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The map label for this gene is dltA [H]

Identifier: 49184304

GI number: 49184304

Start: 1321335

End: 1322846

Strand: Reverse

Name: dltA [H]

Synonym: BAS1287

Alternate gene names: 49184304

Gene position: 1322846-1321335 (Counterclockwise)

Preceding gene: 49184305

Following gene: 49184303

Centisome position: 25.3

GC content: 37.24

Gene sequence:

>1512_bases
ATGAAGTTATTAGAACAAATTGAAAAGTGGGCTATTGAAACGCCTGATCAAACTGCTTTTGTTTGGCGAGATGCGAAAAT
TACGTACAAACAATTAAAGGAAGATTCTGATGCGTTAGCACATTGGATTTCTTCTGAGTATCCAGATGATCGTTCACCAA
TTATGGTGTATGGCCATATGCAACCTGAAATGATTATTAACTTTTTAGGATGTGTAAAAGCTGGACATGCTTATATTCCT
GTAGATTTATCTATCCCAGCTGATCGTGTACAACGTATCGCTGAAAATTCTGGTGCGAAATTACTTTTATCAGCAGCAGT
AACTGTAACTGATTTACCAGTTCGCATTGTAAGTGAAGACAACTTAAAAGATATTTTCTTTACTCATAAAGGGAACACTC
CAAATCCTGAACATGCGGTAAAAGGTGATGAGAACTTCTACATTATTTACACATCAGGAAGCACAGGTAATCCGAAAGGG
GTTCAGATTACTTATAACTGCCTTGTAAGCTTTACACAATGGGCTGTAGAAGACTTCAACTTACAAACAGGGCAAGTATT
CTTAAACCAAGCACCTTTCTCATTCGATTTATCTGTCATGGATATTTACCCATCATTAGTAACAGGTGGTACACTTTGGG
CAATCGATAAAGATATGATTGCACGTCCAAAAGACTTGTTTGCTTCTTTAGAGCAATCGGATATACAAGTATGGACTTCA
ACACCATCTTTCGCAGAGATGTGTTTAATGGAAGCATCTTTCTCTGAGAGTATGCTACCAAACATGAAAACATTCTTATT
CTGCGGTGAAGTATTACCAAATGAAGTAGCTAGAAAATTAATTGAGCGTTTCCCGAAAGCAACAATTATGAATACGTATG
GTCCAACAGAAGCTACTGTCGCTGTAACAGGTATTCACGTTACAGAAGAAGTGCTTGATCAATACAAATCACTTCCAGTT
GGCTACTGTAAATCAGATTGTCGCCTTCTTATTATGAAAGAAGATGGCACGATTGCACCTGATGGTGAAAAAGGTGAAAT
CGTAATTGTCGGTCCAAGCGTAAGCGTTGGATATTTAGGAAGCCCTGAATTAACAGAAAAAGCATTTACTATGATTGACG
GTGAGCGCGCCTATAAAACAGGCGATGCTGGCTATGTTGAAAATGGTCTTCTATTCTATAATGGTCGTCTTGATTTCCAA
ATTAAGCTGCATGGTTATCGAATGGAATTAGAAGAAATTGAGCATCATCTTCGTGCGTGTTCTTACGTAGAAGGAGCAGT
TATCGTTCCAATTAAAAAAGGTGAGAAATACGATTATTTATTAGCGGTTGTTGTTCCTGGAGAACATTCATTTGAAAAAG
AATTCAAATTAACATCTGCAATCAAAAAAGAACTCAATGAGCGATTACCAAACTACATGATTCCACGTAAATTCATGTAT
CAATCTTCTATTCCAATGACACCAAATGGAAAGGTAGATCGCAAAAAATTATTGAGTGAGGTTACAGCATGA

Upstream 100 bases:

>100_bases
TTATTACCTTGCAATTTTATTTGCATTACTTTGGTTGTATGGATTCCATGATACAAACACAAGTACATTTATTTACAACG
AATTTTAGGGTGGGAACGTT

Downstream 100 bases:

>100_bases
CCGCATATGGATCATTTTATTTTTTCGCTATAGTGGGCATTTTATTAATACCTACTATCATAGCTGGATTAAAAGGTAAA
ATGTTGCGTAAATATAATGC

Product: D-alanine--poly(phosphoribitol) ligase subunit 1

Products: NA

Alternate protein names: D-alanine-D-alanyl carrier protein ligase; DCL; D-alanine-activating enzyme; DAE [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MKLLEQIEKWAIETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHMQPEMIINFLGCVKAGHAYIP
VDLSIPADRVQRIAENSGAKLLLSAAVTVTDLPVRIVSEDNLKDIFFTHKGNTPNPEHAVKGDENFYIIYTSGSTGNPKG
VQITYNCLVSFTQWAVEDFNLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWTS
TPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEATVAVTGIHVTEEVLDQYKSLPV
GYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYLGSPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDFQ
IKLHGYRMELEEIEHHLRACSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFMY
QSSIPMTPNGKVDRKKLLSEVTA

Sequences:

>Translated_503_residues
MKLLEQIEKWAIETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHMQPEMIINFLGCVKAGHAYIP
VDLSIPADRVQRIAENSGAKLLLSAAVTVTDLPVRIVSEDNLKDIFFTHKGNTPNPEHAVKGDENFYIIYTSGSTGNPKG
VQITYNCLVSFTQWAVEDFNLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWTS
TPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEATVAVTGIHVTEEVLDQYKSLPV
GYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYLGSPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDFQ
IKLHGYRMELEEIEHHLRACSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFMY
QSSIPMTPNGKVDRKKLLSEVTA
>Mature_503_residues
MKLLEQIEKWAIETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHMQPEMIINFLGCVKAGHAYIP
VDLSIPADRVQRIAENSGAKLLLSAAVTVTDLPVRIVSEDNLKDIFFTHKGNTPNPEHAVKGDENFYIIYTSGSTGNPKG
VQITYNCLVSFTQWAVEDFNLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWTS
TPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEATVAVTGIHVTEEVLDQYKSLPV
GYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYLGSPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDFQ
IKLHGYRMELEEIEHHLRACSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFMY
QSSIPMTPNGKVDRKKLLSEVTA

Specific function: Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp [H]

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=361, Percent_Identity=26.3157894736842, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI187761345, Length=396, Percent_Identity=26.7676767676768, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI187761343, Length=396, Percent_Identity=26.7676767676768, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI156151445, Length=547, Percent_Identity=22.8519195612431, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI157311624, Length=500, Percent_Identity=23.8, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI157311622, Length=500, Percent_Identity=23.8, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI58082049, Length=504, Percent_Identity=23.4126984126984, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI38505220, Length=533, Percent_Identity=22.1388367729831, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1786801, Length=532, Percent_Identity=30.0751879699248, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI145693145, Length=529, Percent_Identity=23.2514177693762, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786810, Length=517, Percent_Identity=23.7911025145068, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI221142682, Length=466, Percent_Identity=22.5321888412017, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32563687, Length=497, Percent_Identity=24.1448692152917, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17550940, Length=434, Percent_Identity=25.8064516129032, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17556356, Length=485, Percent_Identity=26.8041237113402, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17558820, Length=502, Percent_Identity=23.9043824701195, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71985884, Length=368, Percent_Identity=23.0978260869565, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17557194, Length=441, Percent_Identity=22.9024943310658, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17531443, Length=530, Percent_Identity=21.5094339622642, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17560308, Length=366, Percent_Identity=25.1366120218579, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17560140, Length=506, Percent_Identity=22.5296442687747, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17538037, Length=433, Percent_Identity=24.2494226327945, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6319591, Length=571, Percent_Identity=24.8686514886165, Blast_Score=133, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6319699, Length=358, Percent_Identity=22.0670391061453, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24648676, Length=521, Percent_Identity=26.1036468330134, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI18859661, Length=538, Percent_Identity=22.8624535315985, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21356441, Length=255, Percent_Identity=27.4509803921569, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355225, Length=532, Percent_Identity=21.6165413533835, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24581924, Length=368, Percent_Identity=22.554347826087, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010072 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.1.1.13 [H]

Molecular weight: Translated: 56435; Mature: 56435

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLEQIEKWAIETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHM
CCHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEECC
QPEMIINFLGCVKAGHAYIPVDLSIPADRVQRIAENSGAKLLLSAAVTVTDLPVRIVSED
CHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCEEEEEEEEEEECCCEEEECCC
NLKDIFFTHKGNTPNPEHAVKGDENFYIIYTSGSTGNPKGVQITYNCLVSFTQWAVEDFN
CCEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHCC
LQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWTS
CCCCEEEEECCCCEECEEHHHHHHHHHCCCEEEEECHHHHCCCHHHHHHCCCCCEEEEEC
TPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEATV
CCHHHHHHHHHHCCCHHHCCCHHHHHHCCHHCHHHHHHHHHHHCCCEEEEECCCCCCEEE
AVTGIHVTEEVLDQYKSLPVGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYLG
EEEEEHHHHHHHHHHHCCCCCEECCCCEEEEEECCCCCCCCCCCCEEEEECCCCEECCCC
SPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDFQIKLHGYRMELEEIEHHLRAC
CCCHHHHHHHEECCCHHEECCCCCEEECCEEEECCEEEEEEEEECEEECHHHHHHHHHHH
SYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFMY
HHCCCEEEEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
QSSIPMTPNGKVDRKKLLSEVTA
CCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MKLLEQIEKWAIETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHM
CCHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEECC
QPEMIINFLGCVKAGHAYIPVDLSIPADRVQRIAENSGAKLLLSAAVTVTDLPVRIVSED
CHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCEEEEEEEEEEECCCEEEECCC
NLKDIFFTHKGNTPNPEHAVKGDENFYIIYTSGSTGNPKGVQITYNCLVSFTQWAVEDFN
CCEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHCC
LQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWTS
CCCCEEEEECCCCEECEEHHHHHHHHHCCCEEEEECHHHHCCCHHHHHHCCCCCEEEEEC
TPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEATV
CCHHHHHHHHHHCCCHHHCCCHHHHHHCCHHCHHHHHHHHHHHCCCEEEEECCCCCCEEE
AVTGIHVTEEVLDQYKSLPVGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYLG
EEEEEHHHHHHHHHHHCCCCCEECCCCEEEEEECCCCCCCCCCCCEEEEECCCCEECCCC
SPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDFQIKLHGYRMELEEIEHHLRAC
CCCHHHHHHHEECCCHHEECCCCCEEECCEEEECCEEEEEEEEECEEECHHHHHHHHHHH
SYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFMY
HHCCCEEEEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
QSSIPMTPNGKVDRKKLLSEVTA
CCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA