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The map label for this gene is dnaA

Identifier: 49183040

GI number: 49183040

Start: 408

End: 1748

Strand: Direct

Name: dnaA

Synonym: BAS0001

Alternate gene names: 49183040

Gene position: 408-1748 (Clockwise)

Preceding gene: NA

Following gene: 49183041

Centisome position: 0.01

GC content: 35.42

Gene sequence:

>1341_bases
TTGGAAAACATCTCTGATTTATGGAACAGCGCCTTAAAAGAACTCGAAAAAAAGGTCAGTAAACCAAGTTATGAAACATG
GTTAAAATCAACAACCGCACATAATTTAAAGAAAGATGTATTAACAATTACGGCTCCAAATGAATTCGCCCGTGATTGGT
TAGAATCTCATTATTCAGAGCTAATTTCGGAAACACTTTATGATTTAACGGGGGCAAAATTAGCTATTCGCTTTATTATT
CCCCAAAGTCAAGCTGAAGAGGAGATTGATCTTCCTCCTGCTAAACCAAATGCAGCACAAGATGATTCTAATCATTTACC
ACAGAGTATGCTAAACCCAAAATATACGTTTGATACATTTGTTATTGGCTCTGGTAACCGTTTTGCTCACGCTGCTTCAT
TGGCCGTAGCCGAAGCGCCAGCTAAAGCATATAATCCCCTCTTTATTTATGGGGGAGTTGGACTTGGAAAAACCCATTTA
ATGCATGCAATTGGCCATTATGTAATTGAACATAACCCAAATGCCAAAGTTGTATATTTATCATCAGAAAAATTTACAAA
TGAATTCATTAATTCTATTCGTGATAATAAAGCGGTCGATTTTCGTAATAAATACCGCAATGTAGATGTTTTATTGATAG
ATGATATTCAATTTTTAGCGGGAAAAGAACAAACTCAAGAAGAGTTTTTCCATACATTCAATGCATTACACGAAGAAAGT
AAACAAATTGTAATTTCCAGTGATCGGCCACCAAAAGAAATTCCAACTTTAGAAGATCGTCTTCGTTCTCGCTTTGAATG
GGGACTCATTACGGATATTACGCCACCAGATTTAGAAACACGAATTGCGATTTTACGTAAAAAGGCAAAGGCTGAAGGAC
TTGATATACCAAATGAGGTCATGCTTTATATCGCAAATCAAATCGATTCAAATATTCGTGAACTAGAAGGTGCACTCATC
CGCGTTGTAGCTTATTCATCTTTAATTAACAAGGATATTAATGCTGATTTAGCAGCTGAAGCACTTAAAGATATTATTCC
AAATTCTAAACCAAAAATTATCTCCATTTATGATATTCAAAAAGCTGTTGGAGATGTTTATCAAGTAAAATTAGAAGATT
TCAAGGCGAAAAAGCGCACAAAGTCAGTTGCCTTTCCTCGCCAAATTGCAATGTATTTGTCACGCGAACTGACAGATTCC
TCCTTACCTAAAATAGGTGAAGAATTTGGTGGACGTGATCATACAACCGTTATCCATGCCCATGAAAAAATTTCTAAGCT
ACTTAAGACGGATACGCAATTACAAAAACAAGTTGAAGAAATTAACGATATTTTAAAGTAG

Upstream 100 bases:

>100_bases
TAAAATACGTTTCGTATAAATATACATTTTATATTTATTCAGGTTGTACATTTGTTGCACAACCTTATTCTTTTACCATC
TTAGTAAAGGAGGGACACCT

Downstream 100 bases:

>100_bases
TAGCTGAATAGTGTGAATAACTTCCCTTGTTTTACGCACAGTCTATCCACATGTAGATAGACTGTTTTTACATCTTTCAA
CGGGGTTATCCACATATCCA

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MENISDLWNSALKELEKKVSKPSYETWLKSTTAHNLKKDVLTITAPNEFARDWLESHYSELISETLYDLTGAKLAIRFII
PQSQAEEEIDLPPAKPNAAQDDSNHLPQSMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL
MHAIGHYVIEHNPNAKVVYLSSEKFTNEFINSIRDNKAVDFRNKYRNVDVLLIDDIQFLAGKEQTQEEFFHTFNALHEES
KQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPPDLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALI
RVVAYSSLINKDINADLAAEALKDIIPNSKPKIISIYDIQKAVGDVYQVKLEDFKAKKRTKSVAFPRQIAMYLSRELTDS
SLPKIGEEFGGRDHTTVIHAHEKISKLLKTDTQLQKQVEEINDILK

Sequences:

>Translated_446_residues
MENISDLWNSALKELEKKVSKPSYETWLKSTTAHNLKKDVLTITAPNEFARDWLESHYSELISETLYDLTGAKLAIRFII
PQSQAEEEIDLPPAKPNAAQDDSNHLPQSMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL
MHAIGHYVIEHNPNAKVVYLSSEKFTNEFINSIRDNKAVDFRNKYRNVDVLLIDDIQFLAGKEQTQEEFFHTFNALHEES
KQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPPDLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALI
RVVAYSSLINKDINADLAAEALKDIIPNSKPKIISIYDIQKAVGDVYQVKLEDFKAKKRTKSVAFPRQIAMYLSRELTDS
SLPKIGEEFGGRDHTTVIHAHEKISKLLKTDTQLQKQVEEINDILK
>Mature_446_residues
MENISDLWNSALKELEKKVSKPSYETWLKSTTAHNLKKDVLTITAPNEFARDWLESHYSELISETLYDLTGAKLAIRFII
PQSQAEEEIDLPPAKPNAAQDDSNHLPQSMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL
MHAIGHYVIEHNPNAKVVYLSSEKFTNEFINSIRDNKAVDFRNKYRNVDVLLIDDIQFLAGKEQTQEEFFHTFNALHEES
KQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPPDLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALI
RVVAYSSLINKDINADLAAEALKDIIPNSKPKIISIYDIQKAVGDVYQVKLEDFKAKKRTKSVAFPRQIAMYLSRELTDS
SLPKIGEEFGGRDHTTVIHAHEKISKLLKTDTQLQKQVEEINDILK

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=445, Percent_Identity=44.4943820224719, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI226510964, Length=201, Percent_Identity=24.8756218905473, Blast_Score=72, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_BACAA (C3P8P5)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002864658.1
- ProteinModelPortal:   C3P8P5
- EnsemblBacteria:   EBBACT00000130583
- GeneID:   7851992
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_0001
- GeneTree:   EBGT00050000000588
- ProtClustDB:   PRK00149
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 50495; Mature: 50495

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENISDLWNSALKELEKKVSKPSYETWLKSTTAHNLKKDVLTITAPNEFARDWLESHYSE
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHH
LISETLYDLTGAKLAIRFIIPQSQAEEEIDLPPAKPNAAQDDSNHLPQSMLNPKYTFDTF
HHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCEEEEEE
VIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAIGHYVIEHNPNAKVVYL
EEECCCCHHHHHHHHHHHCCHHHCCCEEEECCCCCCHHHHHHHHHHHHEEECCCEEEEEE
SSEKFTNEFINSIRDNKAVDFRNKYRNVDVLLIDDIQFLAGKEQTQEEFFHTFNALHEES
CCHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEECCHHHHHCCHHHHHHHHHHHHHHHHCC
KQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPPDLETRIAILRKKAKAEGLDIPNEV
CEEEEECCCCCCCCCCHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHCCCCCCHHH
MLYIANQIDSNIRELEGALIRVVAYSSLINKDINADLAAEALKDIIPNSKPKIISIYDIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEHHH
KAVGDVYQVKLEDFKAKKRTKSVAFPRQIAMYLSRELTDSSLPKIGEEFGGRDHTTVIHA
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEH
HEKISKLLKTDTQLQKQVEEINDILK
HHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MENISDLWNSALKELEKKVSKPSYETWLKSTTAHNLKKDVLTITAPNEFARDWLESHYSE
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHH
LISETLYDLTGAKLAIRFIIPQSQAEEEIDLPPAKPNAAQDDSNHLPQSMLNPKYTFDTF
HHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCEEEEEE
VIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAIGHYVIEHNPNAKVVYL
EEECCCCHHHHHHHHHHHCCHHHCCCEEEECCCCCCHHHHHHHHHHHHEEECCCEEEEEE
SSEKFTNEFINSIRDNKAVDFRNKYRNVDVLLIDDIQFLAGKEQTQEEFFHTFNALHEES
CCHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEECCHHHHHCCHHHHHHHHHHHHHHHHCC
KQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPPDLETRIAILRKKAKAEGLDIPNEV
CEEEEECCCCCCCCCCHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHCCCCCCHHH
MLYIANQIDSNIRELEGALIRVVAYSSLINKDINADLAAEALKDIIPNSKPKIISIYDIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEHHH
KAVGDVYQVKLEDFKAKKRTKSVAFPRQIAMYLSRELTDSSLPKIGEEFGGRDHTTVIHA
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEH
HEKISKLLKTDTQLQKQVEEINDILK
HHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA