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The map label for this gene is acuC [H]

Identifier: 49187557

GI number: 49187557

Start: 4467874

End: 4469040

Strand: Direct

Name: acuC [H]

Synonym: BAS4563

Alternate gene names: 49187557

Gene position: 4467874-4469040 (Clockwise)

Preceding gene: 49187556

Following gene: 49187561

Centisome position: 85.45

GC content: 42.67

Gene sequence:

>1167_bases
ATGAGTAGCGCGTTTATTTATTCGGATGACTTTCGGGGCTATTCATTTAGCCCTGATCATCCCTTTAACCAACTGCGCGT
CACACTTACGTATGATTTATTACAAAAGGGCGGTTTCATCTCTCCTTCCCAAATCATCTCACCACGGATGGCTACAGATG
AAGAGATTGCCTACATTCATACAGAGGAGTACATAAATGCGGTAAAACGTGCTGGAGAAGGTAAGTTAGAAAAATCAATT
GCGATGACATATGGACTCGGAACAGAAGATACACCAATGTTTCCAAATATGCACGAAGCAAGCGCATTACTCGTTGGCGG
TACGTTAACCGCTGTCGATGCTGTTCTTTCTGGGAAAGTAAAACACGCTCTCAATTTAGGTGGTGGCTTACATCATGGCT
TCCGTGGCAAAGCATCTGGCTTTTGCATTTATAACGATAGTTCCATCGCAATGAAATATATTCAAAAGAAGTACGGTTTA
CGCGTTTTATATATTGATACGGATGCTCATCACGGTGATGGTGTACAGTGGTCCTTTTATGACGATCCTAACGTATGCAC
CATTTCACTACATGAAACTGGTCGATATTTATTCCCTGGAACTGGCGCTGTAAACGAACGCGGACAAGGTAATGGCTATA
GTTATTCTTTTAACGTTCCACTCGATGCTTTTACAGAAGACGAATCGTTTTTAGATTCCTATCGAACTGTTGTAAAAGAA
GTGGCCGCATACTTTAAACCGGATATTATTTTAACGCAAAATGGTGCTGACGCACATTACTACGACCCACTTACACACCT
TTGCGCAACGATGAATATTTACCGCGAGATACCAAAGCTCGCTCGCGAAATCGCTAACGAATATTGCGAAGGTCGCTGGA
TTGCTGTCGGCGGCGGTGGCTATGACCACTGGCGTGTCGTCCCAAGAGCTTGGGCACTCATTTGGCTCGAAATGAACAAC
ATCCAAAACATCTCAGGTTATCTCCCTCCAGAATGGATTGACGCTTGGAAAGGACAAGCTGAAACAGAACTTCCTCTCAC
ATGGGAAGATCCAAACAACATGTATAAACCTATCCCCCGCAAACCAGAAATTGAAGAAAAGAACGCATTAACTGTAGCAA
AATCCCTTGAAATTATTCGGAATAATATGAAAAAATCTTTGTACTAA

Upstream 100 bases:

>100_bases
TCGTTTTCCGCATTCAAACGATGAATCCACTAAAAGTGATTGATGCACTTGAAGCAGAAGGCTACCGCGTATTATGGCCA
AACATTATGGGGATGCAAGC

Downstream 100 bases:

>100_bases
ACGAAAAGGAGGCTCGTTTTTGAATAGCCTCCTTTTATTTAAAACTTGCTATTATTGTCGATTTCTGTCGGTAAGTCGAT
ATATTTTAATAATCGCTGAT

Product: acetoin utilization protein AcuC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MSSAFIYSDDFRGYSFSPDHPFNQLRVTLTYDLLQKGGFISPSQIISPRMATDEEIAYIHTEEYINAVKRAGEGKLEKSI
AMTYGLGTEDTPMFPNMHEASALLVGGTLTAVDAVLSGKVKHALNLGGGLHHGFRGKASGFCIYNDSSIAMKYIQKKYGL
RVLYIDTDAHHGDGVQWSFYDDPNVCTISLHETGRYLFPGTGAVNERGQGNGYSYSFNVPLDAFTEDESFLDSYRTVVKE
VAAYFKPDIILTQNGADAHYYDPLTHLCATMNIYREIPKLAREIANEYCEGRWIAVGGGGYDHWRVVPRAWALIWLEMNN
IQNISGYLPPEWIDAWKGQAETELPLTWEDPNNMYKPIPRKPEIEEKNALTVAKSLEIIRNNMKKSLY

