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The map label for this gene is hemY [H]

Identifier: 49185262

GI number: 49185262

Start: 2253919

End: 2255319

Strand: Direct

Name: hemY [H]

Synonym: BAS2253

Alternate gene names: 49185262

Gene position: 2253919-2255319 (Clockwise)

Preceding gene: 49185261

Following gene: 49185264

Centisome position: 43.11

GC content: 32.98

Gene sequence:

>1401_bases
ATGAAAACGGTTGTTGTTATCGGTGGAGGTATAACGGGACTTTCTACTATGTTTTATTTAGAAAAATTCAAAAAGGATAA
TAATATCGATTTAAATTTAATCCTTGTAGAAAAAGAAGAGTACTTAGGTGGTAAAATCCATAGTGTAGAAGAAAAGGATT
TTATTATGGAATCAGGAGCGGATTCTATTGTTGCACGTAATGAACATGTTATGCCACTTGTAAAAGATTTAAATTTAGAA
GGAGAAATGGTATATAACGAGACGGGTATTTCTTACATATATTCTGATAATACTTTACATCCAATTCCGTCTGACACTAT
ATTTGGGATACCGATGAGTGTCGAGTCGTTGTTTAGCAGTACGCTAGTATCAACGAAGGGGAAAATTGTTGCTTTAAAAG
ATTTTATAACGAAAAATAAAGAGTTTACAAAAGATACATCCCTTTCCCTATTTTTAGAAAGCTTTTTAGGGAAAGAATTA
GTAGAAAGACAAATTGCGCCAGTGCTTTCAGGTGTATATTCTGGTAAATTGAACGAGCTTACAATGGCATCTACATTACC
ATATTTACTGGACTATAAAAATAAATATGGAAGTATTATTAAAGGTTTTGAAGAGAATAAAAAACAGTTTCAATCAGCAG
GAAACAAAAAGTTCGTATCATTTAAAGGTGGATTATCTACGATTATTGATCGTTTAGAAGAAATGCTGACTGAGACGGTT
GTTAAGAAAGGTGCTGTAACGACAGCTGTAAGCAAACAAGGTGATCGCTATGAAATCTCTTTTGCAAATCACGATTCAAT
CCACGCTGATTATGTTGTTTTAGCAGCTCCGCATGATATCGCAGAAACTTTATTACAGTCTAATGAGTTAAACGAACAGT
TTCATACATTTAAAAACTCATCTCTTGTAAGTATTTACTTAGGATTTGACATACTAGATGAACAATTACCGGCGGACGGT
ACAGGATTTATCGTAACGGAAAACAGTGATTTACATTGTGATGCTTGTACATGGACAAGCCGGAAGTGGAAACATACATC
TGGAAAACAAAAACTATTAGTGAGAATGTTTTATAAGAGTACTAATCCAGTATATGAAACGATTAAAAATTATAGTGAAG
AAGAATTAGTACGGGTTGCTTTATATGATATTGAAAAGAGTCTCGGAATTAAAGGTGAACCAGAAGTAGTTGAAGTGACA
AATTGGAAAGATTTAATGCCGAAATATCATTTAGAACATAATCAAGCGCTTCAAACATTACAAGAAAAAATGATGAATCT
TTACCCTAATATATACTTAGCTGGCGCTTCCTATTATGGTGTTGGTATTGGTGCGTGTATTGGAAATGGAAAGAACATTG
CAAATGAAATCATTGCAACATTAAATGAACCATCAAATTAA

Upstream 100 bases:

>100_bases
TAATTTCTTACAGAATGCGCAAGTTGCTAGTCGAATATAAGGACTTTTGGGTATAATAAGAAAGGAATTATTAATTGTAT
CGGTTAGGAGCGCAGCACAT

Downstream 100 bases:

>100_bases
TATAGAATAAATAAATAAAATGTCCCTCCATTATAACGGAGGGACATTTTATTTATTTTACTTGAATTGAGACTTTTTTG
TTAGTTGTATTATTCTCGGT

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MKTVVVIGGGITGLSTMFYLEKFKKDNNIDLNLILVEKEEYLGGKIHSVEEKDFIMESGADSIVARNEHVMPLVKDLNLE
GEMVYNETGISYIYSDNTLHPIPSDTIFGIPMSVESLFSSTLVSTKGKIVALKDFITKNKEFTKDTSLSLFLESFLGKEL
VERQIAPVLSGVYSGKLNELTMASTLPYLLDYKNKYGSIIKGFEENKKQFQSAGNKKFVSFKGGLSTIIDRLEEMLTETV
VKKGAVTTAVSKQGDRYEISFANHDSIHADYVVLAAPHDIAETLLQSNELNEQFHTFKNSSLVSIYLGFDILDEQLPADG
TGFIVTENSDLHCDACTWTSRKWKHTSGKQKLLVRMFYKSTNPVYETIKNYSEEELVRVALYDIEKSLGIKGEPEVVEVT
NWKDLMPKYHLEHNQALQTLQEKMMNLYPNIYLAGASYYGVGIGACIGNGKNIANEIIATLNEPSN

Sequences:

