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The map label for this gene is moaA [H]

Identifier: 49187615

GI number: 49187615

Start: 4517551

End: 4518309

Strand: Reverse

Name: moaA [H]

Synonym: BAS4622

Alternate gene names: 49187615

Gene position: 4518309-4517551 (Counterclockwise)

Preceding gene: 49187616

Following gene: 49187614

Centisome position: 86.41

GC content: 38.87

Gene sequence:

>759_bases
ATGAAAAGAGAGAAATTTGGCAGAAAGGGAGGGTGGCGATGCAGGAGATGGTTACAGATTTTTTTTGGACGCCCACTTCA
AGATTTACGCATATCTGTCATTGATCGTTGCAATTTTAGATGTACATATTGTATGCCAGCGGAAGTGTTTGGGCCAGATT
ATGCTTTTTTGAAAGATGAGTTTTTACTGACGTTTGATGAAATTGAGCGTGTAGCAAAACTATTTGTTAGCATCGGTGTA
CGAAAAATTAGACTTACTGGTGGCGAGCCACTACTTCGTAAAGATTTAGCAAAACTTATTGCACGTCTCGTGAAAATTGA
CGGGCTATTAGATATAGGGTTAACGACCAATGCAATTCATTTAACAAAGCAAGCGAAAGTATTAAAAGAAGCTGGATTAC
ATAGAGTAAATGTTAGCTTGGATGCAATAGATGATGATGTATTTAAGGCTATTAATGGCCGGAATATTAATACGAAACCT
GTTATAAAGGGGATTATGGCTGCAAAAGAAGCCGGACTTGATGTAAAGGTAAACATGGTTGTGAAAAAAGGGATGAACGA
TCATCAAGTACTTCCGATGGCTGCGTATTTTAAAGAGCAAGGAATCCCACTTAGGTTCATTGAGTTTATGGATGTTGGTA
GTACAAATGGATGGAACTTTGATCAAGTTGTTACGAAGCGAGAGTTAATTGAGATGATTCATCGCGTGTATCCGCTTGAG
CCAGCTGAAGCGCATTATTTTGGTGAAGTTGCGAAGTGA

Upstream 100 bases:

>100_bases
TTTTTTATCTCCTTATTTGTATGTAGTCTCATTGATTAGGAAAGTTTTACTTTATTCACATGAGTAAAAACATCGCAGTT
CGAAAATATATTATAATAGA

Downstream 100 bases:

>100_bases
TATCGTTACGTTGGAACAAATGTTGAAGTCGGTTTTATTACTTCTGTGTCTGAGTCATTTTGTTCTTCTTGTACGAGAGC
GAGAATTTCGGCAGATGGAA

Product: molybdenum cofactor biosynthesis protein A, N-terminus

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MKREKFGRKGGWRCRRWLQIFFGRPLQDLRISVIDRCNFRCTYCMPAEVFGPDYAFLKDEFLLTFDEIERVAKLFVSIGV
RKIRLTGGEPLLRKDLAKLIARLVKIDGLLDIGLTTNAIHLTKQAKVLKEAGLHRVNVSLDAIDDDVFKAINGRNINTKP
VIKGIMAAKEAGLDVKVNMVVKKGMNDHQVLPMAAYFKEQGIPLRFIEFMDVGSTNGWNFDQVVTKRELIEMIHRVYPLE
PAEAHYFGEVAK

Sequences:

>Translated_252_residues
MKREKFGRKGGWRCRRWLQIFFGRPLQDLRISVIDRCNFRCTYCMPAEVFGPDYAFLKDEFLLTFDEIERVAKLFVSIGV
RKIRLTGGEPLLRKDLAKLIARLVKIDGLLDIGLTTNAIHLTKQAKVLKEAGLHRVNVSLDAIDDDVFKAINGRNINTKP
VIKGIMAAKEAGLDVKVNMVVKKGMNDHQVLPMAAYFKEQGIPLRFIEFMDVGSTNGWNFDQVVTKRELIEMIHRVYPLE
PAEAHYFGEVAK
>Mature_252_residues
MKREKFGRKGGWRCRRWLQIFFGRPLQDLRISVIDRCNFRCTYCMPAEVFGPDYAFLKDEFLLTFDEIERVAKLFVSIGV
RKIRLTGGEPLLRKDLAKLIARLVKIDGLLDIGLTTNAIHLTKQAKVLKEAGLHRVNVSLDAIDDDVFKAINGRNINTKP
VIKGIMAAKEAGLDVKVNMVVKKGMNDHQVLPMAAYFKEQGIPLRFIEFMDVGSTNGWNFDQVVTKRELIEMIHRVYPLE
PAEAHYFGEVAK

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=240, Percent_Identity=40.4166666666667, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI22027536, Length=240, Percent_Identity=40.4166666666667, Blast_Score=159, Evalue=3e-39,
Organism=Escherichia coli, GI1786999, Length=193, Percent_Identity=41.4507772020725, Blast_Score=145, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI32566329, Length=213, Percent_Identity=36.6197183098592, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI32566331, Length=213, Percent_Identity=36.6197183098592, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17561210, Length=217, Percent_Identity=36.405529953917, Blast_Score=134, Evalue=3e-32,
Organism=Drosophila melanogaster, GI28574488, Length=217, Percent_Identity=38.2488479262673, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI28574490, Length=217, Percent_Identity=38.2488479262673, Blast_Score=145, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 28780; Mature: 28780

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKREKFGRKGGWRCRRWLQIFFGRPLQDLRISVIDRCNFRCTYCMPAEVFGPDYAFLKDE
CCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCHHHCCCCHHHHHHH
FLLTFDEIERVAKLFVSIGVRKIRLTGGEPLLRKDLAKLIARLVKIDGLLDIGLTTNAIH
HEEEHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCEEE
LTKQAKVLKEAGLHRVNVSLDAIDDDVFKAINGRNINTKPVIKGIMAAKEAGLDVKVNMV
HHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEE
VKKGMNDHQVLPMAAYFKEQGIPLRFIEFMDVGSTNGWNFDQVVTKRELIEMIHRVYPLE
EECCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCC
PAEAHYFGEVAK
CCCHHHHCCCCC
>Mature Secondary Structure
MKREKFGRKGGWRCRRWLQIFFGRPLQDLRISVIDRCNFRCTYCMPAEVFGPDYAFLKDE
CCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCHHHCCCCHHHHHHH
FLLTFDEIERVAKLFVSIGVRKIRLTGGEPLLRKDLAKLIARLVKIDGLLDIGLTTNAIH
HEEEHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCEEE
LTKQAKVLKEAGLHRVNVSLDAIDDDVFKAINGRNINTKPVIKGIMAAKEAGLDVKVNMV
HHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEE
VKKGMNDHQVLPMAAYFKEQGIPLRFIEFMDVGSTNGWNFDQVVTKRELIEMIHRVYPLE
EECCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCC
PAEAHYFGEVAK
CCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA