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The map label for this gene is yhaU [H]

Identifier: 49187630

GI number: 49187630

Start: 4534019

End: 4535200

Strand: Reverse

Name: yhaU [H]

Synonym: BAS4639

Alternate gene names: 49187630

Gene position: 4535200-4534019 (Counterclockwise)

Preceding gene: 49187631

Following gene: 49187629

Centisome position: 86.74

GC content: 38.16

Gene sequence:

>1182_bases
ATGGATACTTTAATCTTTGAAGTTGGAACTGCGTTAGTATTAGTAGCTTTTGCAGCTATCCTCGCTGCAAAGTTAAAGTT
TTCGATTATTCCGTTTCTCATTATTCTTGGTATGTTAGTGGGGCCGCATGCCCCTGATTTAGGACTTATCGATTTAAGGT
TTATTGAAAGCGGAGAAGTTATTTCCTTCCTCGGCCGCGTTGGCGTCATATTCCTCCTATTCTACTTAGGTTTAGAATTC
TCAATAAAAAAATTAATTAAATCAGGAAAATCAATTGCTTTTGGGGGGACTGTCCACATATCACTTAATTTCCTATTAGG
TTTGCTTTATGGATATGTGATGGGCTTCCCCTTATTAGAGACGTTAATTATTGCTGGAATCATTACAATTTCATCAAGTG
CAATTGTTGCAAAAGTCATTGTTGATTTAAGAAGATCTGGTAATAAAGAGACGGAGCTGATTTTAGGAATCATTATGTTT
GATGATATCTTTTTAGCGGTATATTTATCAGTCGTTTCAGGATTAGTACTCGGAGGGGCAACGTCATTTGCAGGTGCTCT
TACGTCGGTGTTAATTGCAGTAGGGTATATGCTCCTATTTTTTGTAATCGCTAGAAAAGCTACGCCGTTTTTAAATAAAG
TATTAGATATTTCGTCTAACGAAATTTTCATAATCGTAATATTTGCTATTTTATTTTTCGTAGCAGGATTTTCCGAAACA
ATTCATGTTGCGGAAGCGATTGGAGCTTTATTATTAGGACTCGTCTTTTCTGAAACGGAGCATAGCGATCGAATTGAAAA
GCTCGTCGTCCCATTCCGTGATTTCTTTGGAGCCATATTCTTTTTCAGCTTCGGTTTAAGTATAGATCCGTTTTCGCTTG
GAGGCGCAGTATGGTTGGCATTAGGAGCAGTTTTCATTACTATCATCGGTAATTTTACTGCTGGAATGATTGCGGGGAGT
AAAGCCGGGTTATCCCATAAGGCTTCTACGAATATAGGCTTAACACTCGTATCACGCGGAGAGTTCTCCATTATTGTAGC
AAATATCGGGATTGCGGGTGGCTTAATGGCAGCGATTAAACCGTTCTCTGCACTGTACGTTTTAATATTAGCATCGTTAG
GACCGTTATTAACGAAAGAGTCTGGGAGAATATACTCTCTACTAGATAAGTTGTTTAAATGA

Upstream 100 bases:

>100_bases
TATTATTGAAGCTGGCGATATGCTTGTGTTATCGGGCGCGAGACATGAAGTGAAAAGAATTATTAATGAATTGCTTTCAG
CAGGAGGTGATTCATAATCG

Downstream 100 bases:

>100_bases
AGTGCTAAAGAACGTGCAAAGCGAGAAAAAGAAGTTGGGTAATATATAAAGAGGCTGCATGAAGTTCATGCAGCCTCTTT
ATATATTGTTATTGTTGTCG

Product: sodium/hydrogen exchanger family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MDTLIFEVGTALVLVAFAAILAAKLKFSIIPFLIILGMLVGPHAPDLGLIDLRFIESGEVISFLGRVGVIFLLFYLGLEF
SIKKLIKSGKSIAFGGTVHISLNFLLGLLYGYVMGFPLLETLIIAGIITISSSAIVAKVIVDLRRSGNKETELILGIIMF
DDIFLAVYLSVVSGLVLGGATSFAGALTSVLIAVGYMLLFFVIARKATPFLNKVLDISSNEIFIIVIFAILFFVAGFSET
IHVAEAIGALLLGLVFSETEHSDRIEKLVVPFRDFFGAIFFFSFGLSIDPFSLGGAVWLALGAVFITIIGNFTAGMIAGS
KAGLSHKASTNIGLTLVSRGEFSIIVANIGIAGGLMAAIKPFSALYVLILASLGPLLTKESGRIYSLLDKLFK

Sequences:

>Translated_393_residues
MDTLIFEVGTALVLVAFAAILAAKLKFSIIPFLIILGMLVGPHAPDLGLIDLRFIESGEVISFLGRVGVIFLLFYLGLEF
SIKKLIKSGKSIAFGGTVHISLNFLLGLLYGYVMGFPLLETLIIAGIITISSSAIVAKVIVDLRRSGNKETELILGIIMF
DDIFLAVYLSVVSGLVLGGATSFAGALTSVLIAVGYMLLFFVIARKATPFLNKVLDISSNEIFIIVIFAILFFVAGFSET
IHVAEAIGALLLGLVFSETEHSDRIEKLVVPFRDFFGAIFFFSFGLSIDPFSLGGAVWLALGAVFITIIGNFTAGMIAGS
KAGLSHKASTNIGLTLVSRGEFSIIVANIGIAGGLMAAIKPFSALYVLILASLGPLLTKESGRIYSLLDKLFK
>Mature_393_residues
MDTLIFEVGTALVLVAFAAILAAKLKFSIIPFLIILGMLVGPHAPDLGLIDLRFIESGEVISFLGRVGVIFLLFYLGLEF
SIKKLIKSGKSIAFGGTVHISLNFLLGLLYGYVMGFPLLETLIIAGIITISSSAIVAKVIVDLRRSGNKETELILGIIMF
DDIFLAVYLSVVSGLVLGGATSFAGALTSVLIAVGYMLLFFVIARKATPFLNKVLDISSNEIFIIVIFAILFFVAGFSET
IHVAEAIGALLLGLVFSETEHSDRIEKLVVPFRDFFGAIFFFSFGLSIDPFSLGGAVWLALGAVFITIIGNFTAGMIAGS
KAGLSHKASTNIGLTLVSRGEFSIIVANIGIAGGLMAAIKPFSALYVLILASLGPLLTKESGRIYSLLDKLFK

Specific function: Potassium/proton antiporter that mediates the efflux of potassium ions from the cell. Potassium antiport activity requires the presence of khtT. Has higher activity at alkaline pH. Can also mediate rubidium/proton antiport. Has no permeability for sodium

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=279, Percent_Identity=28.673835125448, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1786685, Length=351, Percent_Identity=27.3504273504274, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786232, Length=262, Percent_Identity=25.9541984732824, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 41864; Mature: 41864

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTLIFEVGTALVLVAFAAILAAKLKFSIIPFLIILGMLVGPHAPDLGLIDLRFIESGEV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHH
ISFLGRVGVIFLLFYLGLEFSIKKLIKSGKSIAFGGTVHISLNFLLGLLYGYVMGFPLLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEEHHHHHHHHHHHHHHHHHHHH
TLIIAGIITISSSAIVAKVIVDLRRSGNKETELILGIIMFDDIFLAVYLSVVSGLVLGGA
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
TSFAGALTSVLIAVGYMLLFFVIARKATPFLNKVLDISSNEIFIIVIFAILFFVAGFSET
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEHHHHHHHHHHHHCCHHH
IHVAEAIGALLLGLVFSETEHSDRIEKLVVPFRDFFGAIFFFSFGLSIDPFSLGGAVWLA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LGAVFITIIGNFTAGMIAGSKAGLSHKASTNIGLTLVSRGEFSIIVANIGIAGGLMAAIK
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCEEEEEEECCHHHHHHHHHH
PFSALYVLILASLGPLLTKESGRIYSLLDKLFK
HHHHHHHHHHHHHCHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MDTLIFEVGTALVLVAFAAILAAKLKFSIIPFLIILGMLVGPHAPDLGLIDLRFIESGEV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHH
ISFLGRVGVIFLLFYLGLEFSIKKLIKSGKSIAFGGTVHISLNFLLGLLYGYVMGFPLLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEEHHHHHHHHHHHHHHHHHHHH
TLIIAGIITISSSAIVAKVIVDLRRSGNKETELILGIIMFDDIFLAVYLSVVSGLVLGGA
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
TSFAGALTSVLIAVGYMLLFFVIARKATPFLNKVLDISSNEIFIIVIFAILFFVAGFSET
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEHHHHHHHHHHHHCCHHH
IHVAEAIGALLLGLVFSETEHSDRIEKLVVPFRDFFGAIFFFSFGLSIDPFSLGGAVWLA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LGAVFITIIGNFTAGMIAGSKAGLSHKASTNIGLTLVSRGEFSIIVANIGIAGGLMAAIK
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCEEEEEEECCHHHHHHHHHH
PFSALYVLILASLGPLLTKESGRIYSLLDKLFK
HHHHHHHHHHHHHCHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]