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The map label for this gene is comEB [H]

Identifier: 49187220

GI number: 49187220

Start: 4141294

End: 4141851

Strand: Reverse

Name: comEB [H]

Synonym: BAS4224

Alternate gene names: 49187220

Gene position: 4141851-4141294 (Counterclockwise)

Preceding gene: 49187222

Following gene: 49187219

Centisome position: 79.21

GC content: 35.48

Gene sequence:

>558_bases
ATGGAACGAATTTCATGGGATCAATATTTTATGACGCAAAGCCATTTGCTATCTTTACGTAGTACATGTACAAGGCTTGC
AGTAGGAGCAACAATCGTTCGTGATAAACGAATTATTGCTGGTGGATATAATGGTTCAATTAAAGGTGGCGTACATTGTA
TAGATGATGGATGCTACGTTATTGATAATCATTGTGTTCGTACAATTCACGCAGAAATGAATGCTTTGTTACAATGTGCA
AAATTTGGCGTGAAAACGGAGGAAGCGGAAATTTATGTTACGCATTTTCCGTGTTTACAATGTTGTAAGGCGATTATACA
AAGTGGTATTACAGCGGTTTATTATGCACAGGATTATAAAAATCATCCGTATGCCGTAGAGTTATTTGAAAAAGCGAATG
TAACGGTAAAACACGTTCCGTTAGAATATGATATTGCAGCATTAGAGGATCAAAAGCGTCATATGGAGTTGAAAGAACTA
TTTGCATCTTTAGAAAAAGAGAACTTATCAATGGAAGAATTACAGCATGTATTCACGAAAGCAAAAATGATGCTATAA

Upstream 100 bases:

>100_bases
CTCTGGAAAAAATAAAAGATCAAATTATTATTCCGTAAAAGATTGACGAAGTTTTTCTTCATTCGCTACACTACAAGTAG
ACAAAAAGTAGGTGAAGAAT

Downstream 100 bases:

>100_bases
GGAGTGAGTATGAGTTGCAAGGACAATGGGGCTACGTTGCAATCTCATTTATAATAGGGATTGCAATCGCCTTCTCCTCT
TCAGTTGTATTGCTGACTTG

Product: ComE operon protein 2

Products: dUMP; NH3

Alternate protein names: NA

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MERISWDQYFMTQSHLLSLRSTCTRLAVGATIVRDKRIIAGGYNGSIKGGVHCIDDGCYVIDNHCVRTIHAEMNALLQCA
KFGVKTEEAEIYVTHFPCLQCCKAIIQSGITAVYYAQDYKNHPYAVELFEKANVTVKHVPLEYDIAALEDQKRHMELKEL
FASLEKENLSMEELQHVFTKAKMML

Sequences:

>Translated_185_residues
MERISWDQYFMTQSHLLSLRSTCTRLAVGATIVRDKRIIAGGYNGSIKGGVHCIDDGCYVIDNHCVRTIHAEMNALLQCA
KFGVKTEEAEIYVTHFPCLQCCKAIIQSGITAVYYAQDYKNHPYAVELFEKANVTVKHVPLEYDIAALEDQKRHMELKEL
FASLEKENLSMEELQHVFTKAKMML
>Mature_185_residues
MERISWDQYFMTQSHLLSLRSTCTRLAVGATIVRDKRIIAGGYNGSIKGGVHCIDDGCYVIDNHCVRTIHAEMNALLQCA
KFGVKTEEAEIYVTHFPCLQCCKAIIQSGITAVYYAQDYKNHPYAVELFEKANVTVKHVPLEYDIAALEDQKRHMELKEL
FASLEKENLSMEELQHVFTKAKMML

Specific function: Dispensable for transformability [H]

COG id: COG2131

COG function: function code F; Deoxycytidylate deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI61742819, Length=150, Percent_Identity=34.6666666666667, Blast_Score=64, Evalue=6e-11,
Organism=Homo sapiens, GI61742821, Length=150, Percent_Identity=34.6666666666667, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321938, Length=142, Percent_Identity=36.6197183098592, Blast_Score=99, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24667298, Length=183, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24667302, Length=183, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR013404
- InterPro:   IPR015517
- InterPro:   IPR016193
- InterPro:   IPR016473 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.12

Molecular weight: Translated: 21081; Mature: 21081

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
8.1 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
8.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERISWDQYFMTQSHLLSLRSTCTRLAVGATIVRDKRIIAGGYNGSIKGGVHCIDDGCYV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEECCCCCCCCCCEEEECCCCEE
IDNHCVRTIHAEMNALLQCAKFGVKTEEAEIYVTHFPCLQCCKAIIQSGITAVYYAQDYK
ECCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHCCCEEEEEECCCC
NHPYAVELFEKANVTVKHVPLEYDIAALEDQKRHMELKELFASLEKENLSMEELQHVFTK
CCCEEEEEECCCCCEEEECCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
AKMML
HHHCC
>Mature Secondary Structure
MERISWDQYFMTQSHLLSLRSTCTRLAVGATIVRDKRIIAGGYNGSIKGGVHCIDDGCYV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEECCCCCCCCCCEEEECCCCEE
IDNHCVRTIHAEMNALLQCAKFGVKTEEAEIYVTHFPCLQCCKAIIQSGITAVYYAQDYK
ECCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHCCCEEEEEECCCC
NHPYAVELFEKANVTVKHVPLEYDIAALEDQKRHMELKELFASLEKENLSMEELQHVFTK
CCCEEEEEECCCCCEEEECCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
AKMML
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dCMP; H2O

Specific reaction: dCMP + H2O = dUMP + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]