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The map label for this gene is nrdB [H]

Identifier: 46446983

GI number: 46446983

Start: 1612788

End: 1613759

Strand: Reverse

Name: nrdB [H]

Synonym: pc1349

Alternate gene names: 46446983

Gene position: 1613759-1612788 (Counterclockwise)

Preceding gene: 46446984

Following gene: 46446982

Centisome position: 66.84

GC content: 36.52

Gene sequence:

>972_bases
ATGCAGGTGACTGAACCTATATTGCGAGAAAATAAAGATCGTTTTGTTCTTTTCCCTATTAATCATGCCGAAATTTGGCA
AATGTACAAAAAAGCAGAAGCGAGTTTTTGGACAGCAGAAGAAATTGATTTAACTTCTGATCTTTTAGATTGGGACCGTA
AGCTTAACAACGATGAAAAATATTTCATCAAACACATACTAGCATTTTTTGCAGCCAGTGATGGAATTGTCAATGAAAAT
TTAGCCGTTAATTTCATGAGTGAGGTGCAATATCCGGAAGCGCGTTGTTTTTATGGTTTTCAAATTATGATGGAAAATAT
TCATTCAGAGGCATATTCGTTGCTAATTGATACTTATATTAAAGATCCTACTGATAAAAATCGACTCTTCAAAGCTTTAG
AAACAATCCCATGCATCTCAAATAAGGCTGATTGGGCATTGAGATGGATTTCGCAAGGGAGTTTTAGTGAGCGTCTAGTC
GCTTTCGCTGCTGTGGAAGGAATCTTTTTTTCGGGGAGTTTTTGTTCTATTTTTTGGCTTAAAAAACGAGGGTTAATGCC
TGGATTAAGTTTTGCTAATGAACTAATTTCAAGAGATGAGGGGCTTCATTGTGATTTTGCTTGCCTGCTTTATTCTCAGC
TTAACAATAAACTTCCTTTAGAAACGCTTCAGGCTATTATTTCGCATGCGGTGGCTATTGAAAAGGAATTTGTACAAGAT
GCACTTCCCGTTCGCTTAATTGGAATGAATGCCACTCTCATGTGTCAATATATTGAATTTGTTGCTGACCGTCTTCTGGT
TGCACTTGGATCTCCTAAGTTGTACAACGTTGACAATCCATTTGATTTTATGGATCTGATTTCCATGCCGGGGAAAACAA
ATTTTTTCGAAAGGCGGGTATCAGAATATCAAAAATCAGGAGTGATGTCAACGAAAGAAAATCATGTATTTACCATTCAC
GAAGATTTTTAA

Upstream 100 bases:

>100_bases
TTCTTGCACGCTCTTTTCCCTTTTGTCATTTTTTTAATGTACTCATGCTATTTCAAAATAGCGATGGAACTGTATTGCTT
TAATTTAAAAGGAATTTTTT

Downstream 100 bases:

>100_bases
GGGAGTAAATCATGTTTGTTACTAAACGAGACGGACGTAAACAAGAAGTTAAATTTGATAAAATTACAGCTCGCATTCTC
AAGCTTTGCTATGGGCTAGA

Product: ribonucleoside-diphosphate reductase small chain

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MQVTEPILRENKDRFVLFPINHAEIWQMYKKAEASFWTAEEIDLTSDLLDWDRKLNNDEKYFIKHILAFFAASDGIVNEN
LAVNFMSEVQYPEARCFYGFQIMMENIHSEAYSLLIDTYIKDPTDKNRLFKALETIPCISNKADWALRWISQGSFSERLV
AFAAVEGIFFSGSFCSIFWLKKRGLMPGLSFANELISRDEGLHCDFACLLYSQLNNKLPLETLQAIISHAVAIEKEFVQD
ALPVRLIGMNATLMCQYIEFVADRLLVALGSPKLYNVDNPFDFMDLISMPGKTNFFERRVSEYQKSGVMSTKENHVFTIH
EDF

Sequences:

>Translated_323_residues
MQVTEPILRENKDRFVLFPINHAEIWQMYKKAEASFWTAEEIDLTSDLLDWDRKLNNDEKYFIKHILAFFAASDGIVNEN
LAVNFMSEVQYPEARCFYGFQIMMENIHSEAYSLLIDTYIKDPTDKNRLFKALETIPCISNKADWALRWISQGSFSERLV
AFAAVEGIFFSGSFCSIFWLKKRGLMPGLSFANELISRDEGLHCDFACLLYSQLNNKLPLETLQAIISHAVAIEKEFVQD
ALPVRLIGMNATLMCQYIEFVADRLLVALGSPKLYNVDNPFDFMDLISMPGKTNFFERRVSEYQKSGVMSTKENHVFTIH
EDF
>Mature_323_residues
MQVTEPILRENKDRFVLFPINHAEIWQMYKKAEASFWTAEEIDLTSDLLDWDRKLNNDEKYFIKHILAFFAASDGIVNEN
LAVNFMSEVQYPEARCFYGFQIMMENIHSEAYSLLIDTYIKDPTDKNRLFKALETIPCISNKADWALRWISQGSFSERLV
AFAAVEGIFFSGSFCSIFWLKKRGLMPGLSFANELISRDEGLHCDFACLLYSQLNNKLPLETLQAIISHAVAIEKEFVQD
ALPVRLIGMNATLMCQYIEFVADRLLVALGSPKLYNVDNPFDFMDLISMPGKTNFFERRVSEYQKSGVMSTKENHVFTIH
EDF

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI4557845, Length=321, Percent_Identity=67.601246105919, Blast_Score=457, Evalue=1e-129,
Organism=Homo sapiens, GI260064013, Length=321, Percent_Identity=67.601246105919, Blast_Score=457, Evalue=1e-129,
Organism=Homo sapiens, GI42544136, Length=321, Percent_Identity=66.6666666666667, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI289177074, Length=321, Percent_Identity=66.6666666666667, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI289177076, Length=296, Percent_Identity=65.2027027027027, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17551968, Length=325, Percent_Identity=64.6153846153846, Blast_Score=426, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI193206379, Length=295, Percent_Identity=55.2542372881356, Blast_Score=313, Evalue=7e-86,
Organism=Caenorhabditis elegans, GI17567153, Length=221, Percent_Identity=53.393665158371, Blast_Score=226, Evalue=9e-60,
Organism=Saccharomyces cerevisiae, GI6322434, Length=328, Percent_Identity=65.2439024390244, Blast_Score=451, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6321619, Length=309, Percent_Identity=50.1618122977346, Blast_Score=308, Evalue=7e-85,
Organism=Drosophila melanogaster, GI18079279, Length=321, Percent_Identity=67.2897196261682, Blast_Score=454, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 37297; Mature: 37297

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00368 RIBORED_SMALL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVTEPILRENKDRFVLFPINHAEIWQMYKKAEASFWTAEEIDLTSDLLDWDRKLNNDEK
CCCCCCHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHH
YFIKHILAFFAASDGIVNENLAVNFMSEVQYPEARCFYGFQIMMENIHSEAYSLLIDTYI
HHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDPTDKNRLFKALETIPCISNKADWALRWISQGSFSERLVAFAAVEGIFFSGSFCSIFWL
CCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHEECCCHHEEEEE
KKRGLMPGLSFANELISRDEGLHCDFACLLYSQLNNKLPLETLQAIISHAVAIEKEFVQD
HHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
ALPVRLIGMNATLMCQYIEFVADRLLVALGSPKLYNVDNPFDFMDLISMPGKTNFFERRV
CCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHCCCCCCHHHHHHH
SEYQKSGVMSTKENHVFTIHEDF
HHHHHCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MQVTEPILRENKDRFVLFPINHAEIWQMYKKAEASFWTAEEIDLTSDLLDWDRKLNNDEK
CCCCCCHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHH
YFIKHILAFFAASDGIVNENLAVNFMSEVQYPEARCFYGFQIMMENIHSEAYSLLIDTYI
HHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDPTDKNRLFKALETIPCISNKADWALRWISQGSFSERLVAFAAVEGIFFSGSFCSIFWL
CCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHEECCCHHEEEEE
KKRGLMPGLSFANELISRDEGLHCDFACLLYSQLNNKLPLETLQAIISHAVAIEKEFVQD
HHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
ALPVRLIGMNATLMCQYIEFVADRLLVALGSPKLYNVDNPFDFMDLISMPGKTNFFERRV
CCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHCCCCCCHHHHHHH
SEYQKSGVMSTKENHVFTIHEDF
HHHHHCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]