>Translated_466_residues
MKTVVVIGGGITGLSTMFYLEKFKKDNNIDLNLILVEKEEYLGGKIHSVEEKDFIMESGADSIVARNEHVMPLVKDLNLE
GEMVYNETGISYIYSDNTLHPIPSDTIFGIPMSVESLFSSTLVSTKGKIVALKDFITKNKEFTKDTSLSLFLESFLGKEL
VERQIAPVLSGVYSGKLNELTMASTLPYLLDYKNKYGSIIKGFEENKKQFQSAGNKKFVSFKGGLSTIIDRLEEMLTETV
VKKGAVTTAVSKQGDRYEISFANHDSIHADYVVLAAPHDIAETLLQSNELNEQFHTFKNSSLVSIYLGFDILDEQLPADG
TGFIVTENSDLHCDACTWTSRKWKHTSGKQKLLVRMFYKSTNPVYETIKNYSEEELVRVALYDIEKSLGIKGEPEVVEVT
NWKDLMPKYHLEHNQALQTLQEKMMNLYPNIYLAGASYYGVGIGACIGNGKNIANEIIATLNEPSN
>Mature_466_residues
MKTVVVIGGGITGLSTMFYLEKFKKDNNIDLNLILVEKEEYLGGKIHSVEEKDFIMESGADSIVARNEHVMPLVKDLNLE
GEMVYNETGISYIYSDNTLHPIPSDTIFGIPMSVESLFSSTLVSTKGKIVALKDFITKNKEFTKDTSLSLFLESFLGKEL
VERQIAPVLSGVYSGKLNELTMASTLPYLLDYKNKYGSIIKGFEENKKQFQSAGNKKFVSFKGGLSTIIDRLEEMLTETV
VKKGAVTTAVSKQGDRYEISFANHDSIHADYVVLAAPHDIAETLLQSNELNEQFHTFKNSSLVSIYLGFDILDEQLPADG
TGFIVTENSDLHCDACTWTSRKWKHTSGKQKLLVRMFYKSTNPVYETIKNYSEEELVRVALYDIEKSLGIKGEPEVVEVT
NWKDLMPKYHLEHNQALQTLQEKMMNLYPNIYLAGASYYGVGIGACIGNGKNIANEIIATLNEPSN

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=493, Percent_Identity=25.1521298174442, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4506001, Length=493, Percent_Identity=25.1521298174442, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24649745, Length=491, Percent_Identity=23.8289205702648, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 52129; Mature: 52129

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVVVIGGGITGLSTMFYLEKFKKDNNIDLNLILVEKEEYLGGKIHSVEEKDFIMESGA
CCEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEEEECHHHCCCCEECCCHHHHHHHCCC
DSIVARNEHVMPLVKDLNLEGEMVYNETGISYIYSDNTLHPIPSDTIFGIPMSVESLFSS
CCEEECCCCCCHHHHHCCCCCEEEEECCCCEEEEECCEECCCCCCCEEECCCCHHHHHHH
TLVSTKGKIVALKDFITKNKEFTKDTSLSLFLESFLGKELVERQIAPVLSGVYSGKLNEL
HHHHCCCCEEEEHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
TMASTLPYLLDYKNKYGSIIKGFEENKKQFQSAGNKKFVSFKGGLSTIIDRLEEMLTETV
EHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHH
VKKGAVTTAVSKQGDRYEISFANHDSIHADYVVLAAPHDIAETLLQSNELNEQFHTFKNS
HHCCCCEEHHHCCCCEEEEEECCCCCCCCCEEEEECCHHHHHHHHHCCCHHHHHHHHCCC
SLVSIYLGFDILDEQLPADGTGFIVTENSDLHCDACTWTSRKWKHTSGKQKLLVRMFYKS
CEEEEEECHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHC
TNPVYETIKNYSEEELVRVALYDIEKSLGIKGEPEVVEVTNWKDLMPKYHLEHNQALQTL
CCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHCCCCCCCHHHHHHHH
QEKMMNLYPNIYLAGASYYGVGIGACIGNGKNIANEIIATLNEPSN
HHHHHHHCCCEEEECCCCCCCEEEEEECCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKTVVVIGGGITGLSTMFYLEKFKKDNNIDLNLILVEKEEYLGGKIHSVEEKDFIMESGA
CCEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEEEECHHHCCCCEECCCHHHHHHHCCC
DSIVARNEHVMPLVKDLNLEGEMVYNETGISYIYSDNTLHPIPSDTIFGIPMSVESLFSS
CCEEECCCCCCHHHHHCCCCCEEEEECCCCEEEEECCEECCCCCCCEEECCCCHHHHHHH
TLVSTKGKIVALKDFITKNKEFTKDTSLSLFLESFLGKELVERQIAPVLSGVYSGKLNEL
HHHHCCCCEEEEHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
TMASTLPYLLDYKNKYGSIIKGFEENKKQFQSAGNKKFVSFKGGLSTIIDRLEEMLTETV
EHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHH
VKKGAVTTAVSKQGDRYEISFANHDSIHADYVVLAAPHDIAETLLQSNELNEQFHTFKNS
HHCCCCEEHHHCCCCEEEEEECCCCCCCCCEEEEECCHHHHHHHHHCCCHHHHHHHHCCC
SLVSIYLGFDILDEQLPADGTGFIVTENSDLHCDACTWTSRKWKHTSGKQKLLVRMFYKS
CEEEEEECHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHC
TNPVYETIKNYSEEELVRVALYDIEKSLGIKGEPEVVEVTNWKDLMPKYHLEHNQALQTL
CCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHCCCCCCCHHHHHHHH
QEKMMNLYPNIYLAGASYYGVGIGACIGNGKNIANEIIATLNEPSN
HHHHHHHCCCEEEECCCCCCCEEEEEECCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]