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The map label for this gene is pncB [H]

Identifier: 49183590

GI number: 49183590

Start: 610399

End: 611862

Strand: Reverse

Name: pncB [H]

Synonym: BAS0565

Alternate gene names: 49183590

Gene position: 611862-610399 (Counterclockwise)

Preceding gene: 49183593

Following gene: 49183582

Centisome position: 11.7

GC content: 36.61

Gene sequence:

>1464_bases
ATGACTTATTATAAAGACGATAGCTATGCCTTACATACAGATTTATATCAAATTAATATGGCTTATACATATTGGAAAGA
TGGTATTCACAATCGCCGCTCGGTGTTTGATTTATACTTTCGAAAGCTTCCATTCGAGAACGGTTATGCTGTTTTTGCTG
GTCTTGAAAAAATTGTAGAGTACATAGAAAACTTCAGCTTTACCGAAAGCGATATCGCTTATTTAGCAGAATTACAATTT
GAAGAAGAATTTCTTCATTATTTACAAAATATGAAATTCACTGGTACGGTTCGTAGTATGCAAGAAGGTGAAGTTGTGTT
TAATAACGAGCCTTTATTACGTGTTGATGCACCGCTTGGTGAAGCACAAATTATTGAAACTGCACTGTTAAACATTGTGA
ATTACCAAACATTAATTGCAACAAAAGCAGCTCGTATGAAGCACGCTGCAAATAACGATGAACTTTTAGAGTTCGGCACA
AGACGTGCCCACGAGTTCGATGCAGCCCTTTGGGGCACACGCGCTGCCTTTATTGGTGGTTTCTCCTCTACAAGCAACGT
ACGGGCTGGAAAACGCTTTGGGATACCTGTAGCCGGCACACATGCGCACTCTTTCGTTCAAGCTTATCGCGATGAATATG
TTGCCTTTAAGAAATACGCTGAAACTCATAAAAAATGTGTCTTTCTCGTTGATACATATGACACATTAAAATCTGGTGTG
CCAAATGCAATTCGTGTCGCGAAAGAGTTTGGGGATCGCATCGATTTTTATGGCATTCGCCTCGATAGTGGTGATATGGC
TTATTTATCTAAAAAGGCAAGAAAACTACTAGACGAAGCCGGGTTTACAAACACAAAAATTATTGCTTCTAGCGATTTAG
ATGAATACACAATTATGCACTTGAAATCTCAAGGAGCAAAAATTAATGTATGGGGCGTTGGAACAAAATTGATTACGTCC
TTTGAACAACCAGCGTTAGGAGCTGTTTATAAACTAGTTGCGATTGAAGATACTGATGGAAAATTAAATGATACAATTAA
AATTTCATCTAACCCTGAAAAAATTACTACTCCAGGACTTAAACGAATTTATCGCATTATCAATCGAGTAAACGATCATG
CTGAAGGCGATTATATTGCATTAGATTATGAAGAACCCGGAAAAGAAGAACGCTTAAAAATGTTTCATCCTGTTCACACG
TATATAAGTAAATTTGTAACAAACTTTGAAGCTCGCGAACTGCATAAAGACATTTTCGTTAACGGTGAAAGAACATATGA
ACTACCAAGTATATTAGATATTCAAAAATATAATGAACAGAGCCTCTCTCTATTTTGGGAAGAATATATGCGAACTTTAA
ACCCTGAAGAATACCCTGTCGATTTAAGCCAAGAGTGCTGGGATCATAAAATGAATTACATTCAAACAGTTCGAGAACAA
GTTGAAAAAAACATACAAAAGTAA

Upstream 100 bases:

>100_bases
TTTCATTTTTTTCCCTCTTGACTCTTCTTTCATATCCATTCTTTGCTACGATGGGTGAAAAATTGGTATACTATAACCAA
ATTATGGAGGTGTTTTCGCG

Downstream 100 bases:

>100_bases
ACAGAGAAGTTTCCCCTTCTCTGTTTTTTCAATACTATATGGATATTTGTAAAAAATATATTAAAATAATAAGACGAATA
TATTTTGTTTGTAAATTTTA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MTYYKDDSYALHTDLYQINMAYTYWKDGIHNRRSVFDLYFRKLPFENGYAVFAGLEKIVEYIENFSFTESDIAYLAELQF
EEEFLHYLQNMKFTGTVRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVNYQTLIATKAARMKHAANNDELLEFGT
RRAHEFDAALWGTRAAFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQAYRDEYVAFKKYAETHKKCVFLVDTYDTLKSGV
PNAIRVAKEFGDRIDFYGIRLDSGDMAYLSKKARKLLDEAGFTNTKIIASSDLDEYTIMHLKSQGAKINVWGVGTKLITS
FEQPALGAVYKLVAIEDTDGKLNDTIKISSNPEKITTPGLKRIYRIINRVNDHAEGDYIALDYEEPGKEERLKMFHPVHT
YISKFVTNFEARELHKDIFVNGERTYELPSILDIQKYNEQSLSLFWEEYMRTLNPEEYPVDLSQECWDHKMNYIQTVREQ
VEKNIQK

Sequences:

>Translated_487_residues
MTYYKDDSYALHTDLYQINMAYTYWKDGIHNRRSVFDLYFRKLPFENGYAVFAGLEKIVEYIENFSFTESDIAYLAELQF
EEEFLHYLQNMKFTGTVRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVNYQTLIATKAARMKHAANNDELLEFGT
RRAHEFDAALWGTRAAFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQAYRDEYVAFKKYAETHKKCVFLVDTYDTLKSGV
PNAIRVAKEFGDRIDFYGIRLDSGDMAYLSKKARKLLDEAGFTNTKIIASSDLDEYTIMHLKSQGAKINVWGVGTKLITS
FEQPALGAVYKLVAIEDTDGKLNDTIKISSNPEKITTPGLKRIYRIINRVNDHAEGDYIALDYEEPGKEERLKMFHPVHT
YISKFVTNFEARELHKDIFVNGERTYELPSILDIQKYNEQSLSLFWEEYMRTLNPEEYPVDLSQECWDHKMNYIQTVREQ
VEKNIQK
>Mature_486_residues
TYYKDDSYALHTDLYQINMAYTYWKDGIHNRRSVFDLYFRKLPFENGYAVFAGLEKIVEYIENFSFTESDIAYLAELQFE
EEFLHYLQNMKFTGTVRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVNYQTLIATKAARMKHAANNDELLEFGTR
RAHEFDAALWGTRAAFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQAYRDEYVAFKKYAETHKKCVFLVDTYDTLKSGVP
NAIRVAKEFGDRIDFYGIRLDSGDMAYLSKKARKLLDEAGFTNTKIIASSDLDEYTIMHLKSQGAKINVWGVGTKLITSF
EQPALGAVYKLVAIEDTDGKLNDTIKISSNPEKITTPGLKRIYRIINRVNDHAEGDYIALDYEEPGKEERLKMFHPVHTY
ISKFVTNFEARELHKDIFVNGERTYELPSILDIQKYNEQSLSLFWEEYMRTLNPEEYPVDLSQECWDHKMNYIQTVREQV
EKNIQK

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=515, Percent_Identity=31.4563106796116, Blast_Score=251, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI71997947, Length=519, Percent_Identity=37.3795761078998, Blast_Score=313, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI71997952, Length=519, Percent_Identity=37.3795761078998, Blast_Score=313, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI71997955, Length=206, Percent_Identity=47.5728155339806, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24581587, Length=519, Percent_Identity=34.8747591522158, Blast_Score=271, Evalue=8e-73,
Organism=Drosophila melanogaster, GI161076680, Length=204, Percent_Identity=44.1176470588235, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24581595, Length=204, Percent_Identity=44.1176470588235, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI28574709, Length=204, Percent_Identity=44.1176470588235, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24581593, Length=204, Percent_Identity=44.1176470588235, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24581591, Length=204, Percent_Identity=44.1176470588235, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 56212; Mature: 56081

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYYKDDSYALHTDLYQINMAYTYWKDGIHNRRSVFDLYFRKLPFENGYAVFAGLEKIVE
CCEECCCCEEEEEEEEEEEEEEEEHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
YIENFSFTESDIAYLAELQFEEEFLHYLQNMKFTGTVRSMQEGEVVFNNEPLLRVDAPLG
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHCCCCCCEEECCCCEEEEECCCC
EAQIIETALLNIVNYQTLIATKAARMKHAANNDELLEFGTRRAHEFDAALWGTRAAFIGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCC
FSSTSNVRAGKRFGIPVAGTHAHSFVQAYRDEYVAFKKYAETHKKCVFLVDTYDTLKSGV
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHCC
PNAIRVAKEFGDRIDFYGIRLDSGDMAYLSKKARKLLDEAGFTNTKIIASSDLDEYTIMH
CHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEE
LKSQGAKINVWGVGTKLITSFEQPALGAVYKLVAIEDTDGKLNDTIKISSNPEKITTPGL
EECCCCEEEEEECCHHHHHHCCCCHHHHEEEEEEEECCCCCCCCEEEECCCCCCCCCHHH
KRIYRIINRVNDHAEGDYIALDYEEPGKEERLKMFHPVHTYISKFVTNFEARELHKDIFV
HHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHEE
NGERTYELPSILDIQKYNEQSLSLFWEEYMRTLNPEEYPVDLSQECWDHKMNYIQTVREQ
CCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VEKNIQK
HHHHCCC
>Mature Secondary Structure 
TYYKDDSYALHTDLYQINMAYTYWKDGIHNRRSVFDLYFRKLPFENGYAVFAGLEKIVE
CEECCCCEEEEEEEEEEEEEEEEHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
YIENFSFTESDIAYLAELQFEEEFLHYLQNMKFTGTVRSMQEGEVVFNNEPLLRVDAPLG
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHCCCCCCEEECCCCEEEEECCCC
EAQIIETALLNIVNYQTLIATKAARMKHAANNDELLEFGTRRAHEFDAALWGTRAAFIGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCC
FSSTSNVRAGKRFGIPVAGTHAHSFVQAYRDEYVAFKKYAETHKKCVFLVDTYDTLKSGV
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHCC
PNAIRVAKEFGDRIDFYGIRLDSGDMAYLSKKARKLLDEAGFTNTKIIASSDLDEYTIMH
CHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEE
LKSQGAKINVWGVGTKLITSFEQPALGAVYKLVAIEDTDGKLNDTIKISSNPEKITTPGL
EECCCCEEEEEECCHHHHHHCCCCHHHHEEEEEEEECCCCCCCCEEEECCCCCCCCCHHH
KRIYRIINRVNDHAEGDYIALDYEEPGKEERLKMFHPVHTYISKFVTNFEARELHKDIFV
HHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHEE
NGERTYELPSILDIQKYNEQSLSLFWEEYMRTLNPEEYPVDLSQECWDHKMNYIQTVREQ
CCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VEKNIQK
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]