Sequences:

>Translated_388_residues
MSSAFIYSDDFRGYSFSPDHPFNQLRVTLTYDLLQKGGFISPSQIISPRMATDEEIAYIHTEEYINAVKRAGEGKLEKSI
AMTYGLGTEDTPMFPNMHEASALLVGGTLTAVDAVLSGKVKHALNLGGGLHHGFRGKASGFCIYNDSSIAMKYIQKKYGL
RVLYIDTDAHHGDGVQWSFYDDPNVCTISLHETGRYLFPGTGAVNERGQGNGYSYSFNVPLDAFTEDESFLDSYRTVVKE
VAAYFKPDIILTQNGADAHYYDPLTHLCATMNIYREIPKLAREIANEYCEGRWIAVGGGGYDHWRVVPRAWALIWLEMNN
IQNISGYLPPEWIDAWKGQAETELPLTWEDPNNMYKPIPRKPEIEEKNALTVAKSLEIIRNNMKKSLY
>Mature_387_residues
SSAFIYSDDFRGYSFSPDHPFNQLRVTLTYDLLQKGGFISPSQIISPRMATDEEIAYIHTEEYINAVKRAGEGKLEKSIA
MTYGLGTEDTPMFPNMHEASALLVGGTLTAVDAVLSGKVKHALNLGGGLHHGFRGKASGFCIYNDSSIAMKYIQKKYGLR
VLYIDTDAHHGDGVQWSFYDDPNVCTISLHETGRYLFPGTGAVNERGQGNGYSYSFNVPLDAFTEDESFLDSYRTVVKEV
AAYFKPDIILTQNGADAHYYDPLTHLCATMNIYREIPKLAREIANEYCEGRWIAVGGGGYDHWRVVPRAWALIWLEMNNI
QNISGYLPPEWIDAWKGQAETELPLTWEDPNNMYKPIPRKPEIEEKNALTVAKSLEIIRNNMKKSLY

Specific function: Role in growth and sporulation on acetoin or butanediol. Involved in the breakdown of these compounds used as a carbon source [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128862, Length=314, Percent_Identity=32.1656050955414, Blast_Score=165, Evalue=8e-41,
Organism=Homo sapiens, GI13128860, Length=310, Percent_Identity=32.5806451612903, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI8923769, Length=294, Percent_Identity=32.9931972789116, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI293336691, Length=256, Percent_Identity=34.765625, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI20070354, Length=315, Percent_Identity=30.7936507936508, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI262073092, Length=206, Percent_Identity=35.4368932038835, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI30795202, Length=332, Percent_Identity=29.5180722891566, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI30795204, Length=333, Percent_Identity=30.03003003003, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI17158039, Length=333, Percent_Identity=30.03003003003, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI153085395, Length=267, Percent_Identity=32.2097378277154, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI226529806, Length=233, Percent_Identity=33.4763948497854, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI169234807, Length=263, Percent_Identity=31.5589353612167, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI148539870, Length=263, Percent_Identity=31.5589353612167, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI62750347, Length=309, Percent_Identity=31.3915857605178, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI62750349, Length=309, Percent_Identity=31.3915857605178, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI13128864, Length=290, Percent_Identity=30, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI262073088, Length=197, Percent_Identity=35.5329949238579, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI217272877, Length=259, Percent_Identity=26.6409266409266, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI209862883, Length=253, Percent_Identity=26.4822134387352, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17508561, Length=309, Percent_Identity=33.9805825242718, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17561978, Length=314, Percent_Identity=33.1210191082803, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17534739, Length=313, Percent_Identity=30.6709265175719, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI193209491, Length=305, Percent_Identity=28.8524590163934, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI193206283, Length=310, Percent_Identity=27.4193548387097, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17540332, Length=310, Percent_Identity=27.4193548387097, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17540334, Length=310, Percent_Identity=27.4193548387097, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI25154020, Length=323, Percent_Identity=24.4582043343653, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25154022, Length=323, Percent_Identity=24.7678018575851, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193207430, Length=258, Percent_Identity=24.8062015503876, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17537347, Length=225, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323999, Length=321, Percent_Identity=32.0872274143302, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6321244, Length=325, Percent_Identity=32.3076923076923, Blast_Score=169, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6324307, Length=306, Percent_Identity=30.3921568627451, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6325325, Length=235, Percent_Identity=25.9574468085106, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24644244, Length=314, Percent_Identity=32.1656050955414, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24657891, Length=310, Percent_Identity=31.9354838709677, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24642144, Length=289, Percent_Identity=30.1038062283737, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24642146, Length=289, Percent_Identity=30.1038062283737, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24642142, Length=289, Percent_Identity=30.1038062283737, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI281360899, Length=289, Percent_Identity=30.1038062283737, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI281360799, Length=311, Percent_Identity=27.9742765273312, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281360801, Length=310, Percent_Identity=28.0645161290323, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24641720, Length=310, Percent_Identity=28.0645161290323, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24649807, Length=255, Percent_Identity=24.7058823529412, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003085
- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 43673; Mature: 43542

