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The map label for this gene is disA

Identifier: 49183117

GI number: 49183117

Start: 93603

End: 94676

Strand: Direct

Name: disA

Synonym: BAS0083

Alternate gene names: 49183117

Gene position: 93603-94676 (Clockwise)

Preceding gene: 49183116

Following gene: 49183118

Centisome position: 1.79

GC content: 37.34

Gene sequence:

>1074_bases
ATGGAAGAAAACAAGCAACGTGTCAAAAGTATGATTAATATTTTACAACTTGTGGCCCCGGGAACACCACTGCGCGAAGG
GATAGATAATGTACTTCGTGCACAAACAGGAGGATTAATTGTTCTTGGATATAACGAGCAGATTAAAAGTATTGTTGATG
GAGGTTTTCATATTAATTGTGCATTCTCCCCGGCTAGTTTATACGAATTAGCAAAAATGGATGGGGCACTTATTTTAAAT
GAAACTGGAAGTAAAATTTTGATTGCGAATGCACAGTTAGTTCCAGAGTCATCTATCGACTCTATCGAGACAGGTATGCG
CCACCGAACGGCGGAGCGTGTAGCAAAGCAGACAGGCAGCCTTGTTGTGGCTATTTCACAAAGGCGTAACGTAATTACGC
TATATCAAGGTAATTTACGTTATACACTAAAAGATATAGGTGTTATTTTAACAAAGGCAAACCAAGCTATCCAAACGTTA
GAAAAATATAAGGCTGTATGGAACGATGGGATTACGAATTTGGGCATTCTAGAATTTGAAGAGGTTGTTACAATGTCCGA
GGTCGTTCATGTTTTACATAGTGTTGAAATGGTATTACGTATTAAAAATGAAATATTGAGCTATATTCATGAATTGGGAA
CAGAAGGTAGGTTAATTCGTTTACAACTTACGGAACTACTAGCCGATTTAGAAGCAGAAGCGGCGCTATTAATTAAAGAT
TACTATCAAGAAAAAACACAAGATCATCATCAAATTTTGAAAAAGTTACAAGAACTTGCGAATACACAACTTCTAGAGGA
TAGTGATTTAGTTAAATTGCTTGGATACCCGGGACAAACGAGTTTAGAAGAAAGTGTGACGCCGAGAGGATACCGAATCA
CAAGCAAAATTTCGCGTGTTCCACCACTTATCATTGAAAATTTAATTAATCGATTTAAAACTTTGCAAGGCGTTTGTCGT
GCAACGATTAATGAATTAGATGATGTGGAAGGAATTGGGGAAGTCAGGGCGAAGAAAATACGAGAAGGCCTAAAAAGAAT
TCAAGAGCATCTCTATATGAGTAGACACAATTAA

Upstream 100 bases:

>100_bases
TAGAAAAAATTTGGGAGGATGGACAATTCCGGATGGGATTGAGGTAGTCGGTGTATCTAATTTAGGAGAAGCGCTTCGTT
TGACATTAGGAGGCTAGGCT

Downstream 100 bases:

>100_bases
GAATATTACATTGATTCCATAATATAACGACACTAGAACATTTTTGGTATATGATATGATATATTGGTAAATAAAACTAT
TTATAAAAAAACACGTCCGC

Product: DNA integrity scanning protein DisA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILN
ETGSKILIANAQLVPESSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTL
EKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKD
YYQEKTQDHHQILKKLQELANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCR
ATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN

Sequences:

>Translated_357_residues
MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILN
ETGSKILIANAQLVPESSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTL
EKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKD
YYQEKTQDHHQILKKLQELANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCR
ATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
>Mature_357_residues
MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILN
ETGSKILIANAQLVPESSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTL
EKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKD
YYQEKTQDHHQILKKLQELANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCR
ATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN

Specific function: Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, disA pauses at

COG id: COG1623

COG function: function code R; Predicted nucleic-acid-binding protein (contains the HHH domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the disA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DISA_BACAA (C3P9M9)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002864735.1
- ProteinModelPortal:   C3P9M9
- SMR:   C3P9M9
- EnsemblBacteria:   EBBACT00000125516
- GeneID:   7852801
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_0099
- GeneTree:   EBGT00050000001567
- ProtClustDB:   PRK13482
- HAMAP:   MF_01438
- InterPro:   IPR018906
- InterPro:   IPR003390
- InterPro:   IPR003583
- InterPro:   IPR010994
- SMART:   SM00278

Pfam domain/function: PF10635 DisA-linker; PF02457 DisA_N; SSF47781 RuvA_2_like

EC number: NA

Molecular weight: Translated: 40096; Mature: 40096

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINC
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCEEEEE
AFSPASLYELAKMDGALILNETGSKILIANAQLVPESSIDSIETGMRHRTAERVAKQTGS
ECCHHHHHHHHHCCCEEEEECCCCEEEEECCEECCCCCHHHHHHHHHHHHHHHHHHHCCC
LVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFE
EEEEEECCCCEEEEEECCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
EVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHH
YYQEKTQDHHQILKKLQELANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRV
HHHHHCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCHHHCCCCCCEEHHHHHHHC
PPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINC
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCEEEEE
AFSPASLYELAKMDGALILNETGSKILIANAQLVPESSIDSIETGMRHRTAERVAKQTGS
ECCHHHHHHHHHCCCEEEEECCCCEEEEECCEECCCCCHHHHHHHHHHHHHHHHHHHCCC
LVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFE
EEEEEECCCCEEEEEECCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
EVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHH
YYQEKTQDHHQILKKLQELANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRV
HHHHHCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCHHHCCCCCCEEHHHHHHHC
PPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA