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The map label for this gene is hemL

Identifier: 46447382

GI number: 46447382

Start: 2087714

End: 2089012

Strand: Reverse

Name: hemL

Synonym: pc1748

Alternate gene names: 46447382

Gene position: 2089012-2087714 (Counterclockwise)

Preceding gene: 46447390

Following gene: 46447379

Centisome position: 86.52

GC content: 39.03

Gene sequence:

>1299_bases
ATGATTAGCCGTCCCATCAGCCAACAAATTTATTCAAACTTAAATCGAGTCATTCCTGGGGGCGTTAATTCTCCAGTTCG
AGCCTGCGCTAATATGGGACAAATTCCGATGATCATCGATCATGCCTATCGTGATACTTTAGTGGATGTGGATGGAAAAA
CTTACGTTGATTATTGTGGGTCTTGGGGAGCTTTAATTCACGGCCATGCGCATCCATCTATTCTTGAAGCTGTGCAACAA
CGAATGAAAAAAGGAACCAGTTTTGGGATTACCACGTCTATTGAGGGGGAACTCGCTCAAGAAGTCATTAAATTAATTGA
TTCAGTCGAAAAAATTAGATTTGTTTCGTCGGGAACTGAAGCAACCATGAGTGCGGTTCGCTTAGCGCGTGGATATACCA
ATAAAGAATTCATTGTAAAGTTTAACGGTAATTATCATGGACATGCTGATTTTTTTTTAGTTCAGGCGGGATCCGGTGTT
TTAGAAGTTTCTCCCTCAGCCTCATCCGCAGGGATTCCTGCTGATATTGTTAAACAAACACTATGTTTACCTTATAATGA
TATTGAAGCTTGCCGCCAGATCTTTCATCATTCCGATTATCGACATAAAATAGCAGCTATTATTTTAGAACCTATTGCAG
GAAATATGGGAGTTATTCCAGCTTCTCAAGAATTTATGCAGTTTTTGAGGAAAGAAACTTTAGCGATGGGAGCGTTACTG
ATTTTTGATGAGGTCATGACTGGATTTAGAGTCGCCTTGAAAGGAGCACAGGACATTTACCCTGTTGAACCTGATTTAAC
TTGTTTTGGTAAAATTATAGGAGGCGGATTTCCCGCGGCTGCTTTTGGCGGCCGAGAAGAGATTATGAATCTGTTAGCCC
CGTTAGGCTCTGTTTATCAAGCCGGGACACTTTCTGGTAACCCCATAGCAATGGAAGCTGGCTTGCAAAGCTTACGTTTA
ATTCAACAACCGGGTTTTTACGAAGAATTGCACAGAAAAACAGATTTACTTTTAAACCCTATTAAAGAAACCATTAAAAA
AAACAATTGGCCAATTTGTATTCAACAAGCCGGATCCATGTTTACTTTGTTTTTCTGTAAAAATAGAGTCCGTAACTTAG
AAGATGCACTGAAAGCGAACACAACTATTTTTGCAAACTTTTTCAGAAAGCTATTTGATCAAGGCATTTATATCCCTCCT
TCTCAGCATGAAGCTTGGTTTATTTCTCAAGCTCATGAAGAGTCTAATTTAATCAAAACGCAATCTGCCATTTTGACTTT
TTTAGAAGAAAATTTTTAG

Upstream 100 bases:

>100_bases
CTTCTAGCTTACAATTTTATATGCATAATTCTTGCGATTTTATAAGCTTTGAACAATAAATTAAACCCCGATTTTGTTTT
TTAATTCTATGGTAAGTGAT

Downstream 100 bases:

>100_bases
AAATTAATCGTTTAATTTTAATATTGCCATTAAATTGTCAGCCAGAAAATATTCAGAAAATAAATATTTATGATGAGAGG
AATAGAAAAATTTGGGCATC

Product: glutamate-1-semialdehyde 2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MISRPISQQIYSNLNRVIPGGVNSPVRACANMGQIPMIIDHAYRDTLVDVDGKTYVDYCGSWGALIHGHAHPSILEAVQQ
RMKKGTSFGITTSIEGELAQEVIKLIDSVEKIRFVSSGTEATMSAVRLARGYTNKEFIVKFNGNYHGHADFFLVQAGSGV
LEVSPSASSAGIPADIVKQTLCLPYNDIEACRQIFHHSDYRHKIAAIILEPIAGNMGVIPASQEFMQFLRKETLAMGALL
IFDEVMTGFRVALKGAQDIYPVEPDLTCFGKIIGGGFPAAAFGGREEIMNLLAPLGSVYQAGTLSGNPIAMEAGLQSLRL
IQQPGFYEELHRKTDLLLNPIKETIKKNNWPICIQQAGSMFTLFFCKNRVRNLEDALKANTTIFANFFRKLFDQGIYIPP
SQHEAWFISQAHEESNLIKTQSAILTFLEENF

Sequences:

