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The map label for this gene is mtnA [H]

Identifier: 49183360

GI number: 49183360

Start: 358303

End: 359349

Strand: Direct

Name: mtnA [H]

Synonym: BAS0332

Alternate gene names: 49183360

Gene position: 358303-359349 (Clockwise)

Preceding gene: 49183359

Following gene: 49183361

Centisome position: 6.85

GC content: 38.49

Gene sequence:

>1047_bases
ATGATGGAAGAGCAATTAATACCAATTCAGTGGAAAGACGATGCTTTAGTTTTATTAGATCAAACATTATTACCAAATGA
AGTTGTCTATGAATCTTTCAATACAGCTGAAGGTGTGTGGGATGCCATTCAAGTAATGAAAGTACGAGGAGCGCCAGCGA
TTGGTGTTTCAGCAGCTTATGGTGTGTATTTAGGGGTAAAGGAATTTGTTGAAAGTACGGAAGCTGAATTTATTGATGAA
GTAAAAAGGGTATGTGCATATTTGGCCACATCAAGACCGACAGCAGTAAACTTATTTTGGGCACTTGAAAGAATGGAAAG
TGTAGCGACAGATCATACTCATCTATCAATCACACAGTTGAAAGATAGATTACTAGAAGAGGCAAAAGAGATTCATAGGG
AAGATGAAGAAATTAACCGTCAAATTGGAGAACATGCATTAACGTTATTCCATGATGGAATGGGAGTATTAACACATTGT
AATGCTGGTGCGTTAGCGACGACTAAGTATGGTACTGCGACAGCTCCGATGTACTTAGCGAAAGAAAAAGGATGGGACTT
AAAAATCTATTCCGATGAAACGCGTCCTAGATTACAAGGTTCAACGTTAACAGCATTAGAATTGCAGCGAGCGGGAATTG
ATGTCACTGTCATTACGGATAATATGGCAGCTATGGTTATGTCACAAGGGAAGATTGATGCGGTAATCGTTGGATGCGAC
CGTGTGGCAGCAAACGGTGATGTAGCAAATAAAATTGGAACATTAGGCGTATCTATTTTAGCGAAATACTACAACATTCC
GTTTTATGTAGCAGCACCAACACCGACAATTGACTTAAAAACACCGACAGGAAAAGAAATTCCGATTGAGGAAAGAGATG
CTTCTGAAGTAATTAATCGTTTCGGACAGTATTCTGCTCCGAAAGAAAGTAAAGTATATAATCCAGCATTTGATGTCACG
CCACATGAAAATGTAACAGCGATTATTACGGAAAAAGGGATTGTAAAAGCACCGTTTACGGAGAATTTAAAAAAGTTATT
TCAATAA

Upstream 100 bases:

>100_bases
AAAGAAATTTATTTTACGAGCGAATCAATATAAAACAGGTACAAGCTTTGTAGAAACGTTAAAAGAACAGTCAATGCACT
ATGCGAAGTAAGGGGAGAAG

Downstream 100 bases:

>100_bases
GTAGATAGAGTTAAAAAGTCAGTCATCATAAGCTTTATACTTAGGGGGATGTATATGTTATTACAAAAAGAGAGAGAAGA
GATTGTAGCGTACGGAAAGA

Product: methylthioribose-1-phosphate isomerase

Products: NA

Alternate protein names: M1Pi 1; MTR-1-P isomerase 1; S-methyl-5-thioribose-1-phosphate isomerase 1 [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MMEEQLIPIQWKDDALVLLDQTLLPNEVVYESFNTAEGVWDAIQVMKVRGAPAIGVSAAYGVYLGVKEFVESTEAEFIDE
VKRVCAYLATSRPTAVNLFWALERMESVATDHTHLSITQLKDRLLEEAKEIHREDEEINRQIGEHALTLFHDGMGVLTHC
NAGALATTKYGTATAPMYLAKEKGWDLKIYSDETRPRLQGSTLTALELQRAGIDVTVITDNMAAMVMSQGKIDAVIVGCD
RVAANGDVANKIGTLGVSILAKYYNIPFYVAAPTPTIDLKTPTGKEIPIEERDASEVINRFGQYSAPKESKVYNPAFDVT
PHENVTAIITEKGIVKAPFTENLKKLFQ

Sequences:

>Translated_348_residues
MMEEQLIPIQWKDDALVLLDQTLLPNEVVYESFNTAEGVWDAIQVMKVRGAPAIGVSAAYGVYLGVKEFVESTEAEFIDE
VKRVCAYLATSRPTAVNLFWALERMESVATDHTHLSITQLKDRLLEEAKEIHREDEEINRQIGEHALTLFHDGMGVLTHC
NAGALATTKYGTATAPMYLAKEKGWDLKIYSDETRPRLQGSTLTALELQRAGIDVTVITDNMAAMVMSQGKIDAVIVGCD
RVAANGDVANKIGTLGVSILAKYYNIPFYVAAPTPTIDLKTPTGKEIPIEERDASEVINRFGQYSAPKESKVYNPAFDVT
PHENVTAIITEKGIVKAPFTENLKKLFQ
>Mature_348_residues
MMEEQLIPIQWKDDALVLLDQTLLPNEVVYESFNTAEGVWDAIQVMKVRGAPAIGVSAAYGVYLGVKEFVESTEAEFIDE
VKRVCAYLATSRPTAVNLFWALERMESVATDHTHLSITQLKDRLLEEAKEIHREDEEINRQIGEHALTLFHDGMGVLTHC
NAGALATTKYGTATAPMYLAKEKGWDLKIYSDETRPRLQGSTLTALELQRAGIDVTVITDNMAAMVMSQGKIDAVIVGCD
RVAANGDVANKIGTLGVSILAKYYNIPFYVAAPTPTIDLKTPTGKEIPIEERDASEVINRFGQYSAPKESKVYNPAFDVT
PHENVTAIITEKGIVKAPFTENLKKLFQ

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=338, Percent_Identity=39.9408284023669, Blast_Score=221, Evalue=6e-58,
Organism=Homo sapiens, GI23943880, Length=328, Percent_Identity=37.1951219512195, Blast_Score=178, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI17557462, Length=339, Percent_Identity=35.693215339233, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17557123, Length=273, Percent_Identity=28.9377289377289, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6325375, Length=393, Percent_Identity=34.3511450381679, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6322878, Length=279, Percent_Identity=26.1648745519713, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21357667, Length=361, Percent_Identity=36.5650969529086, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24651647, Length=361, Percent_Identity=36.5650969529086, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI18543295, Length=219, Percent_Identity=26.9406392694064, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 38438; Mature: 38438

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMEEQLIPIQWKDDALVLLDQTLLPNEVVYESFNTAEGVWDAIQVMKVRGAPAIGVSAAY
CCCCCCCCEEECCCEEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHH
GVYLGVKEFVESTEAEFIDEVKRVCAYLATSRPTAVNLFWALERMESVATDHTHLSITQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCEEHHHHH
KDRLLEEAKEIHREDEEINRQIGEHALTLFHDGMGVLTHCNAGALATTKYGTATAPMYLA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCCCCEEEE
KEKGWDLKIYSDETRPRLQGSTLTALELQRAGIDVTVITDNMAAMVMSQGKIDAVIVGCD
CCCCCEEEEECCCCCCCCCCCEEEEEEHHHCCCEEEEEECCHHHHHHCCCCEEEEEEECC
RVAANGDVANKIGTLGVSILAKYYNIPFYVAAPTPTIDLKTPTGKEIPIEERDASEVINR
EECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEECCCCCCCCCCCCCCHHHHHHH
FGQYSAPKESKVYNPAFDVTPHENVTAIITEKGIVKAPFTENLKKLFQ
HHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEECCHHHHHHHHCC
>Mature Secondary Structure
MMEEQLIPIQWKDDALVLLDQTLLPNEVVYESFNTAEGVWDAIQVMKVRGAPAIGVSAAY
CCCCCCCCEEECCCEEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHH
GVYLGVKEFVESTEAEFIDEVKRVCAYLATSRPTAVNLFWALERMESVATDHTHLSITQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCEEHHHHH
KDRLLEEAKEIHREDEEINRQIGEHALTLFHDGMGVLTHCNAGALATTKYGTATAPMYLA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCCCCEEEE
KEKGWDLKIYSDETRPRLQGSTLTALELQRAGIDVTVITDNMAAMVMSQGKIDAVIVGCD
CCCCCEEEEECCCCCCCCCCCEEEEEEHHHCCCEEEEEECCHHHHHHCCCCEEEEEEECC
RVAANGDVANKIGTLGVSILAKYYNIPFYVAAPTPTIDLKTPTGKEIPIEERDASEVINR
EECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEECCCCCCCCCCCCCCHHHHHHH
FGQYSAPKESKVYNPAFDVTPHENVTAIITEKGIVKAPFTENLKKLFQ
HHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEECCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA