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The map label for this gene is dsbD [H]

Identifier: 46447479

GI number: 46447479

Start: 2205325

End: 2207568

Strand: Reverse

Name: dsbD [H]

Synonym: pc1845

Alternate gene names: 46447479

Gene position: 2207568-2205325 (Counterclockwise)

Preceding gene: 46447488

Following gene: 46447478

Centisome position: 91.43

GC content: 38.37

Gene sequence:

>2244_bases
ATGAACAATTATATTCGTTTCTTTTTATTATTAATTGGGTTTGCTTCCCCCCTACCGTCTTTTGCCACATTCGAAGGTTC
TGCCCATGTACAAGTTCAGTTAATTCAAGAAGAAGAGACAATTCAGCCAGGCCATCCTTTTTGGGTTGCCCTTCATCTTA
AAATCGAAGATGATTGGCACGTGTACTGGAAAAATCCGGGGGATGCGGGAATACCATTAAAAGTTGAGTGGACATTACCT
CTCGGGTTTGAAGTGGGGCCTTTACAATGGCCTTTTCCTGGAAAATTTAAGGTGGCTGATATGGTGGGATTTGGATATGA
AGGAGAAGTTGTCCTACTAAGTTTAATTACCCCTCCTGCTAATCTCTCTATTGGACAAACTTTCCAATTGAATGCTAAAC
TCAAATGGCTTGTTTGTTCAGATCTTACGTGTCAGCCAGGATCAACAACGACAGCTCTTCAAGTTGTCACTCAAAATGAT
GCGCCAAAATTAAAAACTGAAACGGCTACTCTTTTTTCCCAAGCACGTTTGAAAATTCCCAGTTTTCATGCAGAAGTAAA
AACTGTGCGTAAATCAGGAATTGTCCAAATTGAAATGCCTCACGCGAATCAAATACCAAATGTTGACCCCGTTATTGGAG
TTTATTTTTTTCCTGAAGAAAAGGATGTTATTGATTATAAAGTTGATCCTGTTCTTGCTGCTGCTTCTAAGCAAGATCAG
CGATTTTTAGTCAATTTAAAAGGAAGCGATGAGATTGGGGCTAAAAGTCAGACTTTAAAAGGTGTTTTGGTGGTGCATAC
TCAGCAAGGGAATGAAGAAAGTGTCCAAGCTTTTGATATAGATACACCAATCCACGAAGTTGGCGAAAAAGAGTTAATCA
GTCATTTGGACACTCACTCGATAAGATCTTCCACGCTTGAAATGGAAACTCAAAAAACCCAAGCATCATCTTTTGAGTTT
GAAGGAGGAATTGCTCTTGCTCTTTTATTTGCTTTTTTAGGGGGGATGATTCTAAATTTAATGCCTTGCGTTTTACCTGT
TATGTCATTCAAAGTGATGAGCTTTGTTAAAATGGCCGGTCAAAGTCGTTCTTTAACGATCAAACATGGTTTAATGTTTT
CTTTAGGAGTCATTCTCTCATTTTGGCTATTAGCTTCTGCAATGCTAACTCTACGTGCTTATGGTCAAGCTGTGGGTTGG
GGATTTCAATTGCAAGAGCCTATTTTTGTGGTTATTTTAGCCTCTGTTTTATTTATATTTGCATTGAGTTTATTTGGACT
TTTTGAGTGGGGAATGTTTTTTGCTTCTTGGGCGGGGCAGACGCAAGCTGAAAAAGCAACTCAATGGTCTGGTTACATGG
GTTCTTTCTTAAGTGGAGTTTTAGCAACAGCTGTTGCTACACCTTGCACAGGGCCTTTTTTAGGCTCTGCTGTGGGATTT
GCTGTCACATTACCTGTTTTTCAATCATTACTAATTTTTACATTGCTTGGATTAGGAATGTGCTTTCCTTATTTATTACT
TGCTAGTTTTCCCGCTTTTTTGCGGTTTATGCCCAAACCTGGTCCATGGATGGAAACTTTTAAAGAACTTATGGGATTTG
TTTTACTAATCACTGTCTTATGGTTAATGTGGGTATTTAGTGCACAGACAAATACTTTTTCTCTTATTTGCTTAATAGCT
GGTTTCTTGAGCTTTGCTATAGGAGCTTGGATTTATGGGAAAGGGAGTCATCCTCTTATAAGTTCAAAAAAGCGAATAAT
CGCTTATGTCACCGCCTTATTCTTCATCTTAATGGGTATAGAAGCTATTATTTTACCAAAAGATTCGTGGAATGATAGTT
CAACTTTTTCTCAGATTGGAAATGCAGAGTGGGCTGGATGGGAGGTATTTTCACCGGAACGAGTTGCCGAATTAAGAAAA
CAAGGAAGACCTGTTCTGATTGATTTTACCGCTAAATGGTGTTTGATTTGTCAGGCCAATCATATCGTTTTAGGTTCTAA
AGAAGTTGATAAAAAACTTTCGGAAAAAGGTGTTGTTAAAATGATAGCCGATTGGACCAAGAATGATCCAGTGATTACTG
AGGCTTTGAGCCAATTTGGACGCAATAGTGTGCCCCTCTATGTTTTTTATGGAAGTGATCAGAAGCAAGAGCCTACTATT
TTACCTCAAGTACTCACTTCTGATATTGTCAAAGAACACATTAATTCAGTTTTGAATTCTAAAGAGGTAGCATGGATAGA
ATGA

Upstream 100 bases:

>100_bases
TTTGACTTTCAAAGAATAAACAAAACTCACGCAAAGTGAAATTTCATCCCCCTTCATTTGAAAGGCTTCAATAAGCCGTA
TAAAGCCAGGAGATGTTTGA

Downstream 100 bases:

>100_bases
GCTATTCTCTTTCATTTATTGACTCTCACGCCCATTTAACAAGTTCTCCTGTTTACGAACAAATCGATGTTCTTTTGGAA
AGAGCGCAAAAAGAGCACGT

Product: putative thiol-disulfide interchange protein

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 747; Mature: 747

Protein sequence:

>747_residues
MNNYIRFFLLLIGFASPLPSFATFEGSAHVQVQLIQEEETIQPGHPFWVALHLKIEDDWHVYWKNPGDAGIPLKVEWTLP
LGFEVGPLQWPFPGKFKVADMVGFGYEGEVVLLSLITPPANLSIGQTFQLNAKLKWLVCSDLTCQPGSTTTALQVVTQND
APKLKTETATLFSQARLKIPSFHAEVKTVRKSGIVQIEMPHANQIPNVDPVIGVYFFPEEKDVIDYKVDPVLAAASKQDQ
RFLVNLKGSDEIGAKSQTLKGVLVVHTQQGNEESVQAFDIDTPIHEVGEKELISHLDTHSIRSSTLEMETQKTQASSFEF
EGGIALALLFAFLGGMILNLMPCVLPVMSFKVMSFVKMAGQSRSLTIKHGLMFSLGVILSFWLLASAMLTLRAYGQAVGW
GFQLQEPIFVVILASVLFIFALSLFGLFEWGMFFASWAGQTQAEKATQWSGYMGSFLSGVLATAVATPCTGPFLGSAVGF
AVTLPVFQSLLIFTLLGLGMCFPYLLLASFPAFLRFMPKPGPWMETFKELMGFVLLITVLWLMWVFSAQTNTFSLICLIA
GFLSFAIGAWIYGKGSHPLISSKKRIIAYVTALFFILMGIEAIILPKDSWNDSSTFSQIGNAEWAGWEVFSPERVAELRK
QGRPVLIDFTAKWCLICQANHIVLGSKEVDKKLSEKGVVKMIADWTKNDPVITEALSQFGRNSVPLYVFYGSDQKQEPTI
LPQVLTSDIVKEHINSVLNSKEVAWIE

Sequences:

>Translated_747_residues
MNNYIRFFLLLIGFASPLPSFATFEGSAHVQVQLIQEEETIQPGHPFWVALHLKIEDDWHVYWKNPGDAGIPLKVEWTLP
LGFEVGPLQWPFPGKFKVADMVGFGYEGEVVLLSLITPPANLSIGQTFQLNAKLKWLVCSDLTCQPGSTTTALQVVTQND
APKLKTETATLFSQARLKIPSFHAEVKTVRKSGIVQIEMPHANQIPNVDPVIGVYFFPEEKDVIDYKVDPVLAAASKQDQ
RFLVNLKGSDEIGAKSQTLKGVLVVHTQQGNEESVQAFDIDTPIHEVGEKELISHLDTHSIRSSTLEMETQKTQASSFEF
EGGIALALLFAFLGGMILNLMPCVLPVMSFKVMSFVKMAGQSRSLTIKHGLMFSLGVILSFWLLASAMLTLRAYGQAVGW
GFQLQEPIFVVILASVLFIFALSLFGLFEWGMFFASWAGQTQAEKATQWSGYMGSFLSGVLATAVATPCTGPFLGSAVGF
AVTLPVFQSLLIFTLLGLGMCFPYLLLASFPAFLRFMPKPGPWMETFKELMGFVLLITVLWLMWVFSAQTNTFSLICLIA
GFLSFAIGAWIYGKGSHPLISSKKRIIAYVTALFFILMGIEAIILPKDSWNDSSTFSQIGNAEWAGWEVFSPERVAELRK
QGRPVLIDFTAKWCLICQANHIVLGSKEVDKKLSEKGVVKMIADWTKNDPVITEALSQFGRNSVPLYVFYGSDQKQEPTI
LPQVLTSDIVKEHINSVLNSKEVAWIE
>Mature_747_residues
MNNYIRFFLLLIGFASPLPSFATFEGSAHVQVQLIQEEETIQPGHPFWVALHLKIEDDWHVYWKNPGDAGIPLKVEWTLP
LGFEVGPLQWPFPGKFKVADMVGFGYEGEVVLLSLITPPANLSIGQTFQLNAKLKWLVCSDLTCQPGSTTTALQVVTQND
APKLKTETATLFSQARLKIPSFHAEVKTVRKSGIVQIEMPHANQIPNVDPVIGVYFFPEEKDVIDYKVDPVLAAASKQDQ
RFLVNLKGSDEIGAKSQTLKGVLVVHTQQGNEESVQAFDIDTPIHEVGEKELISHLDTHSIRSSTLEMETQKTQASSFEF
EGGIALALLFAFLGGMILNLMPCVLPVMSFKVMSFVKMAGQSRSLTIKHGLMFSLGVILSFWLLASAMLTLRAYGQAVGW
GFQLQEPIFVVILASVLFIFALSLFGLFEWGMFFASWAGQTQAEKATQWSGYMGSFLSGVLATAVATPCTGPFLGSAVGF
AVTLPVFQSLLIFTLLGLGMCFPYLLLASFPAFLRFMPKPGPWMETFKELMGFVLLITVLWLMWVFSAQTNTFSLICLIA
GFLSFAIGAWIYGKGSHPLISSKKRIIAYVTALFFILMGIEAIILPKDSWNDSSTFSQIGNAEWAGWEVFSPERVAELRK
QGRPVLIDFTAKWCLICQANHIVLGSKEVDKKLSEKGVVKMIADWTKNDPVITEALSQFGRNSVPLYVFYGSDQKQEPTI
LPQVLTSDIVKEHINSVLNSKEVAWIE

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=408, Percent_Identity=25.4901960784314, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 82761; Mature: 82761