>Translated_432_residues
MISRPISQQIYSNLNRVIPGGVNSPVRACANMGQIPMIIDHAYRDTLVDVDGKTYVDYCGSWGALIHGHAHPSILEAVQQ
RMKKGTSFGITTSIEGELAQEVIKLIDSVEKIRFVSSGTEATMSAVRLARGYTNKEFIVKFNGNYHGHADFFLVQAGSGV
LEVSPSASSAGIPADIVKQTLCLPYNDIEACRQIFHHSDYRHKIAAIILEPIAGNMGVIPASQEFMQFLRKETLAMGALL
IFDEVMTGFRVALKGAQDIYPVEPDLTCFGKIIGGGFPAAAFGGREEIMNLLAPLGSVYQAGTLSGNPIAMEAGLQSLRL
IQQPGFYEELHRKTDLLLNPIKETIKKNNWPICIQQAGSMFTLFFCKNRVRNLEDALKANTTIFANFFRKLFDQGIYIPP
SQHEAWFISQAHEESNLIKTQSAILTFLEENF
>Mature_432_residues
MISRPISQQIYSNLNRVIPGGVNSPVRACANMGQIPMIIDHAYRDTLVDVDGKTYVDYCGSWGALIHGHAHPSILEAVQQ
RMKKGTSFGITTSIEGELAQEVIKLIDSVEKIRFVSSGTEATMSAVRLARGYTNKEFIVKFNGNYHGHADFFLVQAGSGV
LEVSPSASSAGIPADIVKQTLCLPYNDIEACRQIFHHSDYRHKIAAIILEPIAGNMGVIPASQEFMQFLRKETLAMGALL
IFDEVMTGFRVALKGAQDIYPVEPDLTCFGKIIGGGFPAAAFGGREEIMNLLAPLGSVYQAGTLSGNPIAMEAGLQSLRL
IQQPGFYEELHRKTDLLLNPIKETIKKNNWPICIQQAGSMFTLFFCKNRVRNLEDALKANTTIFANFFRKLFDQGIYIPP
SQHEAWFISQAHEESNLIKTQSAILTFLEENF

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=362, Percent_Identity=26.7955801104972, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI13994255, Length=327, Percent_Identity=26.605504587156, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI37574042, Length=340, Percent_Identity=25.8823529411765, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI226442709, Length=308, Percent_Identity=25.974025974026, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI226442705, Length=339, Percent_Identity=25.9587020648968, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI284507298, Length=276, Percent_Identity=26.4492753623188, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1786349, Length=418, Percent_Identity=49.0430622009569, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1789016, Length=354, Percent_Identity=31.9209039548023, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI1788044, Length=314, Percent_Identity=34.3949044585987, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1789759, Length=305, Percent_Identity=31.8032786885246, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI145693181, Length=338, Percent_Identity=27.810650887574, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1787560, Length=337, Percent_Identity=27.893175074184, Blast_Score=115, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI25144271, Length=329, Percent_Identity=27.0516717325228, Blast_Score=104, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6324432, Length=340, Percent_Identity=26.4705882352941, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323470, Length=389, Percent_Identity=24.1645244215938, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357415, Length=301, Percent_Identity=26.9102990033223, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI161085790, Length=336, Percent_Identity=26.7857142857143, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI28574759, Length=336, Percent_Identity=26.7857142857143, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21356575, Length=381, Percent_Identity=23.8845144356955, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_PARUW (Q6MAC7)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_008747.1
- ProteinModelPortal:   Q6MAC7
- SMR:   Q6MAC7
- STRING:   Q6MAC7
- GeneID:   2781344
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc1748
- NMPDR:   fig|264201.1.peg.1748
- eggNOG:   COG0001
- HOGENOM:   HBG725944
- OMA:   HANEKIV
- PhylomeDB:   Q6MAC7
- ProtClustDB:   CLSK2762480
- BioCyc:   CPRO264201:PC1748-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 47739; Mature: 47739

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISRPISQQIYSNLNRVIPGGVNSPVRACANMGQIPMIIDHAYRDTLVDVDGKTYVDYCG
CCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHCEEECCCCHHHHHCC
SWGALIHGHAHPSILEAVQQRMKKGTSFGITTSIEGELAQEVIKLIDSVEKIRFVSSGTE
CCCCEEECCCCHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCCHH
ATMSAVRLARGYTNKEFIVKFNGNYHGHADFFLVQAGSGVLEVSPSASSAGIPADIVKQT
HHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEECCCCEEEECCCCCCCCCCHHHHHHH
LCLPYNDIEACRQIFHHSDYRHKIAAIILEPIAGNMGVIPASQEFMQFLRKETLAMGALL
HCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
IFDEVMTGFRVALKGAQDIYPVEPDLTCFGKIIGGGFPAAAFGGREEIMNLLAPLGSVYQ
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHH
AGTLSGNPIAMEAGLQSLRLIQQPGFYEELHRKTDLLLNPIKETIKKNNWPICIQQAGSM
CCCCCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCE
FTLFFCKNRVRNLEDALKANTTIFANFFRKLFDQGIYIPPSQHEAWFISQAHEESNLIKT
EEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHH
QSAILTFLEENF
HHHHHHHHHHCC
>Mature Secondary Structure
MISRPISQQIYSNLNRVIPGGVNSPVRACANMGQIPMIIDHAYRDTLVDVDGKTYVDYCG
CCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHCEEECCCCHHHHHCC
SWGALIHGHAHPSILEAVQQRMKKGTSFGITTSIEGELAQEVIKLIDSVEKIRFVSSGTE
CCCCEEECCCCHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCCHH
ATMSAVRLARGYTNKEFIVKFNGNYHGHADFFLVQAGSGVLEVSPSASSAGIPADIVKQT
HHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEECCCCEEEECCCCCCCCCCHHHHHHH
LCLPYNDIEACRQIFHHSDYRHKIAAIILEPIAGNMGVIPASQEFMQFLRKETLAMGALL
HCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
IFDEVMTGFRVALKGAQDIYPVEPDLTCFGKIIGGGFPAAAFGGREEIMNLLAPLGSVYQ
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHH
AGTLSGNPIAMEAGLQSLRLIQQPGFYEELHRKTDLLLNPIKETIKKNNWPICIQQAGSM
CCCCCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCE
FTLFFCKNRVRNLEDALKANTTIFANFFRKLFDQGIYIPPSQHEAWFISQAHEESNLIKT
EEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHH
QSAILTFLEENF
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA