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The map label for this gene is fabH2

Identifier: 49184705

GI number: 49184705

Start: 1710150

End: 1711133

Strand: Reverse

Name: fabH2

Synonym: BAS1691

Alternate gene names: 49184705

Gene position: 1711133-1710150 (Counterclockwise)

Preceding gene: 49184708

Following gene: 49184700

Centisome position: 32.73

GC content: 36.28

Gene sequence:

>984_bases
ATGAATTCTAAATCCCGTATTACTGCAATTGGCACTCATGTTCCAAATCAAATATTATCTAATAATGATTTAGAAAAAAT
GATCGATACGAATGATGAATGGATTGTACAAAGAACAGGAATGAAGGAAAGAAGAATCGCTAGCGAAGATGAATACTCCT
CAAACTTAGCCATTAAAGCAGTTGAAAATTTATGTACAACATATAAGAAAAACTTAGAAGATGTCGACTGTATCATTGTC
GCTACTACTACTGCTGATTACGTTTTCCCTAGTGTTGCTTGCCAAATACAACAATACTTCAACATACCTCATACAATGGC
ATTTGATTTAAATGCCACTTGCGCTGGTTTCACATATGGCTTGCACGTCGGTAATAGCTTGATTACTTCTGGATCACATA
AAAAAGTACTTGTCGTAGCGACAGAGACATTATCAAAAGTTACTGATTACACCGATAGAACGACCTGCATTTTATTTGGC
GATGGTGCTGGAGCTATTTTATTAGAAAGAGATGAAAACAAACCAAGCTTTATCGCGTATCATATGGGCACAAATGGGCA
CGGCGGTATTCATCTATATAGAACAAACTTATCTACTACTATGAATGACACTCCACTGCAAACAAATGAAAAAATCGTTC
AAAATGGGAGAGAAGTATATAAATGGGCAACACGCACAGTGCCAGTAGGTATAAAAGAACTGTTACATACTGCAAATATG
AAAATGGATGATATAGACTGGTTCATTCCTCATAGCGCTAACTTACGAATGATTGAATCTATTTGTGAAAAATCTCAAAT
TCCAATACACAAAACATTAACGAGCGTGGAATATATGGGGAATACCTCTTCTGTCTCTATTCCACTCGCTCTAGATTTAG
CTAGAAAAAAAGGGAAATTAAATAACGGAGACACACTTTTACTGTACGGATTTGGCGGTGGTCTTACACATTTAGGCCTT
ATTGTGGAGTGGGATTTAAGCTAA

Upstream 100 bases:

>100_bases
CATAGTAAGCTAAGTCGTTCAATACACTAAAAATCTATATTGACATTTTTATAACCTGATATTAGTATCAGGTTATAAAA
TAAAGTTAGGAGCTGTTCCT

Downstream 100 bases:

>100_bases
ACATATAAAAAAGAGGTTCTAGTTAGTAACTAGAACCTCACTTCAATTTCGTTACCCTTTTCGGGACCATATCACAACAG
GGATAAGCATGAAAGCTAAA

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III protein 2; Beta-ketoacyl-ACP synthase III 2; KAS III 2

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MNSKSRITAIGTHVPNQILSNNDLEKMIDTNDEWIVQRTGMKERRIASEDEYSSNLAIKAVENLCTTYKKNLEDVDCIIV
ATTTADYVFPSVACQIQQYFNIPHTMAFDLNATCAGFTYGLHVGNSLITSGSHKKVLVVATETLSKVTDYTDRTTCILFG
DGAGAILLERDENKPSFIAYHMGTNGHGGIHLYRTNLSTTMNDTPLQTNEKIVQNGREVYKWATRTVPVGIKELLHTANM
KMDDIDWFIPHSANLRMIESICEKSQIPIHKTLTSVEYMGNTSSVSIPLALDLARKKGKLNNGDTLLLYGFGGGLTHLGL
IVEWDLS

Sequences:

