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The map label for this gene is fosB2

Identifier: 49186816

GI number: 49186816

Start: 3778899

End: 3779318

Strand: Direct

Name: fosB2

Synonym: BAS3818

Alternate gene names: 49186816

Gene position: 3778899-3779318 (Clockwise)

Preceding gene: 49186782

Following gene: 49186829

Centisome position: 72.27

GC content: 29.52

Gene sequence:

>420_bases
ATGCTACAGGGCATTAACCATATTTGTTTTTCTGTATCAAACTTGGAAAAATCTATTGAATTCTATCAAAAAATACTTCA
AGCAAAATTATTAGTAAAAGGTAGAAAATTAGCGTATTTTGATTTAAATGGATTATGGATTGCTTTAAATGTTGAAGAAG
ATATACCAAGAAATGAAATTAAGCAATCTTATACACATATGGCTTTCACTGTAACTAATGAAGCATTAGACCATTTAAAA
GAAGTATTAATTCAAAATGATGTTAATATTTTACCTGGCCGAGAAAGAGATGAGAGAGACCAAAGATCTCTTTACTTTAC
AGATCCAGATGGCCATAAGTTTGAGTTCCACACTGGCACTTTGCAAAACCGGTTAGAGTACTATAAAGAAGATAAAAAAC
ATATGACTTTTTACATATAA

Upstream 100 bases:

>100_bases
AAATAACTATTTTGTAGTAATCCTTTATAAATCGCGCATAAACTTTTATAATCTTTATATAAAAATATTGAAAATCATTT
AATTATAGGGGGCGTTTTTT

Downstream 100 bases:

>100_bases
TAAGAAAGCTAGGGCTTTCTTATTTTTTATCAAATAACGCTTTTGTTTAGTTTTCTTTATATTCAATTTTGCTAGCATCT
ATCGTTTCAATATTTTCAAT

Product: fosfomycin resistance protein FosB

Products: NA

Alternate protein names: Fosfomycin resistance protein 2

Number of amino acids: Translated: 139; Mature: 139

Protein sequence:

>139_residues
MLQGINHICFSVSNLEKSIEFYQKILQAKLLVKGRKLAYFDLNGLWIALNVEEDIPRNEIKQSYTHMAFTVTNEALDHLK
EVLIQNDVNILPGRERDERDQRSLYFTDPDGHKFEFHTGTLQNRLEYYKEDKKHMTFYI

Sequences:

>Translated_139_residues
MLQGINHICFSVSNLEKSIEFYQKILQAKLLVKGRKLAYFDLNGLWIALNVEEDIPRNEIKQSYTHMAFTVTNEALDHLK
EVLIQNDVNILPGRERDERDQRSLYFTDPDGHKFEFHTGTLQNRLEYYKEDKKHMTFYI
>Mature_139_residues
MLQGINHICFSVSNLEKSIEFYQKILQAKLLVKGRKLAYFDLNGLWIALNVEEDIPRNEIKQSYTHMAFTVTNEALDHLK
EVLIQNDVNILPGRERDERDQRSLYFTDPDGHKFEFHTGTLQNRLEYYKEDKKHMTFYI

Specific function: Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fosfomycin resistance protein family. FosB subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOSB2_BACAA (C3P6D6)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002868202.1
- ProteinModelPortal:   C3P6D6
- SMR:   C3P6D6
- EnsemblBacteria:   EBBACT00000126297
- GeneID:   7853016
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_4133
- GeneTree:   EBGT00050000001020
- ProtClustDB:   PRK04101
- GO:   GO:0005737
- HAMAP:   MF_01512
- InterPro:   IPR004360
- InterPro:   IPR022858

Pfam domain/function: PF00903 Glyoxalase

EC number: NA

Molecular weight: Translated: 16525; Mature: 16525

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQGINHICFSVSNLEKSIEFYQKILQAKLLVKGRKLAYFDLNGLWIALNVEEDIPRNEI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCHHHH
KQSYTHMAFTVTNEALDHLKEVLIQNDVNILPGRERDERDQRSLYFTDPDGHKFEFHTGT
HHHHHHHEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEECCH
LQNRLEYYKEDKKHMTFYI
HHHHHHHHHCCCCEEEEEC
>Mature Secondary Structure
MLQGINHICFSVSNLEKSIEFYQKILQAKLLVKGRKLAYFDLNGLWIALNVEEDIPRNEI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCHHHH
KQSYTHMAFTVTNEALDHLKEVLIQNDVNILPGRERDERDQRSLYFTDPDGHKFEFHTGT
HHHHHHHEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEECCH
LQNRLEYYKEDKKHMTFYI
HHHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA