Definition Bacillus anthracis str. Sterne chromosome, complete genome.
Accession NC_005945
Length 5,228,663

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The map label for this gene is tilS/hprT [H]

Identifier: 49183098

GI number: 49183098

Start: 68976

End: 69518

Strand: Direct

Name: tilS/hprT [H]

Synonym: BAS0063

Alternate gene names: 49183098

Gene position: 68976-69518 (Clockwise)

Preceding gene: 49183097

Following gene: 49183099

Centisome position: 1.32

GC content: 34.81

Gene sequence:

>543_bases
ATGATGAATCAAGATATCGAAAAAGTATTAATTTCTGAAGAGCAAATACAAGAAAAGGTGCTCGAATTAGGTGCGATTAT
TGCAGAGGATTATAAAAACACAGTACCTCTTGCGATTGGTGTACTAAAGGGTGCAATGCCATTCATGGCAGATTTATTAA
AGAGAACAGATACATATCTTGAAATGGATTTTATGGCTGTATCTAGTTACGGTCACTCTACTGTTTCAACAGGCGAAGTG
AAAATTTTGAAAGACCTTGATACTTCTGTAGAAGGTCGCGATATTTTAATCGTTGAAGATATTATTGATAGCGGTCTTAC
GCTAAGTTACTTAGTAGACCTATTTAAATATCGTAAAGCGAAGTCTGTAAAAATCGTTACGTTATTAGATAAACCAACAG
GCCGCAAGGTAGATTTGAAAGCGGATTATGTTGGATTTACTGTACCGCATGAATTTGTTGTAGGATATGGATTAGATTAT
AAAGAGCAGTACCGTAATCTTCCTTATGTAGGAGTATTAAAACCAAGCGTTTACTCAAATTAA

Upstream 100 bases:

>100_bases
TGAAGCGATCTGCATTTGCTATCTCGAAAGAGACAGCAAAGAAGGATAAATATATGATTATTCACTACAAAAGCAAGGAG
TCTTCCGGGAGGATAATGAA

Downstream 100 bases:

>100_bases
TTAAATACAGGCGTCACAATTGTATAGGAAAGTTTTTCTATGTTACGATTTACTATAGTGTTTATGCCGTGAGAGGAGGT
TAGGAATGAATCGTATCTTC

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: tRNA(Ile)-lysidine synthase; tRNA(Ile)-2-lysyl-cytidine synthase; tRNA(Ile)-lysidine synthetase; Hypoxanthine-guanine phosphoribosyltransferase; HGPRT; HGPRTase [H]

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MMNQDIEKVLISEEQIQEKVLELGAIIAEDYKNTVPLAIGVLKGAMPFMADLLKRTDTYLEMDFMAVSSYGHSTVSTGEV
KILKDLDTSVEGRDILIVEDIIDSGLTLSYLVDLFKYRKAKSVKIVTLLDKPTGRKVDLKADYVGFTVPHEFVVGYGLDY
KEQYRNLPYVGVLKPSVYSN

Sequences:

>Translated_180_residues
MMNQDIEKVLISEEQIQEKVLELGAIIAEDYKNTVPLAIGVLKGAMPFMADLLKRTDTYLEMDFMAVSSYGHSTVSTGEV
KILKDLDTSVEGRDILIVEDIIDSGLTLSYLVDLFKYRKAKSVKIVTLLDKPTGRKVDLKADYVGFTVPHEFVVGYGLDY
KEQYRNLPYVGVLKPSVYSN
>Mature_180_residues
MMNQDIEKVLISEEQIQEKVLELGAIIAEDYKNTVPLAIGVLKGAMPFMADLLKRTDTYLEMDFMAVSSYGHSTVSTGEV
KILKDLDTSVEGRDILIVEDIIDSGLTLSYLVDLFKYRKAKSVKIVTLLDKPTGRKVDLKADYVGFTVPHEFVVGYGLDY
KEQYRNLPYVGVLKPSVYSN

Specific function: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionin

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=180, Percent_Identity=37.7777777777778, Blast_Score=111, Evalue=3e-25,
Organism=Homo sapiens, GI9910262, Length=180, Percent_Identity=33.8888888888889, Blast_Score=98, Evalue=4e-21,
Organism=Escherichia coli, GI87081689, Length=166, Percent_Identity=48.7951807228916, Blast_Score=170, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17510817, Length=181, Percent_Identity=32.0441988950276, Blast_Score=93, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR012094
- InterPro:   IPR012796
- InterPro:   IPR012795
- InterPro:   IPR020825
- InterPro:   IPR000836
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3; PF00156 Pribosyltran; PF11734 TilS_C [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20209; Mature: 20209

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNQDIEKVLISEEQIQEKVLELGAIIAEDYKNTVPLAIGVLKGAMPFMADLLKRTDTYL
CCCHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHCHHH
EMDFMAVSSYGHSTVSTGEVKILKDLDTSVEGRDILIVEDIIDSGLTLSYLVDLFKYRKA
HHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCEEEEEHHHHCCCCHHHHHHHHHHHHCC
KSVKIVTLLDKPTGRKVDLKADYVGFTVPHEFVVGYGLDYKEQYRNLPYVGVLKPSVYSN
CCEEEEEEECCCCCCEEEEEECEEEEECCHHHHEECCCCHHHHHCCCCEEEEECCHHCCC
>Mature Secondary Structure
MMNQDIEKVLISEEQIQEKVLELGAIIAEDYKNTVPLAIGVLKGAMPFMADLLKRTDTYL
CCCHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHCHHH
EMDFMAVSSYGHSTVSTGEVKILKDLDTSVEGRDILIVEDIIDSGLTLSYLVDLFKYRKA
HHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCEEEEEHHHHCCCCHHHHHHHHHHHHCC
KSVKIVTLLDKPTGRKVDLKADYVGFTVPHEFVVGYGLDYKEQYRNLPYVGVLKPSVYSN
CCEEEEEEECCCCCCEEEEEECEEEEECCHHHHEECCCCHHHHHCCCCEEEEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]