>Translated_327_residues
MNSKSRITAIGTHVPNQILSNNDLEKMIDTNDEWIVQRTGMKERRIASEDEYSSNLAIKAVENLCTTYKKNLEDVDCIIV
ATTTADYVFPSVACQIQQYFNIPHTMAFDLNATCAGFTYGLHVGNSLITSGSHKKVLVVATETLSKVTDYTDRTTCILFG
DGAGAILLERDENKPSFIAYHMGTNGHGGIHLYRTNLSTTMNDTPLQTNEKIVQNGREVYKWATRTVPVGIKELLHTANM
KMDDIDWFIPHSANLRMIESICEKSQIPIHKTLTSVEYMGNTSSVSIPLALDLARKKGKLNNGDTLLLYGFGGGLTHLGL
IVEWDLS
>Mature_327_residues
MNSKSRITAIGTHVPNQILSNNDLEKMIDTNDEWIVQRTGMKERRIASEDEYSSNLAIKAVENLCTTYKKNLEDVDCIIV
ATTTADYVFPSVACQIQQYFNIPHTMAFDLNATCAGFTYGLHVGNSLITSGSHKKVLVVATETLSKVTDYTDRTTCILFG
DGAGAILLERDENKPSFIAYHMGTNGHGGIHLYRTNLSTTMNDTPLQTNEKIVQNGREVYKWATRTVPVGIKELLHTANM
KMDDIDWFIPHSANLRMIESICEKSQIPIHKTLTSVEYMGNTSSVSIPLALDLARKKGKLNNGDTLLLYGFGGGLTHLGL
IVEWDLS

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=312, Percent_Identity=38.4615384615385, Blast_Score=232, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH2_BACAN (Q81JF6)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_844246.1
- RefSeq:   YP_018464.1
- RefSeq:   YP_027957.1
- ProteinModelPortal:   Q81JF6
- SMR:   Q81JF6
- EnsemblBacteria:   EBBACT00000012882
- EnsemblBacteria:   EBBACT00000014763
- EnsemblBacteria:   EBBACT00000019691
- GeneID:   1086168
- GeneID:   2817393
- GeneID:   2851898
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_1826
- KEGG:   bar:GBAA_1826
- KEGG:   bat:BAS1691
- TIGR:   BA_1826
- TIGR:   GBAA_1826
- GeneTree:   EBGT00050000001269
- HOGENOM:   HBG649927
- OMA:   REVYKWA
- ProtClustDB:   PRK12879
- BioCyc:   BANT260799:BAS1691-MONOMER
- BioCyc:   BANT261594:GBAA1826-MONOMER
- BRENDA:   2.3.1.180
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 36281; Mature: 36281

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: ACT_SITE 114-114 ACT_SITE 251-251 ACT_SITE 281-281

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSKSRITAIGTHVPNQILSNNDLEKMIDTNDEWIVQRTGMKERRIASEDEYSSNLAIKA
CCCCCEEEEEECCCCHHHHCCCCHHHHHCCCCCEEEEECCCHHHHCCCCCCCCCCHHHHH
VENLCTTYKKNLEDVDCIIVATTTADYVFPSVACQIQQYFNIPHTMAFDLNATCAGFTYG
HHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEE
LHVGNSLITSGSHKKVLVVATETLSKVTDYTDRTTCILFGDGAGAILLERDENKPSFIAY
EECCCHHEECCCCCEEEEEEEHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCEEEE
HMGTNGHGGIHLYRTNLSTTMNDTPLQTNEKIVQNGREVYKWATRTVPVGIKELLHTANM
ECCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHCCHHHHHHHHCCCCCCHHHHHHHCCC
KMDDIDWFIPHSANLRMIESICEKSQIPIHKTLTSVEYMGNTSSVSIPLALDLARKKGKL
CCCCCEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEEEEEHHHCCCC
NNGDTLLLYGFGGGLTHLGLIVEWDLS
CCCCEEEEEECCCCCCEEEEEEEEECC
>Mature Secondary Structure
MNSKSRITAIGTHVPNQILSNNDLEKMIDTNDEWIVQRTGMKERRIASEDEYSSNLAIKA
CCCCCEEEEEECCCCHHHHCCCCHHHHHCCCCCEEEEECCCHHHHCCCCCCCCCCHHHHH
VENLCTTYKKNLEDVDCIIVATTTADYVFPSVACQIQQYFNIPHTMAFDLNATCAGFTYG
HHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEE
LHVGNSLITSGSHKKVLVVATETLSKVTDYTDRTTCILFGDGAGAILLERDENKPSFIAY
EECCCHHEECCCCCEEEEEEEHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCEEEE
HMGTNGHGGIHLYRTNLSTTMNDTPLQTNEKIVQNGREVYKWATRTVPVGIKELLHTANM
ECCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHCCHHHHHHHHCCCCCCHHHHHHHCCC
KMDDIDWFIPHSANLRMIESICEKSQIPIHKTLTSVEYMGNTSSVSIPLALDLARKKGKL
CCCCCEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEEEEEHHHCCCC
NNGDTLLLYGFGGGLTHLGLIVEWDLS
CCCCEEEEEECCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629