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The map label for this gene is coaE

Identifier: 49187474

GI number: 49187474

Start: 4390791

End: 4391393

Strand: Reverse

Name: coaE

Synonym: BAS4479

Alternate gene names: 49187474

Gene position: 4391393-4390791 (Counterclockwise)

Preceding gene: 49187475

Following gene: 49187473

Centisome position: 83.99

GC content: 35.49

Gene sequence:

>603_bases
ATGACGGTAGTAATTGGATTAACGGGAGGTATTGCAAGCGGAAAAAGTACAGTATCTCAAATGTTTCGCGAGCTCAGTAT
ACCAGTTATTGATGCAGATATTATTGCAAGAGAAGTTGTAGAAAAAGGAAAACCAGCATATAACAAAATTGTAGAAGTGT
TTGGAACGGAAGTATTACAAGAAGATGGAGAACTGGATCGACCGAAATTAGGAAGTGTCGTTTTCTATAATGAAGAGAAA
CGATTGCAGTTAAACAAAATTGTTCATCCTGCAGTGCGTGAGGAAATGAATAGGCAAAAGGAAATGTACATAAAAGAAGG
TATGCAAGCGGTTGTGTTAGATATTCCTCTCTTATTTGAAAGTAAATTAACAAGTCTCGTTGACCGCGTTTTAGTTGTAG
CAGTTAAGCCACATACGCAATTAGAACGTTTAATGAAGCGAAATAATTTTTCAGAAGAAGAAGCAACAGCTCGTATTCAA
TCTCAAATGCCGTTAGAAGAAAAAGTGAAAAATGCAGATGAAGTGATAAATAATGATGGCACAATTATGGGAACGAAAAC
ACAATTACAGGCGATTTTAAAGAAATGGAACATTATTGACTAA

Upstream 100 bases:

>100_bases
ATTCCTGCCTGGGGTATTACTCATTATTATTGGAATTTGGAAAATGTAAGTACGGGCGTGGAACATTAGTTTCGCGCCTT
TTATTATGAGGAGGGTTATG

Downstream 100 bases:

>100_bases
AAAATTGTGAAATTAATGAAAATGCTTAGTGACATATCCCCTTTTTGTGTTATACTATTATTGGGATTGGAGATAAATAG
TATAACGCATTCAAGGGGGA

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MTVVIGLTGGIASGKSTVSQMFRELSIPVIDADIIAREVVEKGKPAYNKIVEVFGTEVLQEDGELDRPKLGSVVFYNEEK
RLQLNKIVHPAVREEMNRQKEMYIKEGMQAVVLDIPLLFESKLTSLVDRVLVVAVKPHTQLERLMKRNNFSEEEATARIQ
SQMPLEEKVKNADEVINNDGTIMGTKTQLQAILKKWNIID

Sequences:

>Translated_200_residues
MTVVIGLTGGIASGKSTVSQMFRELSIPVIDADIIAREVVEKGKPAYNKIVEVFGTEVLQEDGELDRPKLGSVVFYNEEK
RLQLNKIVHPAVREEMNRQKEMYIKEGMQAVVLDIPLLFESKLTSLVDRVLVVAVKPHTQLERLMKRNNFSEEEATARIQ
SQMPLEEKVKNADEVINNDGTIMGTKTQLQAILKKWNIID
>Mature_199_residues
TVVIGLTGGIASGKSTVSQMFRELSIPVIDADIIAREVVEKGKPAYNKIVEVFGTEVLQEDGELDRPKLGSVVFYNEEKR
LQLNKIVHPAVREEMNRQKEMYIKEGMQAVVLDIPLLFESKLTSLVDRVLVVAVKPHTQLERLMKRNNFSEEEATARIQS
QMPLEEKVKNADEVINNDGTIMGTKTQLQAILKKWNIID

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=187, Percent_Identity=47.5935828877005, Blast_Score=179, Evalue=1e-45,
Organism=Homo sapiens, GI191252795, Length=187, Percent_Identity=47.5935828877005, Blast_Score=179, Evalue=1e-45,
Organism=Homo sapiens, GI110227607, Length=201, Percent_Identity=35.8208955223881, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI110227605, Length=201, Percent_Identity=35.8208955223881, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI110227603, Length=201, Percent_Identity=35.8208955223881, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI110227601, Length=201, Percent_Identity=35.8208955223881, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI205277394, Length=201, Percent_Identity=35.8208955223881, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI1786292, Length=181, Percent_Identity=41.9889502762431, Blast_Score=132, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17554944, Length=182, Percent_Identity=44.5054945054945, Blast_Score=158, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI25143409, Length=171, Percent_Identity=32.7485380116959, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320402, Length=198, Percent_Identity=43.9393939393939, Blast_Score=160, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24644728, Length=180, Percent_Identity=45, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24658602, Length=198, Percent_Identity=32.8282828282828, Blast_Score=109, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_BACAN (Q6HSG2)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_847031.1
- RefSeq:   YP_021473.1
- RefSeq:   YP_030726.1
- ProteinModelPortal:   Q6HSG2
- SMR:   Q6HSG2
- EnsemblBacteria:   EBBACT00000012721
- EnsemblBacteria:   EBBACT00000014911
- EnsemblBacteria:   EBBACT00000023864
- GeneID:   1083978
- GeneID:   2815066
- GeneID:   2851567
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_4828
- KEGG:   bar:GBAA_4828
- KEGG:   bat:BAS4479
- TIGR:   BA_4828
- TIGR:   GBAA_4828
- GeneTree:   EBGT00050000001187
- HOGENOM:   HBG650290
- OMA:   IIAREVV
- ProtClustDB:   PRK00081
- BioCyc:   BANT260799:BAS4479-MONOMER
- BioCyc:   BANT261594:GBAA4828-MONOMER
- BRENDA:   2.7.1.24
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 22577; Mature: 22445

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS51219 DPCK; PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVVIGLTGGIASGKSTVSQMFRELSIPVIDADIIAREVVEKGKPAYNKIVEVFGTEVLQ
CEEEEEECCCCCCCHHHHHHHHHHHCCCEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
EDGELDRPKLGSVVFYNEEKRLQLNKIVHPAVREEMNRQKEMYIKEGMQAVVLDIPLLFE
CCCCCCCCCCCCEEEECCCHHHHHHHHHCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
SKLTSLVDRVLVVAVKPHTQLERLMKRNNFSEEEATARIQSQMPLEEKVKNADEVINNDG
HHHHHHHHHHHHHEECCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHCCHHHHHCCCC
TIMGTKTQLQAILKKWNIID
CEEECHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TVVIGLTGGIASGKSTVSQMFRELSIPVIDADIIAREVVEKGKPAYNKIVEVFGTEVLQ
EEEEEECCCCCCCHHHHHHHHHHHCCCEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
EDGELDRPKLGSVVFYNEEKRLQLNKIVHPAVREEMNRQKEMYIKEGMQAVVLDIPLLFE
CCCCCCCCCCCCEEEECCCHHHHHHHHHCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
SKLTSLVDRVLVVAVKPHTQLERLMKRNNFSEEEATARIQSQMPLEEKVKNADEVINNDG
HHHHHHHHHHHHHEECCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHCCHHHHHCCCC
TIMGTKTQLQAILKKWNIID
CEEECHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629