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The map label for this gene is mutM

Identifier: 49187476

GI number: 49187476

Start: 4392150

End: 4392980

Strand: Reverse

Name: mutM

Synonym: BAS4481

Alternate gene names: 49187476

Gene position: 4392980-4392150 (Counterclockwise)

Preceding gene: 49187477

Following gene: 49187475

Centisome position: 84.02

GC content: 38.27

Gene sequence:

>831_bases
ATGCCTGAATTACCAGAGGTTGAAAACGTCAGACGGACACTTGAAAATCTTGTAACAGGAAAAACAATTGAAGACGTCAT
TGTTACCTATCCCAAAATAGTAAAACGCCCAGATGATGCAGAAATCTTTAAAGAAATGCTAAAAGGCGAGACGATTGAAA
ATATAAAGCGAAGAGGAAAGTTTTTGCTTTTATATGTAACGAATTATGTTATTGTTTCACATTTGCGTATGGAAGGTAAG
TTTTTACTGCATCAAGAGGATGAACCAATTGATAAGCATACGCACGTCCGTTTCTTGTTTACAGATGGAACTGAATTACA
TTATAAAGATGTGAGAAAGTTCGGTACGATGCATCTCTTTAAAAAAGGTGAGGAAATGAATCAAATGCCTCTAGCTGACT
TAGGTCCAGAGCCATTTGATGCTGAATTGACACCACAGTATTTACATGAGAGATTGCAAAAGACAAATCGGAAAATAAAA
GTTGTATTGTTAGACCAGCGTCTTTTAGTAGGACTTGGAAATATATATGTAGATGAAGTTTTATTCCGTTCTCAAATTCA
CCCAGAACGAGAAGCGTCTTCTTTAACAGCGGAAGAAATTGAGCGGATTTATGAGGCGACTGTTACAACGTTAGGCGAAG
CCGTGAAACGTGGCGGAAGTACGATTCGAACGTATATCAACTCACAAGGGCAAATTGGCTCATTCCAAGAACTTCTAAAT
GTATATGGAAAAAAAGGAGAACCGTGTGTGACTTGCGGTACGATATTAGAAAAAACAGTTGTTGGCGGAAGAGGAACGCA
TTACTGCCCGATTTGTCAGCCTAGAATATAG

Upstream 100 bases:

>100_bases
ACCAGAAGTAATGGAGCATGCAATTGAACTGGCAGTTCCACTGAAAGTTGATTATTCTTACGGTCCAACTTGGTACGACG
CAAAATAAGGAAGTGATGAA

Downstream 100 bases:

>100_bases
AAAAGAGATAACATCGGATAGGCATTTGTCATATACATACAGCAGAGCTATGTATAAGGGAGGAGCTTACCGATGTACCT
TTATTTATCTCTTATTTTAT

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MPELPEVENVRRTLENLVTGKTIEDVIVTYPKIVKRPDDAEIFKEMLKGETIENIKRRGKFLLLYVTNYVIVSHLRMEGK
FLLHQEDEPIDKHTHVRFLFTDGTELHYKDVRKFGTMHLFKKGEEMNQMPLADLGPEPFDAELTPQYLHERLQKTNRKIK
VVLLDQRLLVGLGNIYVDEVLFRSQIHPEREASSLTAEEIERIYEATVTTLGEAVKRGGSTIRTYINSQGQIGSFQELLN
VYGKKGEPCVTCGTILEKTVVGGRGTHYCPICQPRI

Sequences:

>Translated_276_residues
MPELPEVENVRRTLENLVTGKTIEDVIVTYPKIVKRPDDAEIFKEMLKGETIENIKRRGKFLLLYVTNYVIVSHLRMEGK
FLLHQEDEPIDKHTHVRFLFTDGTELHYKDVRKFGTMHLFKKGEEMNQMPLADLGPEPFDAELTPQYLHERLQKTNRKIK
VVLLDQRLLVGLGNIYVDEVLFRSQIHPEREASSLTAEEIERIYEATVTTLGEAVKRGGSTIRTYINSQGQIGSFQELLN
VYGKKGEPCVTCGTILEKTVVGGRGTHYCPICQPRI
>Mature_275_residues
PELPEVENVRRTLENLVTGKTIEDVIVTYPKIVKRPDDAEIFKEMLKGETIENIKRRGKFLLLYVTNYVIVSHLRMEGKF
LLHQEDEPIDKHTHVRFLFTDGTELHYKDVRKFGTMHLFKKGEEMNQMPLADLGPEPFDAELTPQYLHERLQKTNRKIKV
VLLDQRLLVGLGNIYVDEVLFRSQIHPEREASSLTAEEIERIYEATVTTLGEAVKRGGSTIRTYINSQGQIGSFQELLNV
YGKKGEPCVTCGTILEKTVVGGRGTHYCPICQPRI

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=273, Percent_Identity=39.1941391941392, Blast_Score=196, Evalue=1e-51,
Organism=Escherichia coli, GI1786932, Length=282, Percent_Identity=28.0141843971631, Blast_Score=105, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_BACAN (Q81L04)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_847033.1
- RefSeq:   YP_021475.1
- RefSeq:   YP_030728.1
- ProteinModelPortal:   Q81L04
- SMR:   Q81L04
- EnsemblBacteria:   EBBACT00000009645
- EnsemblBacteria:   EBBACT00000016445
- EnsemblBacteria:   EBBACT00000020438
- GeneID:   1083979
- GeneID:   2815023
- GeneID:   2851564
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_4830
- KEGG:   bar:GBAA_4830
- KEGG:   bat:BAS4481
- TIGR:   BA_4830
- TIGR:   GBAA_4830
- GeneTree:   EBGT00050000000934
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- ProtClustDB:   PRK01103
- BioCyc:   BANT260799:BAS4481-MONOMER
- BioCyc:   BANT261594:GBAA4830-MONOMER
- BRENDA:   3.2.2.23
- BRENDA:   4.2.99.18
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 31654; Mature: 31523

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 60-60 ACT_SITE 264-264 BINDING 93-93 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVENVRRTLENLVTGKTIEDVIVTYPKIVKRPDDAEIFKEMLKGETIENIKRRGK
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHCCC
FLLLYVTNYVIVSHLRMEGKFLLHQEDEPIDKHTHVRFLFTDGTELHYKDVRKFGTMHLF
EEEEHHHHHHHHHHHHHCCEEEEECCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHH
KKGEEMNQMPLADLGPEPFDAELTPQYLHERLQKTNRKIKVVLLDQRLLVGLGNIYVDEV
HCCCHHCCCCCHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHH
LFRSQIHPEREASSLTAEEIERIYEATVTTLGEAVKRGGSTIRTYINSQGQIGSFQELLN
HHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHH
VYGKKGEPCVTCGTILEKTVVGGRGTHYCPICQPRI
HHCCCCCCEEHHHHHHHHHHCCCCCCEECCCCCCCC
>Mature Secondary Structure 
PELPEVENVRRTLENLVTGKTIEDVIVTYPKIVKRPDDAEIFKEMLKGETIENIKRRGK
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHCCC
FLLLYVTNYVIVSHLRMEGKFLLHQEDEPIDKHTHVRFLFTDGTELHYKDVRKFGTMHLF
EEEEHHHHHHHHHHHHHCCEEEEECCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHH
KKGEEMNQMPLADLGPEPFDAELTPQYLHERLQKTNRKIKVVLLDQRLLVGLGNIYVDEV
HCCCHHCCCCCHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHH
LFRSQIHPEREASSLTAEEIERIYEATVTTLGEAVKRGGSTIRTYINSQGQIGSFQELLN
HHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHH
VYGKKGEPCVTCGTILEKTVVGGRGTHYCPICQPRI
HHCCCCCCEEHHHHHHHHHHCCCCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629