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAFIYSDDFRGYSFSPDHPFNQLRVTLTYDLLQKGGFISPSQIISPRMATDEEIAYIH
CCCCEEEECCCCCCCCCCCCCCCCEEEEEEEHHHHCCCCCCHHHHCCCCCCCCCCEEEEE
TEEYINAVKRAGEGKLEKSIAMTYGLGTEDTPMFPNMHEASALLVGGTLTAVDAVLSGKV
HHHHHHHHHHCCCCCHHHHEEEEECCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHCHH
KHALNLGGGLHHGFRGKASGFCIYNDSSIAMKYIQKKYGLRVLYIDTDAHHGDGVQWSFY
HHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCEEEEEEECCCCCCCCEEEEEE
DDPNVCTISLHETGRYLFPGTGAVNERGQGNGYSYSFNVPLDAFTEDESFLDSYRTVVKE
CCCCEEEEEEECCCCEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHH
VAAYFKPDIILTQNGADAHYYDPLTHLCATMNIYREIPKLAREIANEYCEGRWIAVGGGG
HHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
YDHWRVVPRAWALIWLEMNNIQNISGYLPPEWIDAWKGQAETELPLTWEDPNNMYKPIPR
CCHHEECCCEEEEEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCCEEECCCCCCCCCCCC
KPEIEEKNALTVAKSLEIIRNNMKKSLY
CCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSAFIYSDDFRGYSFSPDHPFNQLRVTLTYDLLQKGGFISPSQIISPRMATDEEIAYIH
CCCEEEECCCCCCCCCCCCCCCCEEEEEEEHHHHCCCCCCHHHHCCCCCCCCCCEEEEE
TEEYINAVKRAGEGKLEKSIAMTYGLGTEDTPMFPNMHEASALLVGGTLTAVDAVLSGKV
HHHHHHHHHHCCCCCHHHHEEEEECCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHCHH
KHALNLGGGLHHGFRGKASGFCIYNDSSIAMKYIQKKYGLRVLYIDTDAHHGDGVQWSFY
HHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCEEEEEEECCCCCCCCEEEEEE
DDPNVCTISLHETGRYLFPGTGAVNERGQGNGYSYSFNVPLDAFTEDESFLDSYRTVVKE
CCCCEEEEEEECCCCEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHH
VAAYFKPDIILTQNGADAHYYDPLTHLCATMNIYREIPKLAREIANEYCEGRWIAVGGGG
HHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
YDHWRVVPRAWALIWLEMNNIQNISGYLPPEWIDAWKGQAETELPLTWEDPNNMYKPIPR
CCHHEECCCEEEEEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCCEEECCCCCCCCCCCC
KPEIEEKNALTVAKSLEIIRNNMKKSLY
CCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]