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The map label for this gene is ykwC [H]

Identifier: 49184721

GI number: 49184721

Start: 1726644

End: 1727528

Strand: Reverse

Name: ykwC [H]

Synonym: BAS1707

Alternate gene names: 49184721

Gene position: 1727528-1726644 (Counterclockwise)

Preceding gene: 49184724

Following gene: 49184716

Centisome position: 33.04

GC content: 54.46

Gene sequence:

>885_bases
ATGGAGAACCCGCACCGTTCACCTGTTACAGTTATCGGCTTAGGTCCGATGGGCCAGGCGCTAGCTGGTGCATTCCTGAT
GAACGGTCACCCTACGACATTATGGAACCGAACTGCCGAAAAAGCCGATTACCTTATTTCTCAGGGGGCGACCCTTTCAA
ATTCAGTCACCGGCGCGGTCTCTGCAAGCCCCCTGGTGATCATTTGTGTTCTGGACTATAATGTCGTCCATGAAGTCCTT
GGCCCCGTGGGAGATGCCCTGAAGGGACGGACACTGGTGAACCTCACTGCCGACTCGCCCAAACGTGCCCGTGAAATGGC
CACATGGGCTGCCCAACACGGAGTCGATTACCTCGATGGGGCAATTATGACCCCTACTCCGACCATCGGGACACCTGCGG
CTTCCGTCCTGTATAGTGGACCAGAATCCATCTTTAAGGTCCACCAACCGACCTTAGCAAGCTTAGGTGGCACTACTTCT
TATCTTGGGGCGGATCCTGGCCGGGCGGCGGCATATGATGTGGCCCTACTCGATCTCTTTTGGACATCCATGAGCGGTTA
CGCTCACGCTCTCGCACTTGCCACTGCCGAGAATATTCCGGCAAAGGAGTTCGCTATCTATGCCCAGGGTATCATAGACA
TCTTGCCCGACATCATGGCTTATTTGGCAAGCGAAGTAGACTCGGGTCACTACCCTGGTGACAAGTCCAATATCATCTCA
GCCTCGGCAGGAATGGAACACATTATCCATGCTGCTCAACACCACGGCCTCGACGTTAGCGTTCTGAGTGCTGCAATGGC
CGTAACCCAGCAGGCCATCAACGAGGGCTATGGAACCGACGGATTCTCACGCTTGACCGAACTGCTAAAAAAACCGTCTG
CATAA

Upstream 100 bases:

>100_bases
AAGTTTGAACATCTGAAAGGAGGCATTTTCATTGAAGAAAAATGACCAAAGTGAGAAAAAACAAAATATCAGTCAAGTAT
CAGATACAGATGTATCTGTG

Downstream 100 bases:

>100_bases
CATCATATTCGTCTGTAGAGATCCCGGGTTCCGCCATGGTCGCGGACTGGGATCTTCAATTATTCCGTTGTTTCAACTAA
GGGAATTTCCATTTCTCATT

Product: dehydrogenase

Products: (R)-Glycerate; Nicotinamide adenine dinucleotide [C]

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MENPHRSPVTVIGLGPMGQALAGAFLMNGHPTTLWNRTAEKADYLISQGATLSNSVTGAVSASPLVIICVLDYNVVHEVL
GPVGDALKGRTLVNLTADSPKRAREMATWAAQHGVDYLDGAIMTPTPTIGTPAASVLYSGPESIFKVHQPTLASLGGTTS
YLGADPGRAAAYDVALLDLFWTSMSGYAHALALATAENIPAKEFAIYAQGIIDILPDIMAYLASEVDSGHYPGDKSNIIS
ASAGMEHIIHAAQHHGLDVSVLSAAMAVTQQAINEGYGTDGFSRLTELLKKPSA

Sequences:

>Translated_294_residues
MENPHRSPVTVIGLGPMGQALAGAFLMNGHPTTLWNRTAEKADYLISQGATLSNSVTGAVSASPLVIICVLDYNVVHEVL
GPVGDALKGRTLVNLTADSPKRAREMATWAAQHGVDYLDGAIMTPTPTIGTPAASVLYSGPESIFKVHQPTLASLGGTTS
YLGADPGRAAAYDVALLDLFWTSMSGYAHALALATAENIPAKEFAIYAQGIIDILPDIMAYLASEVDSGHYPGDKSNIIS
ASAGMEHIIHAAQHHGLDVSVLSAAMAVTQQAINEGYGTDGFSRLTELLKKPSA
>Mature_294_residues
MENPHRSPVTVIGLGPMGQALAGAFLMNGHPTTLWNRTAEKADYLISQGATLSNSVTGAVSASPLVIICVLDYNVVHEVL
GPVGDALKGRTLVNLTADSPKRAREMATWAAQHGVDYLDGAIMTPTPTIGTPAASVLYSGPESIFKVHQPTLASLGGTTS
YLGADPGRAAAYDVALLDLFWTSMSGYAHALALATAENIPAKEFAIYAQGIIDILPDIMAYLASEVDSGHYPGDKSNIIS
ASAGMEHIIHAAQHHGLDVSVLSAAMAVTQQAINEGYGTDGFSRLTELLKKPSA

Specific function: Glyoxylate catabolism. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=195, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28574115, Length=217, Percent_Identity=24.8847926267281, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: 1.1.1.60 [C]

Molecular weight: Translated: 30722; Mature: 30722

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENPHRSPVTVIGLGPMGQALAGAFLMNGHPTTLWNRTAEKADYLISQGATLSNSVTGAV
CCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SASPLVIICVLDYNVVHEVLGPVGDALKGRTLVNLTADSPKRAREMATWAAQHGVDYLDG
CCCCEEEEEEECHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCHHHCC
AIMTPTPTIGTPAASVLYSGPESIFKVHQPTLASLGGTTSYLGADPGRAAAYDVALLDLF
EEECCCCCCCCCHHHHHHCCHHHHHHHCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
WTSMSGYAHALALATAENIPAKEFAIYAQGIIDILPDIMAYLASEVDSGHYPGDKSNIIS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
ASAGMEHIIHAAQHHGLDVSVLSAAMAVTQQAINEGYGTDGFSRLTELLKKPSA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MENPHRSPVTVIGLGPMGQALAGAFLMNGHPTTLWNRTAEKADYLISQGATLSNSVTGAV
CCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SASPLVIICVLDYNVVHEVLGPVGDALKGRTLVNLTADSPKRAREMATWAAQHGVDYLDG
CCCCEEEEEEECHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCHHHCC
AIMTPTPTIGTPAASVLYSGPESIFKVHQPTLASLGGTTSYLGADPGRAAAYDVALLDLF
EEECCCCCCCCCHHHHHHCCHHHHHHHCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
WTSMSGYAHALALATAENIPAKEFAIYAQGIIDILPDIMAYLASEVDSGHYPGDKSNIIS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
ASAGMEHIIHAAQHHGLDVSVLSAAMAVTQQAINEGYGTDGFSRLTELLKKPSA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-Hydroxy-3-oxopropanoate; H+; Nicotinamide adenine dinucleotide - reduced [C]

Specific reaction: 2-Hydroxy-3-oxopropanoate + H+ + Nicotinamide adenine dinucleotide - reduced --> (R)-Glycerate + Nicotinamide adenine dinucleotide [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]