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The map label for this gene is mtaD

Identifier: 49184742

GI number: 49184742

Start: 1748425

End: 1749732

Strand: Direct

Name: mtaD

Synonym: BAS1729

Alternate gene names: 49184742

Gene position: 1748425-1749732 (Clockwise)

Preceding gene: 49184741

Following gene: 49184745

Centisome position: 33.44

GC content: 37.84

Gene sequence:

>1308_bases
TTGAAAACAACTTATGTAAACGCTACAATCGTAACGATGAATGAACAAAACGAAGTGATAGAAAATGGATATATCATTGT
AGAAAATGATAAAATTATAGATGTAAATAGCGGAGAATTCGCTAGTGATTTTGAAGTAGATGAAGTAATTGACATGAAAG
GAAAGTGGGTTTTACCAGGGCTTGTAAATACACATACACACGTTGTAATGAGTCTCTTAAGAGGTATTGGTGATGATATG
TTATTACAACCATGGCTTGAGACGAGAATTTGGCCACTTGAAAGTCAATTTACGCCAGAACTTGCGGTTGCTAGTACGGA
ACTAGGATTACTTGAAATGGTGAAAAGTGGTACAACATCATTCTCTGATATGTTTAATCCAATTGGAGTAGATCAAGATG
CAATTATGGAAACGGTATCAAGGAGCGGGATGCGAGCTGCTGTTTCAAGAACTTTATTTAGCTTTGGAACGCAAGAGGAT
GAAAAGAAAGCAATTGAAGAAGCTGAGAAATATGTGAAGCGTTACTATAACGAAAGTGGTATGTTAACTACGATGGTTGC
ACCGCATAGTCCATATACATGCAGTACAGAACTGTTAGAAGAGTGTGCACGTATTGCAGTAGAAAATCAAACGATGGTTC
ATATTCACCTTTCGGAAACAGAGCGTGAAGTACGTGATATTGAAGCACAGTACGGAAAACGTCCAGTAGAATATGTAGCA
AGCTGCGGATTGTTTAAACGTCCAACAGTTATTGCACACGGTGTAGTATTAAATGACAATGAGCGTGCATTTTTAGCAGA
ACATGACGTTCGAGTAGCTCATAATCCGAATAGTAATTTAAAACTAGGTTCTGGTATAGCGAACGTAAAAGCGATGCTAG
AAGCGGGAATGAAAGTAGGAATTGCAACAGATAGTGTGGCATCTAACAACAATTTAGATATGTTTGAAGAAATGCGTATC
GCAACATTATTACAAAAAGGTATTCATCAAGATGCAACAGCGTTACCGGTTGAAACAGCTCTTACACTTGCAACTAAAGG
AGCGGCTGAAGTAATCGGCATGAAACAAACGGGATCACTTGAGGTTGGAAAGTGTGCTGATTTCATTACAATTGATCCAT
CTAATAAGCCTCATTTACAACCAGCGGATGAAGTGTTATCACACCTTGTATATGCTGCTAGTGGAAAAGATATAAGCGAT
GTAATTATTAACGGAAAACGTGTCGTTTGGAATGGCGAATGTAAAACGTTAGATGAAGAGCGTATTATATTTGAAGCAAG
TCGTTATAAACGAGGTTTACAAAGATAG

Upstream 100 bases:

>100_bases
AAGAATTCAAATTATCTTTTGACTCTTAATCTTTAATAAGTTACTATAATGGTGGTAACTTATTAAAGGGAACTTCATAG
AGTTGAAAGGGGAAATACTT

Downstream 100 bases:

>100_bases
GTATTTTTAGGCTGTGGAGAAAGACTTCTCCACAGCCTGTTTTTGTGTCTGAACCTTTTTTATTAATAAAACAGAAGAGA
ATGATTTAGATAAAATCACT

Product: chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MKTTYVNATIVTMNEQNEVIENGYIIVENDKIIDVNSGEFASDFEVDEVIDMKGKWVLPGLVNTHTHVVMSLLRGIGDDM
LLQPWLETRIWPLESQFTPELAVASTELGLLEMVKSGTTSFSDMFNPIGVDQDAIMETVSRSGMRAAVSRTLFSFGTQED
EKKAIEEAEKYVKRYYNESGMLTTMVAPHSPYTCSTELLEECARIAVENQTMVHIHLSETEREVRDIEAQYGKRPVEYVA
SCGLFKRPTVIAHGVVLNDNERAFLAEHDVRVAHNPNSNLKLGSGIANVKAMLEAGMKVGIATDSVASNNNLDMFEEMRI
ATLLQKGIHQDATALPVETALTLATKGAAEVIGMKQTGSLEVGKCADFITIDPSNKPHLQPADEVLSHLVYAASGKDISD
VIINGKRVVWNGECKTLDEERIIFEASRYKRGLQR

Sequences:

>Translated_435_residues
MKTTYVNATIVTMNEQNEVIENGYIIVENDKIIDVNSGEFASDFEVDEVIDMKGKWVLPGLVNTHTHVVMSLLRGIGDDM
LLQPWLETRIWPLESQFTPELAVASTELGLLEMVKSGTTSFSDMFNPIGVDQDAIMETVSRSGMRAAVSRTLFSFGTQED
EKKAIEEAEKYVKRYYNESGMLTTMVAPHSPYTCSTELLEECARIAVENQTMVHIHLSETEREVRDIEAQYGKRPVEYVA
SCGLFKRPTVIAHGVVLNDNERAFLAEHDVRVAHNPNSNLKLGSGIANVKAMLEAGMKVGIATDSVASNNNLDMFEEMRI
ATLLQKGIHQDATALPVETALTLATKGAAEVIGMKQTGSLEVGKCADFITIDPSNKPHLQPADEVLSHLVYAASGKDISD
VIINGKRVVWNGECKTLDEERIIFEASRYKRGLQR
>Mature_435_residues
MKTTYVNATIVTMNEQNEVIENGYIIVENDKIIDVNSGEFASDFEVDEVIDMKGKWVLPGLVNTHTHVVMSLLRGIGDDM
LLQPWLETRIWPLESQFTPELAVASTELGLLEMVKSGTTSFSDMFNPIGVDQDAIMETVSRSGMRAAVSRTLFSFGTQED
EKKAIEEAEKYVKRYYNESGMLTTMVAPHSPYTCSTELLEECARIAVENQTMVHIHLSETEREVRDIEAQYGKRPVEYVA
SCGLFKRPTVIAHGVVLNDNERAFLAEHDVRVAHNPNSNLKLGSGIANVKAMLEAGMKVGIATDSVASNNNLDMFEEMRI
ATLLQKGIHQDATALPVETALTLATKGAAEVIGMKQTGSLEVGKCADFITIDPSNKPHLQPADEVLSHLVYAASGKDISD
VIINGKRVVWNGECKTLDEERIIFEASRYKRGLQR

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family

Homologues:

Organism=Homo sapiens, GI4758426, Length=381, Percent_Identity=27.2965879265092, Blast_Score=125, Evalue=1e-28,
Organism=Escherichia coli, GI1789249, Length=371, Percent_Identity=26.4150943396226, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI87082177, Length=444, Percent_Identity=25.6756756756757, Blast_Score=105, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17540282, Length=407, Percent_Identity=25.3071253071253, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319963, Length=351, Percent_Identity=27.9202279202279, Blast_Score=113, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24643849, Length=443, Percent_Identity=26.6365688487585, Blast_Score=138, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTAD_BACAA (C3P768)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002866281.1
- ProteinModelPortal:   C3P768
- SMR:   C3P768
- EnsemblBacteria:   EBBACT00000125805
- GeneID:   7848230
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_1934
- GeneTree:   EBGT00050000003455
- ProtClustDB:   PRK15493
- HAMAP:   MF_01281
- InterPro:   IPR006680
- InterPro:   IPR011059

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.4.28

Molecular weight: Translated: 48144; Mature: 48144

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: BINDING 94-94 BINDING 150-150 BINDING 189-189 BINDING 219-219 BINDING 304-304

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTYVNATIVTMNEQNEVIENGYIIVENDKIIDVNSGEFASDFEVDEVIDMKGKWVLPG
CCEEEEEEEEEEECCCCHHHHCCEEEEECCEEEECCCCCCCCCCCHHHHHCCCCCEECCC
LVNTHTHVVMSLLRGIGDDMLLQPWLETRIWPLESQFTPELAVASTELGLLEMVKSGTTS
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCC
FSDMFNPIGVDQDAIMETVSRSGMRAAVSRTLFSFGTQEDEKKAIEEAEKYVKRYYNESG
HHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCC
MLTTMVAPHSPYTCSTELLEECARIAVENQTMVHIHLSETEREVRDIEAQYGKRPVEYVA
CEEEEECCCCCCCCHHHHHHHHHHHEECCCEEEEEEECHHHHHHHHHHHHHCCCHHHHHH
SCGLFKRPTVIAHGVVLNDNERAFLAEHDVRVAHNPNSNLKLGSGIANVKAMLEAGMKVG
HCCCCCCCCEEEEEEEEECCCCEEEEECCEEEEECCCCCCEECCCHHHHHHHHHCCCEEE
IATDSVASNNNLDMFEEMRIATLLQKGIHQDATALPVETALTLATKGAAEVIGMKQTGSL
EECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHEEECCCCCE
EVGKCADFITIDPSNKPHLQPADEVLSHLVYAASGKDISDVIINGKRVVWNGECKTLDEE
ECCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHEECCCEEEECCCCCCCCCH
RIIFEASRYKRGLQR
HHEEEHHHHHHCCCC
>Mature Secondary Structure
MKTTYVNATIVTMNEQNEVIENGYIIVENDKIIDVNSGEFASDFEVDEVIDMKGKWVLPG
CCEEEEEEEEEEECCCCHHHHCCEEEEECCEEEECCCCCCCCCCCHHHHHCCCCCEECCC
LVNTHTHVVMSLLRGIGDDMLLQPWLETRIWPLESQFTPELAVASTELGLLEMVKSGTTS
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCC
FSDMFNPIGVDQDAIMETVSRSGMRAAVSRTLFSFGTQEDEKKAIEEAEKYVKRYYNESG
HHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCC
MLTTMVAPHSPYTCSTELLEECARIAVENQTMVHIHLSETEREVRDIEAQYGKRPVEYVA
CEEEEECCCCCCCCHHHHHHHHHHHEECCCEEEEEEECHHHHHHHHHHHHHCCCHHHHHH
SCGLFKRPTVIAHGVVLNDNERAFLAEHDVRVAHNPNSNLKLGSGIANVKAMLEAGMKVG
HCCCCCCCCEEEEEEEEECCCCEEEEECCEEEEECCCCCCEECCCHHHHHHHHHCCCEEE
IATDSVASNNNLDMFEEMRIATLLQKGIHQDATALPVETALTLATKGAAEVIGMKQTGSL
EECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHEEECCCCCE
EVGKCADFITIDPSNKPHLQPADEVLSHLVYAASGKDISDVIINGKRVVWNGECKTLDEE
ECCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHEECCCEEEECCCCCCCCCH
RIIFEASRYKRGLQR
HHEEEHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA