFLASFYYSKQIAKPLLKINDTTKKIAHLDFTEQIPITSKDEIGDLSKNINTLSNKLNSHIGQLEQDIEKERKLEKTRKE
FISGVSHELKTPLSIMKSCISILKDGVAEHKKEYYFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDPFYIDTVMEAI
CEHLSVEIEKKELRVHKHIGPFEVVANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEKDHIKVCIENKGTHIEEEQLD
KIWDRFYRVDAARQRSQGGTGLGLAISKNILELHDAEYGAENTEDGVLFYFYLPKKA

Sequences:

>Translated_617_residues
MKKGIVLKLFTLTTALCMLILATIFIGQTIFFKQYYANRKVEDIKVNLNSFEKNYLNYAGNTEEIKRLEQDFLRENNTWI
TTLDQNGNLKHADDFYFEVTIDRKQQKSFGQQIFRIPLYNLINIEEIDNKSSNPFLGQEIYFSGVKKEESFIPFSFSLGK
QNLNGSNKPLEKAFNEKMSKLDQEKKKAAEEQFGKEKKPVVQEQAAQEPDVHIRGRVTKVQLPDVTGPINPIYKNSIFLD
NIKEFQTDLLLKESKHIQYATQTMDYEKNDIKYKLLIKPIKEKDESVTYIYAMASLQPVDEAVQMVQDYYIYIIAFVVVL
IFLASFYYSKQIAKPLLKINDTTKKIAHLDFTEQIPITSKDEIGDLSKNINTLSNKLNSHIGQLEQDIEKERKLEKTRKE
FISGVSHELKTPLSIMKSCISILKDGVAEHKKEYYFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDPFYIDTVMEAI
CEHLSVEIEKKELRVHKHIGPFEVVANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEKDHIKVCIENKGTHIEEEQLD
KIWDRFYRVDAARQRSQGGTGLGLAISKNILELHDAEYGAENTEDGVLFYFYLPKKA
>Mature_617_residues
MKKGIVLKLFTLTTALCMLILATIFIGQTIFFKQYYANRKVEDIKVNLNSFEKNYLNYAGNTEEIKRLEQDFLRENNTWI
TTLDQNGNLKHADDFYFEVTIDRKQQKSFGQQIFRIPLYNLINIEEIDNKSSNPFLGQEIYFSGVKKEESFIPFSFSLGK
QNLNGSNKPLEKAFNEKMSKLDQEKKKAAEEQFGKEKKPVVQEQAAQEPDVHIRGRVTKVQLPDVTGPINPIYKNSIFLD
NIKEFQTDLLLKESKHIQYATQTMDYEKNDIKYKLLIKPIKEKDESVTYIYAMASLQPVDEAVQMVQDYYIYIIAFVVVL
IFLASFYYSKQIAKPLLKINDTTKKIAHLDFTEQIPITSKDEIGDLSKNINTLSNKLNSHIGQLEQDIEKERKLEKTRKE
FISGVSHELKTPLSIMKSCISILKDGVAEHKKEYYFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDPFYIDTVMEAI
CEHLSVEIEKKELRVHKHIGPFEVVANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEKDHIKVCIENKGTHIEEEQLD
KIWDRFYRVDAARQRSQGGTGLGLAISKNILELHDAEYGAENTEDGVLFYFYLPKKA

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance. VanS activates vanR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=287, Percent_Identity=26.8292682926829, Blast_Score=135, Evalue=1e-32,
Organism=Escherichia coli, GI1786600, Length=233, Percent_Identity=26.6094420600858, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1790346, Length=225, Percent_Identity=26.6666666666667, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87081816, Length=334, Percent_Identity=23.3532934131737, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI1786783, Length=268, Percent_Identity=27.9850746268657, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1789149, Length=248, Percent_Identity=27.8225806451613, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI145693157, Length=227, Percent_Identity=26.431718061674, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1787894, Length=333, Percent_Identity=21.6216216216216, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI48994928, Length=203, Percent_Identity=27.0935960591133, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1790861, Length=232, Percent_Identity=24.5689655172414, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1786912, Length=227, Percent_Identity=25.5506607929515, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1788279, Length=364, Percent_Identity=25.8241758241758, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1790436, Length=236, Percent_Identity=25.8474576271186, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1790551, Length=298, Percent_Identity=23.1543624161074, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788713, Length=243, Percent_Identity=23.4567901234568, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1787374, Length=313, Percent_Identity=21.7252396166134, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI87082128, Length=315, Percent_Identity=19.6825396825397, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1789808, Length=225, Percent_Identity=24, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 71556; Mature: 71556

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKGIVLKLFTLTTALCMLILATIFIGQTIFFKQYYANRKVEDIKVNLNSFEKNYLNYAG
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHCCC
NTEEIKRLEQDFLRENNTWITTLDQNGNLKHADDFYFEVTIDRKQQKSFGQQIFRIPLYN
CHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHH
LINIEEIDNKSSNPFLGQEIYFSGVKKEESFIPFSFSLGKQNLNGSNKPLEKAFNEKMSK
HCCHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHH
LDQEKKKAAEEQFGKEKKPVVQEQAAQEPDVHIRGRVTKVQLPDVTGPINPIYKNSIFLD
HHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCHHCCCEEHH
NIKEFQTDLLLKESKHIQYATQTMDYEKNDIKYKLLIKPIKEKDESVTYIYAMASLQPVD
HHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCHH
EAVQMVQDYYIYIIAFVVVLIFLASFYYSKQIAKPLLKINDTTKKIAHLDFTEQIPITSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCC
DEIGDLSKNINTLSNKLNSHIGQLEQDIEKERKLEKTRKEFISGVSHELKTPLSIMKSCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
SILKDGVAEHKKEYYFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDPFYIDTVMEAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHH
CEHLSVEIEKKELRVHKHIGPFEVVANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEK
HHHHCCCHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCC
DHIKVCIENKGTHIEEEQLDKIWDRFYRVDAARQRSQGGTGLGLAISKNILELHDAEYGA
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCCC
ENTEDGVLFYFYLPKKA
CCCCCCEEEEEEECCCC
>Mature Secondary Structure
MKKGIVLKLFTLTTALCMLILATIFIGQTIFFKQYYANRKVEDIKVNLNSFEKNYLNYAG
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHCCC
NTEEIKRLEQDFLRENNTWITTLDQNGNLKHADDFYFEVTIDRKQQKSFGQQIFRIPLYN
CHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHH
LINIEEIDNKSSNPFLGQEIYFSGVKKEESFIPFSFSLGKQNLNGSNKPLEKAFNEKMSK
HCCHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHH
LDQEKKKAAEEQFGKEKKPVVQEQAAQEPDVHIRGRVTKVQLPDVTGPINPIYKNSIFLD
HHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCHHCCCEEHH
NIKEFQTDLLLKESKHIQYATQTMDYEKNDIKYKLLIKPIKEKDESVTYIYAMASLQPVD
HHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCHH
EAVQMVQDYYIYIIAFVVVLIFLASFYYSKQIAKPLLKINDTTKKIAHLDFTEQIPITSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCC
DEIGDLSKNINTLSNKLNSHIGQLEQDIEKERKLEKTRKEFISGVSHELKTPLSIMKSCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
SILKDGVAEHKKEYYFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDPFYIDTVMEAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHH
CEHLSVEIEKKELRVHKHIGPFEVVANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEK
HHHHCCCHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCC
DHIKVCIENKGTHIEEEQLDKIWDRFYRVDAARQRSQGGTGLGLAISKNILELHDAEYGA
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCCC
ENTEDGVLFYFYLPKKA
CCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8631706; 12663927 [H]