BacMap

Definition	Bacillus anthracis str. Sterne chromosome, complete genome.
Accession	NC_005945
Length	5,228,663

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The map label for this gene is ppiB [H]

Identifier: 49186970

GI number: 49186970

Start: 3915705

End: 3916142

Strand: Reverse

Name: ppiB [H]

Synonym: BAS3972

Alternate gene names: 49186970

Gene position: 3916142-3915705 (Counterclockwise)

Preceding gene: 49186972

Following gene: 49186969

Centisome position: 74.9

GC content: 40.87

Gene sequence:

>438_bases
ATGAAAACTTTAGGATACATATTAATGGAAAATGGTGAAAAAATCGATTTAGAATTTTTCCCAGAAGAGGCACCAAAAAC
TGTAGAAAACTTTAAAAAACTAGCAGAGCAAGGATTTTATGATGGTGTGACATTCCACCGCGTTATTCCTGGCTTCGTAA
GCCAAGGTGGAGATCCAACAGGAACAGGTGCAGGTGGCCCAGGTTACTCTATCCCATGTGAAACTGATGGAAATCCTCAT
AGACACCTTGTAGGATCACTTTCTATGGCTCATGCTGGCCGTAACACAGGCGGTAGCCAATTCTTTATCGTTCATGAGCC
GCAGCCACACTTAGATGGTGTACATACTGTATTTGGTAAAGCAACAAGCGGTATTGAAACGGTATTAAACATGCGTCAAG
GTGATGTAATGAAAGAAGTTAAAGTTTGGGAAGAATAA

Upstream 100 bases:

>100_bases
ACATTTCAAAAAAGAAGTATGTAGATTGTCGGATTCTTTTTGTTTCTAGTCATGAATGTGGTAATATAGTGCTGAGATAG
TTGAAAGGAGACATATACGT

Downstream 100 bases:

>100_bases
TTTAATGAGAAAAGAGAGCTATTGCTCTCTTTTTTATTTTTAATAGGAATGGGTATTGCGTTTACGGTACATGATACAAG
TAGTAATGTGATTGTAGTGA

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin-type

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 145; Mature: 145

Protein sequence:

>145_residues
MKTLGYILMENGEKIDLEFFPEEAPKTVENFKKLAEQGFYDGVTFHRVIPGFVSQGGDPTGTGAGGPGYSIPCETDGNPH
RHLVGSLSMAHAGRNTGGSQFFIVHEPQPHLDGVHTVFGKATSGIETVLNMRQGDVMKEVKVWEE

Sequences:

>Translated_145_residues
MKTLGYILMENGEKIDLEFFPEEAPKTVENFKKLAEQGFYDGVTFHRVIPGFVSQGGDPTGTGAGGPGYSIPCETDGNPH
RHLVGSLSMAHAGRNTGGSQFFIVHEPQPHLDGVHTVFGKATSGIETVLNMRQGDVMKEVKVWEE
>Mature_145_residues
MKTLGYILMENGEKIDLEFFPEEAPKTVENFKKLAEQGFYDGVTFHRVIPGFVSQGGDPTGTGAGGPGYSIPCETDGNPH
RHLVGSLSMAHAGRNTGGSQFFIVHEPQPHLDGVHTVFGKATSGIETVLNMRQGDVMKEVKVWEE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=117, Percent_Identity=51.2820512820513, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI19557636, Length=117, Percent_Identity=48.7179487179487, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI7706339, Length=117, Percent_Identity=47.8632478632479, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI64276486, Length=128, Percent_Identity=42.1875, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI10863927, Length=140, Percent_Identity=43.5714285714286, Blast_Score=93, Evalue=7e-20,
Organism=Homo sapiens, GI4826932, Length=126, Percent_Identity=45.2380952380952, Blast_Score=90, Evalue=8e-19,
Organism=Homo sapiens, GI256017253, Length=125, Percent_Identity=47.2, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI221139811, Length=125, Percent_Identity=47.2, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI256017251, Length=125, Percent_Identity=47.2, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI178057341, Length=128, Percent_Identity=46.875, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI310127646, Length=140, Percent_Identity=41.4285714285714, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI310114371, Length=140, Percent_Identity=41.4285714285714, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI310119221, Length=140, Percent_Identity=41.4285714285714, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI209417936, Length=124, Percent_Identity=44.3548387096774, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI30102944, Length=124, Percent_Identity=44.3548387096774, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI219842199, Length=124, Percent_Identity=44.3548387096774, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI310129267, Length=138, Percent_Identity=42.0289855072464, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI310120620, Length=138, Percent_Identity=42.0289855072464, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI4505991, Length=122, Percent_Identity=47.5409836065574, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI310110104, Length=121, Percent_Identity=45.4545454545455, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI6631100, Length=130, Percent_Identity=42.3076923076923, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI5031987, Length=122, Percent_Identity=46.7213114754098, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI150418007, Length=143, Percent_Identity=39.8601398601399, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI4758950, Length=117, Percent_Identity=47.8632478632479, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI42560244, Length=129, Percent_Identity=41.8604651162791, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI169164185, Length=139, Percent_Identity=40.2877697841727, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI169163623, Length=139, Percent_Identity=40.2877697841727, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI303305009, Length=135, Percent_Identity=39.2592592592593, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI169163387, Length=139, Percent_Identity=40.2877697841727, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI45439316, Length=138, Percent_Identity=38.4057971014493, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI310127745, Length=127, Percent_Identity=44.8818897637795, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI310119290, Length=127, Percent_Identity=44.8818897637795, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI310114540, Length=127, Percent_Identity=44.8818897637795, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI5174637, Length=124, Percent_Identity=39.5161290322581, Blast_Score=77, Evalue=4e-15,
Organism=Homo sapiens, GI5454154, Length=131, Percent_Identity=40.4580152671756, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI239751853, Length=142, Percent_Identity=38.7323943661972, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI113428306, Length=142, Percent_Identity=38.7323943661972, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI169214050, Length=142, Percent_Identity=38.7323943661972, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI310132444, Length=142, Percent_Identity=37.3239436619718, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI310113152, Length=142, Percent_Identity=37.3239436619718, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI22547212, Length=135, Percent_Identity=42.2222222222222, Blast_Score=73, Evalue=7e-14,
Organism=Homo sapiens, GI7657473, Length=135, Percent_Identity=42.2222222222222, Blast_Score=73, Evalue=7e-14,
Organism=Homo sapiens, GI22547215, Length=135, Percent_Identity=42.2222222222222, Blast_Score=73, Evalue=9e-14,
Organism=Homo sapiens, GI20911035, Length=143, Percent_Identity=33.5664335664336, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1789763, Length=134, Percent_Identity=35.8208955223881, Blast_Score=69, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=135, Percent_Identity=45.1851851851852, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17532641, Length=130, Percent_Identity=41.5384615384615, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17506311, Length=123, Percent_Identity=45.5284552845528, Blast_Score=94, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17539498, Length=126, Percent_Identity=44.4444444444444, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71997782, Length=137, Percent_Identity=40.1459854014599, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71980590, Length=117, Percent_Identity=39.3162393162393, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71980594, Length=117, Percent_Identity=39.3162393162393, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17551282, Length=135, Percent_Identity=42.962962962963, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17565860, Length=133, Percent_Identity=41.3533834586466, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17551284, Length=135, Percent_Identity=42.962962962963, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17506307, Length=139, Percent_Identity=43.1654676258993, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17552780, Length=121, Percent_Identity=46.2809917355372, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17566266, Length=129, Percent_Identity=41.8604651162791, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17559074, Length=129, Percent_Identity=41.0852713178295, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17552782, Length=132, Percent_Identity=39.3939393939394, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI32563659, Length=135, Percent_Identity=35.5555555555556, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17552784, Length=130, Percent_Identity=38.4615384615385, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17532643, Length=125, Percent_Identity=37.6, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323562, Length=121, Percent_Identity=47.1074380165289, Blast_Score=91, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6320359, Length=122, Percent_Identity=47.5409836065574, Blast_Score=87, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6321848, Length=134, Percent_Identity=44.0298507462687, Blast_Score=82, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320510, Length=114, Percent_Identity=44.7368421052632, Blast_Score=77, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6323246, Length=130, Percent_Identity=41.5384615384615, Blast_Score=76, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19922376, Length=140, Percent_Identity=42.8571428571429, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17986117, Length=118, Percent_Identity=45.7627118644068, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24650807, Length=129, Percent_Identity=44.9612403100775, Blast_Score=93, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21357249, Length=123, Percent_Identity=40.650406504065, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19922912, Length=125, Percent_Identity=46.4, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI20130249, Length=124, Percent_Identity=46.7741935483871, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17647301, Length=116, Percent_Identity=46.551724137931, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI45549139, Length=122, Percent_Identity=45.9016393442623, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24664125, Length=122, Percent_Identity=45.9016393442623, Blast_Score=83, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21357783, Length=122, Percent_Identity=45.9016393442623, Blast_Score=83, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24652460, Length=117, Percent_Identity=37.6068376068376, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24586038, Length=132, Percent_Identity=37.1212121212121, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17136360, Length=124, Percent_Identity=38.7096774193548, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355677, Length=144, Percent_Identity=31.9444444444444, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 15774; Mature: 15774

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLGYILMENGEKIDLEFFPEEAPKTVENFKKLAEQGFYDGVTFHRVIPGFVSQGGDPT
CCCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCC
GTGAGGPGYSIPCETDGNPHRHLVGSLSMAHAGRNTGGSQFFIVHEPQPHLDGVHTVFGK
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHC
ATSGIETVLNMRQGDVMKEVKVWEE
CCHHHHHHHHHHCCHHHHHHHHCCC
>Mature Secondary Structure
MKTLGYILMENGEKIDLEFFPEEAPKTVENFKKLAEQGFYDGVTFHRVIPGFVSQGGDPT
CCCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCC
GTGAGGPGYSIPCETDGNPHRHLVGSLSMAHAGRNTGGSQFFIVHEPQPHLDGVHTVFGK
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHC
ATSGIETVLNMRQGDVMKEVKVWEE
CCHHHHHHHHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7934829; 8022278; 9384377; 8755892 [H]