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The map label for this gene is thlA [H]

Identifier: 49186930

GI number: 49186930

Start: 3881767

End: 3882942

Strand: Reverse

Name: thlA [H]

Synonym: BAS3932

Alternate gene names: 49186930

Gene position: 3882942-3881767 (Counterclockwise)

Preceding gene: 49186931

Following gene: 49186928

Centisome position: 74.26

GC content: 41.16

Gene sequence:

>1176_bases
ATGCATAATGTTGTTATTACAGCTGCAGTTCGTTCGCCAATTGGAACTTTTGGGGGAGCGCTAAAAAATGTAACGCCAGT
AGAATTAGCTGTTCCTGTACTTCAGGAAGCTGTAAAACGAGGCGGGGTAGAACCACACGAAGTGGATGAAGTGATTTTAG
GTCATTGTATTCAAAGAACTGATGAAGCAAATACGGCGAGAACGGCTGCATTAGCGGCAGGATTTCCTGACACAGTTACG
GGCTATACAATCCAACGCCAATGTTCTTCAGGTATGCAAGCAATTATGTCGGCTGCAATGCAAATTCAATTAGGTGTAAG
TGAAGTTGTTGTTGCAGGTGGAGTAGAAGCAATGAGTTCAAGCCCCTATGCATTGAAACAACACCGCTGGGGACAACGCC
TACAACACGGAGAAATTCGTGATACGGTGTGGGAAGTGTTAGAAGATCCGATTCATCATATTATGATGGGGGAAACAGCG
GAAAATTTAGTTGAACAATATGAAATTACAAGAGAGGAACAAGATGAAGTTGCGCTTCGCAGTCATACATTGGCACTGAA
GGCAATCGAGTCTGGATACTTTGACGATCAAATTGTTCCTATTACAATAAAAGAACGTAGAAAAGAAGTAGTATTTTCGA
AGGATGAACATCCACGTGCTGATATTACAGCAGAAAAATTAGCTGGGTTAAAACCAGCTTTCCGTAAAGATGGATCTGTA
ACGGCAGGGAATGCATCTGGCCTGAATGACGGAAGCGCGGTTCTAGTATTAATGAGCGAAGAAAAAGCGAAAGAAAAAGG
CTTACAACCGTTAGCTAGAATTGTTGGATATTCAGTAGCTGGAGTAGATCCAAAAATTATGGGGATTGGACCAGCACCAG
CAATTCGTAAAGGATTAGAAAAAGTAGATTGGTCATTAGAAGATGCAGATTTACTGGAAATTAATGAAGCTTTCGCTGCA
CAATACTTAGCTGTAGAGAAAGAATTAGGTTTAGATCGTGAAAAAGTGAATGTAAATGGTAGTGGTGTAGGACTTGGACA
TCCAATTGGTTGTACAGGAGCTCGTATTACTGTAAGTTTAATTCATGAATTAAAAAGACGCGGGTTAGAAAAAGGAATTG
CCTCTCTATGCGTCGGCGGCGGTATTGGAGTAGCATTATTTATAGAAGCACTATAA

Upstream 100 bases:

>100_bases
GATTTTTTAGTATGTTTATAGTATGATAGGTGTAGACATACATCTTATGGAATTTCACCTAAAAACTGACTAGGGTACAT
AAGAGAGGGGCAAGTGCAAA

Downstream 100 bases:

>100_bases
AAAAGAAGCAGCAATCGCTGCTTCTTTTTTTTAAGAATCAAATAAATGATGAAATAATCGATCGCGATTTTCAAAGAAAA
GTTTCGTTGTTTGATAATGC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MHNVVITAAVRSPIGTFGGALKNVTPVELAVPVLQEAVKRGGVEPHEVDEVILGHCIQRTDEANTARTAALAAGFPDTVT
GYTIQRQCSSGMQAIMSAAMQIQLGVSEVVVAGGVEAMSSSPYALKQHRWGQRLQHGEIRDTVWEVLEDPIHHIMMGETA
ENLVEQYEITREEQDEVALRSHTLALKAIESGYFDDQIVPITIKERRKEVVFSKDEHPRADITAEKLAGLKPAFRKDGSV
TAGNASGLNDGSAVLVLMSEEKAKEKGLQPLARIVGYSVAGVDPKIMGIGPAPAIRKGLEKVDWSLEDADLLEINEAFAA
QYLAVEKELGLDREKVNVNGSGVGLGHPIGCTGARITVSLIHELKRRGLEKGIASLCVGGGIGVALFIEAL

Sequences:

>Translated_391_residues
MHNVVITAAVRSPIGTFGGALKNVTPVELAVPVLQEAVKRGGVEPHEVDEVILGHCIQRTDEANTARTAALAAGFPDTVT
GYTIQRQCSSGMQAIMSAAMQIQLGVSEVVVAGGVEAMSSSPYALKQHRWGQRLQHGEIRDTVWEVLEDPIHHIMMGETA
ENLVEQYEITREEQDEVALRSHTLALKAIESGYFDDQIVPITIKERRKEVVFSKDEHPRADITAEKLAGLKPAFRKDGSV
TAGNASGLNDGSAVLVLMSEEKAKEKGLQPLARIVGYSVAGVDPKIMGIGPAPAIRKGLEKVDWSLEDADLLEINEAFAA
QYLAVEKELGLDREKVNVNGSGVGLGHPIGCTGARITVSLIHELKRRGLEKGIASLCVGGGIGVALFIEAL
>Mature_391_residues
MHNVVITAAVRSPIGTFGGALKNVTPVELAVPVLQEAVKRGGVEPHEVDEVILGHCIQRTDEANTARTAALAAGFPDTVT
GYTIQRQCSSGMQAIMSAAMQIQLGVSEVVVAGGVEAMSSSPYALKQHRWGQRLQHGEIRDTVWEVLEDPIHHIMMGETA
ENLVEQYEITREEQDEVALRSHTLALKAIESGYFDDQIVPITIKERRKEVVFSKDEHPRADITAEKLAGLKPAFRKDGSV
TAGNASGLNDGSAVLVLMSEEKAKEKGLQPLARIVGYSVAGVDPKIMGIGPAPAIRKGLEKVDWSLEDADLLEINEAFAA
QYLAVEKELGLDREKVNVNGSGVGLGHPIGCTGARITVSLIHELKRRGLEKGIASLCVGGGIGVALFIEAL

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=44.3877551020408, Blast_Score=347, Evalue=8e-96,
Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=44.4730077120823, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI4501853, Length=394, Percent_Identity=40.6091370558376, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI4557237, Length=397, Percent_Identity=39.7984886649874, Blast_Score=260, Evalue=1e-69,
Organism=Homo sapiens, GI4504327, Length=428, Percent_Identity=34.8130841121495, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=29.0488431876607, Blast_Score=145, Evalue=9e-35,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=49.1094147582697, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI87082165, Length=394, Percent_Identity=46.7005076142132, Blast_Score=345, Evalue=2e-96,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=42.643391521197, Blast_Score=305, Evalue=5e-84,
Organism=Escherichia coli, GI48994986, Length=398, Percent_Identity=39.6984924623116, Blast_Score=257, Evalue=7e-70,
Organism=Escherichia coli, GI1788683, Length=401, Percent_Identity=30.4239401496259, Blast_Score=185, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI133906874, Length=388, Percent_Identity=49.4845360824742, Blast_Score=371, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI25147385, Length=389, Percent_Identity=37.0179948586118, Blast_Score=251, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=36.9620253164557, Blast_Score=234, Evalue=7e-62,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=32.1596244131455, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=29.5918367346939, Blast_Score=158, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6325229, Length=402, Percent_Identity=38.5572139303483, Blast_Score=251, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6322031, Length=401, Percent_Identity=38.4039900249377, Blast_Score=239, Evalue=6e-64,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=46.9387755102041, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=44.5012787723785, Blast_Score=317, Evalue=8e-87,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=41.4758269720102, Blast_Score=281, Evalue=7e-76,
Organism=Drosophila melanogaster, GI17137578, Length=424, Percent_Identity=35.1415094339623, Blast_Score=210, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41884; Mature: 41884

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNVVITAAVRSPIGTFGGALKNVTPVELAVPVLQEAVKRGGVEPHEVDEVILGHCIQRT
CCCEEEEHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
DEANTARTAALAAGFPDTVTGYTIQRQCSSGMQAIMSAAMQIQLGVSEVVVAGGVEAMSS
CCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHCC
SPYALKQHRWGQRLQHGEIRDTVWEVLEDPIHHIMMGETAENLVEQYEITREEQDEVALR
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
SHTLALKAIESGYFDDQIVPITIKERRKEVVFSKDEHPRADITAEKLAGLKPAFRKDGSV
HHHHHHHHHHCCCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHCCCCE
TAGNASGLNDGSAVLVLMSEEKAKEKGLQPLARIVGYSVAGVDPKIMGIGPAPAIRKGLE
ECCCCCCCCCCCEEEEEECCHHHHHHCHHHHHHHHCCHHCCCCCEEEECCCCHHHHHHHH
KVDWSLEDADLLEINEAFAAQYLAVEKELGLDREKVNVNGSGVGLGHPIGCTGARITVSL
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCCCCCCCHHHHHHH
IHELKRRGLEKGIASLCVGGGIGVALFIEAL
HHHHHHHHHHHHHHHHHHCCCCEEHHHEECC
>Mature Secondary Structure
MHNVVITAAVRSPIGTFGGALKNVTPVELAVPVLQEAVKRGGVEPHEVDEVILGHCIQRT
CCCEEEEHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
DEANTARTAALAAGFPDTVTGYTIQRQCSSGMQAIMSAAMQIQLGVSEVVVAGGVEAMSS
CCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHCC
SPYALKQHRWGQRLQHGEIRDTVWEVLEDPIHHIMMGETAENLVEQYEITREEQDEVALR
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
SHTLALKAIESGYFDDQIVPITIKERRKEVVFSKDEHPRADITAEKLAGLKPAFRKDGSV
HHHHHHHHHHCCCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHCCCCE
TAGNASGLNDGSAVLVLMSEEKAKEKGLQPLARIVGYSVAGVDPKIMGIGPAPAIRKGLE
ECCCCCCCCCCCEEEEEECCHHHHHHCHHHHHHHHCCHHCCCCCEEEECCCCHHHHHHHH
KVDWSLEDADLLEINEAFAAQYLAVEKELGLDREKVNVNGSGVGLGHPIGCTGARITVSL
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCCCCCCCHHHHHHH
IHELKRRGLEKGIASLCVGGGIGVALFIEAL
HHHHHHHHHHHHHHHHHHCCCCEEHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]