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The map label for this gene is yfhQ [H]

Identifier: 49183519

GI number: 49183519

Start: 515026

End: 516123

Strand: Direct

Name: yfhQ [H]

Synonym: BAS0491

Alternate gene names: 49183519

Gene position: 515026-516123 (Clockwise)

Preceding gene: 49183517

Following gene: 49183521

Centisome position: 9.85

GC content: 36.98

Gene sequence:

>1098_bases
TTGACACTTGAAATATTAAATAACTTTAACATAGAGCAGTTTCAAAATGATTTAATTGGTTGGTTTGAAAAAGAGCAACG
TGACTTACCGTGGCGTAAAAATAAAGATCCATACCGCGTTTGGGTTTCAGAAATTATGTTGCAGCAAACGAGGGTAGAAG
CTGTAAAACCATATTACGCGAATTTTATGGGGAAGTTTCCTACTCTAGAAGCTTTGGCCAATGCTGATGATGAAGAAGTG
TTAAAAGCATGGGAAGGTTTAGGGTATTATTCTAGAGCGCGAAATTTACATGCGGCTGTAAAAGAAGTAAAAGAAGTATA
TGGCGGGATTGTGCCAAGTGATGTAAAGAAGATTGAGAAATTAAAAGGAGTCGGCCCCTATACAAAAGGTGCTATTTTAA
GTATCGCATATGGCATACCAGAGCCGGCAGTTGACGGAAATGTTGTGCGTGTATTGTCTCGTATTTTATCAGTATGGGAT
GACATTGCAAAACCGAAAACTAGAAAAGTGTTTGAAGAGATTGTGCGTGAAATTATTTCGGCTGAAAATCCATCTTATTT
TAATCAAGGTTTGATGGAATTAGGAGCACTGATTTGTATTCCTAAAAATCCAGCATGCTTACTTTGTCCTGTTCGTGAGC
ATTGCAGGGGATATGCTGAAGGTGTTCAAAAGGAATTACCAGTAAAAAGTAAAGCGAAAGCTCCTACGATGGTACCGATT
GTTGCAGGAGTACTTCAAACGGAAGATGGTCGTTACGTCATTAATAAACGTCCAAGTACCGGTTTATTAGCTAATATGTG
GGAGTTTCCGAATGTTGAACTTGGCGAAGGGATTCGTAATCAGAAGGAACAGCTTATAGATTATATGAAGGAAAAATTTG
AGCTTTCGATTTCTATTGAAGAATACGCAATGAATGTACAACATACGTTTACACATCGTACTTGGGATATATTCGTATTT
TATGGAAAAGTAACTGGTGATATTGTTGAAACAGATACATTGAAATTTGTATCGAAAGAAGCATTTGAGCAGTTACCTTT
CTCTAAATCGCATCGTACGATTTATGAGAATTGTGTTGAGAAAATTACAATGCAATAA

Upstream 100 bases:

>100_bases
TCAAGTCCTTTGCCTTCTATTTCCTATGTCATCTTACTTAAATTTTTTCCTAAAATCTTTATAATAGTACTTATATGCAA
AAAAATGAGGGGGATCAAGT

Downstream 100 bases:

>100_bases
ACAAAAAAAGTGTTCCCAGGTTGGGAACACTTTTTTAATCGTAAGAAATTTTTGTCCCATGAGTCCAACTAGCTTCACCT
TCTTGTAAGCCACCTCTTGA

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MTLEILNNFNIEQFQNDLIGWFEKEQRDLPWRKNKDPYRVWVSEIMLQQTRVEAVKPYYANFMGKFPTLEALANADDEEV
LKAWEGLGYYSRARNLHAAVKEVKEVYGGIVPSDVKKIEKLKGVGPYTKGAILSIAYGIPEPAVDGNVVRVLSRILSVWD
DIAKPKTRKVFEEIVREIISAENPSYFNQGLMELGALICIPKNPACLLCPVREHCRGYAEGVQKELPVKSKAKAPTMVPI
VAGVLQTEDGRYVINKRPSTGLLANMWEFPNVELGEGIRNQKEQLIDYMKEKFELSISIEEYAMNVQHTFTHRTWDIFVF
YGKVTGDIVETDTLKFVSKEAFEQLPFSKSHRTIYENCVEKITMQ

Sequences:

>Translated_365_residues
MTLEILNNFNIEQFQNDLIGWFEKEQRDLPWRKNKDPYRVWVSEIMLQQTRVEAVKPYYANFMGKFPTLEALANADDEEV
LKAWEGLGYYSRARNLHAAVKEVKEVYGGIVPSDVKKIEKLKGVGPYTKGAILSIAYGIPEPAVDGNVVRVLSRILSVWD
DIAKPKTRKVFEEIVREIISAENPSYFNQGLMELGALICIPKNPACLLCPVREHCRGYAEGVQKELPVKSKAKAPTMVPI
VAGVLQTEDGRYVINKRPSTGLLANMWEFPNVELGEGIRNQKEQLIDYMKEKFELSISIEEYAMNVQHTFTHRTWDIFVF
YGKVTGDIVETDTLKFVSKEAFEQLPFSKSHRTIYENCVEKITMQ
>Mature_364_residues
TLEILNNFNIEQFQNDLIGWFEKEQRDLPWRKNKDPYRVWVSEIMLQQTRVEAVKPYYANFMGKFPTLEALANADDEEVL
KAWEGLGYYSRARNLHAAVKEVKEVYGGIVPSDVKKIEKLKGVGPYTKGAILSIAYGIPEPAVDGNVVRVLSRILSVWDD
IAKPKTRKVFEEIVREIISAENPSYFNQGLMELGALICIPKNPACLLCPVREHCRGYAEGVQKELPVKSKAKAPTMVPIV
AGVLQTEDGRYVINKRPSTGLLANMWEFPNVELGEGIRNQKEQLIDYMKEKFELSISIEEYAMNVQHTFTHRTWDIFVFY
GKVTGDIVETDTLKFVSKEAFEQLPFSKSHRTIYENCVEKITMQ

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI190358497, Length=402, Percent_Identity=31.0945273631841, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI6912520, Length=402, Percent_Identity=31.0945273631841, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI115298648, Length=402, Percent_Identity=31.0945273631841, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI115298650, Length=402, Percent_Identity=31.0945273631841, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI115298654, Length=402, Percent_Identity=31.0945273631841, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI115298652, Length=402, Percent_Identity=31.0945273631841, Blast_Score=202, Evalue=4e-52,
Organism=Escherichia coli, GI1789331, Length=335, Percent_Identity=36.4179104477612, Blast_Score=203, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 41781; Mature: 41649

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLEILNNFNIEQFQNDLIGWFEKEQRDLPWRKNKDPYRVWVSEIMLQQTRVEAVKPYYA
CEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NFMGKFPTLEALANADDEEVLKAWEGLGYYSRARNLHAAVKEVKEVYGGIVPSDVKKIEK
HHHCCCCHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
LKGVGPYTKGAILSIAYGIPEPAVDGNVVRVLSRILSVWDDIAKPKTRKVFEEIVREIIS
HHCCCCCCCCHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
AENPSYFNQGLMELGALICIPKNPACLLCPVREHCRGYAEGVQKELPVKSKAKAPTMVPI
CCCCCHHHHHHHHHCCEEEECCCCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
VAGVLQTEDGRYVINKRPSTGLLANMWEFPNVELGEGIRNQKEQLIDYMKEKFELSISIE
HHHHHCCCCCCEEEECCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEHH
EYAMNVQHTFTHRTWDIFVFYGKVTGDIVETDTLKFVSKEAFEQLPFSKSHRTIYENCVE
HHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
KITMQ
HHCCC
>Mature Secondary Structure 
TLEILNNFNIEQFQNDLIGWFEKEQRDLPWRKNKDPYRVWVSEIMLQQTRVEAVKPYYA
EEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NFMGKFPTLEALANADDEEVLKAWEGLGYYSRARNLHAAVKEVKEVYGGIVPSDVKKIEK
HHHCCCCHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
LKGVGPYTKGAILSIAYGIPEPAVDGNVVRVLSRILSVWDDIAKPKTRKVFEEIVREIIS
HHCCCCCCCCHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
AENPSYFNQGLMELGALICIPKNPACLLCPVREHCRGYAEGVQKELPVKSKAKAPTMVPI
CCCCCHHHHHHHHHCCEEEECCCCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
VAGVLQTEDGRYVINKRPSTGLLANMWEFPNVELGEGIRNQKEQLIDYMKEKFELSISIE
HHHHHCCCCCCEEEECCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEHH
EYAMNVQHTFTHRTWDIFVFYGKVTGDIVETDTLKFVSKEAFEQLPFSKSHRTIYENCVE
HHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
KITMQ
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]