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNYIRFFLLLIGFASPLPSFATFEGSAHVQVQLIQEEETIQPGHPFWVALHLKIEDDWH
CCHHHHHHHHHHHHHCCCCCCEECCCCCEEEEEEEECCCCCCCCCCEEEEEEEEECCCEE
VYWKNPGDAGIPLKVEWTLPLGFEVGPLQWPFPGKFKVADMVGFGYEGEVVLLSLITPPA
EEECCCCCCCCCEEEEEEEECCCEECCCCCCCCCCEEEEHHCCCCCCCCEEEEEEECCCC
NLSIGQTFQLNAKLKWLVCSDLTCQPGSTTTALQVVTQNDAPKLKTETATLFSQARLKIP
CCCCCCEEEECCEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCC
SFHAEVKTVRKSGIVQIEMPHANQIPNVDPVIGVYFFPEEKDVIDYKVDPVLAAASKQDQ
CHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCEEEECCCHHHHCCCCCC
RFLVNLKGSDEIGAKSQTLKGVLVVHTQQGNEESVQAFDIDTPIHEVGEKELISHLDTHS
EEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCHHHCCHHHHHHHHHHHH
IRSSTLEMETQKTQASSFEFEGGIALALLFAFLGGMILNLMPCVLPVMSFKVMSFVKMAG
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QSRSLTIKHGLMFSLGVILSFWLLASAMLTLRAYGQAVGWGFQLQEPIFVVILASVLFIF
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
ALSLFGLFEWGMFFASWAGQTQAEKATQWSGYMGSFLSGVLATAVATPCTGPFLGSAVGF
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
AVTLPVFQSLLIFTLLGLGMCFPYLLLASFPAFLRFMPKPGPWMETFKELMGFVLLITVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
WLMWVFSAQTNTFSLICLIAGFLSFAIGAWIYGKGSHPLISSKKRIIAYVTALFFILMGI
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCHHCCHHHHHHHHHHHHHHHCC
EAIILPKDSWNDSSTFSQIGNAEWAGWEVFSPERVAELRKQGRPVLIDFTAKWCLICQAN
CEEEECCCCCCCCHHHHHCCCCCCCCEECCCHHHHHHHHHCCCCEEEEECCCEEEEEECC
HIVLGSKEVDKKLSEKGVVKMIADWTKNDPVITEALSQFGRNSVPLYVFYGSDQKQEPTI
EEEECCHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCH
LPQVLTSDIVKEHINSVLNSKEVAWIE
HHHHHHHHHHHHHHHHHHCCCCEEEEC
>Mature Secondary Structure
MNNYIRFFLLLIGFASPLPSFATFEGSAHVQVQLIQEEETIQPGHPFWVALHLKIEDDWH
CCHHHHHHHHHHHHHCCCCCCEECCCCCEEEEEEEECCCCCCCCCCEEEEEEEEECCCEE
VYWKNPGDAGIPLKVEWTLPLGFEVGPLQWPFPGKFKVADMVGFGYEGEVVLLSLITPPA
EEECCCCCCCCCEEEEEEEECCCEECCCCCCCCCCEEEEHHCCCCCCCCEEEEEEECCCC
NLSIGQTFQLNAKLKWLVCSDLTCQPGSTTTALQVVTQNDAPKLKTETATLFSQARLKIP
CCCCCCEEEECCEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCC
SFHAEVKTVRKSGIVQIEMPHANQIPNVDPVIGVYFFPEEKDVIDYKVDPVLAAASKQDQ
CHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCEEEECCCHHHHCCCCCC
RFLVNLKGSDEIGAKSQTLKGVLVVHTQQGNEESVQAFDIDTPIHEVGEKELISHLDTHS
EEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCHHHCCHHHHHHHHHHHH
IRSSTLEMETQKTQASSFEFEGGIALALLFAFLGGMILNLMPCVLPVMSFKVMSFVKMAG
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QSRSLTIKHGLMFSLGVILSFWLLASAMLTLRAYGQAVGWGFQLQEPIFVVILASVLFIF
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
ALSLFGLFEWGMFFASWAGQTQAEKATQWSGYMGSFLSGVLATAVATPCTGPFLGSAVGF
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
AVTLPVFQSLLIFTLLGLGMCFPYLLLASFPAFLRFMPKPGPWMETFKELMGFVLLITVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
WLMWVFSAQTNTFSLICLIAGFLSFAIGAWIYGKGSHPLISSKKRIIAYVTALFFILMGI
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCHHCCHHHHHHHHHHHHHHHCC
EAIILPKDSWNDSSTFSQIGNAEWAGWEVFSPERVAELRKQGRPVLIDFTAKWCLICQAN
CEEEECCCCCCCCHHHHHCCCCCCCCEECCCHHHHHHHHHCCCCEEEEECCCEEEEEECC
HIVLGSKEVDKKLSEKGVVKMIADWTKNDPVITEALSQFGRNSVPLYVFYGSDQKQEPTI
EEEECCHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCH
LPQVLTSDIVKEHINSVLNSKEVAWIE
HHHHHHHHHHHHHHHHHHCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]