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The map label for this gene is era [H]

Identifier: 49187195

GI number: 49187195

Start: 4115232

End: 4116137

Strand: Reverse

Name: era [H]

Synonym: BAS4199

Alternate gene names: 49187195

Gene position: 4116137-4115232 (Counterclockwise)

Preceding gene: 49187196

Following gene: 49187194

Centisome position: 78.72

GC content: 35.76

Gene sequence:

>906_bases
ATGAATAGAAAAGGTTATAAATCAGGTTTTGTCTCTATTATTGGCAGACCGAATGTTGGGAAATCTACATTTTTAAATCG
TATTATTGGTCAAAAAATTGCTATTATGAGTGACAAGCCACAAACAACTCGTAATAAAATTCAAGGCGTATATACAGAAA
ATGATTCACAAGTAATTTTCATTGATACACCAGGAATACATAAACCTAAACATAAACTAGGCGACTTCATGGTGAAGATG
GCGCAAACGACATTAAAAGAAGTTGATATCGTTCTGTTTATGGTTAATGCTGTCGAAGGCTTTGGTCGTGGTGAAGAATT
CATCATTGAGAAGTTAAAAGAAACGAAACAACCAGTATTTCTAGTTATTAATAAAATTGACCAAGTTCACCCAGAACAAT
TATTAGAGTTAATTGATCAATATCGCAAATTACATGACTTTGCAGAAATCGTACCAATTTCTGCATTAGACGGTAATAAT
GCGGAAGCTCTAATTGGAACAATTAAAAAGTATTTACCGGAAGGACCACAATACTACCCAGATAATCAAGTAACGGATCA
TCCGGAGAGATTTATTATTGCAGAGCTTATTCGTGAGAAAGTACTACATTTAACACGTGAAGAAGTGCCGCATTCTGTAG
CTGTTGTTATCGATGCAATTCAAAAACGCGAGGGCGGAGCGGTTTATATCAATGCAACGATTGTTGTTGAACGTCCGTCG
CAAAAAGGGATTATTATCGGAAAACAAGGGAAGATGTTAAAAGAAGTCGGTAAGCGAGCTCGTTTTGATATTGAAGCATT
ACTTGGTTCTAAAGTATTTTTAGAAGTATGGGTAAAAGTGCAAAAAGATTGGCGTAATAAAATGTCTCAGCTTCGTGACC
TTGGTTTCCGCGAAGACGAGTATTAA

Upstream 100 bases:

>100_bases
AAACAGGATACGAAAGTATACCTATCAAATTTACATGGTGACGTTCAAGAGACAACAGTCGGAGAATTGTTACCAGGAGC
ATTTTTAGCGGAGGATTTAC

Downstream 100 bases:

>100_bases
AATAGAGTAAAGCTGTAATCAGCGGATGTTTTGTTCATCCGCTGATTATTGGTTTTTATGAGTTTTGATAAATTAGGAAA
AATTTTTCTCACATGAAAAT

Product: GTP-binding protein Era

Products: NA

Alternate protein names: Bex protein [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MNRKGYKSGFVSIIGRPNVGKSTFLNRIIGQKIAIMSDKPQTTRNKIQGVYTENDSQVIFIDTPGIHKPKHKLGDFMVKM
AQTTLKEVDIVLFMVNAVEGFGRGEEFIIEKLKETKQPVFLVINKIDQVHPEQLLELIDQYRKLHDFAEIVPISALDGNN
AEALIGTIKKYLPEGPQYYPDNQVTDHPERFIIAELIREKVLHLTREEVPHSVAVVIDAIQKREGGAVYINATIVVERPS
QKGIIIGKQGKMLKEVGKRARFDIEALLGSKVFLEVWVKVQKDWRNKMSQLRDLGFREDEY

Sequences:

>Translated_301_residues
MNRKGYKSGFVSIIGRPNVGKSTFLNRIIGQKIAIMSDKPQTTRNKIQGVYTENDSQVIFIDTPGIHKPKHKLGDFMVKM
AQTTLKEVDIVLFMVNAVEGFGRGEEFIIEKLKETKQPVFLVINKIDQVHPEQLLELIDQYRKLHDFAEIVPISALDGNN
AEALIGTIKKYLPEGPQYYPDNQVTDHPERFIIAELIREKVLHLTREEVPHSVAVVIDAIQKREGGAVYINATIVVERPS
QKGIIIGKQGKMLKEVGKRARFDIEALLGSKVFLEVWVKVQKDWRNKMSQLRDLGFREDEY
>Mature_301_residues
MNRKGYKSGFVSIIGRPNVGKSTFLNRIIGQKIAIMSDKPQTTRNKIQGVYTENDSQVIFIDTPGIHKPKHKLGDFMVKM
AQTTLKEVDIVLFMVNAVEGFGRGEEFIIEKLKETKQPVFLVINKIDQVHPEQLLELIDQYRKLHDFAEIVPISALDGNN
AEALIGTIKKYLPEGPQYYPDNQVTDHPERFIIAELIREKVLHLTREEVPHSVAVVIDAIQKREGGAVYINATIVVERPS
QKGIIIGKQGKMLKEVGKRARFDIEALLGSKVFLEVWVKVQKDWRNKMSQLRDLGFREDEY

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. Binds both GDP and GTP. Complements

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=326, Percent_Identity=26.3803680981595, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1788919, Length=294, Percent_Identity=40.1360544217687, Blast_Score=234, Evalue=4e-63,
Organism=Escherichia coli, GI87082120, Length=179, Percent_Identity=33.5195530726257, Blast_Score=95, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6323665, Length=196, Percent_Identity=26.530612244898, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646434, Length=312, Percent_Identity=25.3205128205128, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 34334; Mature: 34334

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRKGYKSGFVSIIGRPNVGKSTFLNRIIGQKIAIMSDKPQTTRNKIQGVYTENDSQVIF
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHCEEEECCCCEEEE
IDTPGIHKPKHKLGDFMVKMAQTTLKEVDIVLFMVNAVEGFGRGEEFIIEKLKETKQPVF
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEE
LVINKIDQVHPEQLLELIDQYRKLHDFAEIVPISALDGNNAEALIGTIKKYLPEGPQYYP
EEEHHHHCCCHHHHHHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHCCCCCCCCC
DNQVTDHPERFIIAELIREKVLHLTREEVPHSVAVVIDAIQKREGGAVYINATIVVERPS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEEEEEECCC
QKGIIIGKQGKMLKEVGKRARFDIEALLGSKVFLEVWVKVQKDWRNKMSQLRDLGFREDE
CCCEEECCCCHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
Y
C
>Mature Secondary Structure
MNRKGYKSGFVSIIGRPNVGKSTFLNRIIGQKIAIMSDKPQTTRNKIQGVYTENDSQVIF
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHCEEEECCCCEEEE
IDTPGIHKPKHKLGDFMVKMAQTTLKEVDIVLFMVNAVEGFGRGEEFIIEKLKETKQPVF
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEE
LVINKIDQVHPEQLLELIDQYRKLHDFAEIVPISALDGNNAEALIGTIKKYLPEGPQYYP
EEEHHHHCCCHHHHHHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHCCCCCCCCC
DNQVTDHPERFIIAELIREKVLHLTREEVPHSVAVVIDAIQKREGGAVYINATIVVERPS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEEEEEECCC
QKGIIIGKQGKMLKEVGKRARFDIEALLGSKVFLEVWVKVQKDWRNKMSQLRDLGFREDE
CCCEEECCCCHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
Y
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 2526291 [H]