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The map label for this gene is fosB1

Identifier: 49184907

GI number: 49184907

Start: 1916611

End: 1917027

Strand: Direct

Name: fosB1

Synonym: BAS1895

Alternate gene names: 49184907

Gene position: 1916611-1917027 (Clockwise)

Preceding gene: 49184906

Following gene: 49184908

Centisome position: 36.66

GC content: 31.41

Gene sequence:

>417_bases
TTGTTAAAAGGAATCAATCATCTTTGTTTTTCAGTATCTAATTTAGAAGATTCTATTACATTTTACGAAAAAGTATTGGA
AGGAGAATTATTAGTTAGAGGAAGAAAACTTGCATATTTTAATATATGTGGAGTATGGATAGCGCTTAATGAAGAAATAC
ATATTCCAAGAAAAGAGATTCATCAATCTTATACACATATTGCGTTTTCTGTTGAACAGAAAGACTTTGAACGTCTACTG
CAGCGATTAGAAGAAAACGATGTTCATATTTTACAAGGAAGAGAACGGGATGTAAGGGATTGTGAATCTATATATTTTGT
TGATCCAGACGGGCATAAGTTTGAATTTCATTCAGGGACATTGCAAGAAAGGCTTAATTACTATAGGGAAGATAAACCTC
ATATGACGTTTTACTAA

Upstream 100 bases:

>100_bases
GGGGACTTCAGTTATAAATGGGCATATATTACAAAAAAATAGTATAATAAAAGATGAGTGAATTTTCGCTCATCTTTTAT
TTGTATAGGAGGAATTAGAG

Downstream 100 bases:

>100_bases
AGGGGAAAGAAGTTGCATGCGCTTGTAATTGGTGGAACAGGAATGCTAAAGAGGGTTTCTATATGGCTTTGTGAGAAAAG
GTTTCATGTTTCTATTATTG

Product: fosfomycin resistance protein FosB

Products: NA

Alternate protein names: Fosfomycin resistance protein 1

Number of amino acids: Translated: 138; Mature: 138

Protein sequence:

>138_residues
MLKGINHLCFSVSNLEDSITFYEKVLEGELLVRGRKLAYFNICGVWIALNEEIHIPRKEIHQSYTHIAFSVEQKDFERLL
QRLEENDVHILQGRERDVRDCESIYFVDPDGHKFEFHSGTLQERLNYYREDKPHMTFY

Sequences:

>Translated_138_residues
MLKGINHLCFSVSNLEDSITFYEKVLEGELLVRGRKLAYFNICGVWIALNEEIHIPRKEIHQSYTHIAFSVEQKDFERLL
QRLEENDVHILQGRERDVRDCESIYFVDPDGHKFEFHSGTLQERLNYYREDKPHMTFY
>Mature_138_residues
MLKGINHLCFSVSNLEDSITFYEKVLEGELLVRGRKLAYFNICGVWIALNEEIHIPRKEIHQSYTHIAFSVEQKDFERLL
QRLEENDVHILQGRERDVRDCESIYFVDPDGHKFEFHSGTLQERLNYYREDKPHMTFY

Specific function: Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fosfomycin resistance protein family. FosB subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOSB1_BACAA (C3P803)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002866430.1
- ProteinModelPortal:   C3P803
- SMR:   C3P803
- EnsemblBacteria:   EBBACT00000129262
- GeneID:   7847976
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_2109
- GeneTree:   EBGT00050000001020
- ProtClustDB:   PRK04101
- GO:   GO:0005737
- HAMAP:   MF_01512
- InterPro:   IPR004360
- InterPro:   IPR022858

Pfam domain/function: PF00903 Glyoxalase

EC number: NA

Molecular weight: Translated: 16538; Mature: 16538

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKGINHLCFSVSNLEDSITFYEKVLEGELLVRGRKLAYFNICGVWIALNEEIHIPRKEI
CCCCHHHHHEECCCCHHHHHHHHHHHCCHHEECCCEEEEEEEEEEEEEECCCCCCCHHHH
HQSYTHIAFSVEQKDFERLLQRLEENDVHILQGRERDVRDCESIYFVDPDGHKFEFHSGT
HHHHHHEEEEECHHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEECCCCCEEEECCCC
LQERLNYYREDKPHMTFY
HHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLKGINHLCFSVSNLEDSITFYEKVLEGELLVRGRKLAYFNICGVWIALNEEIHIPRKEI
CCCCHHHHHEECCCCHHHHHHHHHHHCCHHEECCCEEEEEEEEEEEEEECCCCCCCHHHH
HQSYTHIAFSVEQKDFERLLQRLEENDVHILQGRERDVRDCESIYFVDPDGHKFEFHSGT
HHHHHHEEEEECHHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEECCCCCEEEECCCC
LQERLNYYREDKPHMTFY
HHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA