Definition Bacillus anthracis str. Sterne chromosome, complete genome.
Accession NC_005945
Length 5,228,663

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The map label for this gene is proI [H]

Identifier: 49183231

GI number: 49183231

Start: 198242

End: 198979

Strand: Reverse

Name: proI [H]

Synonym: BAS0198

Alternate gene names: 49183231

Gene position: 198979-198242 (Counterclockwise)

Preceding gene: 49183233

Following gene: 49183230

Centisome position: 3.81

GC content: 40.51

Gene sequence:

>738_bases
ATGCTAACTAAACATCGAATTCTATTTATTGGTGCTGGTCGTATGGCAGAAGCTATATTTTCCGGATTACTTAAAACAAG
CAAAGAATACATCGAAGAGATTATCGTTTCTAACCGAAGTAACGTAGAAAAGCTAGATCAATTACGAGCGCGATATAATG
TGTCTACTACAACAGATTGGAAACAACATGTTACATCTGTTGATACGATTGTTTTAGCAATGCCGCCTTCTGCACATGAA
GAATTATTAGCAGAGTTATCTCCGTTACTATCGAATCAACTTGTCGTAACGGTAGCTGCTGGCATCAGCCCATCTTATTT
AGAAGAAAGACTTCCCGGGGGGACGCCTGTTGCTTGGATTATGCCAAATACAGCTGCTGAAATTGGAAAGTCTATCTCCT
TATACACGATGGGACAATTCGTAAACGAGACTCATCAAGAAACCCTGCAATTGCTTTTAAGGGGCATTGGTACTTCGCAA
CTTTGTACCGAGGAAGAAGTTCATCAACTTACTGCAGTTACTGGAAGTGCACCAGCCTTCCTTTATTACTTTGCTGAAAG
TTTAATTGAAGCAACAAAAAGTTATGGAGTCGATGAAGCAACCGCAAAACACCTTGTCATTCAAATGATTTCTGGCTCTG
CTTCTATGCTTGAACAAACACAAGATCCAGCTAACCTCCGTGAACAAGTAACAACGCCAGGTGGTTCCACAGCTGAAGGT
CTCAAAGCTTTATATTAA

Upstream 100 bases:

>100_bases
TTATCTATTCCATCTACAATAAGCCTTTTCTTTTTACAAAATTCTCTTAAAAATGGTATCGTTTTTTATAACATATCTCC
ACTAGAAAGGAATAGAGGAT

Downstream 100 bases:

>100_bases
TATAATTTTTCAGAGGCAATTCAAAAAGCAGTAGAAGCAACAAACAAAAAAGCTAGGGGGAAATAATATGAGTTTAACAA
GTTTAAAAGACTATACAACA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase 2; P5CR 2 [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MLTKHRILFIGAGRMAEAIFSGLLKTSKEYIEEIIVSNRSNVEKLDQLRARYNVSTTTDWKQHVTSVDTIVLAMPPSAHE
ELLAELSPLLSNQLVVTVAAGISPSYLEERLPGGTPVAWIMPNTAAEIGKSISLYTMGQFVNETHQETLQLLLRGIGTSQ
LCTEEEVHQLTAVTGSAPAFLYYFAESLIEATKSYGVDEATAKHLVIQMISGSASMLEQTQDPANLREQVTTPGGSTAEG
LKALY

Sequences:

>Translated_245_residues
MLTKHRILFIGAGRMAEAIFSGLLKTSKEYIEEIIVSNRSNVEKLDQLRARYNVSTTTDWKQHVTSVDTIVLAMPPSAHE
ELLAELSPLLSNQLVVTVAAGISPSYLEERLPGGTPVAWIMPNTAAEIGKSISLYTMGQFVNETHQETLQLLLRGIGTSQ
LCTEEEVHQLTAVTGSAPAFLYYFAESLIEATKSYGVDEATAKHLVIQMISGSASMLEQTQDPANLREQVTTPGGSTAEG
LKALY
>Mature_245_residues
MLTKHRILFIGAGRMAEAIFSGLLKTSKEYIEEIIVSNRSNVEKLDQLRARYNVSTTTDWKQHVTSVDTIVLAMPPSAHE
ELLAELSPLLSNQLVVTVAAGISPSYLEERLPGGTPVAWIMPNTAAEIGKSISLYTMGQFVNETHQETLQLLLRGIGTSQ
LCTEEEVHQLTAVTGSAPAFLYYFAESLIEATKSYGVDEATAKHLVIQMISGSASMLEQTQDPANLREQVTTPGGSTAEG
LKALY

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=241, Percent_Identity=34.0248962655602, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI21361454, Length=245, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI24797095, Length=245, Percent_Identity=27.7551020408163, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI24797097, Length=245, Percent_Identity=27.7551020408163, Blast_Score=82, Evalue=4e-16,
Organism=Escherichia coli, GI1786585, Length=243, Percent_Identity=28.3950617283951, Blast_Score=105, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17569021, Length=242, Percent_Identity=31.8181818181818, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17540664, Length=258, Percent_Identity=31.3953488372093, Blast_Score=97, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6320861, Length=258, Percent_Identity=24.8062015503876, Blast_Score=79, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21358587, Length=244, Percent_Identity=28.6885245901639, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24648116, Length=250, Percent_Identity=31.2, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24647700, Length=145, Percent_Identity=29.6551724137931, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 26670; Mature: 26670

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTKHRILFIGAGRMAEAIFSGLLKTSKEYIEEIIVSNRSNVEKLDQLRARYNVSTTTDW
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHH
KQHVTSVDTIVLAMPPSAHEELLAELSPLLSNQLVVTVAAGISPSYLEERLPGGTPVAWI
HHHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCCEEEE
MPNTAAEIGKSISLYTMGQFVNETHQETLQLLLRGIGTSQLCTEEEVHQLTAVTGSAPAF
CCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHCCCCHHH
LYYFAESLIEATKSYGVDEATAKHLVIQMISGSASMLEQTQDPANLREQVTTPGGSTAEG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHCCCCCCHHHH
LKALY
HHHCC
>Mature Secondary Structure
MLTKHRILFIGAGRMAEAIFSGLLKTSKEYIEEIIVSNRSNVEKLDQLRARYNVSTTTDW
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHH
KQHVTSVDTIVLAMPPSAHEELLAELSPLLSNQLVVTVAAGISPSYLEERLPGGTPVAWI
HHHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCCEEEE
MPNTAAEIGKSISLYTMGQFVNETHQETLQLLLRGIGTSQLCTEEEVHQLTAVTGSAPAF
CCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHCCCCHHH
LYYFAESLIEATKSYGVDEATAKHLVIQMISGSASMLEQTQDPANLREQVTTPGGSTAEG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHCCCCCCHHHH
LKALY
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 11418582 [H]