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The map label for this gene is phoR [H]

Identifier: 49184829

GI number: 49184829

Start: 1843184

End: 1844239

Strand: Direct

Name: phoR [H]

Synonym: BAS1817

Alternate gene names: 49184829

Gene position: 1843184-1844239 (Clockwise)

Preceding gene: 49184828

Following gene: 49184831

Centisome position: 35.25

GC content: 34.19

Gene sequence:

>1056_bases
ATGAGTAAATTCAAGATGCTGAAAGTAACAGGAGCGATAATAGCACTCTTTTCTTTTCTTACTATTATTTGGTCTACAGC
ATTTTATGTATCATCTAGTATATTGGATGCCCTTGCAATACATTTATCTCCTTTTGTTACTTACCTCATTAGTGACATAC
TCAGTTTTATATTTATGATTCTTGTTTGGATATTAATTGCAGTATTAATGAGACCGAAGCGAGAGGCGATGATTTGGACT
ATTATTGAACCGATACAAAAAATTGCAAAAGGGGACTTTTCGGTAAAAATACGAAATGAAGAGAAATATGATGGGGAAAT
TGGTGTGCTCGTAAAAAGTATAAACGATATGACAGATGAACTGAATGCGATGGAGAAGATGCGTCAGGAATTTGTTTCGA
ATGTTTCTCATGAAATACAGTCACCATTAACTTCTATAAAAGGGTTTGCTAGAGCACTACAAGATACTAATCTTCCTGAG
GAAAAAAGAAAGCATTATCTTACCATTATTGAAACAGAAACGACGAGATTATCTAAACTAAGTCAAAATTTACTGAAACT
CACCCTATTAGAGTCGGAAGAATATACACCAGAAAGAGTTACTTATCGATTAGATCAACAGTTAAAGCAAATTGTGTTAA
ATAGTGAACCGCTTTGGGCTGAGAAAGAAATTGAATTAGACCTTGATTTAGAAAAAGTGCATATAACTGCTGACCAAGAA
AGTATGAGTCAAGTTTGGATTAATTTAATTCATAATAGTATTAAATTTACTCCAAGTAGCGGTACGATTTCAATCAAGCT
AAAAGAATATGAGACATTAGTAGAAGTACGTATACGTGATACGGGAAGTGGGATATCCGAAGAACAGAAGCAACATATTT
TTGAGCGTTTTTATAAAGCAGACTCTTCACGAAATCGTGCTTATGGAGGAAGTGGTTTAGGTTTAGCGATTGTGAAAAAA
GTACTCGATCTTCATCAGGGGGAAATAAAAGTTGAGAGTGAGGAAGGGAATGGGACGGAATGTATTGTTTGTATTCCAAA
TTATGAAGAGAAATAG

Upstream 100 bases:

>100_bases
TACGTGAGAAGTTTCAAGAAGAGAAGTCGAAATTTAGTATTAAAACAATAAGGGGTTTAGGATATCGCTTAGAGGTAAGT
AAATGAGAAAAAGAGGACGA

Downstream 100 bases:

>100_bases
TGTTAGGAGGGAATCCTTCTAACACTATTTCTCTTTAAAAATACATTTCCCATTACTGCAGCTATACTGATAAGCTTTTC
CTTCGCTATTCATACGGTAT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MSKFKMLKVTGAIIALFSFLTIIWSTAFYVSSSILDALAIHLSPFVTYLISDILSFIFMILVWILIAVLMRPKREAMIWT
IIEPIQKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDTNLPE
EKRKHYLTIIETETTRLSKLSQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQE
SMSQVWINLIHNSIKFTPSSGTISIKLKEYETLVEVRIRDTGSGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAIVKK
VLDLHQGEIKVESEEGNGTECIVCIPNYEEK

Sequences:

>Translated_351_residues
MSKFKMLKVTGAIIALFSFLTIIWSTAFYVSSSILDALAIHLSPFVTYLISDILSFIFMILVWILIAVLMRPKREAMIWT
IIEPIQKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDTNLPE
EKRKHYLTIIETETTRLSKLSQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQE
SMSQVWINLIHNSIKFTPSSGTISIKLKEYETLVEVRIRDTGSGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAIVKK
VLDLHQGEIKVESEEGNGTECIVCIPNYEEK
>Mature_350_residues
SKFKMLKVTGAIIALFSFLTIIWSTAFYVSSSILDALAIHLSPFVTYLISDILSFIFMILVWILIAVLMRPKREAMIWTI
IEPIQKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDTNLPEE
KRKHYLTIIETETTRLSKLSQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQES
MSQVWINLIHNSIKFTPSSGTISIKLKEYETLVEVRIRDTGSGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAIVKKV
LDLHQGEIKVESEEGNGTECIVCIPNYEEK

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=275, Percent_Identity=28, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1786783, Length=308, Percent_Identity=26.9480519480519, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1786600, Length=234, Percent_Identity=29.0598290598291, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1789149, Length=222, Percent_Identity=31.981981981982, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=30, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1790861, Length=229, Percent_Identity=32.3144104803493, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788549, Length=250, Percent_Identity=27.6, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1787894, Length=367, Percent_Identity=25.3405994550409, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1790436, Length=235, Percent_Identity=27.6595744680851, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790346, Length=241, Percent_Identity=27.3858921161826, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI48994928, Length=239, Percent_Identity=27.6150627615063, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1789403, Length=316, Percent_Identity=25.9493670886076, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87082128, Length=303, Percent_Identity=26.0726072607261, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788279, Length=315, Percent_Identity=26.031746031746, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786912, Length=225, Percent_Identity=26.2222222222222, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1789808, Length=305, Percent_Identity=21.9672131147541, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790551, Length=245, Percent_Identity=25.3061224489796, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790300, Length=237, Percent_Identity=26.5822784810127, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 40169; Mature: 40038

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKFKMLKVTGAIIALFSFLTIIWSTAFYVSSSILDALAIHLSPFVTYLISDILSFIFMI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVWILIAVLMRPKREAMIWTIIEPIQKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTDE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHH
LNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDTNLPEEKRKHYLTIIETETTRLSKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEEECCHHHHHHH
SQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQE
HHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECEEEEEEECCHH
SMSQVWINLIHNSIKFTPSSGTISIKLKEYETLVEVRIRDTGSGISEEQKQHIFERFYKA
HHHHHHHHHHHCCCEEECCCCEEEEEEHHHHEEEHEEEECCCCCCCHHHHHHHHHHHHHC
DSSRNRAYGGSGLGLAIVKKVLDLHQGEIKVESEEGNGTECIVCIPNYEEK
CCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCCCC
>Mature Secondary Structure 
SKFKMLKVTGAIIALFSFLTIIWSTAFYVSSSILDALAIHLSPFVTYLISDILSFIFMI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVWILIAVLMRPKREAMIWTIIEPIQKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTDE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHH
LNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDTNLPEEKRKHYLTIIETETTRLSKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEEECCHHHHHHH
SQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQE
HHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECEEEEEEECCHH
SMSQVWINLIHNSIKFTPSSGTISIKLKEYETLVEVRIRDTGSGISEEQKQHIFERFYKA
HHHHHHHHHHHCCCEEECCCCEEEEEEHHHHEEEHEEEECCCCCCCHHHHHHHHHHHHHC
DSSRNRAYGGSGLGLAIVKKVLDLHQGEIKVESEEGNGTECIVCIPNYEEK
CCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]